Services availability and readiness assessment of adolescent sexual and reproductive health in primary healthcare facilities: evidence from selected districts in Ghana by Michel Adurayi Amenah, Jacob Novignon, Ama Pokuaa Fenny, Irene A. Agyepong, Tim Ensor

“…Targeted interventions are necessary to elevate the quality and accessibility of ASRH services, ensuring equitable health care delivery across all regions. Future research should expand to other regions to validate these findings and inform nationwide health strategies.…”
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Identification and characteristics of distressed patients with coronary heart disease and insufficiently controlled medical risk factors: baseline findings and sex differences from... by Christoph Herrmann-Lingen, Christoph Herrmann-Lingen, Monika Sadlonova, Monika Sadlonova, Monika Sadlonova, Monika Sadlonova, Monika Sadlonova, Ingrid Becker, Kristina Bersch, Franziska Geiser, Martin Hellmich, Ingrid Kindermann, Matthias Michal, Mariel Nöhre, Astrid Petersmann, Astrid Petersmann, Rolf Wachter, Rolf Wachter, Rolf Wachter, Birgit Herbeck Belnap, Birgit Herbeck Belnap, Christian Albus

“…Women differed from men in relevant aspects of their RF profiles and mental health and should receive special attention in future analyses and treatment planning for patients with CHD.Clinical Trial RegistrationGerman Clinical Trials Register, https://drks.de/search/de/trial/DRKS00020824, identifier DRKS00020824.…”
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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…The identification of a shared TCRβ chain suggests that immune T cells in KS patients may target a common antigen. Future studies should further explore the immune microenvironment and unique T cell clonotypes, which could pave the way for the development of novel therapeutic strategies for KS patients.…”
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Water, Sanitation and Hygiene in a Conflict Area: A Cross-Sectional Study in South Kordofan, Sudan by Rofida Asmally, Abdelmalik A. Imam, Abdullatif Eissa, Abubakr Saeed, Ahmed Mohamed, Eahaa Abdalla, Mariam Alazraa M. Esmaeel, Mariam Elbashir, Mohamed H. Elbadawi, Mohammed Omer, Raghad Eltayeb, Ranya Mohammed, Tibyan Abdalhamed, Tina Merghani

“…It also sought to identify factors affecting community satisfaction with WASH services and to establish a data-driven basis for future interventions addressing these issues. Methods A cross-sectional study accompanied a medical mission to South Kordofan, selecting 33 villages from South Kordofan based on healthcare, population, and accessibility. …”
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Testing the Feasibility, Acceptability, and Potential Efficacy of an Innovative Digital Mental Health Care Delivery Model Designed to Increase Access to Care: Open Trial of the Dig... by Natalia Macrynikola, Kelly Chen, Erlend Lane, Nic Nguyen, Jennifer Pinto, Shirley Yen, John Torous

“…ConclusionsResults suggest that the Digital Clinic model is feasible, acceptable, and potentially efficacious, warranting a future randomized controlled trial to establish the efficacy of this innovative model of care.…”
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Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone by Jianping Jiang, Astrid V. Cienfuegos-Galletd, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

“…Our findings advance the understanding of multi-drug resistance mechanisms and will aid in preventing the emergence of future MDR clones.…”
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Arginase-1-specific T cells target and modulate tumor-associated macrophages by Mads Hald Andersen, Inés Lecoq, Ayako Wakatsuki Pedersen, Evelina Martinenaite, Shamaila Munir Ahmad, Maria Perez-Penco, Lucia Lara de la Torre, Marion Chapellier, Lars Rønn Olsen, Mia Aaboe-Jørgensen, Hannah Jorinde Glöckner, Anne Mette Askehøj Rømer

“…These findings provide a strong rationale for future clinical development of Arg1-based IMVs to alter the immune-suppressive TME by reprogramming TAMs and promoting a proinflammatory TME.…”
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ANAPUS GYVENIMO IR MIRTIES DUALIZMO: BUDISTINĖ EGZISTENCIJOS INTERPRETACIJA by Agnė Budriūnaitė

“…ANOTHER SIDE OF LIFE–DEATH DUALISM: THE BUDDHIST CONCEPTION OF EXISTENCE Agnė Budriūnaitė  Summary The “ordinary” person of Western society does not recognize his or her death as unavoidable future, tries to forget it and lives as if his or her existence would be life-without-death. …”
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The association between metabolomic profiles of lifestyle and the latent phase of incident chronic kidney disease in the UK Population by Tingting Jin, Yunqi Wu, Siyi Zhang, Ya Peng, Yao Lin, Saijun Zhou, Hongyan Liu, Pei Yu

“…Nuclear magnetic resonance metabolomics offers new insights into renal health, though further validation studies are needed in the future.…”
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Temperature Sensitivity Response of Soil Enzyme Activity to Simulated Climate Change at Growth Stages of Winter Wheat by Yaokun Jiang, Bingbing Lu, Meng Liang, Yang Wu, Yuanze Li, Ziwen Zhao, Guobin Liu, Sha Xue

“…This study is of great significance in exploring the effects of global warming on food production and the mechanism of soil ecosystem functional stability under future climate change.…”
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Scaling climate information services and climate smart agriculture through bundled business models by Desire M. Kagabo, Livingstone Byandaga, Patrick Gatsinzi, Patrick Mvuyibwami, Yvonne U. Munyangeri, Nasson Ntwari, Mathieu Ouedraogo

“…This study reveals a reason for optimism about the future of agriculture; it suggests that scalable bundled CIS-CSA products and services can contribute significantly to attaining climate resilience and food security.…”
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Rehabilitation success and related costs following stroke in a regional hospital: a retrospective analysis based on the Australian National Subacute and Non-Acute Patient (AN-SNAP)... by Fan He, George Mnatzaganian, Michael Njovu, David Rutherford, Tara Alexander, Irene Blackberry

“…These findings may inform rehabilitation practices and may influence future funding strategies for rehabilitation services.…”
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Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study by Miaomiao Shao, Ying Li, Jing Qin, Yuchen Zhou, Yixin Sun, Peiyi Yang, Xisi Wang, Cheng Huang, Yan Su, Wen Zhao

“…Receipt of 5HT3RA plus dexamethasone had a higher likelihood of acute phase complete CIV control versus 5HT3RA. In the future, individualized management of nausea and vomiting, based on existing CINV guidelines and the unique characteristics of children, will be necessary to reduce the incidence of CINV and improve the quality of life for these children.…”
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Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences by Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao

“…Therefore, the remodeled PRRSV TRS mutant generated in this study can serve as a recombination-resistant platform for the rational design of safe PRRS vaccines in the future.…”
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Green Tea Extract (<i>Theaceae</i>; <i>Camellia sinensis</i> L.): A Promising Antimicrobial, Anti-Quorum Sensing and Antibiofilm Candidate Against Multidrug-Resistant <i>Campylobac... by Mona S. Emara, Ahmed M. Ammar, Ashraf M.O. Abdelwahab, Attia A. Elgdawy, Adel Abdelkhalek, Elena Pet, Gabi Dumitrescu, Mirela Ahmadi, Norhan K. Abd El-Aziz

“…Further in vivo studies in animals’ models should be performed to provide evidence of concept for the implementation of this alternative candidate for the mitigation of MDR <i>Campylobacter</i> infections in the future.…”
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Learning how to swim in 5- to 12-year-old children: a scoping review of evidence-based motor learning methods by Carola Minkels, Carola Minkels, John van der Kamp, Ralph de Vries, Peter J. Beek, Peter J. Beek

“…Addressing these shortcomings in future research will improve the evidence-base for the effectiveness of theoretically inspired learning methods for the acquisition of swimming skills in children, and their long-term retention and transfer, which in turn might result in evidence-based innovations in swimming lessons.Systematic Review RegistrationPRISMA (RRID:SCR_018721).…”
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Comprehensive investigation of ergonomic challenges and predictors of work-related musculoskeletal disorders among intensive care unit nurses of Western India through convergent mi... by Sonali Detroja, Rajkumar Mahajan, Ankit Sheth

“…Conclusion The findings underscore urgent need for targeted interventions to address risk factors associated with WRMSDs, including ergonomic training, workplace modifications, and education programs to enhance risk awareness and preventive behaviours. Future research should focus on developing and evaluating comprehensive interventions that integrate both physical and work environment factors to effectively mitigate WRMSDs among ICU nurses.…”
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Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan by Rie Kanamori, Nozomi Aoki, Akio Kanazawa, Mayumi Yuda, Nao Makino, Emi Ohata, Nobuyuki Fukui, Hirotake Mori, Hirohide Yokokawa, Toshio Naito

“…Patient without medication records more than 3 months and no future data more than 6 months were excluded. Patients’ characteristics were compared between the DTG/3TC cohort and the BIC/FTC/TAF cohort by Mantel–Haenszel test to adjust for age. …”
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Composition of the collection of wild apple-tree species and its prospects for use in breeding by O. N. Barsukova

“…., Rosaceae) are an important reserve of sources of economically valuable traits for the needs of present and future breeding. Particular attention was paid to the immunological characteristics of the gene pool. …”
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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses by Ye Ma, Fang Wu, Zeming Yu, Lu Yang

“…These lipid species may potentially serve as biomarkers and future drug targets for the treatment of FRDs.…”
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