What is the influence of single-entry models on access to elective surgical procedures? A systematic review by Deborah A Marshall, Zaheed Damani, Barbara Conner-Spady, Tina Nash, Henry Tom Stelfox, Tom W Noseworthy

“…Background Single-entry models (SEMs) for the management of patients awaiting elective surgical services are designed to increase access and flow through the system of care. We assessed scope of use and influence of SEMs on access (waiting times/throughput) and patient-centredness (patient/provider acceptability).Methods Systematic review of articles published in 6 relevant electronic databases included studies from database inception to July 2016. …”
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A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability by Xiujuan Yang, Zhongzhi Gan, Xiaoling Guo, Xiang Huang, Juan Liu, Yingchun Zheng, Xiaoqiang Zhou, Jingli Lian, Yue Liu, Tingting Yang, Chao Li, Fenying Chen, Fei He, Xiangmin Xu, Yasi Zhou, Qian Liu, Xingkun Yang, Fu Xiong

“…Western blots and QPCR were employed to assess gene expression and protein stability. Flow cytometry was utilized to compare the cell cycle dynamics between wild-type and mutant cells. …”
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A literature review on transformative impacts of blockchain technology on manufacturing management and industrial engineering practices by Dharmendra Hariyani, Poonam Hariyani, Sanjeev Mishra, Milind Kumar Sharma

“…As business performance increasingly depends on decentralized, tamper-proof records to manage transactions and data flows, adopting blockchain technology (BCT) is becoming crucial for remaining competitive in the digital and globalized economy. …”
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The role of optical coherence tomography angiography in assessing diabetic choroidopathy: a systematic review by M. Hossein Nowroozzadeh, Mansoureh Bagheri

“…Conflicting evidence exists regarding the correlation between choriocapillaris flow reduction and DR severity. OCTA may also predict changes in visual function related to choroidal perfusion, though it cannot fully replace clinical examinations. …”
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TIM-3 and TIM-1 Could Regulate Decidual γδTCR Bright T Cells during Murine Pregnancy by Jasper Nörenberg, Matyas Meggyes, Pal Jakso, Eva Miko, Aliz Barakonyi

“…Gamma/delta T cells from the uterus and spleen of pregnant and nonpregnant mice were analyzed by flow cytometry. We confirmed that the rate of γδT cells in the decidua increases during murine pregnancy and half of decidual γδT cells are CD4+. …”
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BAFF and APRIL immunotherapy following Bacille Calmette-Guérin vaccination enhances protection against pulmonary tuberculosis in mice by Min Xie, Chen-Yu Tsai, Joshua Woo, Frank Nuritdinov, Melissa Cristaldo, Narineh M. Odjourian, Rosleine Antilus-Sainte, Maureen Dougher, Martin Gengenbacher, Martin Gengenbacher

“…We have previously shown that unconventional B cell subsets play a role in tuberculosis control.MethodsHigh-dimensional flow cytometry and multiplex cytokine analysis were employed to investigate the effects of immunotherapy on BCG-vaccinated mice in an Mtb challenge model.ResultsIn this study, we investigate the potential of recombinant cytokines targeting B cells – B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) – to modulate BCG immunity and improve protection in mice. …”
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Evaluation of Atrioventricular Valve Regurgitation in Detection of Atrioventricular Septal Defects at First Trimester Ultrasound by Zhen Guo, Yang Yan, Yang Zhili, Xiao Juhua, Xiao Xiaojuan, Chen Jia, Luo Haiyan, Zhou Xin

“…It included routine ultrasound examinations focusing on fetal anatomy, NT measurement, and blood flow analysis across AVVR using both color and directional power Doppler. …”
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Beta-Blocker Therapy Preserves Normal Splenic T-Lymphocyte Numbers Reduced in Proportion to Sepsis Severity in a Sepsis Model by Takeshi Suzuki, Kei Inoue, Toru Igarashi, Jungo Kato, Hiromasa Nagata, Takashige Yamada, Shizuka Minamishima, Hiroshi Morisaki

“…Their spleens were resected under general anesthesia 24 hours after CLP, and the total number of normal splenic T lymphocytes per mouse and the percentage of apoptotic T lymphocytes were evaluated using flow cytometry. In the second experimental study, the effect of the beta-blocker esmolol was examined in CLP-P (group CLP-PE vs. …”
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Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions by Irma Saulle, Irma Saulle, Fiona Limanaqi, Micaela Garziano, Micaela Garziano, Maria Luisa Murno, Valentina Artusa, Valentina Artusa, Sergio Strizzi, Matteo Giovarelli, Carsten Schulte, Jacopo Aiello, Mario Clerici, Mario Clerici, Claudia Vanetti, Mara Biasin

“…In these cells following 3 h or 24 h rhERAP stimulation by Western Blot, RT-qPCR, Elisa, Confocal microscopy, transwell migration assay, Oxygraphy and Flow Cytometry we assessed: i) rhERAP internalization; ii) activation; iii) migration; iv) oxygen consumption rate; v) reactive oxygen species (ROS) accumulation; granule release; vi) phagocytosis; and vii) autophagy.ResultsWe observed that following stimulation rhERAPs: i) were internalized by neutrophils; ii) triggered their activation as witnessed by increased percentage of MAC-1+CD66b+ expressing neutrophils, cytokine expression/release (IL-1β, IL-8, CCL2, TNFα, IFNγ, MIP-1β) and granule enzyme secretion (myeloperoxidase, Elastase); iii) increased neutrophil migration capacity; iv) increased autophagy and phagocytosis activity; v) reduced ROS accumulation and did not influence oxygen consumption rate.ConclusionOur study provides novel insights into the biological role of ERAPs, and indicates that extracellular ERAPs, contribute to shaping neutrophil homeostasis by promoting survival and tolerance in response to stress-related inflammation. …”
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CD155 promotes the progression of colorectal cancer by restraining CD8+ T cells via the PI3K/AKT/NF-κB pathway by Rongpu Liang, Liting Liu, Dongbing Ding, Yiquan Li, Jiannan Ren, Bo Wei

“…We then tested the changes in the PI3K/AKT/NF-κB pathway in CD8+ T cells by flow cytometry. Results We demonstrated that stable CD155 expression was negatively correlated with prognosis in colorectal cancer patients. …”
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Gross domestic product, savings, investment and inflation, an ARDL approach and Toda-Yamamoto causality: Evidence from Zimbabwe by Talent Kondo, Simba Mutsvanga, Tonderai Kanyekanye

“…Furthermore, the study found a distinct causal flow from savings to investment, without feedback in the opposite direction, highlighting the crucial role of a robust savings culture in providing the necessary foundation for sustained investment and economic growth. …”
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Novel, low-cost bioreactor for in vitro electrical stimulation of cardiac cells by Joseph P. Licata, Jonathan A. Gerstenhaber, Peter I. Lelkes

“…Finite element analysis and mathematical modeling were used to model the fluid dynamics and to characterize in detail the delivery of pulsatile electrical signals, providing precise control over stimulation parameters such as voltage, current, and charge.ResultsThe bioreactor developed here provides an easy-to-use, inexpensive platform for culturing hiPSC-CMs under the influence of ES and low-shear fluid flow for enhanced nutrient availability, while its “drop-in” design facilitates real-time observation of cultured cells. …”
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Autonomous Behavior Intelligence Control of Self-Evolution Mobile Robot for High-Voltage Transmission Line in Complex Smart Grid by Wei Jiang, Gan Zuo, De Hua Zou, Hongjun Li, Jiu Jiang Yan, Gao Cheng Ye

“…The movement and working flow of the robot improve the robot operation intelligence and operation efficiency. …”
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Planning of construction supply system in constrained conditions using the dynamic programming method by Ya. D. Ageeva, Yu. A. Chirkunov, A. A. Lapidus

“…The supply system for construction production was optimized for multi-threaded organization of work; based on the optimization results, the optimal distribution of resources was determined and a network diagram of the movement of cargo flows was constructed during the considered stage of building construction. …”
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Mapping evidence on the distribution of uterine fibroids in sub-Saharan Africa: A scoping review protocol. by Vuyisile Ginindza, Makandwe Nyirenda, Mbuzeleni Hlongwa, Themba G Ginindza

“…The Population Concept and Context (PCC) framework will be used and the PRISMA flow diagram will also be used to show the literature search and selection of studies. …”
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INSPIRE Datahub: A Pan-African Integrated Suite of Services For Harmonising Longitudinal Population Health Data Using OHDSI Tools. by Bhattacharjee, Tathagata, Kiwuwa-Muyingo, Sylvia, Kanjala, Chifundo, Maoyi, Molulaqhooa L., Amadi, David, Ochola, Michael, Kadengye, Damazo, Gregory, Arofan, Kiragga, Agnes, Amelia, Taylor, Greenfield, Jay, Slaymaker, Emma, Todd, Jim, INSPIRE Network8

“…It ensures FAIR data by establishing metadata flows, capturing provenance throughout the ETL processes, and providing accessible metadata for potential users. …”
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Financial Management and Performance of Banks in Kabale District: A Case Study of ABSA Bank Kabale. by Turihohabwe, Rominate

“…The study recommended that there should be ensuring that the bank maintains an optimal level of cash reserves to meet daily operational needs and unexpected expenses as this can help in avoiding liquidity crises while minimizing the opportunity cost of holding excessive cash and there should be implementation of the strategies to speed up the collection of receivables since this can include setting clear credit policies, offering discounts for early payments, and regularly reviewing the creditworthiness of clients as faster collections improve cash flow and reduce the risk of bad debts.…”
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Assessment of Birth Preparedness and Complication Readiness among Pregnant Women: A Cross-sectional Study by T Elamathi, K Ananthi, Rimi Singh

“…Results: The mean age for Group-R was 45.00±7.1 years and Group-L 51.95±8.03 years. onset of sensory blockade at the T10 level and the onset of motor blockade in Group-R were slower than in Group-L (p-value <0.05). The time to two-segment regression was significantly faster in Group-R than in Group-L (p-value <0.05). …”
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Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Priya Kishnani, Richa Tailor, Sara Mary Thomas

“…Results: The mean age for Group-R was 45.00±7.1 years and Group-L 51.95±8.03 years. onset of sensory blockade at the T10 level and the onset of motor blockade in Group-R were slower than in Group-L (p-value <0.05). The time to two-segment regression was significantly faster in Group-R than in Group-L (p-value <0.05). …”
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AI for IMPACTS Framework for Evaluating the Long-Term Real-World Impacts of AI-Powered Clinician Tools: Systematic Review and Narrative Synthesis by Christine Jacob, Noé Brasier, Emanuele Laurenzi, Sabina Heuss, Stavroula-Georgia Mougiakakou, Arzu Cöltekin, Marc K Peter

“…However, its clinical adoption has been slower than anticipated, largely due to the absence of comprehensive evaluation frameworks. …”
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