Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation by Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H

“…In the liver, FFQD activated the Ras family small molecule G protein (RAP1)/PI3K/AKT/forkhead box protein 01 (FOX01) pathway, inhibited RAP1 expression, promoted PI3K and AKT phosphorylation, suppressed FOX01 expression, and improved insulin resistance.Conclusion: FFQD may improve insulin resistance, regulate glucose and lipid metabolism, inhibit excessive autophagy, induce macrophage polarization, resist inflammation and oxidative stress, inhibit atherosclerosis, and ultimately improve DMD by activating the RAGE/PI3K/AKT/mTOR and RAP1/PI3K/AKT/FOX01 pathways. …”
Get full text

Baicalin induces apoptosis and autophagy in resistant human hepatocellular carcinoma cell line Bel-7402/5-FU cells via PI3K/AKT pathway by Fei Li, Zilin Lan, Weiwei Jiang, Jianheng Zhou, Jiumao Lin, Jinyan Zhao

“…Baicalin reversed drug resistance in Bel-7402/5-FU cells by inhibiting the PI3K/AKT pathway, which promoted autophagy and apoptosis to restore chemosensitivity. …”
Get full text

ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification by Yan S, Hu X, Wu Y, Ye W, Zhu Y, He Y, Zhan F, Wu W, Ma Z

Subjects: “…5-FU…”
Get full text

Shouhui Tongbian Capsule ameliorates 5-fluorouracil induced constipation in mice by modulating gut microbiota and activating PI3K/AKT/AQP3 signaling pathway by Yawei Zhang, Yawei Zhang, Yang Dong, Yang Dong, Chenghong Sun, Lufan Zhang, Lufan Zhang, Yi Zhang, Yi Zhang, Dan Wang, Dan Wang, Dan Wang, Qian Chen, Qian Chen, Qian Chen, Jingchun Yao, Yuzheng Wu, Yuzheng Wu, Yuzheng Wu, Tao Wang, Tao Wang

“…Additionally, SHTC increased the level of acetic acid and upregulated the expression of AQP3, with activation of PI3K/AKT. Furthermore, the blockade of PI3K reversed the beneficial effect of acetic acid on the expression of AQP3.ConclusionOur findings indicated that SHTC effectively relieved 5-FU-induced constipation in mice, mainly by regulating homeostasis of gut microbiota and activating PI3K/AKT/AQP3 pathway, making it a potential protective agent against chemotherapy-induced constipation.…”
Get full text

Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription. by Shih-Ying Tsai, Fu Huang

Get full text

First observation of Λ c (2595)+ → Λ c + π 0 π 0 $$ {\Lambda}_c^{+}{\pi}^0{\pi}^0 $$ and Λ c (2625)+ → Λ c + π 0 π 0 $$ {\Lambda}_c^{+}{\pi}^0{\pi}^0 $$ by The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H.-R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, X. Y. Chai, J. F. Chang, G. R. Che, Y. Z. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, H. Y. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, S. K. Choi, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Y. Y. Duan, Z. H. Duan, P. Egorov, G. F. Fan, J. J. Fan, Y. H. Fan, J. Fang, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, X. B. Gao, Y. N. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, F. Hanisch, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, Q. P. Hu, S. L. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, P. Huang, X. T. Huang, Y. P. Huang, Y. S. Huang, T. Hussain, F. Hölzken, N. Hüsken, N. in der Wiesche, J. Jackson, S. Janchiv, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, N. Kumar, A. Kupsc, W. Kühn, W. N. Lan, T. T. Lei, Z. H. Lei, M. Lellmann, T. Lenz, C. Li, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, K. Li, K. L. Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. L. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, T. Li, T. Y. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, X. Y. Li, X. Z. Li, Y. Li, Y. G. Li, Z. J. Li, Z. Y. Li, C. Liang, H. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, Y. P. Liao, J. Libby, A. Limphirat, C. C. Lin, C. X. Lin, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. Liu, F. H. Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. H. Liu, H. M. Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, X. Liu, Y. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, J. R. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, L. R. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, R. Y. Ma, T. Ma, X. T. Ma, X. Y. Ma, Y. M. Ma, F. E. Maas, I. MacKay, M. Maggiora, S. Malde, Y. J. Mao, Z. P. Mao, S. Marcello, Y. H. Meng, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, L. S. Nie, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, S. Qian, W. B. Qian, C. F. Qiao, J. H. Qiao, J. J. Qin, L. Q. Qin, L. Y. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, M. Q. Ruan, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, Z. J. Shang, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. Shi, J. L. Shi, J. Y. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, S. S Su, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, M. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, Bo Wang, C. Wang, D. Y. Wang, H. J. Wang, J. J. Wang, J. P. Wang, K. Wang, L. L. Wang, L. W. Wang, M. Wang, N. Y. Wang, S. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. H. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, Lianjie Wu, X. Wu, X. H. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, H. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, M. Xu, Q. J. Xu, Q. N. Xu, W. L. Xu, X. P. Xu, Y. Xu, Y. C. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, W. P. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, J. H. Yang, R. J. Yang, T. Yang, Y. Yang, Y. F. Yang, Y. F. Yang, Y. X. Yang, Y. Z. Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Junhao Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, M. C. Yu, T. Yu, X. D. Yu, C. Z. Yuan, J. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, Ying Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. R. Zhang, H. Y. Zhang, J. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. S. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, P. Zhang, Q. Zhang, Q. Y. Zhang, R. Y. Zhang, S. H. Zhang, Shulei Zhang, X. M. Zhang, X. Y Zhang, X. Y. Zhang, Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. X. Zhang, Z. Y. Zhang, Z. Y. Zhang, Z. Z. Zhang, Zh. Zh. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, L. Zhao, Lei Zhao, M. G. Zhao, N. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, B. M. Zheng, J. P. Zheng, W. J. Zheng, X. R. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, S. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, Z. C. Zhou, A. N. Zhu, J. Zhu, K. Zhu, K. J. Zhu, K. S. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, T. J. Zhu, W. D. Zhu, W. Z. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, J. Zu

Get full text

Fu’s subcutaneous needling facilitates muscle repair by regulating mitochondrial homeostasis in rat with chronic peripheral nervous pain by Po-En Chiu, Po-En Chiu, Zhonghua Fu, Zhonghua Fu, Hung-Chuan Pan, Hung-Chuan Pan, Hung-Chuan Pan, Hung-Chuan Pan, Yi-Ching Tsai, Chia-Yun Tsai, Wei-Jen Hsu, Li-Wei Chou, Li-Wei Chou, Li-Wei Chou, De-Wei Lai, De-Wei Lai

“…This study explored the therapeutic effects of Fu’s subcutaneous needling (FSN) in a chronic constriction injury (CCI) rat model, assessing its impact on neuropathic pain, muscle mass, and structural integrity. …”
Get full text

Targeting DKC1/NF-κB axis suppresses tumorigenesis and enhances 5-FU sensitivity in gastric cancer by Tengkai wang, Hui Zhang, Yaoyao Feng, Yinrong Yang

“…Functional impacts on proliferation (CCK-8/cell cycle analysis), migration (Transwell), apoptosis (Annexin V/PI staining), and chemosensitivity (5-fluorouracil [5-FU] IC50) were assessed. …”
Get full text

Liu-Shen-Wan inhibits PI3K/Akt and TRPV1 signaling alleviating bone cancer pain in rats by Hui Zhang, Jingwen Jiang, Xuewu Chen, Fengting Zhu, Fangfang Fu, Aiying Chen, Lei Fu, Dan Mao

Get full text

Novel application of CHUANG BI FU biologic protein sponge in promoting peripheral nerve injury repair by regulating vascular regeneration by Yunhao Cai, Jiahao Liu, Renwei Han, Zizhao Ma, Kaihang Yu, Ping Wu, Xiaokun Li, Zhouguang Wang, Jian Wang

“…And through cellular level research, it was found that CHUANG BI FU may promote vascular regeneration through the PI3 K–AKT pathway. …”
Get full text

Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway by Shaohui Geng, Jingqi Wen, Chunli Shen, Li Liu, Yijin Jiang, Jingyuan Fu, Yiwei Guan, Zi Ye, Yuanhao Wu, Chen Li, Guangrui Huang

Get full text

Improved Electrochemical Performance of Lithium-Rich Manganese-Based Materials via a PI/MWCNT Composite Coating Layer by Yali Wang, Peiqi Fan, Bingxue Liu, Xiaoyan Li, Yunfeng Fu, Guoshan Du, Jun Liu, Songxuan Chen, Hangyu Sun

Get full text

Around-the-clock noise exposure induces hippocampus apoptosis and subsequent cognitive impairment via the PI3K/SGK1/Foxo3 signaling pathway by Yiming Fu, Pengfang Zheng, Xiaojun She, Yingwen Zhu, Bo Fu, Kefeng Ma, Honglian Yang, Xiujie Gao, Bo Cui

Get full text

Targeting the PI3K-AKT pathway to alleviate 6PPDQ-induced cognitive impairment associated with metabolic syndrome by Leisheng Wang, Yifei Fu, Shiwei Xu, Enhong Chen, Shuo Zhang, Dongjie Yang, Youzhao He, Yuanlong Gu, Yong Mao, Fenglai Yuan, Hao Hu

Get full text

Microneedle‐Delivered PDA@Exo for Multifaceted Osteoarthritis Treatment via PI3K‐Akt‐mTOR Pathway by Zihua Li, Hengli Lu, Limin Fan, Xiaoyi Ma, Zhengwei Duan, Yiwei Zhang, Yuesong Fu, Sen Wang, Yonghao Guan, Dong Yang, Qingjing Chen, Tianyang Xu, Yunfeng Yang

Get full text

Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats by Xueru Xu, Shaoxiong Fu, Xiaomei Shi, Rongguo Liu

Get full text

Targeting Stearoyl‐CoA Desaturase 1 Through PI3K‐AKT‐mTOR Signaling in Head and Neck Squamous Cell Carcinoma by Cheng‐Ming Hsu, Ming‐Yu Yang, Shun‐Fu Chang, Hui‐Chen Su

Get full text

Upregulation of Salmonella-Induced IL-6 Production in Caco-2 Cells by PJ-34, PARP-1 Inhibitor: Involvement of PI3K, p38 MAPK, ERK, JNK, and NF-κB by Fu-Chen Huang

Get full text

Integrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis by Qiaomei Yang, Jingxuan Hong, Jianhui Fu, Xianhua Liu, Xinye Zheng, Junying Jiang, An Zhu, Li Chen, Hao Lin, PengMing Sun

Get full text

COLEC10: A potential tumor suppressor and prognostic biomarker in hepatocellular carcinoma through modulation of EMT and PI3K-AKT pathways by Ke Rui-Sheng, Dai Yun, Tu Yan-ling, Liu Zhao-Hui, Huang Kun-Zhai, Zhang Fu-Xing

Get full text