Effectiveness and safety of the XEN45 gel stent compared to trabeculectomy in primary open-angle glaucoma: the Gold-Standard Pathway Study by Kaweh Mansouri, Xuemin Gu, Ingeborg Stalmans, Herbert A Reitsamer, Iqbal K Ahmed, Vanessa Vera, Antonio Maria Fea, Earl Randy Craven

“…Aim To compare the gel stent to trabeculectomy in the Gold-Standard Pathway Study (GPS) patients with primary open-angle glaucoma (POAG).Methods In the GPS, patients with elevated intraocular pressure (IOP) poorly controlled with IOP-lowering medication were randomised (2:1, gel stent:trabeculectomy). …”
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Sex-Specific Brain Activations during Single-Leg Exercise by Kyoungyoun Park-Braswell, Dustin Grooms, Sandra Shultz, Louisa Raisbeck, Christopher Rhea, Randy Schmitz

“…While muscle activation patterns and movement biomechanics are understood to differ between sexes, it is not well understood how sex influences brain activity for lower extremity movement. Since the brain plays a vital role for voluntary movement and joint stability, it is important to understand the sex differences in brain function in order to better understand neuromuscular control associated with increased musculoskeletal injury risk in female…”
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Rapid antigen testing by community health workers for detection of SARS-CoV-2 in Dhaka, Bangladesh: a cross-sectional study by Mahbubur Rahman, Ayesha Sania, Seonjoo Lee, Tahmina Shirin, A S M Alamgir, Yael K Rayport, Ahmed Nawsher Alam, Joanna Andrecka, Eric Brum, Fergus Chadwick, Tasnuva Chowdhury, Zakiul Hasan, Davina L Hill, Farzana Khan, Mikolaj Kundegorski, Motahara Tasneem, Katie Hampson

“…Sensitivity on saliva rose to 0.48 (95% CI 0.42 to 0.54) with two additional household members tested but remained lower than sensitivity on nasal samples. During the study period, testing in these low-income communities increased fourfold through the mobilisation of community health workers for sample collection.Conclusions Rapid antigen testing on nasal swabs can be effectively performed by community health workers yielding equivalent sensitivity and specificity to the literature. …”
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Knowledge and Use of Caries Detection Methods among Dental Students and Dental Practitioners in Riyadh, Saudi Arabia by Waseem Radwan, Abeer A. AlNasser, Hesah Aloqab, Khalid Al-Saggaf, Nora A. Almuhtab, Bothinah Alnasyan

“…The mean rank for risk assessment practices was significantly lower in GPs compared to consultants P<0.05. Conclusions. …”
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Phenotypic diversity of chickpea (Cicer arietinum L.) landraces accumulated in the Vavilov collection from the centers of the crop origin by M. A. Vishnyаkova, M. O. Burlyaeva, C. B. Bulyntsev, E. V. Seferova, E. S. Plekhanova, S. V. Nuzhdin

“…The smaller degree of variation and primitiveness of the most traits and lower seed productivity in Ethiopian landraces in comparison with Turkish ones indicates a greater breeding advancement of the latter. …”
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Characterization of a chitinase from Trichinella spiralis and its immunomodulatory effects on allergic airway inflammation in mice by Jia Xu, Ye Yao, Qisheng Zhuang, Zixuan Li, Min Zhang, Shouan Wang, Hongxin Hu, Jianbin Ye

“…In an allergic airway inflammation model, rTs-chit reduced weight loss and lung inflammation, lowering inflammatory cell infiltration and Th2 cytokines (IL-4, IL-5, IL-13) while increasing the immunosuppressive cytokine IL-10. …”
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Evaluation of the Cost of Intelligent Upgrades of Transportation Infrastructure for Intelligent Connected Vehicles by Zongwei Liu, Haokun Song, Hong Tan, Han Hao, Fuquan Zhao

“…The route of deploying primary intelligent transportation infrastructure at first and then directly upgrading them to advanced level can well match the functional requirements of ICVs on the basis of lower costs. The costs of RSUs, LIDARS, and edge computing servers as well as data transmission rate of 5G are key elements affecting the costs of intelligent upgrades of transportation infrastructure.…”
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Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway by Zouyu Zhao, Panpan Yu, Yan Wang, Hong Li, Hui Qiao, Chongfeng Sun, Lina Zhu, Ping Yang

“…Results Herein, STEAP3 was strongly expressed in CC tissues and associated with poor prognosis. CC samples exhibited lower levels of STEAP3 methylation than normal samples, and the methylation levels of CpG islands in STEAP3 were association with prognosis. …”
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Gene therapy by hepatocyte growth factor results in regression of experimental liver fibrosis by N. A. Dzhoyashvili, N. I. Kalinina, I. B. Beloglazova, Z. I. Tsokolayeva, P. I. Makarevich, Yu. L. Perov, Ye. V. Parfenova, V. A. Tkachuk

“…Morphometrical analysis demonstrated, that after HGF therapy in the main group of animals the degree of fibrosis (%) was lower in comparison to that in the control group. …”
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Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…RAW 264.7 and HMC3 cells in iHPN displayed an anti-inflammatory phenotype, as shown by increased CD206 and decreased CD86/CD68 expression, along with higher IL-4 and lower TNF-α/IL-1β secretion. Human SH-SY5Y neuroblastoma cells exhibited higher viability and improved neuronal differentiation in iHPN compared to TCP. …”
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Neuregulin1 ameliorates metabolic dysfunction-associated fatty liver disease via the ERK/SIRT1 signaling pathways by Chengan Xu, Shouhao Wang, Di Meng, Mingshan Wang, Rong Yan, Yining Dai

“…Results The expressions of NRG1 in MAFLD cell and animal models were significantly lower than that in the control group. After the intervention of ERK inhibitor PD98059, the expression of NRG1 decreased significantly in vivo, but no significant change was observed in vitro. …”
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Comparative analysis of real-world data on the efficacy and safety of and adherence to ICS/LABA combinations in asthma management by Hee Sun Park, Jungkuk Lee, Hasung Kim, Seong-Dae Woo

“…However, the DPI group exhibited a significantly higher mean proportion of days covered (0.67 ± 0.23 vs. 0.62 ± 0.23; P < 0.001) and a lower risk of discontinuation (adjusted hazard ratio, 0.867; 95% confidence interval, 0.804–0.927; P < 0.001) than did the MDI group, with no significant differences observed between the other subgroups. …”
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The PROMISE-V2 PRIMARY score and SULmax [18F]PSMA-1007 PET/CT in primary staging of prostate cancer by J. Antonio Serna-Macias, M. Lourdes Garcia-Colmenero, Emilly A. Cortes-Mancera, E. David Muñoz-Carpio, Mixel Z. Baltierra-Hernandez

“…In contrast, cases with extrapelvic lymph nodes or metastases (bone, brain, or lung) had lower SULmax values (12.43 ± 8.73 g/mL) (p < 0.001). …”
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The baked side: Cow's milk and egg protein threshold dose distributions in children reacting to baked milk and baked egg by Rocco Luigi Valluzzi, MD, Carla Riccardi, MD, Sara Urbani, MD, Davide Ursi, MD, Deborah Zavettieri, MD, Francesco Di Girolamo, PhD, Lamia Dahdah, MD, Veronica Calandrelli, PharmD, Vincenzo Fierro, MD, Alessandro Fiocchi, MD

“…For egg, they are 6.5 (egg ED01), and 7.5 (egg ED05) times lower than for native form.Compared to the currently used thresholds, they are 1.3 (milk ED01), 1.3 (milk ED05), 11 (egg ED01), and 4.9 (egg ED05) times higher. …”
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Prenatal labor analgesia education program on outcomes for primiparas: study protocol for a randomized controlled trial by Jiali Wu, Jing Chen, Weiwen Zhang, Jiangtao OuYang, Jia Li, Xujuan Zheng

“…Abstract Background A significant number of primiparous women lack awareness of labor epidural analgesia, resulting in lower acceptance of labor epidural analgesia. Additional prenatal education may help primiparas understand labor epidural analgesia and increase labor epidural analgesia rates. …”
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Effect of circulating prolactin, lactation days, and seasonal variations on first artificial insemination pregnancy rates using the PG7G protocol in dairy cows by Mufeed A. Alnimer, Mohamed A. Abedal-Majed, Mohmmad Al-Qaisi, Ahmad I. Shamoun

“…However, the PG7G-63 group exhibited lower PLs. Seasonality markedly influenced reproductive outcomes, with higher P/AI in the moderate season for primiparous cows and in the hot season for multiparous cows. …”
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The Association of Psychological Factors With Willingness to Share Health-Related Data From Technological Devices: Cross-Sectional Questionnaire Study by Marijn Eversdijk, Emma Rixt Douma, Mirela Habibovic, Willem Johan Kop

“…ResultsHigher levels of optimism (β=.093; PPP ConclusionsThe current results suggest that people with higher levels of optimism and psychological flexibility and those with lower social inhibition levels are more likely to share health technology data. …”
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SDRG-Net: Integrating multi-level color transformation encryption and ICNN-IRDO feature analysis for robust diabetic retinopathy diagnosis by Venkata Kotam Raju Poranki, B. Srinivasarao

“…Furthermore, existing DR grading methods have exhibited lower security properties due to the need for image encryption algorithms in the IoMT environment. …”
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Applied machine learning for predicting the properties and carbon and phosphorus fate of pristine and engineered hydrochar by Shiyu Xie, Tao Zhang, Siming You, Santanu Mukherjee, Mingjun Pu, Qing Chen, Yaosheng Wang, Esmat F. Ali, Hamada Abdelrahman, Jörg Rinklebe, Sang Soo Lee, Sabry M. Shaheen

“…FeCl3 impregnation increased Fe-phosphate content, while it reduced H/C and O/C ratios and hydroxyapatite P content, and therefore improved C stability and P availability in the HC-Fe as compared to HC, particularly under lower pH (4), temperature of 220 ℃, and at 120 min. …”
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Emission Characteristics of Hazardous Air Pollutants from Construction Equipment by Sungwoon Jung, Sunmoon Kim, Yunsung Lim, Jongtae Lee, Taekho Chung, Heekyoung Hong, Sunhee Mun, Seunghwan Lee, Woojun Jang, Jaehyun Lim

“…As a result of the after-treatment systems, which utilized a diesel oxidation catalyst (DOC) and selective catalytic reduction (SCR), CO, NMHC, and NOx emissions from the Tier 4-compliant excavator were lower than those from the Tier 3-compliant diesel engine and excavator. …”
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