Impact of predictive selection of LbCas12a CRISPR RNAs upon on‐ and off‐target editing rates in soybean by Linda Rymarquis, Chenxi Wu, Diane Hohorst, Miguel Vega‐Sanchez, Thomas E. Mullen, Vijetha Vemulapalli, Douglas R. Smith

“…In addition, edits at off‐target sites have lower inheritance rates than on‐target edits, suggesting that they occur later in the plant's lifecycle. …”
Get full text

Efficacy of ultrasound guided erector spinae plane block compared to wound infiltration for postoperative analgesia following laparoscopic living donor nephrectomy: a double-blinde... by Sekar Loganathan, Kamal Kajal, Kashish Garg, Sameer Sethi, Deepesh B Kenwar, Amit Sharma, Ashish Aditya, Varun Mahajan, Naveen B Naik, Rajnikant Kumar

“…Results Participants in Group B required significantly less median (IQR) 24-hour morphine compared to Group C [6 (6–9) mg vs. 15 (12–15) mg; median difference 9; 95% CI in median difference 6–12; p < 0.001), longer median (IQR) time to first rescue analgesia [6 (6–8) hours vs. 1 (1–2) hours; p < 0.001], and lower VNRS at rest and during movement at baseline, 0.5, 1, 2, 4, 6, 8, 12, 24 hours. …”
Get full text

Selection and Engineering of Novel Brighter Bioluminescent Reporter Gene and Color- Tuning Luciferase for pH-Sensing in Mammalian Cells by Vanessa R. Bevilaqua, Gabriel F. Pelentir, Moema A. Hausen, Eliana A. R. Duek, Vadim R. Viviani

“…The transfected COS-1 with Mac-Luc and Crt-Luc displayed lower bioluminescence activity and considerably red-shifted spectra (611 and 564 nm, respectively) at 37 °C, whereas Amy-Luc displayed the highest bioluminescence activity and spectral stability at 37 °C inside cells, displaying the most blue-shifted spectrum at such temperatures (548 nm) and the best spectral resolution at different pH values, making it possible to ratiometrically estimate the pH from 6.0 to 8.0. …”
Get full text

TNRC6C Functions as a Tumor Suppressor and Is Frequently Downregulated in Papillary Thyroid Cancer by Zhenqin Cai, Tianyu Zhai, Dilidaer Muhanhali, Yan Ling

“…Our results showed that TNRC6C was downregulated in PTC, and lower expression level of TNRC6C was associated with worse clinicopathological features. …”
Get full text

Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients by Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski

“…Higher serum cystatin C, serum and urine neutrophil gelatinase associated lipocalin (NGAL), urine kidney injury molecule 1 (KIM-1), detectable urine transferrin and IgG, and lower serum uromodulin significantly predicted A2 albuminuria, urine KIM-1/creatinine ratio, and IgG being the best predictors. …”
Get full text

Two Postpartum Blood Collection Devices: The Brass-V Drape and MaternaWell Tray—As Experienced by Birth Attendants and Birthing Women—A Questionnaire-Based Randomised Study by Jade Esau, Timothy Morris, Chris Muller, Christine Els, Liesl de Waard

“…The MaternaWell tray has the benefit of reuse and lower cost and is an acceptable alternative to the Brass-V drape. …”
Get full text

Examining Muscle Activity Differences During Single and Dual Vector Elastic Resistance Exercises by Ryan WG Bench, Sydney E Thompson, Alan C Cudlip, Michael WR Holmes

“…The dual vector exercise in abduction significantly increased mean activation in lower trapezius by 25.6 ± 8.11 %MVC and peak activation in supraspinatus by 29.4 ± 5.94 %MVC (p<0.01). …”
Get full text

The role of the AVAPS ventilation mode combined with TCM monitoring in weaning patients with AECOPD by Nianci Wang, Haidong Qin, Lei Bao

“…In the AVAPS group, the incidence of 48-hour reintubation was lower, the time to reintubation was longer, and length of hospital and ICU stays were shorter (P < 0.05). …”
Get full text

Effects of intracameral dexamethasone injection versus topical steroids post phacoemulsification operation by Alaa I. A. Ghonim, Mervat E. Elgharieb, Amr A.-F. Gab-Alla, Ehab M. Moawad

“…Postoperative cell density and hexagonality were significantly lower in both groups compared with preoperative values. …”
Get full text

Alternative healthcare delivery arrangements in Nepal: a systematic review of comparative effectiveness, safety and cost-effectiveness studies by Rachelle Buchbinder, Shyam Sundar Budhathoki, Denise A O’Connor, Ilana Ackerman, Pramila Rai

“…Changing the way health care is delivered, for example, task shifting that delivers the same care at lower cost, may be one way of improving healthcare system sustainability. …”
Get full text

Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system by Ying Zhao, Yuke Zhong, Liuqing Wu, Jiao Yan, Weitao Lu

“…For females, the top 3 signals with the highest reporting odds ratio (ROR) were anethole trithione, clopenthixol, nikethamide (ROR: 388.88, 212.10, 113.94), while the top 3 signals with the highest lower limit of information component (IC025) were nikethamide, anethole trithione, benzbromarone (IC025: 3.91, 3.15, 2.49). …”
Get full text

Socioeconomic inequalities in health behaviors in children and adolescents: evidence from an Australian cohort by Nirmal Gautam, Mohammad Mafizur Rahman, Rasheda Khanam

“…These findings stress the need for tailored interventions designed to improve the health behaviors of families from lower socioeconomic backgrounds. Additionally, addressing unhealthy dietary behaviors, such as the higher consumption of sweet and savory foods among children from higher SES backgrounds, is equally critical. …”
Get full text

Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context by Charlotte Ocana de Sentuary, Clara Testard, Marion Lagrée, Maxime Leroy, Lisa Gasnier, Alicia Enes-Dias, Constance Leruste, Diariatou Diallo, Michael Génin, Thameur Rakza, François Dubos

“…In a multivariable analysis, the mother's age, lower parity and having a partner in work were significantly associated with nirsevimab acceptance. …”
Get full text

Review: Feed efficiency and metabolic flexibility in livestock by W.M. Rauw, L.H. Baumgard, J.C.M. Dekkers

“…Selection for improved meat production has resulted in pigs with a greater abundance of fast-twitch fibres with lower energy expenditure and higher metabolic efficiency. …”
Get full text

Aerodynamic energy consumption analysis of divided evacuated tube transportation system by Ziwei Zhang, Yingxue Wang, Guanqing Wang, Feilong Li, Dengke Wang, Jianjun Luo

“…Evacuated Tube Transportation (ETT) reduces aerodynamic drag and energy consumption by lowering gas pressure around high-speed trains (HSTs). …”
Get full text

Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii by Aleksandra Maria Kocot, Tomasz Swebocki, Karolina Ciemińska, Adrianna Łupkowska, Małgorzata Kapusta, Dennis Grimon, Ewa Laskowska, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Rabah Boukherroub, Yves Briers, Magdalena Plotka

“…Additionally, MLE-15 and its combination with reline eradicated meropenem-persistent cells of A. baumannii RUH134. Effectiveness in lowering the MIC value of MLE-15 as well as protection against antibiotic-tolerant persister cells, indicate that MLE-15 and reline combination is a promising candidate for effective therapies in bacterial infections, which is especially important in the light of the global crisis of antimicrobial resistance.…”
Get full text

Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs by Jocelyn Mott, Arnon Gal, Antonio Maria Tardo, Alisa Berg, Riley Claude, Alexis Hoelmer, Mei Lun Mui, Avin Arjoonsingh, Chen Gilor

“…Abstract Background The advantages of insulin degludec 100 U/mL (IDeg100) in the treatment of diabetes mellitus (DM) include consistent release, predictable glucose‐lowering effect, and minimal day‐to‐day variability. …”
Get full text

Proteomic profiling of Labeo rohita intestine infected with Edwardsiella tarda: Unveiling the mucosal defense mechanisms, cell adhesion, and cytoskeletal pathways by Nevil Pinto, Mehar Un Nissa, Gowhar Iqbal, Yashwanth BS, Darshan P, Sanjeeva S, Mukunda Goswami

“…Results: In DAPs, 50 proteins were identified as highly abundant, while 32 were identified as lower abundant. In E. tarda infected intestine, protein pathways were involved in defense response to the bacterium (muc-2), pyruvate metabolism (ldhb), integrin-mediated cell adhesion (ilk), actin filament bundle (lcp1), and collagen-containing extracellular matrix (nid2a). …”
Get full text

The job performance and job burnout relationship: a panel data comparison of four groups of academics’ job performance by Miao Lei, Miao Lei, Gazi Mahabubul Alam, Karima Bashir, Karima Bashir

“…Academics’ superior performance was notably linked to lower job burnout and the need for psychological counseling. …”
Get full text

Comparison of Resting Energy Expenditure Using Indirect Calorimetry and Predictive Equations in Trauma Patients: A Pilot Study by Dae Sung Ma, Gil Jae Lee

“…The ESPEN maximum value (1,704.03±449.36 kcal/day) was lower, but this difference was likewise not significant (p=0.127). …”
Get full text