MRD-driven phase 2 study of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma by Manisha Bhutani, Myra Robinson, David Foureau, Shebli Atrash, Barry Paul, Fei Guo, Jason M. Grayson, Anna Ivanina-Foureau, Mauricio Pineda-Roman, Cindy Varga, Reed Friend, Christopher J. Ferreri, Xhevahire Begic, Sarah Norek, Tiffany Drennan, Michelle B. Anderson, James T. Symanowski, Peter M. Voorhees, Saad Z. Usmani

“…The primary outcome was complete response (CR) and stringent CR (≥CR) after induction. Flow cytometry was used to profile T cells. Among 39 patients, 21 (54%) achieved ≥CR after induction (P = .375), with MRD-negative rates of 59% (10−5) and 41% (10−6). …”
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Characteristics of Water Pollution and Evaluation of Water Quality in Subsidence Water Bodies in Huainan Coal Mining Areas, China by Xinyue Deng, Guangzhou Chen

“…The subsidence water bodies in coal mining areas are vulnerable to being polluted by the surrounding mining production wastewater, domestic sewage, and agricultural return flow. Therefore, it is important to grasp the water quality condition of the above water bodies. …”
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Biomarker Profiling for Pyridoxine Dependent Epilepsy in Dried Blood Spots by HILIC-ESI-MS by Elizabeth Mary Mathew, Sudheer Moorkoth, Leslie Lewis, Pragna Rao

“…The samples were extracted using methanol and analysed on a iHILIC fusion plus column with formic acid buffer (pH 2.5): acetonitrile (20:80) at a flow rate of 0.5 mL/min within 3 minutes. The method demonstrated a LOD of 10 ng/mL, LOQ of 50 ng/mL, linearity of r2 ≥ 0.990, and recovery of 92-101.98% for all analytes. …”
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Efficient Differentiation of Mouse Induced Pluripotent Stem Cells into Alveolar Epithelium Type II with a BRD4 Inhibitor by Toru Momozane, Eriko Fukui, Soichiro Funaki, Makoto Fujii, Yuhei Kinehara, Emiko Ito, Shigeru Miyagawa, Yuko Ohno, Yoshiki Sawa, Meinoshin Okumura, Yasushi Shintani

“…First, the murine iPSC line 20D-17 was induced to differentiate into ATII over a period of 26 days (days 0-26) using previously reported embryoid body seeding and stepwise differentiation methods. mRNA expressions of differentiation markers including surfactant protein C (Sftpc) were confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR) results, and 17% of the cells were shown positive for prosurfactant protein C (proSPC) in flow cytometry analysis. Next, those cells were cultured three-dimensionally in Matrigel for an additional 14 days (days 26-40), during which JQ1 was added for 4 days (days 28-32) to remove residual undifferentiated iPSCs. …”
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In vitro assessment of fracture resistance of endodontically treated teeth restored with short fiber reinforced resin based composite and ceramic overlays by Mona Elshirbini Hafez, Ahmed Ata Abd El-ghany, Ahmed Ismail Taha, Ashraf Amin

“…Standardized MOD cavities were prepared in 30 teeth of them, then they were randomly divided into three groups: Group 2: teeth received no coronal restorations; Group 3: MOD cavities restored with packable short fiber reinforced composite (EverX Posterior), followed by 2 mm nanocomposite; and Group 4: MOD cavities restored with flowable short fiber reinforced composite (EverX Flow), followed by 2 mm nanocomposite. For the remaining ten teeth, MOD cavities were prepared, and cusps were reduced to receive ceramic overlays (CeraSmart 270). …”
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Identification and Functional Analysis of EPOR+ Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis by Yanxing Li, Ming Li, Rong Wei, Junlong Wu

“…EPOR-eGFPcre mice were used to determine the expression of EPOR on lung tissue-resident macrophages. Flow cytometry, RT-PCR, and Western blot were examined to define the identity of EPOR+ TAMs in 106 osteosarcoma lung metastasis specimens. …”
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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…Treatment with this IC50 concentration significantly increased ROS generation, induced dramatic DNA damage, and disrupted mitochondrial membrane potential integrity. Flow cytometric analysis revealed apoptosis and necrosis induction following Co3O4NP exposure at the IC50 concentration value. …”
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The Increased Ratio of Blood CD56bright NK to CD56dim NK Is a Distinguishing Feature of Primary Sjögren’s Syndrome by Bingxia Ming, Tong Wu, Shaozhe Cai, Peng Hu, Jungen Tang, Fang Zheng, Cong Ye, Lingli Dong

“…The frequency and absolute number of NK cells and CD56 NK cell subsets in peripheral blood samples were detected by flow cytometry. Other laboratory parameters such as the IgG level and complement protein levels were extracted from the clinical system. …”
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Leiomyosarcomas of the inferior vena cava: diagnostic features on contrast-enhanced CT, ultrasonography and MRI by Xiaolin Xu, Shilei Zhao, Lifang Xue

“…Color Doppler imaging evaluated lumen obstruction in 8 of the 12 patients (66.7%), and high velocity flow signals were detected by Pulsed wave Doppler in 4 of the 12 patients (33.3%). …”
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p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease by Zhihui He, Huaihuai Peng, Min Gao, Guibin Liang, Menghao Zeng, Xuefeng Zhang

“…Then, we knocked down or overexpressed Sp1 and p300 and used the ChIP assay to detect the histone H4 acetylation level in the promoter region of p16, CCK8 to detect cell proliferation, flow cytometry to detect the cell cycle, and β-galactosidase staining to count the proportion of senescent cells. …”
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Stability Analysis of a Weathered-Basalt Soil Slope Using the Double Strength Reduction Method by Xiaoliang Liu, Xin Chen, Mei Su, Shilin Zhang, Dengfeng Lu

“…Once the critical stress state of the slope was exceeded, the plastic sliding block slipped at high speed over a long distance along the rock-soil layer interface, and along the way, it scraped out and carried away the original loose topsoil and gravel blocks, which finally piled up in the form of a debris flow. In addition, the attenuations of the cohesion and friction angle are different. …”
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Operativity of the Taunsa Barrage, Pakistan: Experimental Investigation on the Subsidiary Weir by Muhammad Zahid Ullah, Habib-Ur-Rehman Mughal, Noor Yaseen, Noor Muhammad Khan, Giada Varra, Luca Cozzolino, Renata Della Morte

“…Phase 2 reproduced the post-rehabilitation conditions, including varying discharge values, heights and positions of the SW, to evaluate the stilling basin design concerning the ability to dissipate flow energy. The results demonstrated (i) inadequate tailwater levels and oscillating hydraulic jump formation under increased discharges in pre-rehabilitation conditions (highlighting the poor performance of the original Taunsa Barrage stilling basin and the need for an SW to address these hydraulic deficiencies), and (ii) that the SW, under the design conditions, achieved optimal head loss for discharge values near the design discharge. …”
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Design of a Waste Water Treatment System for Kampala International University-Western Campus. by Tayebwa, Gift

“…By considering the topography of the area, a gravity collection system was considered for the design and using design equations and the data obtained from the field, to obtain the flow of each pipe section, velocity, slope pipe sizes, residual head and head losses the pipe hydraulics were obtained. …”
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Effect of Games and Sports on Academic Performance of Pupils in Primary Schools of Kigarama Sub-County Sheema District. by Arinaitwe, Daltone

“…These activities are natural to man’s life and evidently make his life flow. Studies of these physical activities in man have shown they are cardinal to his physical health intellectual development, talent building, social relations, positive use of leisure time, and longevity of life. …”
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Farmers’ climate change perception, impacts and adaptation strategies in response to drought in the Northwest area of Bangladesh by J.M. Adeeb Salman Chowdhury, Md. Abdul Khalek, Md. Kamruzzaman

“…In the study period drought were mainly affects increased cost of production, declining ground water levels, crop failures and scarcity of soil water, lower income, food scarcity etc. The MNL results showed that age, education, income, family size, farming experience, access to climate, farmer-to-farmer extension, social mobility, and loan subsidies directly influenced adaptation decisions. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Maria Lenk, Jörg Tremmel, Markus Rutsche

“…Nugent who contribute to this debate by arguing that lowering the eligibility age to run for office leads to better representation of the youngest and next-youngest cohorts in parliament. …”
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60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

“…This is because the surgery is effective at lowering weight and improving blood sugar. In some people with diabetes this means that they can come off medications and still have normal blood sugar: this is called diabetes remission. …”
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Presenting a Model of Self-sacrificial behaviors of Leaders in Organizations; Interpretive Structural Modeling (ISM) Method by Amir Hossein Abdallahzadeh, Seyyed Mohammad Moghimi, Hossein Imani

“…In fact, the critical condition, in addition to affecting the higher-level components, also impacts the lower-level components, indicating the significant influence of this variable in the model. …”
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Changes in soft and hard tissue of central incisor before and after distal migration of the maxillary dentition in adult patients with different periodontal phenotypes by CHEN Rui, HAN Shuang, AN Qi

“…In both groups, the height of the lip and palate of the upper jaw decreased to different degrees, and the height of the palatal alveolar bone was lower in the thin gingival group (<i>P </i>&lt; 0.05). …”
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Transition of clinical biomarker status from childhood into adolescence-A prospective study in children from eight European countries. by Anna Floegel, Paola Russo, Toomas Veidebaum, Michael Tornaritis, Dénes Molnár, Lauren Lissner, Stefaan De Henauw, Luis A Moreno, Wolfgang Ahrens, Manuela Marron, Claudia Börnhorst

“…Compared to "normal" children, children classified as "low leptin/IGF-1/HbA1c" were less likely to have a family history of diabetes (0.26 [0.08;0.86]; odds ratio (OR) and 95% confidence interval) or hypertension (0.53 [0.29;0.99]) and the children (0.32 [0.27;0.38]) as well as their mothers (0.93 [0.88;0.98]) had a lower BMI. Children from families with low/medium education had a 55% [9%-119%] higher risk of being in the "dyslipidemia/high leptin" and 49% [1%-121%] higher risk of being in the "inflammation" status as compared to children in the "normal" status. …”
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