A Novel Multiplex LAMP Assay for the Rapid and Accurate Diagnosis of Visceral Leishmaniasis Caused by Leishmania infantum from Iran by Sahar Samsami, Sahar Namavari, Saeed Ataei, Abdolmajid Ghasemian, Ava Yazdanpanah, Neda Sepahi, Gholamreza Hatam, Hossein Faramarzi, Hadi Mirzaei, Razie Ranjbar, Ali Ghanbariasad

“…Nested PCR exhibited a lower detection limit for L. infantum of 4 × 106 plasmid copy number compared to multiplex LAMP and RT-qPCR. …”
Get full text

Improvement of the management system of the pharmaceutical service of the health care institution by Ye.V. Zalyhina

“…Therefore, it can be concluded that the introduction of new approaches to control the prescription of medicines led to a significant (p<0.002) reduction in the level of errors in appointment lists over 4.5 years by 78.44% compared to the initial value; the higher level of errors in appointment lists corresponds to lower costs for medical care, which is a consequence of the unstable situation on the drug market during the pandemic and the war in Ukraine; the improvement of pharmaceutical service management processes was directed to the following areas of work: planning, control, implementation and functioning of the information system, personnel management, performance evaluation, involvement of interested parties for the formation and implementation of decisions.…”
Get full text

Effect of Catheterization Time combined with Volume on Patients with Incomplete Bladder Emptying after Stroke by Huiying ZHANG, Xiuqin SHAO, Tianzi ZOU, Xiaoyue LI, Shuang QUAN, Tongzhou MI

“…Compared with the control group, the micturition volume and bladder capacity of the observation group were significantly higher, and the micturition times and residual urine volume were significantly lower after intervention for three weeks in the observation group, and the difference was statistically significant (<italic>P</italic>&lt;0.05). …”
Get full text

Psychological detachment from work predicts mental wellbeing of working-age adults: Findings from the 'Wellbeing of the Workforce' (WoW) prospective longitudinal cohort study. by Holly Blake, Juliet Hassard, Louise Thomson, Wei Hoong Choo, Teixiera Dulal-Arthur, Maria Karanika-Murray, Lana Delic, Richard Pickford, Lou Rudkin

“…Better psychological wellbeing, lower anxiety and higher life satisfaction at T2 were observed in those who reported better psychological detachment from work at T1 (β = .21, p = .01; β = -.43, p < .001; β = .32, p = .003, respectively), and in those who improved in this recovery activity from T1 to T2 (β = .36, p < .001; β = -.27, p < .001; β = .27, p = .008, respectively), controlling for age, gender and ethnicity.…”
Get full text

Use of supervised and unsupervised approaches to make zonal application maps for variable-rate application of crop growth regulators in commercial cotton fields by Maria C. da S. Andrea, Cristiano F. de Oliveira, Fabrícia C. M. Mota, Rafael C. dos Santos, Edilson F. Rodrigues Junior, Lucas M. Bianchi, Rodrigo S. de Oliveira, Caio M. de Gouveia, Victor G. S. Barbosa, Marco A. Bispo E Silva

“…However, when comparing zonal application maps for specific field-date combinations, the predicted plant height exhibited lower variability compared with field measurements. …”
Get full text

Psychosocial, physical, cognitive and quality of life aspects in primary restless legs syndrome by I. Jarašiūnaitė, R. Kaladytė-Lokominienė

“…General health perception score by SF-36 questionnaire was significantly lower (p=0.032) in RLS group. A moderate negative correlation was found between IRLSSGS scores and the assessment of bodily pain (p<0.001, r=-0.694) and general health perception evaluation (p=0.009, r=-0.585). …”
Get full text

Major facility superfamily sugar transporter protein SsMFSST1 regulates Sporisorium scitamineum mating, pathogenicity, and sugar transport/absorption by Yi Zhang, Yongding He, Meixin Yan, Shilong Zhang, Sisi Zhou, Wankuan Shen

“…It was observed that the expression levels of the key genes Uac1 for cAMP synthesis and Aro8 for tryptophol synthesis were significantly lower in the knockout mutants compared with the wild type. …”
Get full text

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…Importantly, serological response to coronavirus disease 2019 (COVID-19) was not impacted by zanubrutinib. Lower levels of granulocyte colony-stimulating factor, interleukin (IL)-10, monocyte chemoattractant protein-1, IL-4, and IL-13 were observed in zanubrutinib-treated patients. …”
Get full text

Regular versus as-needed treatments for mild asthma in children, adolescents, and adults: a systematic review and network meta-analysis by Prapaporn Pornsuriyasak, Sunatee Sa-nguansai, Kunlawat Thadanipon, Pawin Numthavaj, Gareth J. McKay, John Attia, Ammarin Thakkinstian

“…With varying degrees of heterogeneity, severe exacerbation risk in adolescents/adults might be lower with regular ICS/LABA or AN-ICS/FABA than regular ICS, where AN-ICS/FABA may not be suitable for patients with low FEV1. …”
Get full text

Relationships between the Planetary Health Diet Index, its food groups, and polygenic risk of obesity in the CARTaGENE cohort by Guiomar Masip, Daiva E. Nielsen

“…Conclusions PHDI adherence was associated with a lower BMI, WC, and body fat % and genetic susceptibility to obesity was partly mediated by the intake of red meat and whole grains. …”
Get full text

The role of OCO-3 XCO₂ retrievals in estimating global terrestrial net ecosystem exchanges by X. Wang, F. Jiang, F. Jiang, F. Jiang, H. Wang, Z. Zhang, M. Wu, J. Wang, W. He, W. Ju, W. Ju, J. M. Chen, J. M. Chen

“…The results show that when only the OCO-3 XCO<span class="inline-formula">₂</span> is assimilated (Exp_OCO3), the estimated global land sink is significantly lower than that from the OCO-2 experiment (Exp_OCO2). …”
Get full text

Electroporation assisted delivery of Roussin salt porphyrin-based conjugated carbon nanoparticles for sono–X-ray–photodynamic prostate cancer in vitro and in vivo treatment by Samir Ali Abd El-Kaream, Abed Elrahman Ahmad Mohamad, Sohier Mahmoud El-Kholey, Samia Abd El-Moniem Ebied

“…Furthermore, EP@RRBP-CNP is a promising SXPS that, when used in conjunction with SXPDT, can be very effective in in vitro treating PCa-DU-145 (in a dose-dependent manner cell viability declined, an increase in the cells population during the G0/G1-phase indicates that the cell cycle was arrested, and an increase in cell population in the Pre-G, autophagic cell death, as well as necrosis and early and late apoptosis, indicate that cell death was induced) and MNU/testosterone-PCa-induced mice in vivo (induced antiproliferative genes, p53, Bax, TNFalpha, caspase 3,9, repressed antiangiogenic and antiapoptotic genes, VEGF and Bcl2, respectively), successfully slowing the growth of tumors and even killing cancer cells, as well as lowering oxidative stress (MDA), improving the functions of the kidneys (urea, creatinine), liver (ALT, AST), and antioxidants (GPx, GPx, GST, CAT, GSH, TAC). …”
Get full text

Reliability and Measurement Error of the Qualitative Analysis of Single Leg Loading (QASLS) Tool For Unilateral Tasks by Gemma N Parry, Lee C Herrington, Allan G Munro

“…Qualitative analysis of single leg loading (QASLS) is a new clinical assessment tool for unilateral tasks that utilizes a dichotomous scoring system of ten questions relating to the segmental body regions of the trunk, lower and upper limb. # Purpose To determine the intra and inter-rater, within- and between-session reliability of the QASLS tool during two unilateral movement tasks, and provide insight to measurement error and smallest detectable difference (SDD)…”
Get full text

Evaluation of anatomical and functional success in canalicular laceration repair using anterior segment optical coherence tomography and dacryoscintigraphy by Çisil Erkan Pota, Özge Ekin Geçer Şerifoğlu, Aslı Çetinkaya Yaprak, Hatice Deniz İlhan, Adil Boz

“…Results: Sixteen patients (67 %) had lower, 7 (29 %) had upper canaliculus, and one (4 %) had lacerations in both canaliculi. …”
Get full text

Examining differences in exposure to digital marketing of unhealthy foods reported by Canadian children and adolescents in two policy environments by Laura Vergeer, Carolina Soto, Mariangela Bagnato, Elise Pauzé, Ashley Amson, Tim Ramsay, Dana Lee Olstad, Vivian Welch, Monique Potvin Kent

“…Results The odds of reporting more frequent exposure to marketing of sugary drinks (OR: 0.48; 95% CI: 0.33, 0.69), sugary cereals (OR: 0.59; 95% CI: 0.41, 0.86), salty/savoury snacks (OR: 0.67; 95% CI: 0.47, 0.96), fast food (OR: 0.65; 95% CI: 0.45, 0.92), and desserts/sweet treats (OR: 0.54; 95% CI: 0.37, 0.78) were lower among Quebec children than Ontario children. …”
Get full text

Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients by Wang T, Zhang L, Chen W, Long Y, Zhang Y, Wang L, Hou Z

“…Tao Wang,1,&ast; Liping Zhang,2,&ast; Wei Chen,3 Yubin Long,3 Yingze Zhang,3– 6 Ling Wang,3 Zhiyong Hou3– 6 1Department of Lower Limb Trauma, Beijing Jishuitan Hospital, Guizhou Hospital, Guiyang, Guizhou, People’s Republic of China; 2Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 4Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, Ministry of Education, Shanghai, People’s Republic of China; 5Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, People’s Republic of China; 6NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhiyong Hou, Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. …”
Get full text

Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging by Djawid Hashemi, Djawid Hashemi, Djawid Hashemi, Djawid Hashemi, Karl Jakob Weiß, Karl Jakob Weiß, Karl Jakob Weiß, Patrick Doeblin, Patrick Doeblin, Patrick Doeblin, Moritz Blum, Radu Tanacli, Radu Tanacli, Radu Tanacli, Hana Camdzic, Hana Camdzic, Hans-Dirk Düngen, Hans-Dirk Düngen, Frank Edelmann, Frank Edelmann, Frank Edelmann, Titus Kuehne, Titus Kuehne, Titus Kuehne, Marcus Kelm, Marcus Kelm, Marcus Kelm, Sebastian Kelle, Sebastian Kelle, Sebastian Kelle

“…Patients underwent MRI to assess tissue sodium content in the lower extremity. Tissue sodium content was analyzed in relation to baseline HF parameters, including renal function, natriuretic peptide levels, clinical signs of congestion, diuretic use, and New York Heart Association (NYHA) functional class. …”
Get full text

Clinical Activity of Behcet&rsquo;s Disease Associated with SARS-CoV-2 and Herpes Simplex Virus: Insights from Three Case Reports by Bakti FU, Sufiawati I

“…All patients showed good clinical improvement after treatment.Conclusion: The BD activity index scores of a BD patient with COVID-19 were lower than those with HSV-1 infection. This difference may be due to the recent SARS-CoV-2 infection in the patient, whereas reactivation of chronic latent HSV-1 in the other patients likely contributed to a longer history of clinical manifestations, resulting in increased disease activity.Keywords: autoimmune disease, Behcet’s disease, SARS-CoV-2, HSV-1…”
Get full text

Comparison of the effects of pulse and direct injection flushing methods after intravenous injection of non-irritating drugs (脉冲式和直接推注式冲管方法用于非刺激性药物输注的效果比较)... by WANG Yali (王亚丽), WEI Yongchun (魏永春), E Haiyan (鄂海燕), DONG Yuxia (董玉霞), SUN Lei (孙磊)

“…Results The incidence of blood return and tube blockage in the observation group was lower than that in the control group(P＜0. 05). The phlebitis occurred in neither of the two groups. …”
Get full text

Prospects of two-port vitrectomy in the treatment of patients with epiretinal fibrosis by D.V. Borisova, I.A. Frolychev, N.A. Pozdeeva

“…The surgical technique included the installation of two ports in the opposite quadrants: in the upper hemisphere for the vitreotome and instruments, and in the lower hemisphere — for the infusion cannula with a built-in endo-illuminator-chandelier as a single light source. …”
Get full text