Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch re... by Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia

“…Tumour infiltrating immune cell populations were characterised via flow cytometry. In vitro experiments evaluated STAT3 inhibition in pancreatic stellate cells (PSCs) and myeloid-derived suppressor cells (MDSCs).A phase II trial employing a Simon II stage design tested the clinical efficacy of danvatirsen and durvalumab in non-small cell lung cancer (NSCLC), PDAC and mismatch repair-deficient colorectal cancer (MRD CRC). …”
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Clinical and measurement variables affecting halitosis intensity following cysteine challenge test by Wanki Lee, Jung Hwan Jo, Young-Seok Park, Ji Woon Park

“…The Community Periodontal Index of Treatment Needs (CPITN), Winkel’s Tongue Coating Index, and salivary flow rate were assessed. VSC levels significantly increased immediately after cysteine challenge (p < 0.001 for hydrogen sulfide, p < 0.001 with standard GC and p < 0.05 with portable GC for methyl mercaptan). …”
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Causes of the exceptionally high number of fatalities in the Ahr valley, Germany, during the 2021 flood by B. Rhein, B. Rhein, H. Kreibich

“…This unprecedented flash flood was characterised by high water levels and high flow velocities. The extent of inundation in 2021 far exceeded the official hazard map for the extreme flood scenario. …”
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Correlation between Therapeutic Efficacy of CD34+ Cell Treatment and Directed In Vivo Angiogenesis in Patients with End-Stage Diffuse Coronary Artery Disease by Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Pei-Hsun Sung, Chi-Hsiang Chu, Mel S. Lee, Yuan-Ping Lin, Hon-Kan Yip, Fan-Yen Lee

“…The percentages of circulating EPCs with KDR+/CD34+/CD45−, CD133+/CD34+/CD45−, and CD34+ were determined in each patient using flow cytometry. PBMC-derived EPCs from all patients were subjected to DIVAA through a 14-day implantation in nude mice. …”
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Donor site morbidity following radial forearm free flap reconstruction with split thickness skin grafts using negative pressure wound therapy by Jessica M. Clark, Shannon Rychlik, Jeffrey Harris, Hadi Seikaly, Vincent L. Biron, Daniel A. O’Connell

“…Negative pressure wound dressings (NPD) may increase blood flow and perfusion as compared to static pressure dressings (SPD) designed to minimize shear forces during the healing period. …”
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Preservation of Electronic Records and Performance of Microfinance Institutions: A Case Study of Lyamujungu SACCO Kaharo Branch. by Ainembabazi, Abias

“…The results on types of electronic records kept in Lyamujungu SACCO were bills and receipts, income statement, inventories of goods, financial statements, employment records, cash flow statement and balance sheet, the study findings on the role of preserving Electronic Records towards performance of Lyamujungu SACCO were; enables quicker and cheaper documents compilation, Electronic Records enables staff to access all information anytime, provide access to very large information, provision of online tools and sharing of content, there is little personalization for users, the study findings, on challenges faced in preserving Electronic Records for performance of Lyamujungu SACCO, were inadequate technical knowledge, inadequate skills, adequate communication infrastructure, poor management of records and inadequate finance and the study findings on the possible solutions to challenges faced in preserving Electronic Records in Lyamujungu SACCO for better performance were proper methods of filing, training of records management staff, expanding the file system capacity, improvement in provision of bandwidth and training of records management staff. …”
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HERA: a high-resolution pan-European hydrological reanalysis (1951–2020) by A. Tilloy, D. Paprotny, S. Grimaldi, G. Gomes, A. Bianchi, S. Lange, H. Beck, C. Mazzetti, L. Feyen

“…The availability of consistent estimates of river flow at the global and continental levels is a necessity for assessing changes in the hydrological cycle. …”
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Impact of COVID-19 on Corporate Cash Holdings and Speed of Adjustment by Abbas Aflatooni, Mohammad Khatiri, Farzad Eivani

“…The precautionary motive is considered the primary driver for holding cash as it becomes more important when firms face greater cash flow uncertainty or limited access to external financing during crises (Opler et al., 1999; Almeida et al., 2004). …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…Cultured STAD cells assessed the proliferation of STAD and upregulation of GPX3 expression by CCK8 and flow cytometry. Transwell and wound healing assays assessed the impact of GPX3 on invasion and migration of STAD cells. …”
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Assessment of Water Quality and Heavy Metal Contamination in River Water and Fish Species from the Bangshi River, Tangail, Bangladesh by Mausumi Rehnuma, Jannatul Firdous Jui, Jannatul Hasna, Umme Habiba, Anamul Haque

“…The Bangshi River flows through the industrial regions of Dhaka and Tangail, polluted by various wastes, including industrial effluents. …”
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Russia’s Foreign Trade with the GCC Countries: Dynamics, Characteristics and Opportunities by L. V. Shkvarya

“…The United Arab Emirates (UAE) remains Russia's primary trading partner within the GCC. However, trade flows between Russia and the UAE, as well as other Gulf states, are imbalanced, with Russian exports to the Arabian monarchies significantly exceeding imports from the region. …”
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Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model by Panadda Yotsomnuk, Amarnath Praphakar Rajendran, Daniel Nisakar Meenakshi Sundaram, Luis Carlos Morales, Cezary Kucharski, Mohammad Nasrullah, Wanwisa Skolpap, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Hasan Uludağ

“…The quantitative analysis of gene silencing performed by qPCR as well as immunostaining/flow cytometry indicated significant reduction in both FLT3 expression and FLT3 protein after specific siRNA delivery. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…Dendritic cells were analyzed by flow cytometry for CD11c, CD40, CD80, CD83, CD86, PD-L1, and HLA-DR, and supernatants were analyzed for FGF2, HGF, IL-10, IL-12p70, LIF, MIF, PDGF, PlGF, and IDO. …”
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Comprehensive Monitoring of Construction Spoil Disposal Areas in High-Speed Railways Utilizing Integrated 3S Techniques by Xiaodong Hu, Bo Xia, Yongqi Guo, Yang Yin, Huihua Chen

“…Inadequate monitoring of spoil disposal areas can lead to significant environmental issues, including soil erosion and geological hazards such as landslides and debris flows, while also hindering the recycling and reuse of construction spoil, thereby impeding the achievement of circular economy and sustainable development goals for high-speed railways. …”
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Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer by Fangze Wei, Xiaotian Xu, Jing Wang, Shi Wen Mei, Fu Qiang Zhao, Fei Huang, Ti Xian Xiao, Guo Jing Wang, Baojun Wei, Shengkai Huang, Wei Cui

“…We also compared the biological functions of these cells between MSS and MSI-high CRC and used flow cytometry and coculture experiments to explore their potential regulatory functions. …”
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Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows by Jiawei Zhang, Lei Shi, Xiaorong Zhong, Yunhe Bai, Jun Dou, Lu Zhang, Xiaochao Shi, Bingchun Wu, Zemin Tan, Lin Yan, Jinku Yu, Jingru Zhang, Guo Han, Jiansheng Xiong, Hua Zhang, Xingyuan Cao, Haoshu Luo

“…Abstract To improve the economic benefits, exogenous hormones are used to control follicular development and synchronize ovulation in the batch flow management of gilts and weaned sows. Equine chorionic gonadotropin (eCG) is widely used to stimulate follicular development in both experimental and farm animals. …”
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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…We have applied RNA sequencing, flow cytometry, ELISA, cellular/molecular immunological technology, and mouse models of solid cancers.Results Our study provided evidence that S1PR3 high expression is positively associated with resistance to programmed cell death protein-1 (PD-1)-based immunotherapy and increased T-cell exhaustion. …”
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Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach by Syntia Nusanti, Andhika Rachman, Brigitta Marcia Budihardja, Lourisa Ruth Eldinia, Nadia Delima Andini, Arief Kartasasmita, M Sidik, Seskoati Prayitnaningsih, Alida Roswita Harahap, Aria Kekalih, Tjahjono Darminto Gondhowiardjo

“…All patients were evaluated for E-selectin and P-selectin levels measured using flow cytometry.  Results: A total of 42 subjects comprising 14 hypercoagulation and 28 non-hypercoagulation subjects were included. …”
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Dual‐fluorescence imaging and automated trophallaxis detection for studying multi‐nutrient regulation in superorganisms by Lior Baltiansky, Einav Sarafian‐Tamam, Efrat Greenwald, Ofer Feinerman

“…More broadly, the ability to simultaneously and efficiently track two material flows in a behaving colony provides new opportunities for tackling many open and emerging questions on topics other than nutrition, such as disease spread and social regulation of colony development.…”
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Speciation Analysis of Arsenic Compounds by High-Performance Liquid Chromatography in Combination with Inductively Coupled Plasma Dynamic Reaction Cell Quadrupole Mass Spectrometry... by Hai Anh Vu, Manh Ha Nguyen, Hong-An Vu-Thi, Quan Do-Hong, Xuan Hoang Dang, Thi Ngoc Bich Nguyen, Hong Quan Trinh, Thuy Ly Bich, Tien-Thanh Nguyen, Dung Le-Van, Minh Binh Tu, Dinh Binh Chu

“…Arsenic compounds were detected online by inductively coupled plasma dynamic reaction cell quadrupole mass spectrometry utilizing oxygen as the reaction gas at a flow rate of 0.7 mL·min−1. Five selected arsenic species were baseline separated at the optimum experimental conditions. …”
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