Exploring dental students' knowledge on oral cancer prevention: a cross-sectional study in Moldova, Armenia, and Belarus by Olga Golburean, Diana Uncuta, Gayane Manrikyan, Natalia Shakavets, Izabella Vardanyan, Marina Markaryan, Ferda Özkaya, Daniela-Elena Costea, Tarig Al-Hadi Osman

“…In addition, we found that Students with current or previous cigarette smoking habits had significantly (p-value < 0.001, student`s t-test) lower mean knowledge score (5.96 ± 2.82) when compared to students who have never been smokers (6.98 ± 2.42). …”
Get full text

Causal Effects of Sleep Traits on Angina Pectoris: Mediation by Cardiovascular Risk Factors by Zeng C, Ke Y, Li H, Zhang C, Chen J, Chen M

“…Getting up in the morning reduced the risk of SAP, while longer sleep duration lowered the risk of SAP and UAP. More evidences are required to clarify the roles of sleep traits and risk factors in AP.Keywords: sleep traits, angina pectoris, hypertension, Mendelian randomization, mediation…”
Get full text

Acid-Base Balance in Healthy Adults: Beneficial Effects of Bicarbonate and Sodium-Rich Mineral Water in a Randomized Controlled Trial: The BicarboWater Study by Katharina Mansouri, Theresa Greupner, Edda van de Flierdt, Inga Schneider, Andreas Hahn

“…HBS water consumption led to increased urinary pH (24-hour urine and spontaneous urine, both p<0.001) and bicarbonate levels (p<0.001), accompanied by reduced titratable acids (p<0.001) and ammonium (p<0.001), resulting in a lower renal net acid excretion (p<0.001). These changes occurred in the short term and persisted until the end of the study. …”
Get full text

Diagnostic performance of CT for extrarenal fat invasion in renal cell carcinoma: a meta-analysis and systematic review by Junchao Ma, Enyu Yuan, Shijian Feng, Jin Yao, Chunlei He, Yuntian Chen, Bin Song

“…However, the diagnostic performance of CT has suffered from the limitation of slightly lower accuracy, resulting from the low positive sample in the current studies. …”
Get full text

The analysis of factors influencing patient choice of healthcare providers between tertiary hospitals and community clinics by Silin Wu, Silin Wu, Zhaoxia Lei, Tinglian Liu, Lan Chen, Yang Qin

“…Positive factors for choosing community healthcare included better equipment and medication availability (46.9%), lower costs with higher reimbursement (45.0%), and convenient transport (41.2%). …”
Get full text

Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…<b>Background:</b> Diabetic foot ulcers (DFUs) represent severe complications in diabetic patients, often leading to chronic infections and potentially resulting in nontraumatic lower-limb amputations. The increasing incidence of multidrug-resistant (MDR) bacteria in DFUs complicates treatment strategies and worsens patient prognosis. …”
Get full text

Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with... by Jianrong Zhang, Yu Huang, Hengrui Liang, Wenhua Liang, Jianxing He, Yiyin Zhang, Jiaxi He, Jieyu Wu, Long Jiang, Shiyan Tang, Qihua He, Lindsey Tristine Hamblin, Zhiheng Xu, Yaoqi Chen, Difei Chen, Xinyu Wang, Kexin Deng, Shuhan Jiang, Jiaqing Zhou, Jiaxuan Xu, Xuanzuo Chen

“…Additionally, the articles should report objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) or time to progression (TTP); the treatment effect of these endpoints, OR or HR, should be based on central and local assessments.Results Of 76 included trials involving 45 688 patients, 17 (22%) trials reported their endpoints with statistically inconsistent inferences (p value lower/higher than the probability of type I error) between central and local assessments; among them, 9 (53%) trials had statistically significant inference based on central assessment. …”
Get full text

Global cervical cancer elimination: quantifying the status, progress, and gaps by Liangru Zhou, Yi Li, Hongyun Wang, Ruixi Qin, Zhen Han, Ruifeng Li

“…Focusing on vulnerable populations with lower incomes and regions with stunted economic growth may help alleviate inequity and accelerate CC elimination. …”
Get full text

An Ultra-Low Power, Adaptive All-Digital Frequency-Locked Loop With Gain Estimation and Constant Current DCO by Imran Ali, Hamed Abbasizadeh, Muhammad Riaz Ur Rehman, Muhammad Asif, Seong Jin Oh, Young Gun Pu, Minjae Lee, Keum Cheol Hwang, Youngoo Yang, Kang-Yoon Lee

“…The low power and constant current DCO operates in sub-threshold region and its power consumption is minimized by <inline-formula> <tex-math notation="LaTeX">$g_{m}/I_{D}$ </tex-math></inline-formula> methodology optimization, constant current source for limiting current in DCO core through adaptive low-dropout regulator (LDO) and lowering the supply voltage. The proposed design is integrated in an ADPLL for BLE transceiver and it is fabricated with 1P6M TSMC 55 nm CMOS technology. …”
Get full text

Catastrophizing as a Predictor for Pain Perception and Disability Among Patients Undergoing Spinal Cord Stimulation by Juan Vicente-Mampel, Felipe Hernández-Zaballos, Francisco Javier Falaguera-Vera, David Sánchez-Poveda, Eloy Jaenada-Carrilero, Borja Huertas-Ramírez, Francisco Jose Sánchez-Montero

“…<i>Background and Objectives</i>: The International Society for Modulation defines persistent spinal pain syndrome type 2 (PSPS-type 2), formerly known as failed back surgery syndrome, as a condition where patients continue to experience pain or develop new pain following spinal surgery intended to alleviate back or lower-limb discomfort. PSPS-type 2 is characterized by pain and significant disability, affecting quality of life. …”
Get full text

Low light reduces saffron corm yield by inhibiting starch synthesis by Weijing Yang, Weijing Yang, Xin Li, Xin Li, Fei Chang, Fei Chang, Xue Qiu, Xulong Huang, Xulong Huang, Zhan Feng, Zhan Feng, Jie Yan, Jie Yan, Qinghua Wu, Qinghua Wu, Feiyan Wen, Feiyan Wen, Jin Pei, Jin Pei, Tao Zhou, Tao Zhou

“…At the corm expansion stage, sucrose concentration in leaves and daughter corms under LL conditions was 17.32% and 54.08% higher than under NL, but glucose and starch concentrations in daughter corms were 22.08% and 10.22% lower, respectively. Additionally, the activity of invertase (INV), sucrose synthase in the decomposition direction (SUS) and ADP-glucose pyrophosphorylase (AGPase) in daughter corms were reduced under LL. …”
Get full text

The effect of the relative dose intensity of chemoradiotherapy on the effectiveness of therapy of locally advanced unresectable non-small cell lung cancer by A. E. Glukhareva, G. V. Afonin, I. V. Kolobaev, L. Yu. Grivtsova, S. A. Ivanov, A.  D.  Kaprin

“…To estimate the number of patients with the preservation of relative dose intensity (RDI) ≥ 80 % of first-line antitumor therapy in patients with unresectable non-small cell lung cancer (NSCLC), and to compare the effectiveness of therapy in groups with optimal and lower RDI.Patients and methods. The study included 30 patients (25 men and 5 women) with locally advanced unresectable NSCLC. …”
Get full text

Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…Those affected had a significantly lower mental HRQOL when compared with those who were unaffected. …”
Get full text

Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis by Yingjie Li, Xinran Yu, Peng Li, Xin Li, Lushan Wang

“…Transcriptomic analysis revealed that VaRyhB is critical for iron homeostasis under limited iron conditions, and deletion of VaRyhB resulted in lower expression levels of certain genes for siderophore biosynthesis and transport, thereby leading to impaired growth, reduced siderophore production, and decreased pathogenesis. …”
Get full text

Inflammatory burden index as a prognostic marker in patients with advanced gastric cancer treated with neoadjuvant chemotherapy and immunotherapy by Jiao-Bao Huang, Zhi-Yong Zhou, Jun Lu, Ji-Yun Zhu, Bin Lai, Sheng-Xun Mao, Jia-Qing Cao

“…It was found that the high IBI group had a higher incidence of postoperative complications(32.1%vs14.3%, p=0.001), the proportion of non-TR patients was significantly higher than that of the low IBI group(64.3%vs35.7%, p =0.001), and the high IBI group had a significantly lower OS((47.6% vs 87.6%, p &lt; 0.001).ConclusionIBI is the best inflammatory index to predict the prognosis of advanced gastric cancer treated with neoadjuvant chemotherapy combined with immunotherapy, which will help guide patients’ treatment decisions. …”
Get full text

Investigating the preventive effects of pulsed electromagnetic fields on glucocorticoid-induced osteoporosis in rats by Shuai Ding, Guangquan Zhang, Yanzheng Gao, Zhiqiang Hou, Fuqiang Shao

“…From weeks 2 through 8, the MPSL group rats displayed a marked decrease in BMD and BMC compared to those of the PS group, and at the 4-week and 8-week time points, these values were significantly lower than those of the PEMF group (P < 0.05). Compared with those in the MPSL and PS groups, the expression levels of BMP-2 mRNA markedly increased after PEMF treatment, peaking one week later and sustaining a heightened state for four weeks, but decreased only at the eighth week. …”
Get full text

Assessment of Visual Quality in Eyes with Forme Fruste Keratoconus and Mild and Moderate Keratoconus Based on Optical Quality Analysis System II Parameters by Zhonghao Ren, Liyan Xu, Qi Fan, Kaili Yang, Shengwei Ren, Dongqing Zhao

“…The MTF cutoff, SR, OV-100, OV-20, OV-9 in FFK, mild and moderate keratoconus eyes were significantly lower than those in the normal group (all P<0.05). …”
Get full text

Exploring the purpose and stages of patient and public involvement and engagement (PPIE) in audiology research: a case study approach by Helen Pryce, Nisha Dhanda, Jean Straus

“…Flexible engagement methods were developed to include marginalised communities with lower levels of research engagement. In the first study, the Hearing Loss and Patient Reported Experience Study (HeLP) developed the first Patient-Reported Experience Measure (PREM) in audiology. …”
Get full text

Cost-effectiveness of decentralising acute malnutrition treatment with a standard or simplified treatment protocol: an economic evaluation in the region of Gao, Mali by Bernardette Cichon, Noemí López-Ejeda, Salimata Samake, Cornelia Aton, Abdias Ogobara Dougnon, Mahamadou N’tji Samake, Aliou Bagayoko, Magloire Bunkembo, Alexandra Rutishauser-Perera, Pilar Charle-Cuellar

“…Conclusion This study shows that involving CHWs in acute malnutrition treatment reduces the cost per child treated and is a cost-effective strategy, due to lower treatment costs and greater coverage in the decentralised model. …”
Get full text

Patient-reported symptoms and admission pathways in stroke mimics versus confirmed stroke or transient ischaemic attack: a cross-sectional observational study by Jawad Haider Butt, Christina Kruuse, Heidi Shil Eddelien, Viktor Frederik Idin Sørensen

“…Factors associated with a lower likelihood of mimics were increasing age (OR 0.96, 95% CI 0.95 to 0.98 per year increase), reported limb weakness (OR 0.52, 95% CI 0.30 to 0.89) and difficulty steering (OR 0.51, 95% CI 0.28 to 0.93).There was no difference between groups in the proportion of patients for whom time from symptom onset to healthcare services contact exceeded 3 hours (52.2% vs 53.7%, p=0.78). …”
Get full text