Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study by Stanislav Rejchrt, Milos Hroch, Rudolf Repak, Tomas Fejfar, Tomas Douda, Darina Kohoutova, Eva Peterova, Jan Bures

“…Significant relationship (r>0.7) was found between several pairs of bile acids. Significantly lower bile acid concentrations in malignant biliary stenosis compared to controls without stenosis were found for GLCA (p=0.032), GUDCA (p=0.032), GCDCA (p=0.006), GDCA (p=0.031), GHCA (p=0.005), TUDCA (p=0.044), and TDCA (p=0.036). …”
Get full text

Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients by Minjie Li, Yu Gao, Lin Han, Ping Wang, Jie Li, Junhua Song, Shasha Du, Yunfei Zhang, Yumin Lyu

“…Results: After RT, the mean counts of white blood cells (WBCs), lymphocytes, and platelets significantly decreased, while the red blood cells (RBCs) and hemoglobin notably increased (P ​< ​0.001), while the dic frequency was elevated remarkably, significantly higher in patients with higher-grade (>1) acute skin toxicities compared to those with lower-grade (=1) acute skin toxicities (Z ​= ​−1.985, P ​= ​0.047). …”
Get full text

Clinical Effect of Revascularization Strategies and Pharmacologic Treatment on Long-Term Results in Patients with Advanced Peripheral Artery Disease with TASC C and D Femoropoplite... by Chiu-Yang Lee

“…The endpoints included the events of cardiovascular disease (CVD) and lower-extremity amputation (LEA), 3-year primary patency, and 3-year amputation-free survival (AFS). …”
Get full text

Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machin... by Lele Ye, Chunhao Long, Binbing Xu, Xuyang Yao, Jiaye Yu, Yunhui Luo, Yuan Xu, Zhuofeng Jiang, Zekai Nian, Yawen Zheng, Yaoyao Cai, Xiangyang Xue, Gangqiang Guo

“…Patients with SOC and a high CDI had lower survival rates and poorer prognoses than those with a low CDI. …”
Get full text

New epigenome players in the regulation of PCSK9-H3K4me3 and H3K9ac alterations by statin in hypercholesterolemia by Sushmitha Duddu, Yash T. Katakia, Rituparna Chakrabarti, Pooja Sharma, Praphulla Chandra Shukla

“…Statins are the most effective drugs used worldwide to lower the serum LDL-C by inhibiting the rate-limiting step, HMG-CoA reductase, in cholesterol biosynthesis. …”
Get full text

Senescence-related circRNA circHIF-1α is associated with pancreatic cancer progression by Hao Hua, Yazu Deng, Dijie Zheng, Changhao Wu, Liwen Chen, Binbin Shi, Zhiwei He, Chao Yu

“…Subsequent treatments with DOX and H2O2 resulted in significantly lower levels of circHIF-1α. CircHIF-1α knockdown induces cellular senescence and suppresses PC proliferation in vitro experiments. …”
Get full text

Uric acid to albumin ratio is a novel predictive marker for all-cause and cardiovascular death in diabetic patients: a prospective cohort study by Shengnan Chen, Shengnan Chen, Ming Zhang, Shouye Hu, Xiaolong Shao, Lin Liu, Zhi Yang, Kai Nan

“…Patients in higher quantiles of age and UAR had more rapid progression to all-cause death and higher mortality risk than patients in the lower quantiles. UAR also had good predictive value for cardiovascular death in diabetic patients.ConclusionsUAR may be a simple, cost-effective, and reliable predictive marker for all-cause and cardiovascular death in U.S. diabetic patients. …”
Get full text

Projected range overlap between the predator Teretrius nigrescens and the invasive stored product pest Prostephanus truncatus expands under climate change by Rachel R. Harman, William R. Morrison, III, Alison R. Gerken

“…The overlap of current highly suitable distributions is lower in the native (4.5 %) than the African range (22.2 %); however, the overlap is expected to increase by 86 % in the Americas and 63 % in Africa under the 2070 RCP8.5. …”
Get full text

Tempering temperature effect on the static and impact properties of 51CrV4 and 55Cr3 spring steels by Gülcan Toktaş, Adem Biçer

“…The quenching/tempering processes resulted in strengths that were two to three times higher and lower hardening capacities below 0.05 in comparison to the normalizing treatment. …”
Get full text

Advancements in lamb wave high-frequency devices using diamond-like carbon (DLC) coatings by Jatinder Pal Singh, Ajay Kumar Sao, Babita Sharma, Satyam Garg, Anjali Sharma, Reema Gupta, Lokesh Rana, Mallika Verma, Akhilesh Pandey, Archibald Theodore Nimal, Upendra Mittal, Amit Kumar Vishwakarma, Monika Tomar, Arijit Chowdhuri

“…However, with the incorporation of DLC coating, the frequency increased to 345 MHz with a lower return loss of -19.46 dB. The outcomes of this research underscore the potential of DLC coatings to optimize the Lamb wave device functionalities, promising enhanced performance and broader applications. …”
Get full text

Assessment of the efficacy of palliative sedation in advanced cancer patients by evaluating discomfort levels: a prospective, international, multicenter observational study by Maaike Rijpstra, Kris Vissers, Alazne Belar, Michael Van der Elst, Séverine Marie Surges, Claudio Adile, Rocío Rojí, Yasmine Grassi, Ewald Bronkhorst, Sebastiano Mercadante, Lukas Radbruch, Johan Menten, Carlos Centeno, Evelien Kuip, Jeroen Hasselaar

“…Abstract Background Palliative sedation involves the intentional proportional lowering of the level of consciousness in patients with life-limiting disease who are experiencing refractory suffering. …”
Get full text

Dynamic relationships between environment-related technologies, agricultural value added, transport infrastructure and environmental emissions in the five most populous countries by Yinuo Wang, Arshad Ali, Zhaojie Chen

“…Finally, the threshold level of environment-related technologies shows that as environment-related technologies move from lower threshold levels (≤ − 1.05) to higher threshold levels (> -1.05), agricultural value added and transportation infrastructure investment significantly improve the reduction of environmental contamination. …”
Get full text

Does the 2D Frontal Plane Projection Angle Predict Frontal Plane Knee Moments during Stepping, Landing, and Change of Direction Tasks? by Rachel K Straub, Christopher M Powers

“… # Methods Three-dimensional lower-extremity kinetics and 2D video were obtained from 39 healthy athletes (15 males and 24 females) during execution of six tasks (step down, drop jump, lateral shuffle, deceleration, triple hop, side-step-cut). …”
Get full text

Evolutionary analysis of slope direction deformation in the Gaojiawan landslide based on time-series InSAR and Kalman filtering. by Jingchuan Yao, Runqing Zhan, Jiliang Guo, Wei Wang, Muce Yuan, Guangyu Li, Bo Zhang, Rui Zhang

“…Further discussion and analysis reveal that there is a difference in the slip deformation rate between the upper and lower parts of the slope body, and the shear stress caused by dislocation deformation.…”
Get full text

Characteristics of Newly Diagnosed Type 2 Diabetes in Chinese Older Adults: A National Prospective Cohort Study by Fang Lv, Xiaoling Cai, Dayi Hu, Changyu Pan, Danyi Zhang, Jie Xu, Linong Ji

“…The older NEW2D (n=1362) had a lower BMI, HbA1c%, diastolic blood pressure, triglyceride, low-density lipoprotein cholesterol (LDL-C), and total cholesterol, higher systolic blood pressure, and high-density lipoprotein cholesterol levels at baseline. 47.8%, 66.7%, and 39.4% reached the target of HbA1c<7.0%, BP<140/90 mmHg, and LDL−C<2.6 mmol/L, respectively. …”
Get full text

Analysis of the growth trajectories of junior residents in Japan: a longitudinal cohort study using data from a nationwide e-portfolio system (EPOC2) by Sachiko Ohde, Takahiro Kiuchi, Makoto Takahashi, MASANAGA YAMAWAKI, Tsuguya Fukui, Tsuyoshi Okuhara, Hiroko Okada, Nobutoshi Nawa, Eriko Okada, Ayako Kashimada, Yu Akaishi, Yujiro Tanaka

“…For example, in the self-evaluation of medical knowledge and problem-solving (B-2), a lower percentage of respondents had adequate scores at the beginning of their training compared with other similar items. …”
Get full text

University Leadership: Transparency in Communication with External Stakeholders by Nadiia Artyukhova, Olena Churikanova, Kseniia Bliumska-Danko

“…The results indicated that some universities emerged as transparency leaders, serving as models for others, while those in lower-performing clusters require targeted improvements in their communication strategies. …”
Get full text

β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy by Yihui Huo, Taiyu Shen, Tianyin Feng, Moli Li, Wanli Zhao, Juan J. Loor, Ben Aernouts, Androniki Psifidi, Chuang Xu

“…Abstract Background In perinatal dairy cows, ketosis is a prevalent metabolic disorder that lowers milk output and performance. Mitochondrial dysfunction and chronic inflammation in mammary tissue are linked to elevated blood ketone levels, particularly β-hydroxybutyrate (BHB). …”
Get full text

Serum assisted PD-L1 aptamer screening for improving its stability by Yu Zhou, Haozhe Zhang, Yujing Ding, Changyuan Yu, Hao Li

“…Significantly, Apt-S1 exhibited a lower degradation rate in 10% diluted serum or pure human serum, under the physiological temperature and pH value, compared to Apt-A2. …”
Get full text

Ecdysone receptor strongly influences larval–pupal–adult transition and melanization in Tuta absoluta by Xiaodi Wang, Jiajia Wu, Jianyang Guo, Nianwan Yang, Fanghao Wan, Zhichuang Lü, Wanxue Liu

“…In the few successful pupations, the pupa weights were substantially lower (36.44%) than those of the control group. The color of the pupae was abnormal, and they did not enter their normal black state; the emergence rate of pupae was reduced by 43.45% compared to that of the control group. …”
Get full text