Interleukin-12 Inhibits Tumor Growth and Metastasis Promoted by Tumor-Associated Mesenchymal Stem Cells in Triple-Negative Breast Cancer by Babak Jahangiri, Zahra-Soheila Soheili, Elahe Asadollahi, Mehdi Shamsara, Vahid Shariati, Alireza Zomorodipour

“…Cell proliferation was measured using trypan blue exclusiontechnique, while cell cycle distribution and apoptosis were assessed by flow cytometry. The effects of TA-MSCs ontumor volume, survival rate, and lung metastasis were evaluated by subcutaneous co-injection of MSCs with 4T1 cellsin the right flanks of BALB/c mice (n=5 per group). …”
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Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients by Long-Shan Ji, Qiu-Tian Gao, Ruo-Wen Guo, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Xiao-Jun Zhu, Ya-Ting Gao, Xue-Hua Sun, Yue-Qiu Gao, Man Li

“…The frequencies of Th1, Treg, and dendritic cells (DCs) and expression levels of PD-1/PD-L1 were examined by flow cytometry. Results. In treatment-naïve CHB patients, complete viral suppression rates in HBeAg(−) patients were higher than those in HBeAg(+) patients in both T and C groups. …”
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Dietary supplementation of Astragalus polysaccharide or its nanoparticles enhances testicular hemodynamics, echotexture, scrotal circumference, concentration of testosterone, estra... by Eman Fayez, Ali Salama, Mohamed Ahmed Ismail, Fady Sayed Youssef, Zaher Mohamed Rawash, MR Oshba, Haney Samir

“…Abstract This study investigated, for the first time, the potential role of Astragalus polysaccharide (APS) and APS nanoparticles on testicular blood flow (TBF) and semen quality in Ossimi rams. Fifteen sexually mature Ossimi rams were allocated randomly into two treated groups that orally administered either nano APS (2 g/ram/day; n = 5) or APS (20 g/ram/day; n = 5) for four weeks and a control group (n = 5). …”
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Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice by Weifeng Gu, Tingting Zheng, Wen Li, Xinkai Luo, Xiaowei Xu, Ying Wang, Chaoming Mao, Yongbin Ma, Liyang Dong

“…The therapeutic effects of migrasomes on airway inflammation in ovalbumin (OVA)-induced asthmatic mice were evaluated by hematoxylin-eosin (HE) and periodic-acid schiff (PAS) staining, and their mechanism were further testified by immunofluorescent staining, real-time PCR and flow cytometry. Results Here, we showed that inhibition of migrasomes’ production dramatically impaired the anti-inflammatory effects of hUCMSCs in OVA animals, as evidenced by a notable increase in both the infiltration of inflammatory cells and the number of epithelial goblet cells. …”
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High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity by Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Pradeep A. Menon, Subash Babu

“…Thus, we have studied the unstimulated (UNS), Mycobacterium tuberculosis (Mtb [PPD, WCL]), and mitogen (P/I)-stimulated NK and iNKT cells expressing Type 1 (IFNγ, TNFα, and IL-2), Type 17 (IL-17A, IL-17F, and IL-22) cytokines, cytotoxic (perforin, granzyme B, and granulysin) and immune (GMCSF, PD-1, and CD69) markers in LTB comorbidities by dimensionality reduction and flow cytometry. Our results suggest that LTB DM and PDM individuals express diverse NK and iNKT cell immune clusters compared to LTB NDM individuals. …”
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Prognostic Value of Endothelial Progenitor Cells in Acute Myocardial Infarction Patients by Gongjie Ye, Xiaodan Chen, Yinchao Zhou, Jianqing Zhou, Yongfei Song, Xiaoyong Yang, Lei Yang

“…EPCs, defined as coexpression of CD34+/CD133+ cells or CD133+/CD34+/KDR+, were studied using flow cytometry and categorized by quartiles. Based on the 28-days mortality outcome, the patients were further divided into two groups: death and survival. …”
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Angesinenolide B, A Phthalide Dimeric Peroxide, Exerts Anti-Inflammatory Properties by Suppressing MAPK/STATs Signaling Pathways and ROS Production by Zhang L, Liu Y, Wang H, Guo S, Lv J

“…Fluorescence microscopy and flow cytometry were employed for the determination of ROS generation. …”
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Assessment of the Impact of Floods to the Local Community in Nyarusiza Sub-County Kisoro District. by Murengezi, Innocent

“…During this time, rainwater flows and is collected in dams. When this tired or collected water reaches beyond the storage capacity limit, it ends up in flood. …”
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Village Savings and loan associations and socio-economic empowerment of vulnerable people in Kamuganguzi Sub-County Kabale, District, Uganda. by Deus, Mwijukye, Moses, Agaba

“…The recommendations were; need to improving the health status of women in families as well as children since they are regarded vulnerable in order to let them live happily; there should be improved nutrition and food supply to all families to let children and other members grow healthy and live a happy life; increased household income should be the ultimate goal fostered by credit accessibility in the area which must be done with ease through the start of small and medium enterprises especially women; it is recommended that the vulnerable groups of people have the replacement of the damaged property in case of any loss aiming at keeping standards of living at household level; achieving flexibility to immense development of social capital required the development of the saving culture that promotes regular income to help the community solve their personal problems; the social fund should be a unifying factor that enhances development through increased social networking to allow information flow since information is power.…”
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Village Savings and Loan Associations and Socio-Economic Empowerment of Vulnerable People in Kamuganguzi Sub-County Kabale, District, Uganda by Mwijukye, Deus, Moses, Agaba

“…The recommendations were; need to improving the health status of women in families as well as children since they are regarded vulnerable in order to let them live happily; there should be improved nutrition and food supply to all families to let children and other members grow healthy and live a happy life; increased household income should be the ultimate goal fostered by credit accessibility in the area which must be done with ease through the start of small and medium enterprises especially women; it is recommended that the vulnerable groups of people have the replacement of the damaged property in case of any loss aiming at keeping standards of living at household level; achieving flexibility to immense development of social capital required the development of the saving culture that promotes regular income to help the community solve their personal problems; the social fund should be a unifying factor that enhances development through increased social networking to allow information flow since information is power…”
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Possible scenarios of sustainable supply chain in dairy industry with future research approach by Meysam Abedini, Narges Mohammadalipour, Ashraf Shahmansouri, Mahnaz Rabiei

“…The supply chain includes all activities related to the flow and conversion of goods from the stage of conversion of raw materials to the final products, as well as information flows related to them. …”
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Analysis of some error-causing factors in two-dimensional geoelectrical studies and providing a solution to minimize them by Hosein Moghaddasi, Mohsen Moghaddasi, Ahmad Neyamadpour

“…However, according to the authors of this article, even these values should be considered with caution and we suggest data acquisition with an even lower “n”. In fact, in the real world, and especially in IP/Rs investigation, many factors are the source of noise and we should use lower “n” factors to get the correct and real data. …”
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Characteristics and quality of biofloc in vannamei shrimp culture with different carbon sources by Muhammad Faris Allam, Julie Ekasari, Ichsan Achmad Fauzi, Wiyoto Wiyoto

“…Meanwhile, the water quality between the treatments had relatively close values, but the CL treatment was able to suppress TAN and NO2 lower than the DX and ST treatments during the rearing period. …”
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Trifluridine-tipiracil in previously treated patients with oestrogen receptor-positive, HER2-negative metastatic breast cancer (BOOG 2019-01 TIBET trial): a single-arm, multicentre... by Niels A.D. Guchelaar, Ron H.J. Mathijssen, Maaike de Boer, Marlies L. van Bekkum, Joan B. Heijns, Birgit E.P.J. Vriens, Mandy M. van Rosmalen, Lonneke W. Kessels, Lisanne Hamming, Karin J. Beelen, Peter Nieboer, Susan M. van den Berg, Esther Oomen-de Hoop, Rhodé M. Bijlsma, Monique E.M.M. Bos

“…The primary endpoint was considered met, justifying further research of this treatment regimen, if the lower boundary of the 80% confidence interval (CI) exceeded 30%. …”
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Control of Ectoparasitic Monogenean Infestation on GIFT Tilapia (Oreochromis sp.) using Salt Addition by Yani Hadiroseyani, L.S. Harti, Sri Nuryati

“…The intensity of both parasites was found to be lower as salt concentration increase. Salt concentration of 24 g/l was the most effective concentration to reduce parasites infestation and could totally treat the infested fish within 6 days. …”
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Application of “Tree Hole Listening” psychological support service in emotional management of neurology nurses (“树洞倾听”心理支持服务在神经内科护士情绪管理中的应用)... by FEI Cailian (费才莲), WANG Yu (王瑜), ZHANG Jingyi (张静怡), XIE Juan (谢娟)

“…The post-intervention score of ELS-C (46. 74 ± 7. 84) was notably lower than pre-intervention score (53. 11 ± 7. 06), with a significant difference (P＜0. 05). …”
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Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes: a systematic revi... by Song Liu, Jiaqiang Hu, Chen Zhao, Hang Liu, Chunyang He

“…For blood pressure management, Tirzepatide significantly reduced systolic blood pressure (MD: -6.69 mmHg, 95% CI: -7.62 to -5.75, P-score: 0.84, p < 0.0001) and diastolic blood pressure (MD: -3.73 mmHg, 95% CI: -4.75 to -2.71, P-score: 0.92, p < 0.0001), with nearly all agents lowering systolic blood pressure by more than 5 mmHg. …”
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Study on the status of liver function abnormalities and its related factors in patients with severe mental disorders in Shanghai community by ZHANG Yixuan, CHEN Chunmei, ZHU Youwei, ZHU Yi, HE Siyuan, LIU Yanli, WANG Na, CAI Jun, XIE Bin, ZHANG Weibo

“…Univariate analysis showed that the rate of liver function abnormalities was higher in males than that in females (χ2=45.026, P<0.001), higher in suburbs than that in urban areas (χ2=25.317, P<0.001), higher in those with higher BMI than in those with lower BMI (χ2=63.748, P<0.001), higher in those with elevated blood pressure (BP) than in those without elevated BP (χ2=24.774, P<0.001), higher in those with elevated blood glucose than in those without elevated blood glucose (χ2=43.345, P<0.001), higher in those with abnormal triglyceride (TG) than in those with normal TG (χ2=15.551, P<0.001), and higher in those with abnormal total cholesterol (TC) than in those with normal TC (χ2=10.962, P=0.001). …”
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Faktor Risiko Terjadinya Ulkus Diabetikum pada Pasien Diabetes Mellitus yang Dirawat Jalan dan Inap di RSUP Dr. M. Djamil dan RSI Ibnu Sina Padang by Rizky Loviana Roza, Rudy Afriant, Zulkarnain Edward

“…<br />Kata kunci: faktor risiko, DM, ulkus diabetikum</p><p>Abstract<br />Diabetic foot ulcer is defined as the presence of infection, ulceration and/or destruction of deep tissues associated with neurologic abnormalities and various degrees of peripheral arterial disease (PAD) in the lower limb on patients with diabetes. Foot ulceration is preventable, and relatively simple interventions can reduce amputations by up to 80%. …”
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Early Postoperative Safety of Total Hip Arthroplasty in Systemic Lupus Erythematosus Patients by YANG Xingdong, YU Muyang, XU Yiming, ZHU Wei, HU Mingwei, WENG Xisheng, FENG Bin

“…After propensity score matching, 163 cases from SLE and control groups were included for analysis. (1) Regarding medical complications, compared with control group, SLE group showed significant differences in osteoporosis, respiratory system disorders, gastrointestinal diseases, urinary system disorders, hematologic abnormalities, and secondary or concomitant rheumatic diseases (all P < 0.05). (2) In terms of preoperative laboratory tests, SLE group had lower platelet counts, absolute lymphocyte counts, hemoglobin levels, hematocrit, albumin levels, blood glucose levels, and activated partial thromboplastin times than control group, while C-reactive protein, erythrocyte sedimentation rate, and D-dimer levels were higher (all P < 0.05). (3) Regarding surgical-related indicators, a higher proportion of patients in SLE group had an ASA grade > 2 (15.95% vs. 3.07%, P < 0.001), but intraoperative blood loss was significantly smaller [324.7 (200.0, 500.0) mL vs. 421.8 (200.0, 500.0) mL, P=0.005]. (4) In terms of complications, SLE group exhibited a significantly higher incidence of major complications than control group (8.59% vs. 1.23%, P=0.005), with a relative risk of 1.081 (95% CI: 1.028-1.136). …”
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