Nephroprotective effects of Foeniculum vulgare mill (Apiaceae Family) hydromethanol leaf extract against cisplatin-induced nephrotoxicity on Swiss albino mice by Kibur Hunie Tesfa, Chernet Desalegn Gebeyehu, Tiget Ayelgn Mengstie, Hiwot Tezera Endale

“…The group of mice treated with 200 mg/kg, 400mg/kg of extract, and silymarin control significantly reduced the serum kidney markers and prevented pathological damage to the kidney compared to the negative control group. …”
Get full text

A Comparative Analysis of Blockchain in Enhancing the Drug Traceability in Edible Foods Using Multiple Regression Analysis by K. Suresh Kumar, Vinay Kumar Nassa, Dipesh Uike, Ashima kalra, Ajay Kumar Sahu, Vijay Anant Athavale, V. Saravanan

“…The researcher uses quantitative analysis for the study as it helps in understanding the critical determinants influencing drug traceability in food effectively, the survey method is used to gather the information, and past reviews are also used to possess a better understanding of the subject area effectively.…”
Get full text

Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression by Li Xiang, Wenxu Pan, Huan Chen, Wenjun Du, Shuping Xie, Xinhua Liang, Fangying Yang, Rongwei Niu, Canxin Huang, Minan Luo, Yuxin Xu, Lanlan Geng, Sitang Gong, Wanfu Xu, Junhong Zhao

“…Herein, in comparison to the mannitol group (control group), we found that intestinal M-cell development was inhibited in response to sorbitol treatment as evidenced by impaired enteroids accompanying with decreased early differentiation marker Annexin 5, Marcksl1, Spib, sox8, and mature M-cell marker glycoprotein 2 expression, which was attributed to downregulation of receptor activator of nuclear factor kappa-В ligand (RANKL) expression in vivo and in vitro. …”
Get full text

DNA metabarcoding of benthic algae and associated eukaryotes from Lake Baikal in the face of rapid environmental changes by Yu. S. Bukin, L. S. Kravtsova, T. E. Peretolchina, A. P. Fedotov, A. E. Tupikin, M. R. Kabilov, D. Yu. Sherbakov, E. V. Mincheva

“…About 15 thousand reads of the 18S rRNA marker were obtained by applying NGS (next-generation sequencing). …”
Get full text

Flexible analysis of spatial transcriptomics data (FAST): a deconvolution approach by Meng Zhang, Joel Parker, Lingling An, Yiwen Liu, Xiaoxiao Sun

“…In real data applications, FAST is able to uncover the underlying tissue structures and identify the corresponding marker genes.…”
Get full text

Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage by Marin Kuntić, Ivana Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Dilja Krueger-Burg, Huige Li, Sebastian Steven, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber

“…Noise also increased markers of oxidative stress and inflammation. Treatment of mice with propranolol and phenoxybenzamine prevented endothelial and microvascular dysfunction, which was supported by a decrease in markers of inflammation and oxidative stress in heart tissue and the brain. …”
Get full text

The Evaluation of Diagnostic Role of Cardiac Troponin T (cTnT) in Newborns with Heart Defects by Agata Tarkowska, Wanda Furmaga-Jablonska

“…To evaluate diagnostic usefulness of cTnT in correlation with other markers of circulatory failure and myocardial damage in newborns with heart defects. …”
Get full text

Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth failure/faltering by Jai K Das, Zulfiqar Ahmed Bhutta, Abigail Smith, Aamer Imdad, Emily Tanner-Smith, Melissa François, Fanny F Chen, Olivia J Tsistinas

“…We will consider the following outcomes: mortality, clinical deterioration, antimicrobial resistance, recovery from comorbidity, adverse events, markers of intestinal inflammation, markers of systemic inflammation, hospital-acquired infections, non-response. …”
Get full text

SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden by Bethany K. Hughes, Andrew Davis, Deborah Milligan, Ryan Wallis, Federica Mossa, Michael P. Philpott, Linda J. Wainwright, David A. Gunn, Cleo L. Bishop

“…Abstract Background Senescence classification is an acknowledged challenge within the field, as markers are cell-type and context dependent. Currently, multiple morphological and immunofluorescence markers are required. …”
Get full text

Semen extender triggers a mild physiological inflammatory response in the uterus without disrupting sperm-uterine immune crosstalk in vitro in cattle by Malinda HULUGALLA, Alireza MANSOURI, Elham WAEHAMA, Ihshan AKTHAR, Akio MIYAMOTO

“…Immunofluorescence analyses confirmed the upregulation of the strong inflammatory marker TNF alongside TLR2 and the downregulation of NOD1 in the uterine epithelium, similar to the effects observed with sperm. …”
Get full text

Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations by Marwan Al-Nimer, Rawa Ratha, Taha Mahwi

“…The relationship between BH4 markers with glycemic and hematological indices was assessed by Spearman’s correlation and multivariable regression analysis. …”
Get full text

Evaluation of Serum Leucine-Rich Alpha-2 Glycoprotein as a New Inflammatory Biomarker of Inflammatory Bowel Disease by Tetsuhiro Yoshimura, Keiichi Mitsuyama, Ryosuke Sakemi, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Shuhei Fukunaga, Toshihiro Araki, Masaru Morita, Kozo Tsuruta, Hiroshi Yamasaki, Takuji Torimura

“…This study is aimed at evaluating the utility of serum LRG as a potential inflammatory marker for IBD and to investigate the LRG gene expression in peripheral blood mononuclear cells (PBMCs) as a possible source of serum LRG. …”
Get full text

Monocyte Chemoattractant Protein-1 in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis: Biomarker Potential and Association with Polymorphisms in the MCP-1 and the CC... by Nina Jönsson, Evelina Erlandsson, Lena Gunnarsson, Åsa Pettersson, Sophie Ohlsson

“…This study confirms the previous results of urinary MCP-1 (uMCP-1) as a prognostic marker and explores its potential as a marker of disease activity. …”
Get full text

Molecular identification and phylogenetic relationship of Bangladeshi pufferfish based on mitochondrial COI and 16S rRNA genes by Md Sagir Ahmed, Nafisa Islam, Durjoy Raha Antu, Mysha Mahjabin, Sujan Kumar Datta, Osamu Arakawa

“…This study validates the utility of both COI and 16S rRNA as potential markers for identifying different puffer species. …”
Get full text

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions by Arjun Sinkemani, Feng Wang, Zhiyang Xie, Lu Chen, Cong Zhang, Xiaotao Wu

“…This study is aimed at evaluating the effectiveness of the nucleus pulposus cell (NPC) conditioned medium for promoting the expression of MSCs and at confirming the expression of healthy NP phenotypic markers recently recommended by the Spine Research Interest Group. …”
Get full text

Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma by Lorenza Bridi Todeschini, Rita de Cássia Sant’Anna Alves, Adriana Vial Roehe

“…We aimed to evaluate the correlation between these markers and vulvar SCC and to relate it to the clinical and pathological characteristics. …”
Get full text

LINC00941 affects the proliferation, apoptosis and differentiation of osteoblasts by regulating the miR-335-5p/KAT7 axis by Longjin Liu, Ye Yang, Pengxiao Sun

“…Methods The expression levels of LINC00941, miR-335-5p, KAT7 and osteoblast differentiation-related markers were assessed using RT-qPCR. The proliferation of MC3T3-E1 cells was evaluated through the CCK-8 assay, and cell apoptosis was analyzed via flow cytometry. …”
Get full text

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…VPA impaired the expansion of MB neurospheres enriched in stemness markers and reduced <i>MYC</i> while increasing <i>TP53</i> expression in these neurospheres. …”
Get full text

Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients by Umberto Basile, Mariapaola Marino, Cecilia Napodano, Krizia Pocino, Paolo Emilio Alboini, Francesca Gulli, Amelia Evoli, Carlo Provenzano, Emanuela Bartoccioni

“…From our data, FLCs appear to be a sensitive marker of B cell activation in MG. Further investigations are necessary to exploit their potential as reliable biomarkers of disease activity.…”
Get full text

A Novel Oxidative Stress Mediator in Acute Appendicitis: Thiol/Disulphide Homeostasis by Sefa Ozyazici, Faruk Karateke, Umit Turan, Adnan Kuvvetli, Huseyin Kilavuz, Burak Karakaya, Pınar Ozaltun, Murat Alısık, Ozcan Erel

“…To investigate the role of a novel oxidative stress marker, thiol/disulphide homeostasis, in patients diagnosed with acute appendicitis (AA). …”
Get full text