Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…The molecular mechanisms of Clo-induced tumor cell death were analyzed using western blotting, ELISA, reverse transcription-PCR, immunofluorescence, co-immunoprecipitation (CO-IP), short hairpin RNA, co-culture, chromatin immunoprecipitation, and flow cytometry. Clinical data sets were used to analyze the correlation between stimulator of interferon genes (STING)-NFκB signaling and immune infiltration.Results In this study, Clo significantly reduced the growth of melanoma and lung cancer cells. …”
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Assessing Hydropower Potential in Nepal’s Sunkoshi River Basin: An Integrated GIS and SWAT Hydrological Modeling Approach by Rinki Bhattarai, Binaya Kumar Mishra, Deepa Bhattarai, Dipendra Khatiwada, Pankaj Kumar, Gowhar Meraj

“…The hydropower potential at each identified site was evaluated using estimated stream flow and topographical head at various probability of exceedance (PoE) levels (40%, 45%, 50%, and 60%). …”
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Diagnostic Accuracy of Physical Examination Tests for Suspected Acute Anterior Cruciate Ligament Injury: A Systematic Review and Meta-Analysis by Shigeharu Tanaka, Yu Inoue, Yuki Masuda, Hui Tian, Hungu Jung, Ryo Tanaka

“…The methodological quality of the included studies was mostly favorable. For the domain of flow and timing in the QUADAS-2, three studies did not assess the timing between the reference and index tests. …”
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Failure Modes and Fault Morphology by Adam J. Cawood, David A. Ferrill, Kevin J. Smart

“…Distinct failure behaviors are consistent with patchworks of volume neutral, volume gain, and volume loss zones along the fault surfaces, indicating that the characterized faults likely represent dual conduit-seal systems for fluid flow.…”
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Hydrogeochemistry, Geothermometry, and Genesis of the Hot Springs in the Simao Basin in Southwestern China by Yuqi Zhang, Xun Zhou, Haisheng Liu, Mingxiao Yu, Kuo Hai, Mengru Tan, Dongxue Huo

“…The following mechanisms contribute to the formation of hot springs in the Simao Basin: the groundwater receives recharge from infiltration of precipitation and undergoes deep circulation, during which groundwater is heated by heat flow and incongruently dissolves the subsurface minerals and emerges in the form of hot springs along the permeable fracture or fault zones.…”
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Numerical investigating the impact of fluid properties and oscillation frequency on micro mixer efficiency by Sajad Ghanbari, Mohammad Sefid, Mohammad Ali Sabbaghi

“…For this purpose, a two-dimensional microchannel equipped with an oscillating circular cylinder was used, operating within a Strouhal number range of 0.1–0.55, with an oscillation amplitude of 0.4 cylinder diameters in a direction perpendicular to the flow direction, at a blockage ratio of 13 and Reynolds and Schmidt numbers of 50 and 10, respectively, utilizing a finite volume method based on elements. …”
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SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells by Katie V. Tieu, Madaline Espey, Aarthi Narayanan, Rebecca L. Heise, Farhang Alem, Daniel E. Conway

“…Because endothelial cells are exposed to physiological forces due to blood flow, we examined the effects of cyclic biaxial stretch and fluid shear stress. …”
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Study on a New Method of Link-Based Link Prediction in the Context of Big Data by Chen Jicheng, Chen Hongchang, Li Hanchao

“…In the subsequent sections of the paper, we explain the theory prediction algorithms, precisely the flow-based process. We specifically address the problems on sparse networks that are never discussed with other prediction methods. …”
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YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database by Mengge Wang, Shuhan Duan, Qiuxia Sun, Kaijun Liu, Yan Liu, Zhiyong Wang, Xiangping Li, Lanhai Wei, Yunhui Liu, Shengjie Nie, Kun Zhou, 10K_CPGDP consortium, Yongxin Ma, Huijun Yuan, Bing Liu, Lan Hu, Chao Liu, Guanglin He

“…New evidence was provided for extensive gene flow events between minority ethnic groups and Han Chinese people, based on the integrative Chinese Paternal Genomic Diversity Database. …”
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TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis by Lin Wang, Diqing Ouyang, Lin Li, Yunchuan Cao, Yingwen Wang, Nina Gu, Zhaosi Zhang, Zhao Li, Shuang Tang, Hui Tang, Yuan Zhang, Xiaochuan Sun, Jin Yan

“…Various techniques were used to assess the role of DAM-like cells in TBI and the effects of glycolysis on DAM-like cells, including RT‒qPCR, immunofluorescence assays, behavioural tests, extracellular acidification rate (ECAR) tests, Western blot analysis, cell magnetic sorting and culture, glucose and lactate assays, and flow cytometry. Results DAM-like cells were observed in the acute phase of TBI in mice, and their transformation depended on TREM2 expression. …”
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N-Alkyl-Substituted Isatins Enhance P2X7 Receptor-Induced Interleukin-1β Release from Murine Macrophages by Ronald Sluyter, Kara L. Vine

“…P2X7 activity was determined by flow cytometric measurements of ATP-induced cation dye uptake. …”
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EBV-Negative Monomorphic B-Cell Posttransplant Lymphoproliferative Disorder with Marked Morphologic Pleomorphism and Pathogenic Mutations in ASXL1, BCOR, CDKN2A, NF1, and TP53 by Agata M. Bogusz

“…By immunostaining, the malignant cells were immunoreactive for CD45, CD20, CD79a, PAX5, BCL6, MUM1, and p53 and negative for CD15, CD30, latent membrane protein 1 (LMP1), and EBV-encoded RNA (EBER). Flow cytometry demonstrated lambda light chain restricted CD5 and CD10 negative B-cells. …”
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Performance characteristics of shell and tube heat exchanger using sectoral baffle by Jacob Kolawole Adebayo, Ademola Adebukola Dare, Moses Omolayo Petinrin

“…The SP was run at 323.15 and 278.15 K inlet temperatures for shell and tube, respectively, using water as shell-side fluid at a flow rate ranging from 0.5 to 2.50 kg/s. Velocities, temperatures, and pressure obtained from SP were used to evaluate the Relative Performance Index of all the STBs against SB as control. …”
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FREEDOM OF THE INFORMATION SPACE. IS IT A REALITY OR ILLUSION? by Elena V. Korableva

“…То fit into information flow human should change the way he thinks: develop skills in algorithmic approach to information processing, structured analytical thinking. …”
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A New Big Data Approach to Understanding General Traffic Impacts on Bus Passenger Delays by Yaiza Montero-Lamas, Margarita Novales, Alfonso Orro, Graham Currie

“…The estimated bus delay is obtained by comparing the estimated bus travel time with the bus travel time under free-flow conditions. Finally, estimated bus passenger time savings would be obtained if an exclusive bus lane had been implemented. …”
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Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by William J Murphy, Robert J Canter, Nikhil Joshi, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Louis B Jones, Ugur N Basmaci, Matthew L Settles, Blythe P Durbin-Johnson, Arta Monir Monjazeb, Janai Carr-Ascher, Jonathan A Eisen

“…In the tumor microenvironment, we observed a strong positive correlation between viral relative abundance and natural killer (NK) infiltration, and higher NK infiltration was associated with superior metastasis-free and overall survival by immunohistochemical, flow cytometry, and multiplex immunofluorescence analyses.Conclusions We prospectively demonstrate the presence of a distinct and measurable intratumoral microbiome in patients with STS at multiple time points. …”
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Improving the Military Vocational Training of Cadets at Military Institute by Yu. G. Bychenko, T. M. Balandina

“…The military institute lacks free access to Internet resources, a significant part of the information flow of the external social environment. Administrative technologies of interaction between the teacher and the students prevail, there are no favorable conditions for creative self-realization, complex development of creative projects, self-development of the intellectual potential of cadets, the practice of including cadets in the system of tactical management and self-management, organizing their own leisure time is limited. …”
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Laser Vaporization of Intracoronary Thrombus and Identifying Plaque Morphology in ST-Segment Elevation Myocardial Infarction as Assessed by Optical Coherence Tomography by Yuki Yamanaka, Yoshihisa Shimada, Daisuke Tonomura, Kazunori Terashita, Tatsuya Suzuki, Kentaro Yano, Satoshi Nishiura, Masataka Yoshida, Takao Tsuchida, Hitoshi Fukumoto

“…The mean baseline thrombolysis in myocardial infarction flow grade was 0.4 ± 0.6, which subsequently improved to 2.3 ± 0.7 after MT (p<0.0001) and 2.7 ± 0.5 after ELCA (p=0.0001). …”
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MRD-driven phase 2 study of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma by Manisha Bhutani, Myra Robinson, David Foureau, Shebli Atrash, Barry Paul, Fei Guo, Jason M. Grayson, Anna Ivanina-Foureau, Mauricio Pineda-Roman, Cindy Varga, Reed Friend, Christopher J. Ferreri, Xhevahire Begic, Sarah Norek, Tiffany Drennan, Michelle B. Anderson, James T. Symanowski, Peter M. Voorhees, Saad Z. Usmani

“…The primary outcome was complete response (CR) and stringent CR (≥CR) after induction. Flow cytometry was used to profile T cells. Among 39 patients, 21 (54%) achieved ≥CR after induction (P = .375), with MRD-negative rates of 59% (10−5) and 41% (10−6). …”
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Characteristics of Water Pollution and Evaluation of Water Quality in Subsidence Water Bodies in Huainan Coal Mining Areas, China by Xinyue Deng, Guangzhou Chen

“…The subsidence water bodies in coal mining areas are vulnerable to being polluted by the surrounding mining production wastewater, domestic sewage, and agricultural return flow. Therefore, it is important to grasp the water quality condition of the above water bodies. …”
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