Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway by Yingchao Wu, Yingchao Wu, Liushan Chen, Liushan Chen, Liushan Chen, Liushan Chen, Dajin Pi, Jiaqi Cui, Yuqi Liang, Yuqi Liang, Yuqi Liang, Yuqi Liang, Peng Wu, Mingzi Ouyang, Qian Zuo, Qian Zuo, Qian Zuo, Qian Zuo

“…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.ConclusionTaken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…”
Get full text

Implementation of the principle of transparency (openness) of budget data at the municipal level (on the example of the Republic of Karelia) by T. A. Bokova, T. G. Kadnikova, N. D. Romanova

“…The results of an analytical study on the availability and completeness of placement on the official information resources of the administrations of municipalities of the Republic of Karelia of the data necessary for monitoring and assessing the level of openness of budgetary data of municipalities in the Republic of Karelia are presented. The generalized conclusions on the analysis of «citizens budget» published on the official websites of the municipalities of the Republic of Karelia are presented. …”
Get full text

Elastic constants identification for laminated composites using laser doppler vibrometry and an inversion method based on legendre orthogonal polynomial expansion by Hongye Liu, Lei Wang, Xuan Li, Liang Shen, Chongpeng Qiu, Zenghua Liu, Zhenhua Tian

“…Additionally, it is a generalized approach applicable to laminated composites with various anisotropic lamina properties and layups.…”
Get full text

Novel static calculation approach for reciprocal structures assembled by Archimedes paving curved rods by XIA Yongqiang, XU Yimin, NI Keyi, XIAO Nan, FAN Lei, SONG Fangyuan, JIN Hui

Get full text

Entropy-extreme concept of data gaps filling in a small-sized collection by Viacheslav Kovtun, Krzysztof Grochla, Mohammed Al-Maitah, Saad Aldosary, Oleksii Kozachko

Get full text

Development of the global energy sector based on the innovative principles of the "green" economy by A. A. Ter-Grigoryants, E. V. Sokolenko, A. E. Gerasimova

Get full text

Transitivity, verbal humour and the construction of identity in Trevor Noah’s narratives by Nouran Tarek Soliman, Rabia Abdul-Salim Madhi

“…This descriptive study uses an eclectic approach combining Systemic Functional Grammar (SFG), discourse analysis, and humor studies. The data from both genres was analyzed using the Hallidayan Transitivity model and the General Theory of Verbal Humor (GTVH). …”
Get full text

COVID-19 infection and longevity: an observational and mendelian randomization study by Shizheng Qiu, Jianhua Liu, Jiahe Guo, Zhishuai Zhang, Yu Guo, Yang Hu

“…In all MR methods, generalized summary-data-based Mendelian randomization (GSMR) analysis revealed a significant decrease in longevity due to severe COVID-19 infection (OR = 0.91, 95%CI: 0.84–0.98, P = 0.015). …”
Get full text

Application of conical profile spindle-mandrel joints in multi-purpose machines by V. A. Ilyinykh

Get full text

Risk Assessment of Soil and Water Loss and Secondary Disasters During Pumped Storage Power Station Construction by Ma Xiaoxiao, Zhu Anping, Yu Weiqing, Liu Xin, Li Xuan

“…[Methods] The analytic hierarchy process method was used combined with the fuzzy comprehensive evaluation method to select eight primary indicators and thirty-four secondary indicators from three dimensions for analysis and assessment. …”
Get full text

Calculation of Technological Consumption (Loss) of Electricity in Modern 0.38–10 kV Electrical Distribution Networks by M. I. Fursanov, A. A. Zalotoy, V. V. Makarevich

Get full text

Limits of Application of the <i>jura novit arbiter</i> Principle in International Arbitration: Some Issues of Theory and Practice by D. L. Davydenko, R. N. Muksunova

“…The study examined the issues in the relationship between jura novit arbiter and other principles aimed at narrowing the scope of its functioning.DISCUSSION AND CONCLUSIONS. The results of the analysis allow to draw the following conclusions. First, there are three major constraints put on the arbitrators' discretion: 1) ne ultra petita (not beyond the request), 2) due process in terms of a right to be heard and the foreseeability test, 3) expediency and efficiency of arbitral proceedings. …”
Get full text

THEORETICAL AND METHODOLOGICAL ASPECTS OF USING INFORMATION ANDCOGNITIVE TECHNOLOGIES IN THE TRAINING OF TRANSPORT SPECIALISTS by Lavrentieva Olena, Krupskyi Oleksandr

“…The following methods of semantic and comparative analysis, classification, generalization, and systematization, as well as competency-based, technological, and creative development approaches were used in the research. …”
Get full text

Enhancing Communication Security in Drones Using QRNG in Frequency Hopping Spread Spectrum by J. de Curtò, I. de Zarzà, Juan-Carlos Cano, Carlos T. Calafate

Get full text

Development of the archive of the Moscow Theological Consistory in the first half of the 18th century by Ilya Ivanov

“…The 44th chapter of the General Regulations marked the beginning of the rapid growth of systematic archival work in the Russian Empire. …”
Get full text

Enhancing heart disease prediction with stacked ensemble and MCDM-based ranking: an optimized RST-ML approach by T. Ashika, G. Hannah Grace

“…To assess scalability and generalization, the framework was evaluated using additional datasets, including chronic kidney disease (CKD), obesity levels, and breast cancer. …”
Get full text

DMA Master Curves for Long-Term Life Prediction of Epoxy Resins and Composites Using Time Temperature Superposition by Thiago F. Silvano, Ricardo M. Di Benedetto, Marilia Sonego, Angelo Souza, Antonio C. Ancelotti Junior

“…It was observed that the viscoelastic behavior depends on both frequency and temperature, with a general equivalence between the behavior related to frequency and temperature during the transition processes. …”
Get full text

Molecular docking, molecular dynamics simulation and MM-PB/GBSA analysis for the inhibition of Klebsiella pneumoniae SHV-1 β-lactamase using antimicrobial peptides defensin VvK1 an... by Manisha Mandal, Shyamapada Mandal

“…This computational study aims to explore the inhibition property of two plant-derived AMPs (antimicrobial peptides), defensin VvK1 and snakin-1, against SHV-1 β-lactamase from Klebsiella pneumoniae by molecular docking, MDS (molecular dynamics simulation) and MM-PB/GBSA (Molecular Mechanics-Poisson-Boltzmann/Generalized Born Surface Area) analysis. The AMPs (defensin VvK1 and snakin-1) were docked to SHV-1 β-lactamase for intermolecular (protein-peptide) interaction analysis and binding affinity prediction. …”
Get full text

Bioinformatics functional analysis of let-7a, miR-34a, and miR-199a/b reveals novel insights into immune system pathways and cancer hallmarks for hepatocellular carcinoma by Bangly Soliman, Ahmed Salem, Mohamed Ghazy, Nourhan Abu-Shahba, Mahmoud El Hefnawi

“…In addition, the functional enrichment analysis of these targets that was performed by DAVID functional annotation and REACTOME tools revealed two major immune-related pathways, eight hepatocellular carcinoma hallmarks–linked pathways, and two pathways that mediate interconnected processes between immune system and hepatocellular carcinoma hallmarks. …”
Get full text

METHODS FOR EARLY DETECTION OF LUNG CANCER (REVIEW) by E. O. Rodionov, S. A. Tuzikov, S. V. Miller, D. E. Kulbakin, V. I. Chernov

“…Special attention was paid to the description of modern molecular and genetic biomarkers of lung cancer, such as epigenetic markers, microRNAs, the use of proteomics technology, metabolomics, microbiome research, and biomarkers from liquid biopsy. The analysis of the world literature confirming the prospects of methods of non-invasive diagnostics of tumor processes based on the analysis of exhaled air was carried out. …”
Get full text