Successful treatment of generalized myasthenia gravis with telitacicept: a Chinese case series and literature review by Xiaodong Song, Xiaodong Song, Yang He, Hong Jiang, Yao Yu, Yue Sun, Zhaoxu Zhang

“…Additionally, immunological assessments revealed a decrease in CD19+B lymphocyte counts and acetylcholine receptor (AChR) antibodies. Only one patient reported a mild, transient injection reaction.ConclusionFavorable clinical improvement and mild adverse events for gMG in treated with telitacicept were observed. …”
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Threshold Research on Highway Length under Typical Landscape Patterns Based on Drivers’ Physiological Performance by Xia Zhao, Zhonghua Wei, Zhixia Li, Yong Zhang, Xingyu Feng

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A Scoping Review of Obesity among Indigenous Peoples in Canada by Malek Batal, Stéphane Decelles

“…A scoping review of ever published original research reporting obesity rates (body mass index ≥ 30), among adult Indigenous peoples in Canada, was conducted to identify studies that help close the Canadian Community Health Survey (CCHS) data gap for obesity prevalence in Indigenous populations in Canada and to make comparisons based on ethnicity, sex, time, and geography. …”
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Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells by Debora Dessì, Giacomo Fais, Paolo Follesa, Giorgia Sarais

“…Additionally, we analyzed the expression of genes linked to oxidative stress and neuronal function, including AChE, PON2, Grin1, Gabrd, and c-fos, by RT-PCR. Our findings reveal that Myrtus extract significantly protects against 6-OHDA-induced cytotoxicity, reduces ROS levels, and modulates the expression of key stress-related genes, underscoring its potential as a neuroprotective agent. …”
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Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni by Qilong Huang, Jiawen Yu, Ruibing Peng, Maowang Jiang, Qingxi Han, Xiamin Jiang

“…At the same time, Cu(Ⅱ) exposure led to an increase in the content of the lipid peroxidation product malondialdehyde (MDA) and a significant decrease in the activity of antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT]), energy-metabolizing enzymes (adenylate kinase [AK]), and cholinergic-related enzymes (acetylcholinesterase [AChE], choline acetyltransferase [ChAT]). In conclusion, when the concentration of Cu(Ⅱ) in the environment is ≥ 0.01 mg/L, it causes significant lethality toxicity, developmental toxicity and teratogenicity in S. maindroni embryos. …”
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Comprehensive evaluation of spring barley mutants according to their yield components by A. A. Belozerova, D. A. Bazyuk, N. A. Bome

“…The mutants of the fifth (M5) and sixth (M6) generations were evaluated for a set of traits valuable for breeding in comparison with the original forms and reference cultivars ʻAchaʼ and ʻAbalakʼ. The main productivity characters were analyzed in the laboratory, and breeding indices were calculated (ear potential index, Canadian index, ear linear density index, Mexican index, plant productivity index, and Finnish-Scandinavian index).Results and conclusion. …”
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Taurine Prevented Biochemical Alterations in Chronic Restraint-Stressed Wistar Rats by Iliya, Ezekiel, Agnes Igimi, Odey, Stephen Olawale, Ajayi, Ejike, Daniel Eze, Obioha, Mary

“…The result revealed significant (p < 0.05) increase in the brain AChE activity in taurine 100 mg/kg when compared to the control group. …”
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Archiving of Records in Kanungu Local Government Registry. by Atuhaire, Catherine

“…The challenges faced by records officers in archiving records included; lack of enough data capture tools, inadequate training skills for record staff, integration of records systems, risk of fire, water, and rats, uncoordinated officers working in a similar co-operation, short retention periods for archiving records, costs associated with maintaining records, limited storage space of the achi val repository. The proposed strategies for improving the archival of records in the registry involved monitoring and evaluation process, implementation of policies that govern archives storage, staff training, and a strategic plan. …”
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Assessment of psychological health effects of nurses during 2022–2023 of the COVID-19 pandemic: a descriptive study in Southern Taiwan by Hui-Ru Lin, Yung-Kuo Lee, Chen-Lin Chang, Ching-Hui Kuo, Hsin-Yun Ho, Chi-Jen Wu, Yi-Qian Chen, Cheng-Chun Wu, Yu-Cheng Ho, Tian-Huei Chu, Cheng-Hsin Chuang, Chou-Yuan Ko

“…Emotional distress and mental health were assessed using the BSRS-5 (Brief Symptom Rating Scale) and CHQ-12 (Chinese Health Questionnaire). Correlation and regression analyses were conducted to identify factors influencing emotional distress and mental health outcomes.Results Nurses aged 40–59 (52.85, p = 0.01), those in emergency departments (56.71, p = 0.001), and those caring for COVID-19 patients (50, p = 0.007) reported higher personal exhaustion. …”
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Acceptability and efficacy of the culturally adapted problem management plus intervention for people with disability in Pakistan: a pilot cluster randomized controlled trial by Basharat Hussain, Basharat Hussain, Muhammad Tahir Khalily, Muhammad Tahir Khalily, Ahmed Waqas, Atif Rahman, Ioannis Angelakis, Anum Nisar, Sabir Zaman, Tanveer Akhtar

“…The intervention’s effectiveness and participant satisfaction were assessed using a variety of measures, including the GHQ-12, WHODAS 2.0, DASS-21, and the Client Satisfaction Questionnaire, at baseline, the 8th week, and during a 3-month follow-up. …”
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Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin by J Blahova, P Mikula, P Marsalek, Z Svobodova

“…The exposure to the highest two concentrations resulted in significant changes in plasma indices such as glucose (only group 100 μg/l), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), lipase, creatine kinase (CK), amylase as well as butyrylcholinesterase (BChE). Similar trends were found in both groups exposed to the environmentally relevant concentrations (i.e., 0.1 and 1 μg/l). …”
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Potential and mechanisms of indigenous Indonesian medicinal plants in treating sexual dysfunction: A systematic review and pharmacological network overview by Sukardiman, Roihatul Mutiah, Rosita Handayani

“…The pharmacology network analysis demonstrated that the compounds present in Eurycoma longifolia, specifically stigmasterol, eurycomanone, and eurycomalactone, target 13 genes associated with erectile dysfunction (ED), which include BCL2, AKT1, SOAT1, PCSK9, ACHE, BDNF-AS, TMX2-CTNND1, GSK3B, LINCO1672, TP53, H19, HIF1A, and IL1B. …”
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Foods and Beverages Associated with Smoking Craving in Heated Tobacco Product and Cigarette Smokers: A Cross-sectional Study by Kiho Miyoshi, Yuki Kimura, Misaki Nakahata, Takashi Miyawaki

“…The daily intake of fruit and dairy products was significantly lower in cigarette and HTP smokers than in non-smokers (median fruit intake: nonsmokers, 46.4 g/1000 kcal/day; cigarette smokers, 22.2 g/1000 kcal/day; HTP smokers, 31.4 g/1000 kcal/day; p<0.001; median dairy product intake: nonsmokers, 76.3 g/day; cigarette smokers, 48.2 g/day; HTP smokers, 57.6 g/day; p<0.001) as assessed using a food frequency questionnaire (BDHQ). Conclusions Specific foods and beverages such as alcohol, fruits, and dairy products are related to smoking craving, and their intake differs according to smoking status.…”
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Metabolites Profiling of Manilkara mabokeensis Aubrév Bark and Investigation of Biological Activities by Xavier Worowounga, Rami Rahmani, Armel-Frederic Namkona, Sylvie Cazaux, Jean-Laurent Syssa-Magalé, Hubert Matondo, Jalloul Bouajila

“…Interestingly, gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS) analysis were enabled to identify 23 compounds in the essential oil of M. mabokeensis Aubrév bark, which have not been previously described in the literature. …”
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Pre-probiotic effects of different bacterial species in aquaculture: behavioral, hematological and oxidative stress responses by Alak Gonca, Kotan Recep, Uçar Arzu, Parlak Veysel, Atamanalp Muhammed

“…Physiological changes in blood tissue [hematological indices: erythrocyte count (RBC), leukocyte count (WBC), hemoglobin (Hb), hematocrit (Hct), platelet count (PLT), mean cell hemoglobin concentration (MCHC), mean cell hemoglobin (MCH), and mean cell volume (MCV)], oxidative stress responses in liver and gill tissues [malondialdehyde (MDA) level, antioxidant enzyme activities: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione-S-transferase (GST), glucose-6-phosphate dehydrogenase (G6PD)] and acetylcholinesterase (AChE) activity in brain tissue (as neurotoxic biomarker) were investigated. …”
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The effects of wheat and yam flour diets on the toxicity of three botanical extracts to Tribolium castaneum (Herbst) and the underlying biochemical mechanisms by Emmanuel A. Oyeniyi, Ayodeji P. Akinnuoye

“…The specific activities of α-amylase, alkaline phosphatase (AKP), acid phosphatase (ACP), acetylcholinesterase (AChE), and glutathione S-transferase (GST) were also determined. …”
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Hydrolase-Treated Royal Jelly Attenuates H2O2- and Glutamate-Induced SH-SY5Y Cell Damage and Promotes Cognitive Enhancement in a Rat Model of Vascular Dementia by Nualpun Sirinupong, Worrapanitch Chansuwan, Pratchaya Kaewkaen

“…Rats’ spatial memory was evaluated using Morris water maze and radial arm maze every 7 days after Rt.MCAO throughout a 14-day experimental period, and then, they were sacrificed and the acetylcholinesterase (AChE) activity in the hippocampus was determined. …”
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Biochemical and toxicological evaluation of Solanum viarum fruit extract on Dugesia tigrina by Schaly Felipe, Braguini Welligton Luciano

“…Acetylcholinesterase (AChE) was stimulated by 40.6% and 44.8% after 24 h and 14 days, respectively, at 0.50 g/L AEF. …”
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Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies by Mehrnoosh Khodaeian, Samaneh Enayati, Ozra Tabatabaei-Malazy, Mahsa M. Amoli

“…We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications. …”
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