The impact of primary health care on AIDS incidence and mortality: A cohort study of 3.4 million Brazilians. by Priscila F P S Pinto, James Macinko, Andréa F Silva, Iracema Lua, Gabriela Jesus, Laio Magno, Carlos A S Teles Santos, Maria Yury Ichihara, Mauricio L Barreto, Corrina Moucheraud, Luis E Souza, Inês Dourado, Davide Rasella

“…We also estimated the FHS impact by sex and age and performed a wide range of sensitivity and triangulation analyses; 100% FHS coverage was associated with lower AIDS incidence (rate ratio [RR]: 0.76, 95% CI: 0.68 to 0.84) and mortality (RR: 0.68, 95%CI: 0.56 to 0.82). …”
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Does the Use of Nitroglycerin Patch Improve Local Anaesthetic Effects in Bier’s Block? A Double-Blind Placebo Controlled Study by Ahmed Said Elgebaly

“…Sensory block recovery time was prolonged in Group N (10.56 ± 1.12) than Group C (6.88 ± 1.45), recovery time of motor block was prolonged in Group N (13.04 ± 1.57) than Group C (11.96 ± 1.72). Bandage pain had lower VAS scores in Group N. Postoperative VAS scores showed significant differences between both groups at the following points of measurement: 30 minutes, 1 hour, and 4 hours after bandage deflation. …”
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Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

“…Only 36% of patients attended a follow-up visit within three months, lower than the prespecified benchmark of ≥75%. Monthly treatment rates during the pilot increased by 22.3 (95% CI: 16.2 to 28.4; P < 0.001) and 3.5 (95% CI: –1.6 to 8.7; P = 0.17) patients per month for hypertension and diabetes, respectively. …”
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BRAIN CHANGER. Felice Jacka, 321 pages, Macmillan, 2019 (ISBN: 978-1-76055-651-8) by Cécil J.W. Meulenberg

“…The scientific evidence is drawn from the results with larger cohorts and randomized controlled trials including amongst others: ALSPAC (Avon Longitudinal Study of Parents and Children, United Kingdom); HELFIMED (Healthy Eating for Life with a Mediterranean Diet, Australia); HUSK (Hordaland Health Study, Norway); PREDIMED (Prevenc&iacute;on con Dieta Mediterr&aacute;nea, Spain); SMILES (Supporting the Modification of Lifestyles in Lowered Emotional States, Australia). These and other studies show that wherever the geographical area, plant-based Mediterranean-like diets improve the health outcomes of children, adolescents, adults and ageing individuals affected by mental health illnesses, in cost-effective ways. …”
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Evaluating the Nolla Method for Dental Age Estimation in Children from Northwestern Romania by Ligia Ioana Moga, Abel Emanuel Moca, Raluca Iurcov, Dan Slăvescu, Ligia Luminița Vaida

“…Dental age was consistently lower than chronological age, with a median difference of 1.5 years (IQR: 0.9–2.2 years). …”
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Antidiabetic agent use and clinical outcomes in patients with diabetes hospitalized for COVID-19: a systematic review and meta-analysis by Jordan N. Keels, Isabella R. McDonald, Christopher S. Lee, Andrew A. Dwyer, Andrew A. Dwyer

“…Despite differences among studies, the overall relative risk of mortality among metformin and DPP-4 inhibitor users was 0.432 (95% CI = 0.268-0.695, z = 3.45, p &lt; 0.001) and the overall prevalence of mortality among all antidiabetic users was 16% (95% CI = 13%–19%, z = 10.70, p &lt; 0.001).Conclusions and implicationsSynthesis of findings suggest that patients who remained on oral agents (with/without supplemental insulin therapy) exhibited decreased mortality and lower inflammatory markers. Results indicate that individuals with DM should continue oral antidiabetic agents with additional basal insulin as needed to improve glycemic control and reduce mortality. …”
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Assessment of derangement in biochemical profile in primary open angle glaucoma patients presenting at a tertiary care hospital by Fatima Tuz Zuhra, Mehnaz Khattak, Sana Nadeem, Noreen Atzaz, Attika Khalid, Sami Saeed

“…High frequency of hs-CRP positivity (50 percent) was reported in our patients. Significantly lower uric acid levels were observed in primary open angle glaucoma patients versus controls ie 305.85±79.92 mmol/l vs 344.36±37.24 mmol/l (P value < 0.05). …”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Results: Patients with COVID-19 and <i>C. difficile</i> co-infection had significantly elevated inflammatory markers (CRP, IL-6, NLR) and higher CAR, alongside lower PNI, compared to those with COVID-19 alone (<i>p</i> < 0.001). …”
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A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study by Manli Yan, Wenhua Shi, Ping Gong, Yunsi Xie, Kaiyuan Zhang, Xiang Li, Hua Wei, Hua Wei

“…The findings indicated a significant association between both low and high levels of SUA and HT (Lower OR: 2.043; 95% CI: 1.405-3.019; P &lt; 0.001; Higher OR: 2.369; 95% CI: 0.998-4.999; P = 0.034).ConclusionThis study is the first to reveal a U-shaped association between SUA levels and the risk of HT, suggesting that maintaining SUA levels within the range of 359.0-540.0 μmol/L may help reduce the risk of HT occurrence. …”
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The prognostic value of systemic immune-inflammation index in patients with unresectable hepatocellular carcinoma treated with immune-based therapy by Tian He, Bin Xu, Lu-Na Wang, Zi-Yi Wang, Huan-Chen Shi, Cheng-Jie Zhong, Xiao-Dong Zhu, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Bo Hu, Cheng Huang

“…ROC curves confirmed that SII had superior predictive accuracy compared to common clinical indicators, with predictive relevance even in AFP-negative patients. Furthermore, a lower SII was associated with a higher T cell ratio and an increased number of CD8+ T cells and Granzyme B+ CD8+ T cells in peripheral blood. …”
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PET/CT-derived coronary calcium score may predict cardiac complications in anthracycline-treated patients with lymphoma by Genevieve Douglas, Zoe Loh, Evonne S.Y. Shum, Sze-Ting Lee, Niamh Waters, Garry Hamilton, Geoffrey Chong, Alexandra C. Murphy, Eliza A. Hawkes

“…In noncancer populations, coronary artery calcium scoring (CACS) effectively identifies individuals who may benefit from aggressive CVR modification to lower the risk of cardiovascular events. Emerging evidence suggests that CACS can also predict cancer therapy-related cardiotoxicity, potentially identifying candidates for cardioprotective strategies. …”
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Comparison of In Vitro Antibacterial Activity of Epaltes divaricata and Vetiveria zizanioides against Methicillin-Resistant Staphylococcus aureus by Hasanga Rathnayake, Manikkuwadura Hasara Nethmini De Zoysa, Ruwani Punyakanthi Hewawasam, Weerasinghe Mudiyanselage Dilip Gaya Bandara Wijayaratne

“…But V. zizanioides was more effective since the hexane extract inhibited more than 50% of MRSA strains at significantly a lower MIC value of 0.012 mg/mL. Fractionation, purification, and identification of active compounds will warrant further evaluation of the therapeutic potential of both plant extracts.…”
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Investigation on acute chromium poisoning accident occurred in process of electroplating tank cleaning by Jinbin LUO, Qiang CHEN, Tao LI, Wenlong LI, Binbin ZHU, Fangjun WANG

“…The prescribed treatment included right lower limb expansion skin grafting, hemodialysis and symptomatic support. …”
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Numerical Investigation of Ultra-Wide Low-Frequency Wave Attenuation Using Seismic Metamaterials with Auxetic Slender Strips by Haosheng Liu, Hongbo Zhang

“…By comparing the flexural wave band gap with the transmission spectrum, we attributed this attenuation primarily to the presence of the band gap, a phenomenon often overlooked in previous studies. This attenuation at lower frequencies highlights the potential for effectively reducing low-frequency vibration energy. …”
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Using positive deviance to enhance HIV care retention in South Africa: development of a compassion-focused program to improve the staff and patient experience by Allison J. Ober, Donald H. Skinner, Laura M. Bogart, Leletu Busakwe, Wadene Davids, Hassan Mahomed, Debbie Ling, Virginia Zweigenthal

“…., adjust folder system to lower wait times); and (3) create a welcoming physical environment (e.g., fresh paint and plants in the waiting area). …”
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Performance of seawater-derived Mg(OH)2 as a sustainable coating solution for hydrogen sulfide-induced corrosion mitigation in concrete pipes by Janelle Patricia S. Moa, Bea Angela C. Gaw, John Louis O. Co, Kyle Anderson C. Coo, Kenneth Jae T. Elevado, Cheryl Lyne C. Roxas

“…Results indicated that samples with pure Mg(OH)2 coatings exhibited the highest weight losses, while increased proportions of the commercial coating resulted in progressively lower weight losses. This trend was also reflected in the average post-exposure pH, compressive strength, and surface roughness, with the best performance observed in coatings composed of pure commercially available Mg(OH)₂. …”
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Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer by Keyuan Xiao, Xiang Li, Ihsan Ullah, Wenqing Hu, Kaiqiang Wang, Fan Yang, Chengyu Yang, Chunqi Feng, Liang Zong, Xinghua Li

“…In vitro assays with colorectal cancer cell lines revealed significantly lower ASPP1 expression levels compared to normal colon cells (HCM460), and ASPP1 overexpression experiments showed a marked reduction in colorectal cancer cell proliferation, colony formation, invasion, and migration abilities. …”
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Rational composition engineering for high‐quality Pb–Sn photodetector toward sensitive near‐infrared digital imaging arrays by Huan Li, Yu Gao, Xin Hong, Kanghui Ke, Zilong Ye, Siwei Zhang, Kefei Shi, Zhuo Peng, Hao Yan, Man‐Chung Tang, Youwei Yao, Ben Zhong Tang, Guodan Wei, Feiyu Kang

“…Intriguingly, the dark current of the Cs0.15FA0.85Pb0.5Sn0.5I3 device is four orders of magnitude lower than that of devices made with pristine Pb or Sn only, strongly correlating with its significantly increased built‐in potential and reduced trap density. …”
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Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction by Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap

“…HFmrEF patients had a significantly lower overall mortality rate compared to HFrEF patients (adjusted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.83–0.95; P < 0.001) and a significantly higher overall mortality rate (adjusted HR 1.25, 95% CI 1.17–1.33; P < 0.001) compared to HFpEF patients. …”
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A Rare Case of Mosaic 3pter and 5pter Deletion-Duplication with Autism Spectrum Disorder and Dyskinesia by Luna Bajracharya, Meena Lall, Sunita Bijarnia-Mahay, Praveen Kumar, Imran Mushtaq, Pushpa Saviour, Preeti Paliwal, Anju Joshi, Shruti Agarwal, Praveen Suman

“…He had ataxia, limb dyskinesia, triangular face, microcephaly, upward slanting palpebral fissure, hypertelorism, retrognathia, posteriorly rotated ears, long philtrum, thin lips, broad nasal tip, polydactyly, tappering fingers, and decreased tone in the upper and lower limbs with normal deep tendon reflexes. Magnetic resonance imaging of the brain, ultrasound of the abdomen, and ophthalmological evaluation were normal. …”
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