High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

“…Conclusions High RF titers in long-standing RA were associated with worse disease activity, lower physical functionality, increased extra-articular manifestations, and higher usage of corticosteroids and bDMARDs. …”
Get full text

Association of serum chloride levels with all-cause mortality among patients in surgical intensive care units: a retrospective analysis of the MIMIC-IV database by Quan Ma, Wei Tian, Kaifeng Wang, Bin Xu, Tianyu Lou

“…Particularly, patients in the highest quartile of serum chloride faced significantly lower mortality risks compared to those in the lowest quartile (30 days HR = 0.65, 90 days HR = 0.71, 180 days HR = 0.69, P < 0.001). …”
Get full text

Prevalence, Antimicrobial Resistance, and Associated Factors of Streptococcus pneumoniae Colonization Rate among Old-Age Patients with Respiratory Tract Infection Attending Sheik H... by Surafel Mekuria, Ayichew Seyoum, Zerihun Ataro, Tigist Abebe, Kedir Urgessa

“…A total of 188 individuals greater than or equal to 60 years suspected of both upper and lower respiratory tract infections were included. …”
Get full text

Efficacy, Feasibility, and Acceptability of an Emotional Competence Tele-Intervention for Mandarin-Speaking Children Aged 5 to 7 Years With Developmental Language Disorder: Pilot S... by Hsin-Hui Lu, Shih-Yuan Liang, Yi-Chia Huang

“…ConclusionsMandarin-speaking children aged 5 to 7 years with DLD exhibited lower emotional competence compared with their counterparts with TLD. …”
Get full text

Estimated standard values of aerobic capacity according to sex and age in a Japanese population: A scoping review. by Hiroshi Akiyama, Daiki Watanabe, Motohiko Miyachi

“…Additionally, aerobic capacity is lower in the Japanese population than in other populations across a wide range of age groups. …”
Get full text

Biopsy location and tumor-associated macrophages in predicting malignant glioma recurrence using an in-silico model by Pejman Shojaee, Edwin Weinholtz, Nadine S. Schaadt, Friedrich Feuerhake, Haralampos Hatzikirou

“…Our findings reveal that macrophage density at the tumor edge contributed to a high predictive value of feature importance for the selected regression model. Moreover, there are lower MSE values for the “localized” biopsy in prediction accuracy toward recurrence post-resection compared with “non-localized” specimens in the noisy data. …”
Get full text

A Single-Mode 852-nm Faraday Laser by Zhiyang Wang, Zijie Liu, Jianxiang Miao, Hangbo Shi, Xiaomin Qin, Xiaolei Guan, Jia Zhang, Pengyuan Chang, Tiantian Shi, Jingbiao Chen

“…As for the noise performance of the laser, the typical value of relative intensity noise (RIN) at 10 kHz is lower than &#x2212;134 dBc/Hz. The pahse noise of the laser is superior than the commerical product. …”
Get full text

Experimental Investigations on Charge Induction and Microseismic Characteristics of the Coal and Rock under Different Loading Rates by Yuchun Liu, Ling Ding, Yangfeng Zhao, Yi Fan, Hongfei Li

“…However, the spectrum distribution range of microseismic signals of coal samples is wider than that of sandstone samples, and the spectrum amplitude of coal samples is lower than that of sandstone. With the increase of loading rate, the time of the first generation of high-amplitude signals is advanced, and the stress of specimen becomes smaller when the first generation of high-amplitude signals occurs. …”
Get full text

NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

“…Specifically, NALCN levels were lower in GC tumor tissues and plasma compared to adjacent non-tumor tissues and healthy controls. …”
Get full text

Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort stud... by Jian Chen, Jian Chen, Haixin Huang, Ruichen Zhang, Yueqiang Fu, Chunmei Jing

“…The incidence of septic shock (42.1% vs. 69%, P &lt; 0.001) and AKI (14% vs. 31%, P = 0.005) was significantly lower in the survival group compared to the non-survival group. …”
Get full text

Global regional and national burden of intracerebral hemorrhage between 1990 and 2021 by Zhao-wei Wang, Mei-ping Wan, Jia-hui Tai, Yong Wang, Min-yi Yin

“…However, the burden of ICH remains substantial and unevenly distributed across regions, with lower SDI areas facing a disproportionately higher burden. …”
Get full text

The value of exosomes suppressor of cytokine signaling 1， speckled protein 140 and calcyclin binding protein expressions in peritoneal dialysis effluent in the diagnosis of periton... by Han Xiao-li, Wang Jia-wei, Wei Zhi-feng, Wang Lin-lin, Guo Bao-zhu, Cao Yan-chun, Jin Yu-jie, Liu Sheng-jun

“…The diagnostic value of SOCS1， SP140 and CacyBP expressions in PF was analyzed.ResultsThe mRNA levels of exosomes SOCS1 ［（0.84 ± 0.11） vs （1.00 ± 0.15）］， SP140 ［（0.82 ± 0.12） vs （1.00 ± 0.13）］ and CacyBP ［（0.85 ± 0.09） vs （1.00 ± 0.13）］ in peritoneal dialysis effluent of PF group were significantly lower than those of control group （P<0.05）. In both the PF group， and control group， the mRNA expression levels of exosomes SOCS1， SP140 and CacyBP in peritoneal dialysis effluent were positively correlated with 4 h ultrafiltration dose， and 4 h D/PCr， and negatively correlated with D/D0 （P<0.05）. …”
Get full text

Healthy Life Centres: a 3-month behaviour change programme’s impact on participants’ physical activity levels, aerobic fitness and obesity: an observational study by Ellen Eimhjellen Blom, Eivind Aadland, Ane Kristiansen Solbraa, Line Merethe Oldervoll

“…Objectives Individuals with low socioeconomic status and multimorbidity tend to have lower physical activity (PA) levels than the general population. …”
Get full text

Internalizing and externalizing symptoms in individuals with neurofibromatosis type 1: a systematic review and meta-analysis by Dan Liu, Liyan Yu, Xian Wu, Julia Moreira, Benjamin Felipe Mujica, Elora Shelly Mukhopadhyay, Angelena Novotney, André B. Rietman, Yang Hou

“…Studies that included more participants with NF1 who had ADHD or a lower verbal IQ reported greater group disparities in total internalizing symptoms or aggression. …”
Get full text

Determination of the quantitative content of chlorophylls in leaves by reflection spectra using the random forest algorithm by E. A. Urbanovich, D. A. Afonnikov, S. V. Nikolaev

“…In the f irst case, the predictions of the method based on a random forest had a lower estimate of the standard deviation. In the second case, the predictions of this method had a large error for small values of chlorophyll, while the third-party method had acceptable predictions. …”
Get full text

99mTc(CO)3-Labeled 1-(3-Nitropyridin-2-yl) Piperazine as Potential Radioligand for 5-HT7 Receptors by Sajjad Molavipordanjani

“…This radiotracer displayed moderate affinity for the U87-MG cell line’s 5-HT7R and lower affinity for MCF-7, SKBR3, HT-29, and A549 cell lines. …”
Get full text

Assessment of the variability and correlation of biometric measurements in eyes with cataracts by Jian-Feng Zhao, Chen Yang, Jie Zhou, Hai-Yan Zhang, Yu Geng

“…Males demonstrated significantly longer AL, deeper ACD, thicker LT, larger WTW, and lower Km compared to females (P < 0.05). Although males exhibited a greater anterior segment length (ASL), this difference did not reach statistical significance (P > 0.05). …”
Get full text

Long-term efficacy and safety of alemtuzumab in participants with highly active MS: TOPAZ clinical trial and interim analysis of TREAT-MS real-world study by Tjalf Ziemssen, Ann D. Bass, Bart Van Wijmeersch, Sara Eichau, Stephan Richter, Frank Hoffmann, Nicole M. Armstrong, Magdalena Chirieac, Janete Cunha-Santos, Barry A. Singer

“…Annual treatment-emergent AE incidences declined in TOPAZ and were lower in TREAT-MS. Conclusion: Sustained efficacy of alemtuzumab was observed for clinical and radiological outcomes in participants with HAD in the TOPAZ clinical trial and real-world TREAT-MS study with no new safety signals. …”
Get full text

Signs of Nervous System Sensitization in Female Runners with Chronic Patellofemoral Pain by Brian J. Eckenrode, David M. Kietrys, Allison Brown, J. Scott Parrott, Brian Noehren

“… # Results The PFP group exhibited significantly lower scores on the KOOS-PF (p\<0.001), BPI Pain Severity and Interference Scores (p\<0.001), and UWRI (p\<0.001). …”
Get full text

Correlation analysis between preoperative odontoid incidence and clinical outcomes 2 years after anterior cervical discectomy and fusion by Yan Gong, Hao Liu, Yanchi Gan, Jiahui He, Zelin Zhou, Hang Zhuo, Yu Liu, De Liang, Hui Ren, Xiaobing Jiang, Zhaojun Cheng

“…Conclusion In ACDF, the preoperative OI of patients with CSM was negatively correlated with the VAS and NDI scores at the final postoperative follow-up; Larger preoperative OI corresponded to lower VAS and NDI scores at the final follow-up, leading to comparatively improved 2-year clinical outcomes.…”
Get full text