Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Biomarker analyses of serial blood and tumor samples are planned to clarify predictive markers and molecular mechanisms underlying treatment resistance by multifaceted analytical methods (e.g., flow cytometry, DNA sequencing [DNAseq]/RNA sequencing [RNAseq]). …”
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis by Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian

“…Through gain- and loss-of-function approaches, miR-199a-5p over-expression significantly increased expression of VSMC marker genes and inhibited VSMC proliferation and migration, whilst the opposite effect was observed when endogenous miR-199a-5p was knocked down. …”
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The Croton genera (Euphorbiaceae) and its richness in chemical constituents with potential range of applications by Carlos Andrés Coy-Barrera, Laura Galvis, Maria Juliana Rueda, Sergio Alejandro Torres-Cortés

“…It aims to summarize information gathered worldwide from studies of Croton species concerning ethnobotanical, pharmacological, and other uses over the past ten years and the respective discussion. …”
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Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis by Haoyuan Lyu, Na Fan, Hao Wen, Xin Zhang, Herong Mao, Qinglai Bian, Jiaxu Chen

“…By integrating Spearman correlation analysis with various MR study designs, this study provided a robust framework for identifying key factors influencing hyperuricemia and related health issues, thereby enhancing our understanding of the interplay between inflammatory markers and these health indicators. Conclusions Our study presents strong evidence of the complex interconnection between BMI, neutrophils, triglyceride, and UA, revealing complex causal links and highlighting potential inflammatory states as key mediators. …”
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Impact of behavior change theory-based nursing interventions on cardiac function recovery and quality of life among cardiac surgery patients with cardiopulmonary bypass by Youwei Zhao, Wei Wei, Zhiyuan Wang, Yanbo Dong, Zhenyu Su, Shichao Guo

“…Regarding inflammatory markers, TNF-α and IL-6 levels were significantly reduced in the observation group, while IL-10 levels were significantly elevated compared to the control group (P < 0.05). …”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…Abstract Background Identifying markers or genes crucial for growth traits in Zhongwei goats is pivotal for breeding. …”
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Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Analysis of cell type-specific marker genes predicted age-related loss of photoreceptors and retinal ganglion cells (RGCs) in WSB and NZO, respectively. …”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…Immunohistochemical analysis identified neointima‐specific markers, while NIH progression was assessed in SD rats with four and a half LIM domains protein 1 (Fhl1) knockout and in human saphenous veins (HSV) with adenovirus‐mediated Fhl1 overexpression. …”
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Identifying the predictors of ultra early neurological improvement and its role in functional outcome after endovascular thrombectomy in acute ischemic stroke by Yuzheng Lai, Mohammad Mofatteh, José Fidel Baizabal-Carvallo, José Fidel Baizabal-Carvallo, Jianfeng He, Wenhao Wu, Daohong Wang, Wenshan Yan, Jicai Ma, Sijie Zhou, Yu Sun, Yu Sun, Yi He, Shumei Li, Hao Sun

“…In this study, we aimed to investigate the usage of NIHSS at 1-h time window -ultra-early neurological improvement (UENI)- as a surrogate marker associated with the functional outcomes of AIS patients treated with EVT.MethodsWe included 485 adults (≥18 years old) who underwent emergency EVT at four academic comprehensive stroke centers between 2020 and 2021. …”
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Human-genome single nucleotide polymorphisms affecting transcription factor binding and their role in pathogenesis by E. V. Antontseva, A. O. Degtyareva, E. E. Korbolina, I. S. Damarov, T. I. Merkulova

“…It should be noted that the presence of an association does not allow one to identify a functional, truly disease-associated DNA sequence variant among multiple marker SNPs that are detected due to linkage disequilibrium. …”
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The Use of Electronic Consent (eConsent) Within the Ketamine for Long-Lasting Pain Relief After Surgery (KALPAS) Multicenter Trial by Doan LV, Burr J, Perez R, Martinez H, Cuevas R, Watt K, Wang J

“…When signing the eConsent, however, all potential participants are provided with a concise summary of the informed consent document, an approach not widely used by multicenter studies. eConsent has been noted to be beneficial to research staff when trying to gather informed consent from participants who live far away from the hospital, want to include their family and friends, and for researchers who can approach patients outside of their clinical appointments.Conclusion: The ability to consent patients remotely has allowed for a flexible workflow within sites and a more patient-centric process that focuses on including loved ones in the discussion and scheduling time to speak to a principal investigator. …”
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Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders by Gisela Chelimsky, Pippa Simpson, Liyun Zhang, Doug Bierer, Steve Komas, Balaraman Kalyanaraman, Thomas Chelimsky

“…Mitochondrial energy generation can be easily measured in peripheral mononuclear cells (PMC) as a general marker by the Seahorse XF96 Extracellular Flux Analyzer. …”
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Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Joint associations of race, ethnicity, age, and geographic region may partially inform potential mechanisms underlying these disparities. Funding: Dr. Gathers’ effort on this study was supported by a National Institutes of Health (NIH) Training Grant T32HL098054. …”
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Determinants of Change in Glycemic Status in Individuals with Prediabetes: Results from a Nationwide Cohort Study in Germany by Rebecca Paprott, Christa Scheidt-Nave, Christin Heidemann

“…In conclusion, among the investigated determinants, potentially modifiable anthropometric and metabolic markers were associated with glycemic changes in individuals with HbA1c-defined prediabetes. …”
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Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications by Jiayi He, Huiqian Zhang, Hehua Quan, Qingyuan Wang, Congcong Wen, Yiyan Wang, Yang Zhu, Ren-Shan Ge, Xiaoheng Li

“…Notably, BPB significantly boosted the expressions of histone methylation markers like EEF1A1, SUZ12, EED, EZH2, H3K27me3, and H3K9me3 in vivo. …”
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Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy by Marco Delle Monache, Alessio Petrelli, Alessandra Rossi, Roberto Cecere, Concetta Mirisola, Gianfranco Costanzo, Chiara Francia, Federica Cerini, Andrea Cavani, Lorenzo Nosotti

“…The severity of liver disease in inactive HBsAg carriers can be noninvasively assessed by transient elastography (TE) alone or in association with biochemical markers of fibrosis. Objectives. The study evaluates the effectiveness of the TE compared to common fibrosis scores (FSs), APRI, Forns Index, and FIB4, for identifying significant fibrosis in Italian and foreigner HBsAg carriers. …”
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Intestinal protozoa infections and associated factors among diarrheal under-five children in Borena district, central Ethiopia by Alebie Mesfin, Woynshet Gelaye, Getaneh Alemu

“…The study included a structured questionnaire to gather data regarding sociodemographic characteristics and perceived risk factors for IPIs. …”
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A Study of the Relationship between the Polymorphism and Mutation of rs682429 and rs3781590 in the LRP5 Gene and Bone Metabolism in Postmenopausal Type 2 Diabetic Women in Xinjiang by Jun Li, SiYuan Li, HuiRong Zhao, JiaJia Li, Shuang Wang, YanQiu Shi

“…To explore the expression of the polymorphism and mutation of rs682429 and rs3781590 in the low-density lipoprotein receptor-related protein 5 (LRP5) genotype and to analyse the relationship of bone mineral density (BMD) and bone metabolism markers in postmenopausal women with type-2 diabetes mellitus (T2DM) in Xinjiang, China, to provide a basis for prevention and treatment of the disease. …”
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Food groups, macronutrient intake and objective measures of total carotenoids and fatty acids in 16-to-24-year-olds following different plant-based diets compared to an omnivorous... by Synne Groufh-Jacobsen, Christel Larsson, Isabelle Mulkerrins, Dagfinn Aune, Anine Christine Medin

“…For omega-3, lacto-ovo-vegetarians had intakes below recommendations. Blood marker of total carotenoids did not differ between groups, neither did the reported mean intake (g/MJ) of carotenoid-rich foods. …”
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Ethnobotanical Survey and Conservation Strategies of Medicinal Plants Used in Masulita Sub-County in Wakiso District. by Musoke, Ronald

“…Methods: Sixty respondents were selected using a combination of snowball and purposive sampling methods to gather information on medicinal plant usage and community conservation practices in the Masulita sub-county. …”
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