Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model by Liu RJ, Li M, Zhu Q, Liu HY, Zhang XX, Han XY, Yu MJ, Zhou JW, Han CY

“…Additionally, it demonstrated an enhanced flow of 4.374 ± 0.12 μg/cm2/hour, permeability coefficient was 3.65 ± 0.09 cm/h× 10− 3, and apparent skin deposition was 17.77 ± 1.13 μg/cm2. …”
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Ilaser Submucous Destruction in the Treatment of Hemorrhoids by S. A. Frolov, D. V. Vyshegorodtsev, A. M. Kuzminov, Yu. L. Trubacheva, V. Yu. Korolik, I. S. Bogormistrov, I. A. Mukhin, A. N. Ryndin, A. A. Anarbaeva

“…The performed transrectal ultrasound examination with spectral-wave dopplerography for up to 6 months allowed to diagnose a persistent decrease in blood flow along the terminal branches of the upper rectal artery compared with preoperative values. …”
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Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma by Teitur Sævarsson, Adrián López García de Lomana, Ólafur Sánchez, Veerle van Esch, Gunnar Bjarni Ragnarsson, Siggeir Fannar Brynjólfsson, Eiríkur Steingrímsson, Berglind Ósk Einarsdóttir

“…Effects on PD-L1 protein expression were analyzed via flow cytometry and western blotting. Inhibition of the JAK kinases, NF-κB and STAT3 with small molecule inhibitors, and siRNA mediated knockdown of STAT1 and IRF1 was applied to investigate the molecular mechanism behind IFNγ induced PD-L1 expression in dedifferentiated melanoma cells. …”
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Analyzing Iran's Legislative Criminal Policy in Dealing with Environmental Terrorism, Emphasizing the Need for Criminalization and Preventive Measures by behrouz sepehri, Nourooz Kargari, mohammad ashouri, ghassem ghassemi

“…Introduction: environmental security, is a necessary condition for the health and continuity of human life on earth and due to the vital, widespread and inevitable dependence of humans on the environment, if the environmental security is taken away and it is removed from the possibility of healthy living, as a result of the goal or the means of placing the environment, following environmental terrorism, with various methods such as polluting the natural and man-made environment with dangerous substances, extensive and irreparable damage is caused to human life and health And often, the most obvious effects of damage to the safety and health of the environment appear in the form of epidemics, and on the other hand, the cross-border effects of such actions and the possibility of transferring the said effects from through the flow of air or water or the carriers of disease agents to countries and regions beyond the place of the accident, and the possibility of spreading some of these effects on the life and health of future generations, reveals the seriousness of the danger of environmental terrorism, hence, The purpose of this thesis is to explain the vital necessity of legal, technical and specialized contrast, against environmental terrorism in the form of an efficient criminal policy with international interaction, with emphasizing the extent and irreparability of the effects caused by environmental terrorism, and the necessity and importance of preventive measures.Materials and Methods:  In terms of the goal, the current research will cause expansion the legal theories and doctrine and complete the previous theories with the fundamental method of the research results, and also with the practical approach, effective practical solutions to deal with environmental terrorism will be presented, and on the other hand, the materials and information used in the research, They are collected with the library method and after collecting and categorizing the materials and information, with the descriptive-analytical method, the findings and the collected materials are analyzed logically and legally and they are used as the basis of citation to strengthen the approach of the researcher in the relevant subject.Results: In a comprehensive and efficient criminal policy to contrast against environmental terrorism, in addition to criminalizing this criminal phenomenon along with the real conceptology and in addition to recognizing its specific elements, it is expected that with the necessary criminal measures, specialized measures will be taken to identify and criminalize behaviors that it has a preliminary aspect to dangerous crimes, and it is possible that environmental terrorism is also committed through them, and therefore, in order to prevent this criminal phenomenon, criminalize such behaviors in the form of obstruction crimes seems necessary.Discussion: In Iran's criminal system, environmental terrorism has not been considered as an independent criminal behavior, with specific elements and specific conditions, However, due to the inherent of the behaviors related to environmental terrorism, this type of terrorism is inherently reprehensible, and as a rule, it can be included in various legal elements in the criminal laws, and on the other hand, due to the analogy of some elements of this criminal phenomenon with the destruction of the earth, According to jurisprudence, significant examples of environmental terrorism behaviors can be considered as examples of corruption in the land subject to Article 286 of the Islamic Penal Code (approved in 2012). …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…Methods A novel anti-MSLN×4-1BB bispecific antibody (bsAb) was generated via antibody engineering, and its affinity and activity were detected via enzyme-linked immunosorbent assay (ELISA), flow cytometry, and T-cell activation and luciferase reporter assays. …”
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Effect of Pulsed Electric Field on the Cations Removal from Salt-Affected Soils to Optimize Energy Use Efficiency in Reclamation by Ahmed Abou-Shady

“…The pulsed 25% strategy of the OFF time showed an improvement in current passing at the longest interval of 120 min; the pulsed 50% strategy of the OFF time showed an improvement in current passing at the shorter and longer intervals of 15, 60, and 120 min; however, the interval of 30 min had a negative effect. The cumulative EO flow at the time OFF interval of 60 min was improved by the pulsed 25% strategy throughout the first seven days of operation, and by the end of the trial, the control experiment exhibited high values. …”
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Economic TEHES-Tube Material Evaluation by Absorbability Index under O-S-Dimensions for Minimizing Global Warming and Air Pollution by Exploring Dominance Theory: Green Management... by M. Prabhu, Sri Yogi Kottala, A. Anbazhagan, Anoop Kumar Sahu

“…Such GWAP can be controlled by applying the methods-techniques for optimizing the energy processes, evaluating the high energy absorption material among available materials and technological advancement in energy flow devices, optimizing design of energy systems and low heat emission strategy, etc. …”
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MT1G promotes iron autophagy and inhibits the function of gastric cancer cell lines by intervening in GPX4/SQSTM1 by Kaiqiang Meng, Jian Song, Fan Qi, Jiamin Li, Zhichao Fang, Liang Song

“…Using immunoprecipitation analysis (CO-IP) to elucidate the association between GC cell lines GPX4, SQSTM and ARNTL. Use flow cytometry to detect ROS expression. Observation of autophagy related morphological changes in cells using transmission electron microscopy. …”
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L’aqueduc du Gier : étude des ponts-siphons du Garon à Brignais et Chaponost (Rhône) et de Beaunant à Sainte-Foy-lès-Lyon (Métropole de Lyon) by Kilian Blanc, Laurie Danielou

“…The lime mortar was made from the sand of the rivers flowing under the two bridges; the Yzeron in the case of the Beaunant bridge, the Garon in bridge. …”
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Changes in the visual analyzer occurring as a result of space flight by M.A. Valyakh, N.G. Baeva

“…<br> Over the past few years, NASA officers have repeatedly recorded changes in the visual organ of astronauts after long space missions, in particular, they manifested an optic nerve swelling, a reduction in the anterior-posterior axial length of the eye, a change in blood flow velocity, and hypermetropia. European scientists obtained similar data. …”
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Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…The therapeutic efficacy of HED on UC was assessed by evaluating survival rate and so on. Flow cytometry was employed to assay the percentages of CD4+T cell. …”
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miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

“…After 24 h of 40 μM AFB1 treatment in LMH cells, Edu and flow cytometry confirmed inhibition of cell proliferation and promotion of apoptosis. …”
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OCT-A monitoring of the efficacy of neuroprotective therapy for glaucomatous optic neuropathy by N.G. Glazko, A.E. Egorov

“…</i> </p> <p> <i><b>Conclusions</b>: our findings demonstrate the efficacy of neuroretinoprotection for glaucomatous optic neuropathy due to the improved microcirculation and activation of foveal blood flow.</i> </p> <p> <i><b>Keywords</b>: optical coherence tomography angiography, primary open-angle glaucoma, glaucomatous optic neuropathy, neuroretinoprotection, trophic modified laser coagulation, bovine retinal polypeptides.…”
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Sentralisasi Pengawasan Informasi Jaringan Menggunakan Blockchain Ethereum by Muhammad Fajar Sidiq, Akbari Indra Basuki, Halim Firdaus, Muhammad Aldi Baihaqi

“…Metode pengawasan mengharuskan program controller pada setiap jaringan kantor untuk secara berkala menarik informasi flow-rules dari setiap perangkat jaringan dan melaporkan data tersebut dalam sebuah transaksi ke jejaring blockchain. …”
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3D modelling and simulation of thermal effects and dispersion of particles carrying infectious respiratory agents in a railway transport coach by Patrick Armand, Jérémie Tâche

“…In the first part of our research, we used Computational Fluid Dynamics (CFD) to model and simulate in 3D the transport and dispersion of particles from 1 µm to 1 mm in the turbulent flow generated by the ventilation of the railway coach. …”
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Sistem Deteksi Myocardial Infarction Berdasarkan Pathological Q Waves Dan ST Segment Elevation Menggunakan Metode Support Vector Machine by Ragil Hadi Prasetyo, Edita Rosana Widasari, Agung Setia Budi

“…This study used the AD8232 sensor module as an input to read the electricity flow in the heart. Then the signal read by the sensor is processed in the Arduino Uno and is classified and displays the result on a 16x2 LCD as an output. …”
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South African Open Distance Elearning Student: The Types, Effectiveness, and Preference of Feedback Support by Morakinyo Akintolu, Mohamed Ahmed Mitwally, Moeketsi Letseka

“… Historically feedback is perceived as a unidirectional flow of information from e-tutor to student, however, the feedback mechanisms ecology highlights the significance of establishing links between students and lecturers, as well as students and institutions. …”
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Hypoxia specifically induces CADM3 expression in pulmonary endothelial cells and promotes monocyte adhesion by MENG Xiangqiong, MENG Xiangqiong, CHEN Ting, CHEN Ting

“…Cell adhesion experiments， siRNA interference， immunohistochemical assay， Western blotting， and flow cytometry were used to study the role of CADM3 in hypoxia specific high adhesion of HUVEC monocytes. …”
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SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…Results The present study demonstrated that 3025@ML enhances the chemotherapeutic effect of OXA. 3025@ML + OXA treated T24 and 5637 cells showed that combination therapy significantly reduced cell viability and increased cell death rate. Flow cytometry analysis showed that the combination of 3025@ML and OXA significantly increased the percentage of apoptotic cells in T24 cells. 3025@ML and compound 3 K reduced the levels of FASN in T24 and 5637 cells and increased the anti-tumor activity of OXA. …”
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gga-miR-6634-5p Affects the proliferation and steroid hormone secretion of chicken (Gallus Gallus) granulosa cells by targeting MMP16 by Yixiang Tian, Xing Wu, Zihao Zhang, Yijie Li, Meng Hou, Ruirui Jiang, Donghua Li, Yanhua Zhang, Yulong Guo, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Yadong Tian, Wenting Li, Yuetao Li

“…We found that gga-miR-6634-5p significantly down-regulated the mRNA levels of proliferation-related genes (CCND1, CDK1, and CDK6), decreased cell viability, the number of EdU-labelled positive cells, and the percentage of S-phase cells, as analysed by quantitative real time PCR (qRT-PCR), cell counting kit-8 (CCK-8), 5-ethynyl-2′deoxyuridine (EdU) and flow cytometry analyses (P < 0.01 or P < 0.05). qRT-PCR and enzyme-linked immunosorbent assay (ELISA) results demonstrated that gga-miR-6634-5p up-regulated the expression of steroid synthesis-related genes (CYP19A1, 3β-HSD, StAR and FSHR) (P < 0.01 or P < 0.05), as well as the secretion of estradiol (E2) and progesterone (P4) (P < 0.01 or P < 0.05). …”
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