The Impact of Coronavirus Disease 2019 Pandemic on Female Patients Seeking or Undergoing Fertility Treatment in a Single In Vitro Fertilisation Clinic in Greece: An International,... by Konstantina Pappa, Emmanouil M. Xydias, Apostolos C. Ziogas, Kanelina Bimba, Elias Tsakos, Efstratios Kolibianakis

“…Collected data were cross-tabulated, and the Chi-square test was used as a measurement of the differences between national and cross-border patients. A P value lower than 0.05 was considered statistically significant. …”
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Body mass index impacts the lipid-lowing effects of statins in patients with type 2 diabetes by Lulu Sun, Zhuo Wang, Bai Wang, Yuxiang Jia, Qidi Zhao, Jingjun Zhao, Xingtao Huang

“…Multivariate logistic regression analysis indicated that achieving lipid control, defined as LDL < 2.6 mmol/L, was more likely in obese patients compared to those with normal weight [odds ratio [OR] 3.48, 95% confidence interval [CI]: 1.18, 10.21, p = 0.023].ConclusionsThe effectiveness of statins in lowering lipid levels appears to be influenced by the patient's BMI in patients with T2DM. …”
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Study on the effect of health education on dietotherapy and medicated diet for the community-dwelling elderly in Nanning city (南宁市社区老年人食疗药膳健康教育效果研究)... by LIN Xiaomin (林小敏), QIN Yi (覃毅), LING Xingping (凌鑫萍), HUO Lijuan (霍李娟), CHEN Yu (陈裕)

“…Results The average total score of cognitive assessment was (12. 93±2. 82)points before implementation of health education, which was lower than (18. 83±2. 85)points after implementation of health education(P＜0. 01). …”
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The Loge GDR Was Strongly Associated with NAFLD as a Predictor in Normoalbuminuric Patients with Type 2 Diabetes by Ji B, Gao G, Zhao H, Sheng J, Ma X, Shi S, Ban B

“…The relationship between the loge GDR and NAFLD was analyzed.Results: NAFLD patients showed lower loge GDR values than non-NAFLD (P < 0.001). …”
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Associations of modifiable dementia risk factors with dementia and cognitive decline: evidence from three prospective cohorts by Mengzhao Wang, Changming Fan, Yanbai Han, Yifei Wang, Hejia Cai, Wanying Zhong, Xin Yang, Zhenshan Wang, Hongli Wang, Yiming Han

“…The presence of multiple dementia risk factors correlated with a higher dementia risk; Specifically, compared with more than 5 risk factor events, both having no dementia risk factors and having only one dementia risk factor were associated with a significantly lower risk of dementia (Overall, HR = 0.15, 95% CI: 0.11–0.22, HR = 0.22, 95% CI: 0.18–0.25). …”
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The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023 by Xiaohui Ji, Haomin Tan, Shaoli Huang, Zhongguo Huang, Jianxiong Hu, Jianxiong Hu, Guanhao He, Fengrui Jing, Ziqiang Lin, Mengen Guo, Tao Liu, Wenjun Ma, Wenjun Ma

“…Temperature adaptation capacity increased with air conditioner ownership rates increasing from 25.40, 57.63 to 81.51% at home (Z = −44.35, p &lt; 0.01) and from 22.24, 57.47 to 80.51% in the office/school (Z = −45.95, p &lt; 0.01), and the older adult, women, people with low income, outdoor work, low education, and people from northern China had lower air conditioner ownership rates. The frequency of air conditioner usage when felt hot also escalated significantly both at home (from 42.6%, 54.9, to 63.4%, CMH value = 156.40, p &lt; 0.0001) and in the office/school (from 61.8, 63.1 to 72.7%, CMH value = 65.29, p &lt; 0.0001) during the same periods.ConclusionOur study found that most people perceived climate change and changed behaviors to adapt to heat. …”
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Efficacy and Safety of Ergoferon in Children from 6 Months to 6 Years Old with Acute Respiratory Viral Infections in Contemporary Outpatient Practice: A Multicenter, Double-Blind,... by N. A. Geppe, B. M. Blokhin, O. V. Shamsheva, S. T. Abdrakhmanova, K. A. Alikhanova, G. T. Myrzabekova

“…The incidence of adverse events (AEs) in the Ergoferon group was significantly lower compared to the placebo group (7.0% versus 18.8%; p=0.004) including infectious diseases (3.5% vs 12.5%; p=0.008). …”
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Bacteriological and Physicochemical Qualities of Ebutte River in Ebutte Community, Uhunmwonde Local Government Area, Edo State, Nigeria by Fred Osaro Ekhaise

“…The bacterial counts were shown to be highest in the inhabited point (3) while downstream (points 4 and 5) and upstream (points 1 and 2) recorded lower counts due to little or no human activities. …”
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PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to S. aureus Infection by Hao Jiang, Jiwei Gu, Haiyang Zhao, Sumit Joshi, Joel S. Perlmutter, Robert J. Gropler, Robyn S. Klein, Tammie L. S. Benzinger, Zhude Tu

“…A rodent local muscle bacterial infection model was developed by injecting S. aureus to the lower hind limb of Balb/c mice. The changes of S1PR1 expression in response to bacterial infection and blocking treatment were assessed using ex vivo biodistribution and in vivo positron emission tomography (PET) after intravenous injection of an S1PR1-specific radiotracer [18F]TZ4877. …”
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Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes by Hector Barajas-Martinez, Maya Smith, Dan Hu, Robert J. Goodrow, Colleen Puleo, Can Hasdemir, Charles Antzelevitch, Ryan Pfeiffer, Jacqueline A. Treat, Jonathan M. Cordeiro

“…Coexpression of PXDNL-R391Q with SCN5A-WT displayed lower INa density compared to PXDNL-WT. In addition, coexpression of PXDNL-R391Q with KCND3-WT displayed significantly higher Ito density compared to PXDNL-WT. …”
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Ameliorative effect of curcuminoids in liver fibrosis rat model via regulating GIPC1 gene and modulating MMP-8/TIMP-3 balance mediated by miR-483-5p by Rana Mostafa Adel, Sara Mostafa Kamal, Eman Adel Sherif, Sara Hatem El-shafiey

“…Conclusions This study concludes that CURC can modulate the novel miRNA-483-5p/MMP-8/TIMP-3 pathway and regulate GIPC1 expression, thus providing new perception of CURC as an effective therapeutic agent capable of lowering inflammation and remodeling liver damage. …”
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Altered functional brain connectivity in Dyt1 knock-in mouse models by R. Z. Adury, B. J. Wilkes, P. Girdhar, Y. Li, D. E. Vaillancourt, D. E. Vaillancourt, D. E. Vaillancourt

“…In dGAG animals, we observed significantly lower functional connectivity between key sensorimotor nodes, such as the globus pallidus, somatosensory cortex, thalamus, and cerebellum. …”
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Dietary effects of protected fat, soybean meal, and heat-treated soybean meal on performance, physiological parameters, and behavioral measurements of early-fattening Hanwoo steers... by Jun Sik Woo, Sun Sik Jang, Jeong Hoon Kim, Hong Gu Lee, Keun Kyu Park

“…Rumination during standing was 38% higher, and rumination during lying was 32% lower (p<0.05). Conclusion This study demonstrates 10% of increased levels of dietary TDN using PF and CP considering RUP can prevent performance reduction in early-fattening of heat-stressed Hanwoo steers and have positive effects on performance recovery from post-heat stress.…”
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Causal machine learning models for predicting low birth weight in midwife-led continuity care intervention in North Shoa Zone, Ethiopia by Wudneh Ketema Moges, Awoke Seyoum Tegegne, Aweke A. Mitku, Esubalew Tesfahun, Solomon Hailemeskel

“…The estimated ATE for the S-learner was 0.284, which is lower than the true ATE of 0.216. Additionally, the estimated ITE for both the T-learner and X-learner was less than -0.5, indicating that mothers would not choose to participate in the MLCC program. …”
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Multimodal Pain Recognition in Postoperative Patients: Machine Learning Approach by Ajan Subramanian, Rui Cao, Emad Kasaeyan Naeini, Seyed Amir Hossein Aqajari, Thomas D Hughes, Michael-David Calderon, Kai Zheng, Nikil Dutt, Pasi Liljeberg, Sanna Salanterä, Ariana M Nelson, Amir M Rahmani

“…RR models consistently outperformed other single modalities, particularly for lower pain intensities, while facial muscle activity (electromyogram) was most effective for distinguishing higher pain intensities. …”
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Comparing the effects of Mycozin and Clotrimazole 1% creams on vaginal candidiasis: a triple-blinded randomized controlled trial by Khadije Hajizadeh, Zahra Alivand, Vahideh Rahmani, Leila Mehrannia, Sanam Nami, Behrooz Shokouhi, Mojgan Mirghafourvand

“…After the treatment the frequency of itching in the Clotrimazole group (N = 13; 22.0%) was lower than that of the Mycozin group (N = 26; 43.3%) (OR: 0.37; 95% CI: 0.17 to 0.82; P = 0.013). …”
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Effectiveness of the BNT162b2 XBB.1.5-adapted vaccine against COVID-19 hospitalization related to the JN.1 variant in Europe: a test-negative case-control study using the id.DRIVE... by Jennifer L. Nguyen, Marianna Mitratza, Hannah R. Volkman, Leonie de Munter, Thao Mai Phuong Tran, Catia Marques, Mustapha Mustapha, Srinivas Valluri, Jingyan Yang, Andrés Antón, Irma Casas, Eduardo Conde-Sousa, Laura Drikite, Beate Grüner, Giancarlo Icardi, Gerrit Luit ten Kate, Charlotte Martin, Ainara Mira-Iglesias, Alejandro Orrico-Sánchez, Susana Otero-Romero, Gernot Rohde, Luis Jodar, John M. McLaughlin, Kaatje Bollaerts

“…Summary: Background: Prior studies have reported lower effectiveness of XBB.1.5-adapted vaccines against hospitalization related to the Omicron JN.1 variant than the XBB variant. …”
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MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma by Kah Young Lee, Su Young Oh, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Chang-Geol Shin, Su-Hyung Hong, So-Young Choi

“…In OSCC patient tissues, higher MTMR6 protein levels were associated with cisplatin sensitivity, while cisplatin-resistant tissues had lower MTMR6 expression. Survival analysis of the TCGA HNSCC dataset indicated that low MTMR6 expression correlates with poorer outcomes in cisplatin-treated patients compared to those with high MTMR6 expression. …”
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Serum Fibroblast Growth Factor 21 Levels Are Positively Associated with Metabolic Syndrome in Patients with Type 2 Diabetes by Ruo-Yao Gao, Bang-Gee Hsu, Du-An Wu, Jia-Sian Hou, Ming-Chun Chen

“…Female gender, hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), body weight (BW), body mass index (BMI), body fat mass, fasting glucose, glycated hemoglobin level (HbA1c), triglyceride level (TG), urine albumin-to-creatinine ratio (UACR), insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and FGF21 levels were higher, whereas high-density lipoprotein cholesterol level (HDL-C) and estimated glomerular filtration rate (eGFR) were lower in DM patients with MetS. Univariate linear analysis revealed that hypertension, BMI, WC, body fat mass, SBP, DBP, logarithmically transformed TG (log-TG), low-density lipoprotein cholesterol (LDL-C) level, log-glucose, log-creatinine, log-UACR, log-insulin, and log-HOMA-IR positively correlated, whereas HDL-C and eGFR negatively correlated with serum FGF21 levels in T2DM patients. …”
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Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network me... by Yuhua Jiang, Yingying Wang, Sijia Ma, Linlin Qian, Yeteng Jing, Xi Chen, Jinsheng Yang

“…BackgroundThe objective of this study is to assess the relative efficacy of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab, evolocumab, and inclisiran, in conjunction with potent statins like atorvastatin and rosuvastatin, in patients presenting with hyperlipidemia or heightened cardiovascular risk attributable to elevated low-density lipoprotein cholesterol (LDL-C).MethodsA systematic search was conducted across databases including PubMed, Embase, and the Cochrane Library to explore lipid-lowering therapies in hyperlipidemia from their inception to 7 November 2023. …”
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