A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. by Nadeene E Riddick, Emilia A Hermann, Lamorris M Loftin, Sarah T Elliott, Winston C Wey, Barbara Cervasi, Jessica Taaffe, Jessica C Engram, Bing Li, James G Else, Yingying Li, Beatrice H Hahn, Cynthia A Derdeyn, Donald L Sodora, Cristian Apetrei, Mirko Paiardini, Guido Silvestri, Ronald G Collman

“…Furthermore, animals lacking functional CCR5 had robust plasma viral loads, which were only modestly lower than wild-type animals. SIVsmm primary isolates infected both homozygous mutant and wild-type PBMC in a CCR5-independent manner in vitro, and Envs from both CCR5-null and wild-type infected animals used CXCR6, GPR15 and GPR1 in addition to CCR5 in transfected cells. …”
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The effect of bacterial overgrowth syndrome and bacterial translocation on the course of liver cirrhosis by M. S. Zharkova, M. V. Mayevskaya, V. T. Ivashkin

“…The survival rate for 12 months in the group of patients with bacterial overgrowth syndrome was lower in comparison to patients without bacterial overgrowth (51,7% vs 84,6% respectively, р<0,042). …”
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Clinical Features and Contributing Factors of Excessive Daytime Sleepiness in Chinese Obstructive Sleep Apnea Patients: The Role of Comorbid Symptoms and Polysomnographic Variables by Chuan Shao, Huan Qi, Ruyi Lang, Biyun Yu, Yaodong Tang, Lina Zhang, Xun Wang, Ling Wang

“…Body mass index (BMI) was highest in the severe EDS group (29.1 ± 3.6 kg/m2) (p<0.0001), intermediate in the mild to moderate EDS group (27.9 ± 3.3 kg/m2), and lower in the non-EDS group (26.8 ± 3.3 kg/m2). Logistic regression analysis showed waist circumference, memory loss, work/commute disturbances, and sleep efficiency were independently associated with mild to moderate EDS, and the microarousal index, apnea-hypopnea index (AHI), and saturation impair time below 90% were independent contributing factors of mild to moderate EDS. …”
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Evaluation on Economic Benefits of Adoption of High-quality Rice Cultivars - A Study Based on Survey Data from Rice Farmers in Guangdong Province by Shuting YANG, Zedong YAN, Fengbo CHEN

“…【Result】In terms of yield, high-quality rice had a lower yield compared with ordinary rice. Specifically, the yields of high-quality rice decreased by 10.34% and 0.27% compared with ordinary rice in different plots. …”
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Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or Streptococcus by Anders Brüggemann, Nils P. Hailer

“…For all three groups of bacteria, survival was lower when DAIR was performed in comparison to exchange surgery.DiscussionIn our cohort, there was no difference in infection-free survival between the three groups. …”
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Green approach to synthesis polymer composites based on chitosan with desired linear and non-linear optical characteristics by Dyari M. Mamand, Sarkawt A. Hussen, Shujahadeen B. Aziz

“…The absorption edge of the composite’s films shifted to lower photon energies. Various models were used to determine the optical band gap. …”
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Psychosocial determinants of adherence to public health and social measures (PHSMs) in 18 African Union Member States during the early phase of the COVID-19 pandemic: results of a... by Andrew Johnson, Amanda McClelland, Nandita Murukutla, Akhona Tshangela, Ashish K Gupta, Meena Maharjan, Cecilia Fabrizio, Emily W Myers, Virginia Nkwanzi, Colby A Wilkason, Natalie Lacey, Benjamin Djoudalbaye

“…Adherence to community PHSMs was lower than personal PHSMs since they can impose significant burdens, particularly on the socially vulnerable.…”
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High-density lipoprotein cholesterol as a prognostic marker for 90-day transplant-free mortality in hepatitis B virus-related acute-on-chronic liver failure by Ke Shi, Yi Zhang, Yanqiu Li, Xiaojing Wang, Ying Feng, Xianbo Wang

“…These results were internally validated between January 2020 and December 2023 (n=125).ResultsPatients with lower HDL-C levels exhibited higher mortality rates (adjusted hazard ratio for HDL-C &lt; 0.13 mmol/L: 4.04, 95% confidence interval: 1.35–11.85) compared with those in the reference group (with HDL-C levels above 0.36 mmol/L). …”
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Australian children’s foot, ankle and leg problems in primary care: a secondary analysis of the Bettering the Evaluation and Care of Health (BEACH) data by Hylton B Menz, Christopher Harrison, Peter A Lazzarini, Cylie M Williams, Julie Gordon

“…This data highlights the importance of initiatives supporting contemporary primary care knowledge of diagnoses and management of paediatric lower limb problems to minimise childhood burden of disease.…”
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Cost-Minimization Analysis for Subcutaneous Daratumumab in the Treatment of Newly Diagnosed Multiple Myeloma in Three Gulf Countries by Anas Hamad, Shereen Elazzazy, Ruba Y. Taha, Hani Osman, Sana Alblooshi, Islam Elkonaissi, Mustaqeem A. Siddiqui, Khalil Al-Farsi, Mohammed Al Lamki, Sali Emara, Gihan H. Elsisi

“…**Results:** The model showed that the use of dara-SC in NDMM patients who were eligible or ineligible for ASCT resulted in lower non-drug costs, including premedication drug costs, adverse-effect costs, administration costs, medical staff costs, and indirect costs. …”
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Private, non-profit, and plantation: Oil palm smallholders in management-assistance programs vary in socio-demographics, attitudes, and management practices. by Valentine J Reiss-Woolever, Wakhid Wakhid, Muhammad Ikhsan, Jean-Pierre Caliman, Muhammad Naim, Elfina N Azmi, Sharyn Shufiyan, John Howes, Reza Azmi, Ying Ying Lim, Siti Zulaikah Abdul Jan, Isaac Barrock, Badrul Azhar, Julia Drewer, Caroline Ward, Joshua A Jones, Sarah H Luke, Edgar C Turner, Purnama Hidayat, Damayanti Buchori

“…In Malaysia, farmers partnered with an NGO also had higher yield and fertilizer application than independent farmers, however they used significantly more herbicide and had lower total household income. Our findings demonstrate the wide variety of smallholder farmers in both regions, directly opposing a 'one-size-fits-all' approach to sustainability. …”
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Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients wi... by Junji Hatakeyama, Kensuke Nakamura, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shotaro Aso, Shinya Suganuma, Shuhei Maruyama, Yoshitaka Ogata, Akira Takasu, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Takeshi Yoshida, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida

“…Results Among 334 patients, PICS prevalence rates in the four completed questionnaires were 72.1, 78.5, 77.6, and 82.0%, with cognitive impairment being the most common and lower QOL being noted when multiple impairments coexisted. …”
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Development and validation of a multidimensional, culturally and socially inclusive Child Resilience Questionnaire (parent/caregiver report) to measure factors that support resilie... by Deirdre Gartland, Elisha Riggs, Rebecca Giallo, Stephanie Janne Brown, Karen Glover, Kelsey Hegarty, Amanda Mitchell, Jane Yelland, Josef Szwarc, Sue Casey, Donna Weetra, Mardi Stowe, Sharon Mongta, Helen Herman, Selena White, Tanya Koolmatrie, Georgie Paxton

“…Criterion validity was supported: scales had low to moderate negative correlations with SDQ total difficulty score (Rs= -0.2/–0.5. p&lt;0.001); children with emotion/behavioural difficulties had lower CRQ-P/C scores (β=−14.5, 95% CI −17.5 to −11.6, adjusted for gender).Conclusion The CRQ-P/C is a new multidomain measure of factors supporting resilience in children. …”
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Inequalities in ownership and availability of home-based vaccination records in 82 low- and middle-income countries by Aluísio J D Barros, Cesar G Victora, Daniel R Hogan, M Carolina Danovaro-Holliday, Bianca O Cata-Preta, Thiago M Santos, Andrea Wendt, Luisa Arroyave, Tewodaj Mengistu

“…When an HBR was seen, higher immunisation coverage and lower vaccine dropout rates were observed, but the direction of this association remains unclear.Interpretation HBR coverage levels were remarkably low in many LMICs, particularly among children from the poorest families and those whose mothers had low schooling. …”
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Molecular docking and molecular dynamics simulation studies of inhibitor candidates against Anopheles gambiae 3-hydroxykynurenine transaminase and implications on vector control by Eunice O. Adedeji, Olubanke O. Ogunlana, Gbolahan O. Oduselu, Rainer Koenig, Ezekiel Adebiyi, Opeyemi S. Soremekun, Segun Fatumo

“…Replacement of alkyl attachment on C5 of isoxazole or oxadiazole derivative with a cycloalkyl group yielded compounds with lower binding energy than their straight chain counterparts. …”
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A Systematic Review and Meta-Analysis Comparing the Safety and Efficacy of Spinal Anesthesia and Spinal Anesthesia Combined with Obturator Nerve Block in Transurethral Resection of... by Wanxin Deng, Qiang Zhang, Hongmei Yao

“…The meta-analysis showed that the use of SA + ONB anesthesia during TURBT was associated with a smaller incidence of bladder perforation (RR = 0.24, 95% CI (0.11, 0.53), Z = −3.48, P=0.0005), a smaller incidence of obturator nerve reflex (RR = 0.22, 95% CI (0.13, 0.36), Z = −6.11, P=0.0001), a significantly shorter length of hospital stay (MD = −1.81, 95% CI (−2.65, −0.97), Z = −4.24, P=0.0001), and a significantly lower tumor recurrence rate (RR = 0.46, 95% CI (0.29, 0.73), Z = −3.30, P=0.001) compared with SA alone. …”
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Sign Problem in Tensor-Network Contraction by Jielun Chen, Jiaqing Jiang, Dominik Hangleiter, Norbert Schuch

“…Using results from computational complexity, we observe that the approximate contraction of tensor networks with only positive entries has lower computational complexity as compared to tensor networks with general real or complex entries. …”
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Predicting pregnancy loss and its determinants among reproductive-aged women using supervised machine learning algorithms in Sub-Saharan Africa by Tirualem Zeleke Yehuala, Sara Beyene Mengesha, Nebebe Demis Baykemagn

“…The use of antenatal care and family planning services can significantly impact the risk of pregnancy loss. Women from lower-income backgrounds may face challenges in accessing prenatal care or safe reproductive health services, leading to higher risks of loss. …”
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Projecting the Potential Budget Impact Analysis of Paliperidone Palmitate in Egyptian Adult Patients with Schizophrenia by Gihan Elsisi, Mohamed Ezzat, Mohamed Ramadan

“…Sensitivity analyses showed that the percent of hospitalizations for both oral antipsychotics and PP had the greatest impact on the results. **Conclusion:** The lower hospitalization rates associated with PP offset the increase in drug costs. …”
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Free senior high school devours basic education in Ghana: rescue the children by Inusah Fuseini

“…An educational policy at any level must consider the basic policies of education that enhance inclusivity and equity at the lower levels of education. This will help in maximizing the effective implementation of the policies. …”
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