Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study by Carmen Peral, Alfonso De Lossada Juste, Nadia Lwoff, Nataly Espinoza-Cámac, Miguel Ángel Casado, Tom Burke, Jose Alvir, Sheena Thakkar, Enrico Ferri Grazzi

“…EQ-5D-5L \[SD\] scores were lower in patients with severe HA (0.77 \[0.18\]) and severe HB (0.70 \[0.22\]) compared with patients with moderate HA (0.81 \[0.15\]) and moderate HB (0.86 \[0.17\]). …”
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Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality by Kang Wu, Qiming Gan, Yuhong Pi, Yanjuan Wu, Wenjin Zou, Xiaofen Su, Sun Zhang, Xinni Wang, Xinchun Li, Nuofu Zhang

“…Results In the cohort study, OSA patients exhibited significantly lower fractional amplitude of low-frequency fluctuation and regional homogeneity in the right posterior cerebellar lobe and bilateral superior and middle frontal gyrus, while showing higher levels in the left occipital lobe and left posterior central gyrus. …”
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Functional Dependency as a Marker for Positive SARC-F Screen among Older Persons at the Emergency Department by Edward Chong, Eileen Fabia Goh, Wee Shiong Lim

“…Results SARC-F+ patients were older (86.4±7.6 years), predominantly female (71.5%) and frail (73.9%), more dependent on walking aids (77.2%), and had lower premorbid MBI (median 90.0 [interquartile range 71.0–98.0]) and IADL (4.0 [2.0–5.0]) (both p<0.001). …”
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Outcomes of intravitreal dexamethasone implant (Ozurdex®) in patients with post-surgical macular edema – a real-world scenario by Elder Ohara de Oliveira Júnior, Isabel Ahn, Rodrigo Antonio Brant Fernandes, Arthur Gustavo Fernandes

“…We observed a significant effect of the moment of Ozurdex implantation on VA improvement, so that cases with implantation at the time of oil removal showed lower improvement than cases with implantation at a distinct timing (Coef. 0.19, 95%CI: 0.02 to 0.36, p = 0.027). …”
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Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia by Samuel Dagogo-Jack, Jim Wan, Chimaroke Edeoga, Peace Asuzu

“…African American offspring of parents with type 2 diabetes had higher insulin secretion and DI, and lower insulin sensitivity and clearance, than their European American counterparts. …”
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Effect of Qiao Meridian Massage Combined with Modern Rehabilitation Therapy on Children with Spastic Cerebral Palsy by YANG Qiuping, WANG Huijuan, CHEN Bichan, FANG Xuexia, YANG Yan, YE Yong, TANG Wei, ZHANG Hong

“…Compared with the control group, MAS score of the experimental group was significantly lower after treatment, the ROM of adductor muscles was significantly larger, and GMFM-88 D and E scores were significantly higher (<italic>P</italic>&lt;0.05). …”
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Ultraviolet-Induced Fluorescence Dermoscopy, a Novel Diagnostic Technique in Dermatological Practice: A Systematic Review by Yasmeen Jabeen Bhat, Mohd Shurjeel Ul Islam, Enzo Errichetti

“…When intense UV radiation with shorter wavelengths strikes a target chromophore, visible light (VL) with a longer wavelength and lower energy is produced in the skin. This VL is apparent to the naked eye and is referred to as fluorescence. …”
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Post-operative Rehabilitation for Scapular Muscle Reattachment: A Case Report by Wendy Burke, W Ben Kibler, Tim L Uhl

“… # Case Description A 47-year-old female physical therapist experienced a traction injury to bilateral upper extremities during a medical procedure resulting in bilateral rhomboid, and bilateral lower trapezius muscles were detached from the medial scapular border. …”
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Capsaicin Modulates Ruminal Fermentation and Bacterial Communities in Beef Cattle with High-Grain Diet-Induced Subacute Ruminal Acidosis by Wei You, Haijian Cheng, Xin Hu, Enliang Song, Fugui Jiang

“…The addition of capsaicin increased the alpha diversity of ruminal bacteria relative to the SARA group, as evidenced by a lower Simpson index (<i>p</i> < 0.05), together with increases in the Ace, Chao, and Shannon indices (<i>p</i> < 0.05). …”
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The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise T... by Magdalena Dudek, Marta Kałużna-Oleksy, Filip Sawczak, Agata Kukfisz, Aleksandra Soloch, Jacek Migaj, Maciej Lesiak, Ewa Straburzyńska-Migaj

“…In the sST2 ≥ 52.377 ng/mL group, 55.6% of patients achieved VO₂ < 50%. Subjects with lower sST2 values obtained higher values of PETCO₂ (<i>p</i> < 0.001) and higher values of pulse O₂ (<i>p</i> = 0.01). …”
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Predictors of developing severe COVID-19 among hospitalized patients: a retrospective study by Hussain Abduljaleel Alkhalifa, Ehab Darwish, Zaenb Alsalman, Aman Alfaraj, Abdullah Alkhars, Fatimah Alkhalifa, Mohammed Algaraash, Ahmed Mohammed Elshebiny, Emad Alkhoufi, Khaled Mohamed Amin Elzorkany

“…As the severity of SARS-CoV-2 infection varies among individuals, elucidating risk factors for severe COVID-19 is important for predicting and preventing illness progression, as well as lowering case fatality rates. This work aimed to explore risk factors for developing severe COVID-19 to enhance the quality of care provided to patients and to prevent complications.MethodsA retrospective study was conducted in Saudi Arabia’s eastern province, including all COVID-19 patients aged 18 years or older who were hospitalized at Prince Saud Bin Jalawi Hospital in July 2020. …”
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Analisis Beban Kerja Mental terhadap Aplikasi dengan Antarmuka Cerdas by Murein Miksa Mardhia, Choirul Bariyah

“…The smarter the features provided through the interface, the expected cause is the lower the mental workload that users feel when doing work. …”
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The plight of Ukrainian refugees staying in Sweden under EU:s mass refugee directive: a brief trauma-focused, participatory, online intervention as a pilot feasibility study by Solvig Ekblad, Oksana Gramatik, Yuliia Suprun

“…Older participants were vulnerable with higher stress and lower mean perceived health after the intervention. …”
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Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary by Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill

“…These features were detected at a lower frequency in non-responders and mostly in patients with stable disease.Conclusions A significant fraction of CUP tumors had genomic features previously associated with ICI response. …”
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Análisis comparativo en base a la sostenibilidad ambiental entre bóvedas de albañileria y estructuras de hormigón Comparative analysis on environmental sustainability between mason... by Justo García Sanz Calcedo, Manuel Fortea Luna, Antonio M. Reyes Rodríguez

“…It has been detected that the vault consumes 75% less energy in the construction process, it emits 69% less CO2 into the atmosphere, it has an average manufacturing cost for short spans similar to a conventional slab, but much lower when large spans have to be covered, and it generates 171% less packaging waste from works, but it needs a larger and more skilled labor force. …”
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Chiral Pesticides in Soil and Water and Exchange with the Atmosphere by Terry F. Bidleman, Andi D. Leone, Renee L. Falconer, Tom Harner, Liisa M.M. Jantunen, Karin Wiberg, Paul A. Helm, Miriam L. Diamond, Binh Loo

“…Chlordanes and HEPX are also nonracemic in arctic air, probably the result of soil emissions from lower latitudes. The (+) enantiomer of α-hexachlorocyclohexane (α-HCH) is preferentially metabolised in the Arctic Ocean, arctic lakes and watersheds, the North American Great Lakes, and the Baltic Sea. …”
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Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-<i>co</i>-glycolic Acid (<i>nf</i>PLGA) During Co-Precipitat... by Mohammad Saiful Islam, Somenath Mitra

“…Furthermore, incorporating <i>nf</i>PLGA into the crystal structures greatly accelerated the dissolution rates, with initial rates reaching 650.92 µg/min for DXM-GF-<i>nf</i>PLGA compared to 540.60 µg/min for DXM-GF, while pure GF and DXM showed lower rates. <b>Conclusions</b>: This work demonstrates that <i>nf</i>PLGA incorporation enhances dissolution performance by forming water channels within the API crystal via hydrogen-bonding interactions. …”
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Carbon Stock Estimation in the South Coastal Rehabilitation Area of Java Island by Budiadi Budiadi

“…Average TBC in mangroves (46.08 Mg C/ha) was slightly lower than in CS (51.50 Mg C/ha). In below ground (up to 60 cm depth), wetland sites (AV, RH, MX, SD and GR) significantly stored more SOC than dry land (CS). …”
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Spatial analysis of measles cases and vaccination coverage in the Somali region, eastern Ethiopia by Abdilahi Ibrahim Muse, Abdilahi Ibrahim Muse, Mahdi Yonis Kayat, Mohamed Harir Aden, Jemal Beksisa Shuramu, Shikur Mohammed, Musse Ahmed Ibrahim, Musse Ahmed Ibrahim, Binyam Mohammedbirhan Berhe, Ahmed Abdi Kalinle, Sahardiid Ali Abdilahi

“…It can be prevented by two doses of the measles vaccine, either alone or in combination with measles-rubella (MR), which is a low-cost strategy for lowering morbidity and mortality among children.ObjectivesTo conduct spatial analysis of measles cases and vaccination coverage in the Somali region, Eastern Ethiopia.MethodsThis retrospective study was done by using public health emergency directorate measles data from 2022 to 2023 and four years (July 2019–July 2023) of vaccination data from district health information system version 2.36. …”
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Application of Shenque acupoint (RN8) application with Xiere Tongbian patch to promote the defecation after anorectal surgery (泄热通便贴脐敷促进肛肠疾病术后排便的效果观察)... by LIU Lijuan (刘丽娟), HAO Li (郝丽), XU Yunxia (许云霞), XU Shanying (许山鹰)

“…The rate of discomfort was 16. 00%(8/50)in the intervention group, which was lower than 42. 00%(21/50), with a significant difference (P＜0. 01). …”
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