Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…Sachin Madhusudan More1 *, Md Abdur Rashid,2 Rohini S Kharwade3 *, Murtada Taha,4 Yahya Alhamhoom,2 Gamal Osman Elhassan,5 Purushottam Gangane,3 Turky Omar Asar,6 Ajay Pise,7 Mohammed Kaleem,1 Md Ali Mujtaba8,9 1Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 2Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia; 3Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 4Department of Clinical Laboratory Science, Prince Sultan Military College of Health Sciences, Dhahran, Saudi Arabia; 5Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia; 6Department of Biology, College of Science and Arts at Alkamil, University of Jeddah, Jeddah, Saudi Arabia; 7Department of Regulatory Affairs Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 8Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia; 9Center for Health Research, Northern Border University, Arar, Saudi Arabia* These authors contributed equally to this workCorrespondence: Md Ali Mujtaba; Mohammed Kaleem, Email m.mujtaba@nbu.edu.sa; kaleemmubin88@gmail.comIntroduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. …”
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