Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The most significant inhibitory activity was observed for compound 4e against all cell lines (MG-63, HepG2, A549 and HeLa), still somewhat lower to comparable to that of gedatolisib, but with the highest potency against MG-63 cells. …”
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Changes in health related quality of life in mothers with inflammatory joint disease from year 2000 to 2020 – a comparative cross-sectional study by Hege Svean Koksvik, Ingrid Nilssen, Bente Jakobsen, Hilde Bjørngaard, Marianne Wallenius, Marianne Wallenius, Kjersti Grønning, Kjersti Grønning

“…Compared to the calculated norm scores, the 2020 cohort had significantly lower scores on all scales (p < 0.01) except on the MH scale (p = 0.37).ConclusionMothers with IJD were affected in most dimensions of RAND-36 (SF-36) both in year 2000 and year 2020. …”
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The azimuthal correlation between the leading jet and the scattered lepton in deep inelastic scattering at HERA by ZEUS Collaboration, I. Abt, R. Aggarwal, V. Aushev, O. Behnke, A. Bertolin, I. Bloch, I. Brock, N. H. Brook, R. Brugnera, A. Bruni, P. J. Bussey, A. Caldwell, C. D. Catterall, J. Chwastowski, J. Ciborowski, R. Ciesielski, A. M. Cooper-Sarkar, M. Corradi, R. K. Dementiev, S. Dusini, J. Ferrando, B. Foster, E. Gallo, D. Gangadharan, A. Garfagnini, A. Geiser, G. Grzelak, C. Gwenlan, D. Hochman, N. Z. Jomhari, I. Kadenko, U. Karshon, P. Kaur, R. Klanner, U. Klein, I. A. Korzhavina, N. Kovalchuk, M. Kuze, B. B. Levchenko, A. Levy, B. Löhr, E. Lohrmann, A. Longhin, F. Lorkowski, E. Lunghi, I. Makarenko, J. Malka, S. Masciocchi, K. Nagano, J. D. Nam, Yu. Onishchuk, E. Paul, I. Pidhurskyi, A. Polini, M. Przybycień, A. Quintero, M. Ruspa, U. Schneekloth, T. Schörner-Sadenius, I. Selyuzhenkov, M. Shchedrolosiev, L. M. Shcheglova, N. Sherrill, I. O. Skillicorn, W. Słomiński, A. Solano, L. Stanco, N. Stefaniuk, B. Surrow, K. Tokushuku, O. Turkot, T. Tymieniecka, A. Verbytskyi, W. A. T. Wan Abdullah, K. Wichmann, M. Wing, S. Yamada, Y. Yamazaki, A. F. Żarnecki, O. Zenaiev

“…Perturbative calculations at $$\mathcal {O}(\alpha _{s}^2)$$ O ( α s 2 ) accuracy successfully describe the data within the fiducial region, although a lower level of agreement is observed near $$\Delta \phi \rightarrow \pi $$ Δ ϕ → π for events with high jet multiplicity, due to limitations of the perturbative approach in describing soft phenomena in QCD. …”
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Dysgeusia in MASLD-related advanced chronic liver disease (ACLD): a silent driver towards the “Bermuda” triangle of malnutrition-sarcopenia-frailty severely affecting prognosis by Marcello Dallio, Mario Romeo, Fiammetta Di Nardo, Carmine Napolitano, Paolo Vaia, Giorgia Iadanza, Simone Olivieri, Annachiara Coppola, Marco Niosi, Alessandro Federico

“…Compared with dACLD patients without dysgeusia, dysgeusia-affected dACLD patients presented a lower daily protein intake (g/kg/die) (1.55 ± 0.192 vs 1.34 ± 0.15, p < 0.0001). …”
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The Evaluation of Change in Psychosocial Risk With Caregivers of Children With Chronic Kidney Disease: A Short-term Longitudinal Mixed-Methods Study by Caroline C. Piotrowski, Kira Kudar, Julie Strong, Ashley Giesbrecht, Anne Kazak, Katerina Pappas, Gina Rempel, Aviva Goldberg

“…Families of transplant recipients were found to be at significantly lower psychosocial risk pre-pandemic than families of transplant candidates. …”
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Social determinants and follow-up care after emergency department discharge for traumatic intracranial hemorrhage by Meghan M. Dillan, Joseph Piktel, Adam Perzynski, Mary Jo Roach, Kristen K. Curtis, Yasir Tarabichi, Lance Wilson, Michael L. Kelly

“…ED recidivism rate was 18 %, with 25 % of patients overall having an unscheduled TBI visit. Lower SES was a significant predictor of any TBI revisit (OR 1.39, CI 1.06, 1.82). …”
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Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) by Jesús Villora, José Antonio Pérez, Nieves Guadalupe Acosta, Deiene Rodríguez-Barreto, Pedro Juan Alonso, Mónica B. Betancor, Alexandr Torres, Sergio Álvarez, Covadonga Rodríguez

“…Consequently, and in alignment with our hypothesis, EO was more effective than LO in enriching chicken thigh meat with n-3 LC-PUFA (6.0 vs 4.2%; p<0.05). We concluded that lowering the dietary LA/ALA ratio and increasing the SDA content in poultry diets enhance the potential of chicken metabolism for enriching poultry products with n-3 LC-PUFA. …”
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Meibomian gland alterations in allergic conjunctivitis: insights from a novel quantitative analysis algorithm by Jingting Wei, Jingting Wei, Kunhong Xiao, Qingyuan Cai, Qingyuan Cai, Shenghua Lin, Xiangjie Lin, Yujie Wang, Yujie Wang, Jiawen Lin, Kunfeng Lai, Yunxi Ye, Yuhan Liu, Li Li

“…Tear meniscus height was lower in the allergy group (0.26 ± 0.10 mm) compared to the control group (0.44 ± 0.08 mm) (P &lt; 0.05). …”
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Non-pharmaceutical interventions and epigenetic aging in adults: Protocol for a scoping review. by Alina Liebich, Shenglin Zheng, Theresa Schachner, Jacqueline Mair, Mia Jovanova, Falk Müller-Riemenschneider, Tobias Kowatsch

“…Several non-pharmaceutical interventions can lower the risk of NCDs, including common mental disorders (CMDs), and may slow down biological aging, as evidenced by outcome markers such as epigenetic clocks. …”
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Comparison of outcomes following prepectoral and subpectoral implants for breast reconstruction in patients with breast cancer by Jun Zhang, Ran An, Zhi-Hao Yu, Li Zhang

“…The PIBR group had significantly lower rates of wound infection, capsular contracture, and chest muscle pain compared to the SIBR group. …”
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Response of Natural Forests and Grasslands in Xinjiang to Climate Change Based on Sun-Induced Chlorophyll Fluorescence by Jinrun He, Jinglong Fan, Zhentao Lv, Shengyu Li

“…Natural grasslands showed a significantly stronger response than forests, particularly in areas with lower vegetation cover that are more structurally impacted. …”
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Technology Readiness Level and Self-Reported Health in Recipients of an Implantable Cardioverter Defibrillator: Cross-Sectional Study by Natasha Rosenmeier, David Busk, Camilla Dichman, Kim Mechta Nielsen, Lars Kayser, Mette Kirstine Wagner

“…Participants in profile 4, characterized by the lowest readiness levels, were significantly younger (P=.03) and had lower self-reported health (P<.001) than those in profile 3. …”
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Synthesis, Characterization, and In Vivo Cytokinome Profile of IL-12-Loaded PLGA Nanospheres by Ryan A. Lacinski, Justin E. Markel, Jabeen Noore, Hillary G. Pratt, Brock A. Lindsey

“…As IL-12-NS delivers logarithmically lower amounts of IL-12 than previously administered during human clinical trials, our data reflect the importance of IL-12-NS which safely create a systemic immunostimulatory environment.…”
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Robotic-Arm Assisted Technology's Impact on Knee Arthroplasty and Associated Healthcare Costs by David J. Kolessar, Daniel S. Hayes, Jennifer L. Harding, Ravi T. Rudraraju, Jove H. Graham

“…Postoperative costs were lower for robotic arm–assisted surgeries, and patients used less home health and home rehabilitation. …”
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Sub-Clinical Regional Macular Changes in Self-Reported Diabetic Subjects: Vascular and Retinal Layer Analysis Using Swept-Source OCT by Challa NK, Alghamdi WM, Alluwimi MS, Alshammeri S

“…The FAZ was manually mapped at the SCP on OCTA images.Results: In diabetic subjects, the superficial capillary plexus vessel density (SCPVD) was significantly lower in both the central (P = 0.04) and inferior (P = 0.01) regions compared to the control group. …”
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Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes. by Insa Feinkohl, Naveed Sattar, Paul Welsh, Rebecca M Reynolds, Ian J Deary, Mark W J Strachan, Jackie F Price, Edinburgh Type 2 Diabetes Study-ET2DS Investigators

“…After adjustment for age and sex, raised plasma NT-proBNP was weakly associated with lower 'g' and higher depression scores (ß -0.09, 95% CI -0.13 to -0.03, p = 0.004 and ß 0.08, 95% CI 0.04 to 0.12, p<0.001, respectively). …”
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Functional performance of patients with stroke during inpatient rehabilitation: a cross-sectional study of home and access visits by Melissa J. Krauss, Emily Somerville, Callista Poiter, Rebecca M. Bollinger, Brianna M. Holden, Gabrielle Blenden, Danielle Kretzer, Susan L. Stark

“…Differences in scores between home visit and IRF were significantly greater than between access and IRF for bathing, upper and lower body dressing, bed/chair transfer, walking, and navigating stairs. …”
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Access to support services for individuals who experience intimate partner violence during stressful life events (SLEs) in high-income countries: Protocol for a scoping review. by Dina Idriss-Wheeler, Ziad El-Khatib, Sanni Yaya

“…Studies have linked IPV to poor health, resulting in lower mental, physical, sexual, and reproductive health outcomes. …”
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Genetic parameters and parental and early-life effects of boar semen traits by Pedro Sá, Rodrigo M. Godinho, Marta Gòdia, Claudia A. Sevillano, Barbara Harlizius, Ole Madsen, Henk Bovenhuis

“…Finally, we emphasize the importance of considering maternal effects when analysing semen traits, which results in lower heritability estimates.…”
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Metabolic changes of thalamus assessed by 1H-MRS spectroscopy in patients of cervical spondylotic myelopathy following decompression surgery by Jiangqin Zheng, Yujin Zhang, Baogen Zhao, Ning Wang, Ting Gao, Li Zhang

“…A correlation analysis was conducted to determine the relationship between alterations in pre- and postoperative metabolite ratios (ΔNAA/Cr, ΔCho/Cr, ΔmI/Cr, ΔGlx/Cr) and ΔmJOA.ResultsCompared to the HCs, patients with CSM showed significantly lower pre- and post-operative NAA/Cr (Z = −4.235, p &lt; 0.001; Z = −3.184, p = 0.001), Cho/Cr (Z = −5.050, p &lt; 0.001; (Z = −2.624, p = 0.007) and mI/Cr (Z = −3.739, p = 0.001; Z = −2.014, p = 0.044). …”
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