Temporal and Spatial Evolution Characteristics of Extreme Climate Events in Grand Shangri-La Region from 1961 to 2019 by WU Yang, JIN Hanyu, CHENG Qingping

“…The Grand Shangri-La region connects the Qinghai-Tibet Plateau,the Yunnan-Guizhou Plateau,and the Hengduan Mountains and is of great geographical significance.Five rivers flow through the region,and the climate is vulnerable.Therefore,it is necessary to explore extreme climate changes and their response mechanism,so as to assess regional climate risks and achieve disaster warnings.Based on the daily temperature and precipitation data of 56 meteorological stations from 1961 to 2019,this paper analyzes changes in extreme climate indexes and their correlation with large-scale circulation index in the region by using Mann-Kendall,Sen's slope estimation,Pettitt test,and Pearson correlation analysis.The results show that:① The extreme warm index and the extreme precipitation intensity index (RX1day,R95p,R99p,and SDII) increase significantly,while the cold index (CSDI、FD、ID、TN10p、TX10p) and the number of continuous humid days decrease greatly.In terms of different seasons,the warming amplitude of most of the extreme temperature indexes in winter is higher than that in summer,and the precipitation intensity increases gradually in summer and autumn but decreases slightly in winter.② Spatially,the diurnal temperature range in the north of the Qinghai-Tibet Plateau is higher than that in the south,and the frequency of extremely high-temperature rises,with the high temperature appearing mostly in arid valleys in the south and east of the Qinghai-Tibet Plateau.The precipitation intensity is high in the south and west of the Hengduan Mountains,and persistent precipitation is strong in the Yalong River basin and the upper reaches of the Jinsha River in the north.③ Extreme climate indexes and south China sea summer monsoon index (SCSMI) are significantly correlated in the same year.In addition,there is a one-year response lag between the extreme precipitation index and Arctic oscillation (AO),North Atlantic oscillation (NAO),and Pacific decadal oscillation (PDO).The above analysis shows that the Grand Shangri-La region generally shows warming and humid climate characteristics.The frequency of heavy precipitation in flood season and warm winter events increases and is closely related to large-scale circulation.…”
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Numerical modeling of land subsidence induced by groundwater extraction considering unsaturated effects and using element-free Galerkin (EFG) method by A. Tourei, A. Pak, M. A. Iranmanesh

“…This study aims to provide a coupled flow-deformation model for simulating land subsidence associated with groundwater extraction in aquifers. …”
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An Analysis of the Spatial Characteristics of Jin Ancestral Temple Based on Space Syntax by Chuanjin Hu, Yuanbo Qi, Chongen Wang

“…This design of “separation and connection” combines visual guidance with traffic flow, providing a layered spatial experience that stimulates visitors’ interest in exploration. …”
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CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis by Yuan Zhang, Zhenggong Li, Jiao Wang, Hao Chen, Rui He, Hongkun Wu

“…Cell apoptosis was assessed using flow cytometry and caspase-3 activity assay. The protein levels were measured through western blot. …”
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Efficiency of Using the Auxiliary Boiler for Peak Power Generation by a Steam Turbine of NPP by V. A. Khrustalev, M. V. Garievskii

“…The authors’ priority scheme-parametric developments on the possibility of using the thermal power of the auxiliary boilers to increase the power of the steam turbine of a nuclear power plant unit equipped with WWER reactors unit during peak periods, as well as the enthalpy balance method for calculating heat flows, were applied. The surface area of the additional heater of the regeneration “deaerator – high pressure heaters” system and its cost were calculated. …”
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Using β-Elemene to reduce stemness and drug resistance in osteosarcoma: A focus on the AKT/FOXO1 signaling pathway and immune modulation by Shaochun Zhang, Zhijie Xing, Jing Ke

“…Bioinformatics analysis, flow cytometry, and immunofluorescence staining were used to evaluate signaling pathway activity and macrophage polarization. …”
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А method of surgical correction of genital prolapse in combination with elongation and cicatricial deformation of the cervix in patients of reproductive age. A retrospective study by Albina Kh. Karanasheva, Yulia E. Dobrokhotova

“…In this case, an increase in the maximum flow rate and a decrease in the volume of residual urine were observed (p0.05). …”
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Lifecycle environmental benefits of integrated rational fertilization, biochar, and constructed wetland in mitigating nutrient loading by Yu-Ning Chen, Chihhao Fan, Michal Šereš, Markéta Šerešová, Jan Vymazal, Shu-Yuan Pan

“…In the assessment, rational fertilization used half the fertilizer compared to conventional practices, biochar was applied at 0.1 ton/ha, and horizontal subsurface flow CWs were filled with washed gravel and planted with Phragmites australis. …”
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The Response of Sensitive LULC Changes to Runoff and Sediment Yield in a Semihumid Urban Watershed of the Upper Awash Subbasin Using the SWAT+ Model, Oromia, Ethiopia by Bekan Chelkeba Tumsa

“…The model performance was tested using R2 = 0.88, NSE = 0.9, and PBIAS = −2.36, which indicate good agreement between simulated and observed flow, and R2 = 0.82, NSE = 0.86, and PBIAS = 4.38 for the simulated against recorded sediment yield. …”
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International Aspects of Investment Liberalization in the PRC: A Case of EU-China Cooperation by D. A. Potapov

“…The paper examines the volume, dynamics and key directions of investment flows between China and the EU member-states. The fact that after seven years of difficult negotiations, the EU and China managed to develop a special bilateral regulatory mechanism — EU-China Comprehensive Agreement on Investment — underscores again the importance of this cooperation for both parties. …”
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DATA MINING ALGORITHMS FOR PREDICTION OF STUDENT TEACHERS’ PERFORMANCE IN ICT: A SYSTEMATIC LITERATURE REVIEW by Juma Habibu Shindo, Mohamedi Mohamedi Mjahidi, Mohamed Dewa Waziri

“…It makes for clear reporting and offers a detailed checklist and flow diagram that direct the review procedure. On November 6, 2022, about 196 scholarly articles were downloaded from three digital libraries: Science Direct (38), ACM Digital Library (72), IEEE Xplore (51), and 35 from the Google Scholar search engine. …”
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Aménager la berge en rive droite de la Loire à l’époque romaine à Orléans/Cenabum (Loiret) by Julien Courtois, Émilie Roux-Capron

“…These took the form of level ground, sometimes even streets, along the banks, allowing traffic to flow along the river banks and to access them from the city. …”
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Network characteristics of referrals for chronic disease patients: results from hierarchical medical reform in Shenzhen, China by Fangfang Gong, Junxia Luo, Zhihong Wang, Ping Tang, Guangyu Hu, Ying Zhou, Hanqun Lin

“…Conclusions The referral network has a vertical flow pattern conducive to the division of labour, cooperation, and resource integration of medical institutions in the region, and a hierarchical medical order is taking shape. …”
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miR-486-5p Restrains Extracellular Matrix Production and Oxidative Damage in Human Trabecular Meshwork Cells by Targeting TGF-β/SMAD2 Pathway by Le Xu, Yiming Zhang, Hua Long, Bo Zhou, Haibo Jiang

“…TMCs were disposed with 300 μM H2O2 to establish oxidative damage models in vitro. miR-486-5p mimics and its controls were transfected into TMCs, and cell apoptosis and extracellular matrix production (ECM) genes were measured by flow cytometry, western blotting, and immunofluorescence staining. …”
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Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis by Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang

“…The hallmark gene NF-kappaB-inducing kinase (NIK/MAP3K14) associated with NF-κB and TNF signaling was identified, and the expression levels of NIK in CD19+B cells, CD4+T cells and serum from new-onset MG patients and controls were validated by flow cytometry, qPCR and ELISA. In vitro and in vivo, the effects of NIK inhibitor (B022) on the function of CD19+B cells and CD4+T cells were detected under the MG PBMCs, sorted B cells and experimental autoimmune MG (EAMG) rat model, respectively. …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…Methods The functional depletion effects of PD-L1 positive platelets on TME and immune cells were measured via western blotting, immunofluorescence staining, qRT-PCR, ELISpot and flow cytometry. In vivo, CD274 knockout (KO), CD8a KO, platelet-specific KO (PF4-Cre-Hsp90b1flox/flox) mouse models and a subcutaneous tumour model treated with aspirin and PD-L1 mAb were established in C57BL/6 N mice. …”
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The Diagnostic Capability of Swept Source OCT Angiography in Treatment-Naive Exudative Neovascular Age-Related Macular Degeneration by Daniel Ahmed, Martin Stattin, Anna-Maria Haas, Stefan Kickinger, Maximilian Gabriel, Alexandra Graf, Katharina Krepler, Siamak Ansari-Shahrezaei

“…In 23 of these 32 eyes (71.9%), abnormal flow in cross-sectional SS-OCTA B-scans was identified, giving an overall SS-OCTA sensitivity of 94.3%. …”
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Magnetic Resonance Imaging of Contrast-Induced Acute Renal Injury and Related Pathological Alterations In Vivo by Yanfei Li, Dafa Shi, Haoran Zhang, Xiang Yao, Ke Ren

“…The definitive mechanisms of CI-AKI include contrast medium (CM) nephrotoxicity and CM disturbances in renal blood flow, but how the immune system responds to CM has rarely been mentioned in previous studies, and different cell death pathways have not been clearly distinguished. …”
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Survey algorithm for cold and hot water supply systems of residential buildings by N. A. Makisha, V. A. Chukhin

“…At low velocity of water flow in pipes with a change in the direction of water movement from horizontal to vertical and down, air will accumulate on the horizontal section of the main pipeline, while sediment will accumulate on the horizontal section going to the riser.Conclusions. …”
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Strongly Coupled 𝒫𝒯-Symmetric Models in Holography by Daniel Areán, David Garcia-Fariña, Karl Landsteiner

“…Remarkably, these non-Hermitian lattices flow to a <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="script">PT</mi></semantics></math></inline-formula>-symmetric fixed point in the IR.…”
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