177Lu-FA-DOTA-PEG-PLGA Nanoparticles Show Antitumor Efficiency in Targeting Ovarian Cancer by Ziming Guo, Yi Du, Jun Zhao, Sha Sha, Jian Wang

“…Tumor growth inhibition (TGI) and ascitic fluid volume were calculated to investigate antitumor efficiency. Hematoxylin and eosin (HE) staining was performed to evaluate the safety of nanoparticles. …”
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Time course of fluorescent-labelled oligonucleotide accumulation in cells with the use of folate receptor-targeted cationic liposomes by E. V. Shmendel, O. V. Markov, M. A. Zenkova, M. A. Maslov

“…Cationic liposomes demonstrated efficient FITC-ODN delivery into the cytoplasm of cancer cells. …”
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The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma by Charles J. Weeks, Mohammad Mian, Michael Stokes, Matthew Gold, Anvay Shah, Rohan Vuppala, Katherine J. Kim, Abigayle B. Simon, Jorge Cortes, Anand Jillela, Vamsi Kota

“…The high-folate group had a greater FC (3.26 ± 1.07) compared to the normal-folate group (2.88 ± 1.13, <i>p</i> = 0.013). …”
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Folate-conjugated human serum albumin-encapsulated resveratrol nanoparticles: preparation, characterization, bioavailability and targeting of liver tumors by Bolin Lian, Mingfang Wu, Ziqi Feng, Yiping Deng, Chen Zhong, Xiuhua Zhao

“…The drug capsulation efficiency and drug loading efficiency were 98.36 and 14.66%, respectively. …”
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Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Working on this rationale, the present study was aimed to develop novel and affordable hybrid nanocarriers combined with folate and pH-responsive functionalities for targeted delivery of Resveratrol (FOL-RSV-LPHNCs). …”
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Evaluation of natural compounds as folate biosynthesis inhibitors in Mycobacterium leprae using docking, ADMET analysis, and molecular dynamics simulation by Alanzi Abdullah R., Alharbi Hattan A.

“…This study investigates the potential of natural compounds as FolP protein inhibitors, a key enzyme in the folate biosynthesis pathway critical for M. leprae survival. …”
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Preparation and preclinical evaluation of 18F-labeled folate-RGD peptide conjugate for PET imaging of triple-negative breast carcinoma by Subhani M. Okarvi, Yousef Maliki

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Investigation into the anticancer activity of biosynthesized zinc oxide nanoparticles incorporating 6-gingerols by Noor Hayder Mohammed Al-Hamadani, Vahid Pouresmaeil, Mahshid Sharbatiyan, Masoud Homayouni Tabrizi

“…To overcome these challenges, a novel green method has been developed to produce zinc oxide nanoparticles (ZnO-NPs) modified with chitosan and folate, which can effectively deliver 6-Gin (6-Gin-CZF-NPs) and enhance its anticancer properties. …”
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Synthesis and in vitro evaluation of novel pH-triggered biocompatible folate-chondroitin sulfate-dexamethasone copolymers for delivery of tofacitinib in rheumatoid arthritis by Zahra Ansarypour, Jaber Emami, Farshid Hassanzadeh, Mahmoud Aghaei, Mohsen Minaiyan, Neal M. Davies, Mahboubeh Rezazadeh

“…This study aimed to enhance the efficacy of tofacitinib (Tofa) by synthesizing novel pH-triggered biocompatible polymers, both folate-targeted and non-folate-targeted. Experimental approach: First-generation polymers were synthesized and characterized using FT-IR and 1HNMR spectroscopy. …”
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Investigation of Fe3O4 nanoparticles synthesized via co-precipitation coated with chitosan, PEG, and folate for targeted paclitaxel delivery in fibrosarcoma treatment by Adawiya Haider, Sharafaldin Al-Musawi, Rusul Al-Obaidy, Azhar Haleemd, Mohammed Al-Hindawi, Bakr Taha

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Enhanced efficacy of immune checkpoint inhibitors by folate-targeted multifunctional drug through synergistic therapy inducing ferroptosis and immunogenic cell death in bladder can... by Yibo Shi, Guangrui Fan, Enguang Yang, Yuanfeng Zhang, Hui Ding, Junqiang Tian, Liang Cheng, Hanzhang Wang, Tianzhi Hao, Baodui Wang, Zhiping Wang

“…Results: DIFP-FA, by incorporating doxorubicin and indocyanine green, leverages specific binding to folate receptors for precise targeting and efficient internalization into BC cells. …”
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The spatial orientation of histidine via five-armed alkylamino siloxane improved the properties of the cationic gene delivery vector by Viola B. Morris, Chandra P. Sharma

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Development of Folic Acid Functionalized Bilosomes for Delivery of Vorinostat to Breast Cancer Cells: Characterization and Cytocidal Effects on MCF-7 and 4T1 Breast Cancer Cell Lin... by Alireza Rashidi, Somayeh Taymouri, Mahboubeh Rostami, Mina Mirian

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Polymer-Functionalized Magnetic Nanoparticles for Targeted Quercetin Delivery: A Potential Strategy for Colon Cancer Treatment by Júlia Borges de Macedo, Julia Narayana Schoroeder Bueno, Carla Cristine Kanunfre, José Ricardo de Arruda Miranda, Andris Figueiroa Bakuzis, Priscileila Colerato Ferrari

“…Therefore, this study aimed to develop chitosan (CS) and folate-chitosan (FA-CS)-coated MNP to improve the stability and targeting of the system for quercetin (Q) delivery. …”
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Folic acid-modified celastrol nanoparticles: synthesis, characterization, anticancer activity in 2D and 3D breast cancer models by Siukan Law, Albert Wingnang Leung, Chuanshan Xu

“…The results showed that FCA was synthesized successfully with good solubility, high encapsulation efficiency and loading content. FCA showed the optimal cumulative release at pH 5.0 and high cellular uptake and exhibited significant inhibition on breast cancer cells. …”
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Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood by E. Hamed, M. S. Attia, K. Bassiouny

“…Compounds having the general formula: Kn[M(FO)2(H2O)2]⋅xH2O, where (M=Cu(II) or Fe(III), n=2 or 1 , FO=folate anion, x=2 or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined. …”
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Cancer-specific targeting core–shell nanoparticles with magnetic resonance imaging function: Realizing efficient chemo-photothermal synergistic therapy triggered by near-infrared l... by Hongqi Shi, Run Huang, Rui Miao, Miao Wei, Liujun Wu, Yusong Pan, Zhonglei He, Wenxin Wang, Lei Huang

“…Additionally, the FMS-FA-DOX could be selectively targeted to the two-dimensional (2D) uterine cancer (HeLa) cell model and the three-dimensional (3D) breast cancer (MDA-MB-231) cell microsphere model, it is efficiently internalized via folate receptor-mediated endocytosis, exhibiting dose-dependent anticancer cellular efficacy. …”
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Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue by Xiyin Chen, David Bishai

“…Methods Four policies were considered: Policy A, Do nothing to address folate status in hypertensive patients at risk for stroke; Policy B, Folate supplementation without pre-screening for vitamin B12 deficiency; Policy C, Folate supplementation with pre-screening all patients for B12 deficiency and add B12 supplements if B12 is deficient; and Policy D, Folate supplementation only for those whose folate is deficient, pre-screen all patients for both B12 and folate deficiencies and add B12 supplements if B12 is deficient. …”
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Paroxetine treatment in an animal model of depression improves sperm quality. by Reyhane Aghajani, Marziyeh Tavalaee, Niloofar Sadeghi, Mazdak Razi, Parviz Gharagozloo, Maryam Arbabian, Joël R Drevet, Mohammad Hossein Nasr-Esfahani

“…In males, it has been associated with decreased efficiency of spermatogenesis as well as the production of spermatozoa of reduced structural and functional integrity. …”
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Genome-wide analysis of fitness determinants of Staphylococcus aureus during growth in milk. by Marita Torrissen Mårli, Anne Olsdatter Ohren Nordraak, Vincent de Bakker, Anja Ruud Winther, Xue Liu, Jan-Willem Veening, Davide Porcellato, Morten Kjos

“…Notably, we found that purine biosynthesis, folate cycle pathways, and metal acquisition were particularly important in this environment. …”
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