MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway by Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

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Development and validation of a deep learning-based pathomics signature for prognosis and chemotherapy benefits in colorectal cancer: a retrospective multicenter cohort study by Shenghan Lou, Yanming Huang, Fenqi Du, Jingmin Xue, Genshen Mo, Hao Li, Zhanjiang Yu, Yuanchun Li, Hang Wang, Yuze Huang, Haonan Xie, Wenjie Song, Xinyue Zhang, Huiying Li, Chun Lou, Peng Han, Peng Han, Peng Han

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Acceptability and adherence to a Mediterranean diet in the postnatal period to prevent type 2 diabetes in women with gestational diabetes in the UK: a protocol for a single-arm fea... by Doris Lanz, Julie Dodds, Graham Hitman, Elena Pizzo, Shakila Thangaratinam, Angeliki Bolou, Zoe Drymoussi, Francisco Jose Gonzalez Carreras, Maria del Carmen Pardo Llorente, Amy Thomas, James Heighway, Anita Sanghi, Angela Harden, Teresa Pérez, Mohammed SB Huda, Anita Mehay, Frances Austin

“…Prior to a full-scale trial on Mediterranean-style diet in the postnatal period to prevent type 2 diabetes, a feasibility study is required to assess the acceptability of the diet and evaluate the trial processes.Methods and analysis MEditerranean diet for pReventIon of type 2 diabeTes is a single-arm feasibility study (65 women) with qualitative evaluation of women who have recently given birth and had gestational diabetes. …”
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Facilitating remote and virtual access provision by European research infrastructures – requirements, issues, and recommendations [version 2; peer review: 1 approved, 2 approved wi... by Ivan Rodero, Menattallah Elserafy, Michael RAESS, Johanna Bischof, Omran Alhaddad, Ayoub El Ghadraoui, John Dolan, Ulla Lächele, Marco Galeotti, Oguz Ozkan, Xavier Meyer, John Shepherdson, Hannele Savela, Valentina Tegas, Vanessa Spadetto, Alen Vodopijevec, Susanne Vainio, Claudia Alen Amaro, Bonnie Wolff-Boenisch, Annika Thies

“…Key issues and recommendations are summed up separately for remote access, virtual access, and remote training, complemented by general recommendations for facilitating remote and virtual access to RIs. …”
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PREdiction and Diagnosis using Imaging and Clinical biomarkers Trial in Traumatic Brain Injury (PREDICT-TBI) study protocol: an observational, prospective, multicentre cohort study... by Siva Senthuran, Lewis Campbell, Jennifer Fleming, Virginia Newcombe, Michael Reade, Silvia Manzanero, James Walsham, Nathan Brown, Xuan Vinh To, Clifford Pollard, Fatima Nasrallah, Judith Bellapart, Esther Jacobson, Jason Meyer, Janine Stuart, Tracey Evans, Shekhar S Chandra, Jason Ross, James McCullough

“…Introduction Traumatic brain injury (TBI) is a heterogeneous condition with a broad spectrum of injury severity, pathophysiological processes and variable outcomes. For moderate-to-severe TBI survivors, recovery is often protracted and outcomes can range from total dependence to full recovery. …”
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Tropospheric NO₂ Column over Tibet Plateau According to Geostationary Environment Monitoring Spectrometer: Spatial, Seasonal, and Diurnal Variations by Xue Zhang, Chunxiang Ye, Jhoon Kim, Hanlim Lee, Junsung Park, Yeonjin Jung, Hyunkee Hong, Weitao Fu, Xicheng Li, Yuyang Chen, Xingyi Wu, Yali Li, Juan Li, Peng Zhang, Zhuoxian Yan, Jiaming Zhang, Song Liu, Lei Zhu

“…GEMS observations revealed that the Ω_NO2 over TP is generally low compared with surrounding regions with significant surface emissions, such as India and the Sichuan basin. …”
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Exploring age-related iron dysregulation: effects on longevity, body size, and behavior in C. elegans by Rola S. Zeidan, Pearl Ebea-Ugwuanyi, Shannon Sykes, Natalia Evripidou, Evelyn Pan, Zachary Markovich, Yi Sheng, Sung Min Han, Christiaan Leeuwenburgh, Rui Xiao

“…This study utilizes the model organism C. elegans to examine the roles of iron regulatory genes throughout different life stages, focusing on their effects on iron homeostasis, longevity, mobility, size, and mechanosensation. Our expression analysis indicated that most iron-related genes are generally upregulated by day 15, with some peaking earlier, suggesting their crucial role in mid-life iron regulation. …”
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The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens by Xia Chen, Ming Kong, Chunxi Ma, Manyu Zhang, Zenglei Hu, Min Gu, Xiaoquan Wang, Ruyi Gao, Shunlin Hu, Yu Chen, Xiaowen Liu, Daxin Peng, Xiufan Liu, Jiao Hu

“…By analysing the polymorphism of this residue in various subtype viruses, we found that PA-X 100 was highly variable in H7N9 viruses. Structural analysis revealed that 100 V was generally close to the PA-X endonuclease active site, which may account for its host shutoff activity. …”
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Lithuania's Poles and Russians: two different perspectives by Virginijus Savukynas

“…At the same time, he says that the analysis of the perspectives of the national groups cannot be assessed adequately without proper analysis of the majority identity. …”
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Inhaled Nitric Oxide ReDuce postoperatIve pulmoNAry complicaTions in patiEnts with recent COVID-19 infection (INORDINATE): protocol for a randomised controlled trial by Hui Zhang, Xiaomei Wang, Xue Yang, Ziyu Zheng, Gang Luo, Qianqian Fan, Huang Nie, Baobao Gao, Lini Wang, Chong Lei, Shuxiu Wang, Bingqing Zhao, Hailong Dong

“…The trial aims to include participants who are planning to undergo surgery with general anaesthesia and have been recently infected with SARS-CoV-2 (within 7 weeks). …”
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Improving health and housing outcomes through a simulation and economic model: an evidence-based protocol of a group model building approach to develop an agent-based model by Danielle M. Kline, Pranav Padmanabhan, Pranav Padmanabhan, Sarah E. Brewer, Sarah E. Brewer, Magdalena Cerdá, Elysia Versen, Katherine M. Keyes, Margot Kushel, Margot Kushel, Margot Kushel, Erin C. Wilson, Paul Wesson, Paul Wesson, Ayaz Hyder, Alaina Boyer, Alia Al-Tayyib, Joshua A. Barocas, Joshua A. Barocas

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Research on Hybrid Architecture Neural Networks for Time Series Prediction by Fujin Zhuang, Xiao Chen, Punyaphol Horata, Khamron Sunat

“…Through comparative analysis of various optimization algorithms’ convergence performance and prediction accuracy, this study found that the AdamW optimizer, with its effective weight decay mechanism and adaptive learning rate, demonstrated superior performance in training stability and generalization capability, with MSE and R2 metrics outperforming traditional optimizers. …”
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Biofilm-Forming Lactic Acid Bacteria in Sausages: Isolation, Characterization, and Inhibition Using <i>Eisenia bicyclis</i>-Based Nanoparticles by Do Kyung Oh, Du-Min Jo, Minji Kim, Jeong-Bin Jo, Ji-Hwan Choi, Jeong Mi Choi, Geum-Jae Jeong, Se Yun Jeong, Fazlurrahman Khan, Young-Mog Kim

“…<b>Results:</b> The PG-AuNPs had an average particle size of 98.74 nm and a zeta potential of −29.82 mV, indicating nanoscale dimensions and considerable colloidal stability. Structural analysis confirmed their spherical form and crystalline structure, as well as the presence of phenolic groups in both reduction and stabilization processes. …”
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Reflections and implementation strategies for constructing a standard system for deep coalbed methane exploration and exploitation by Xinjun CHEN, Zengqin LIU, Baojian SHEN, Shihu ZHAO, Jiaqi ZHANG, Jincheng YE

“…Specifically, the short-term objective is to establish a geological and engineering integrated standard framework by focusing on the improvement in exploration accuracy and the optimization of exploitation processes, aiming to drive technological innovations and industrial transformation and upgrading. …”
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Senescence-associated alterations in histone H3 modifications, HP1 alpha levels and distribution, and in the transcriptome of vascular smooth muscle cells in different types of sen... by Agnieszka Gadecka, Marta Koblowska, Helena Kossowska, Roksana Iwanicka-Nowicka, Dorota Janiszewska, Grażyna Mosieniak, Krzysztof Bojakowski, Krzysztof Goryca, Anna Bielak-Zmijewska

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Emergency Medical Care for Victims with Crush Syndrome at the Pre-Hospital Stage by V. Orlyk

“…The study employed historical, bibliosemantic, comparative analysis, and systematic approach methods. Results. …”
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Frontopolar and anterior temporal cortex activation in a moral judgment task: preliminary functional MRI results in normal subjects Ativação do córtex frontopolar e temporal anteri... by Jorge Moll, Paul J. Eslinger, Ricardo de Oliveira-Souza

“…To exclude the effect of emotion on the activation results, individual responses were hemodynamically modeled for event-related fMRI analysis. The general linear model was used to evaluate the brain areas activated by moral judgment. …”
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Level of matrix metalloproteinase-9 and myocardium remodeling in patients with acute postinfarction aneurism of left ventricle by V. D. Syvolap, S. M. Kyselov

“…All patients were examined by general physical examination, standard laboratory tests, electrocardiography, echocardiography. …”
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Competencies of lower-level community health centre leaders in annual health work planning and their influence on district performance in Busoga sub-region: A retrospective study. by Kharim Mwebaza Muluya, Gangu David Muwanguzi, Abdulmujeeb Babatunde Aremu, Naziru Rashid, Irene Wananda, Jonah Fred Kayemba, Collin Ogara, Musa Waibi, John Francis Mugisha, Peter Waiswa

“…<h4>Conclusion</h4>The competencies of lower-level community health centre leaders in fully constituting the health unit management committees, involving heads of departments in the annual planning processes and organizing annual meetings for effective planning, highly contributes to the general performance of districts in the Busoga sub-region. …”
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BORDER CROSSING, GENDER CONSCIOUSNESS AND EMANCIPATION IN POSTCOLONIAL NARRATIVES OF ISIDORE OKPEWHO’S CALL ME BY MY RIGHTFUL NAME, THE VICTIM AND BUCHI EMECHETA’S SECOND CLASS CIT... by Irene AKUMBU WIBEDIMBOM

“…Okpewho and Emecheta in their social structures try to explore the impacts on the self and the internal dynamics of self-processes as these impact on the social behaviour of their female characters. …”
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