Rectal versus vaginal progesterone administration for luteal phase support in the hormone replacement therapy frozen embryo transfer (HRT-FET) cycle: protocol for a non-inferiority randomised controlled trial by Peter Humaidan, Birgit Alsbjerg

“…Introduction This study compares rectal administration with vaginal administration of progesterone as luteal phase support in hormone replacement therapy frozen embryo transfer (HRT-FET) cycles. The reason for comparing the two routes of administration is that rectal administration has been suggested to be more patient friendly.Methods and analysis This study is a randomised controlled trial comparing the ongoing pregnancy rate (OPR) at week 12 in HRT-FET cycles after rectal administered progesterone as the only administered progesterone compared with a vaginal luteal phase support regimen. …”
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UV-fs-LA-ICP-MS Analysis of CO2-Rich Fluid Inclusions in a Frozen State: Example from the Dahu Au-Mo Deposit, Xiaoqinling Region, Central China by Wei Jian, Moritz Albrecht, Bernd Lehmann, Jingwen Mao, Ingo Horn, Yanhe Li, Huishou Ye, Zongyan Li, Guanguan Fang, Yongsheng Xue

“…The concentrations of Li, B, Na, Al, K, Ca, Mn, Fe, Cu, Zn, Rb, Sr, Mo, Ag, Te, Cs, Ba, Au, Pb, and Bi were analyzed in 124 (not all for Al and Ca) fluid inclusions, which have low to moderate salinity and multiphase composition (liquid H2O + liquid CO2  ± vapor CO2  ± solids). …”
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Microbiological hazards associated with the use of water in the post‐harvest handling and processing operations of fresh and frozen fruits, vegetables and herbs (ffFVH). Part 3 (Fresh‐whole FVH process water management plan) by EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Lapo Mughini‐Gras, Maarten Nauta, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Jen Banach, Bin Zhou, Maria Teresa daSilva Felício, Laura Martino, Winy Messens, Angela Botteon

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Microbiological hazards associated with the use of water in the post‐harvest handling and processing operations of fresh and frozen fruits, vegetables and herbs (ffFVH). Part 4 (fresh‐cut FVH process water management plan) by EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Lapo Mughini‐Gras, Maarten Nauta, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Jen Banach, Bin Zhou, Maria Teresa daSilva Felício, Laura Martino, Winy Messens, Angela Botteon

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Daniel Lazare. The Frozen Republic ; How the Constitution Is Paralyzing Democracy.... by Pierre Guerlain

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Impact of Anterior Commissure Involvement and Frozen Guided Resections on Oncological Outcomes after Laser Cordectomy in Early Glottic Cancers – A 10-year Retrospective Analysis from a Tertiary Care Cancer Center in India by Elizabeth Mathew Iype, Ankit Vishwani, Bipin T Varghese, Shaji Thomas, Sahya S Lal

“…The results suggest the need to consider ACI in the T staging of glottic tumors. Frozen positivity helps us in re-excision but signifies that the disease is deeply infiltrative or aggressive and a vigilant follow-up is required for these patients.…”
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Microbiological hazards associated with the use of water in the post‐harvest handling and processing operations of fresh and frozen fruits, vegetables and herbs (ffFVH). Part 2 – A dynamic mass balance model for handling and processing operations in ffFVH using water by EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Lapo Mughini‐Gras, Maarten Nauta, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Jen Banach, Bin Zhou, Maria Teresa daSilva Felício, Laura Martino, Winy Messens, Angela Botteon

“…The mass balance relates to the flux of water and product in a wash tank and the number of microbial cells released in the water, inactivated by the water disinfectant or transferred from the water back to the product. …”
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A study of introduced apple cultivars according to the main components of winter hardiness by simulating damaging factors under controlled conditions by А. M. Galasheva, N. G. Krasova, Z. E. Ozherelieva

“…Most of the plantings of fruit crops in Russia are located in the zone of risky agriculture. In the European part of Russia, in winter, fruit crops are affected by the impacts of weather conditions (spring frosts, droughts, early frosts, low-temperature stress, a short growing season, and thaws). …”
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Endometriosis does not impact aneuploidy rates of products of conception in IVF population by Huijuan Kong, Wenqian Fan, Tian Ye, Linqing Du

“…The results showed that women with EMS had a significantly lower antral follicle count (AFC) (10 ± 5 vs. 14 ± 7, P < 0.01) compared to the control group. …”
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Effects of Massive Transfusion Protocol Implementation in Trauma Patients at a Level I Trauma Center by Hyun Woo Sun, Sang Bong Lee, Sung Jin Park, Chan Ik Park, Jae Hun Kim

“…Purpose This study was conducted to investigate whether rapid and efficient administration of blood products was achieved and whether clinical outcomes were improved by applying a massive transfusion protocol (MTP). Methods From January 2016 to September 2019, the medical records of trauma patients who received at least 10 units of packed red blood cells (PRBC) at Pusan National University Hospital (level I trauma center) were retrospectively reviewed. …”
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Subculture of Germ Cell-Derived Colonies with GATA4-Positive Feeder Cells from Neonatal Pig Testes by Kyung Hoon Lee, Won Young Lee, Jin Hoi Kim, Chan Kyu Park, Jeong Tae Do, Jae Hwan Kim, Young Suk Choi, Nam Hyung Kim, Hyuk Song

“…The subcultured GDCs were maintained up to passage 13 with the fresh feeder cells (FFCs) and then frozen. Eight months later, the frozen GDCs could again form the colonies on FFCs as shown in passages 1 to 13. …”
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Molecular characterization of Pseudomyxoma peritonei with single-cell and bulk RNA sequencing by Ye Jin Ha, Seong-Hwan Park, Seon-Kyu Kim, Ka Hee Tak, Jeong-Hwan Kim, Chan Wook Kim, Yong Sik Yoon, Seon-Young Kim, Jong Lyul Lee

“…Abstract Pseudomyxoma peritonei (PMP), a rare condition characterized by mucinous ascites in the peritoneal cavity, often leads to a poor prognosis. …”
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Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics by Mikhail T. Silk, Nina Mikkilineni, Tarik C. Silk, Emily C. Zabor, Irina Ostrovnaya, Ari A. Hakimi, James J. Hsieh, Etay Ziv, Natasha Rekhtman, Stephen B. Solomon, Jeremy C. Durack

“…Median DNA and RNA yields from 18G needles were significantly greater than those from 20G needles across all organs (p<0.001). Conclusions. Core needle biopsy techniques for cancer diagnostics yield a broad range of DNA and RNA for molecular pathology, though quantities are greater than what has been reported for FFPE processed material. …”
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Temperature-induced flexibility of graphene sheet facilitates RNA duplex unzipping: A molecular dynamics study by Maksym V. Karachevtsev, Victor A. Karachevtsev

“…The distance between base pairs, number of H-bonds in the duplex, and interaction energy between (rA)15 and (rU)15 strands was determined when they were arranged on the flexible graphene sheet in an aqueous environment at 273, 303, and 333 K and compared to data obtained from a frozen graphene sheet. …”
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COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient by Mariana Codevila Buere Pereira, Bruna Ruschel, Bruna Schneider, Vitor Salomão Gonçalves Melo de Melgar, Tatiana Helena Rech

“…TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. We report a case of a healthy young patient presenting with the classic TTP pentad a few days after a diagnosis of COVID-19 confirmed by a positive SARS-CoV-2 RT-PCR test. …”
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Analysis of Necessity and Feasibility for Ground Improvement in Warm and Ice-Rich Permafrost Regions by Honglei Wang, Hu Zhang, Mingtang Chai, Jianming Zhang, Zhizhong Sun, Guoyu Li

“…Characterized by low bearing capacity and high compressibility, warm and ice-rich frozen soil is a kind of problematic soil, which makes the original frozen ground formed by of that unreliable to meet the stability requirements of engineering infrastructures and foundations in permafrost regions. …”
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Using microfluidic shear to assess transfusion requirements in trauma patients by Rachael A Callcut, James T Ross, Anamaria J Robles, Leslie H Vuoncino, Ashli C Barnes, Leonardo W Graeff, Taylor L Anway, Nico T Vincent, Nithya Tippireddy, Kimi M Tanaka, Randi J Mays

“…A decreased maximum PCF showed significant correlation with receiving any transfusion at 6 (p=0.04) and 24 hours (p=0.02) as well as transfusion of pRBCs, fresh frozen plasma, and platelets in the first 6 hours (p=0.03, p=0.03, p=0.03, respectively).Conclusions Assessing coagulopathy in real time remains challenging in trauma patients. …”
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Experimental and Numerical Analyses of the Thermal Regime of a Traditional Embankment in Permafrost Regions by Qihang Mei, Ji Chen, Shouhong Zhang, Xin Hou, Jingyi Zhao, Jinchang Wang, Haiming Dang, Guojun Liu, Guilong Wu

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Study on the Freeze-Thaw Problems in the Winter Construction of the Lianghekou Earth-Core Rockfill Dam and the Countermeasures for Prevention by Qihao Yu, Xiu-Ling Ren, Pan Yue, Gui-Ke Zhang, Jun-Feng Wang, Yan-Hu Mu, En-Long Liu

“…The results show that for the construction site in the seasonally frozen soil area, there is a development process of the short-term frozen soils for the filling soils under the environment with low temperature in winter. …”
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Experimental Study on Electric Resistivity Characteristics of Compacted Loess under Different Loads and Drying-Wetting Cycles by Yu Zhou, Guoyu Li, Wei Ma, Dun Chen, Fei Wang, Yuncheng Mao, Qingsong Du, Jun Zhang, Liyun Tang

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