Cost-Minimization Analysis for Subcutaneous Daratumumab in the Treatment of Newly Diagnosed Multiple Myeloma in Three Gulf Countries by Anas Hamad, Shereen Elazzazy, Ruba Y. Taha, Hani Osman, Sana Alblooshi, Islam Elkonaissi, Mustaqeem A. Siddiqui, Khalil Al-Farsi, Mohammed Al Lamki, Sali Emara, Gihan H. Elsisi

“…**Results:** The model showed that the use of dara-SC in NDMM patients who were eligible or ineligible for ASCT resulted in lower non-drug costs, including premedication drug costs, adverse-effect costs, administration costs, medical staff costs, and indirect costs. …”
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Private, non-profit, and plantation: Oil palm smallholders in management-assistance programs vary in socio-demographics, attitudes, and management practices. by Valentine J Reiss-Woolever, Wakhid Wakhid, Muhammad Ikhsan, Jean-Pierre Caliman, Muhammad Naim, Elfina N Azmi, Sharyn Shufiyan, John Howes, Reza Azmi, Ying Ying Lim, Siti Zulaikah Abdul Jan, Isaac Barrock, Badrul Azhar, Julia Drewer, Caroline Ward, Joshua A Jones, Sarah H Luke, Edgar C Turner, Purnama Hidayat, Damayanti Buchori

“…In Malaysia, farmers partnered with an NGO also had higher yield and fertilizer application than independent farmers, however they used significantly more herbicide and had lower total household income. Our findings demonstrate the wide variety of smallholder farmers in both regions, directly opposing a 'one-size-fits-all' approach to sustainability. …”
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Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients wi... by Junji Hatakeyama, Kensuke Nakamura, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shotaro Aso, Shinya Suganuma, Shuhei Maruyama, Yoshitaka Ogata, Akira Takasu, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Takeshi Yoshida, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida

“…Results Among 334 patients, PICS prevalence rates in the four completed questionnaires were 72.1, 78.5, 77.6, and 82.0%, with cognitive impairment being the most common and lower QOL being noted when multiple impairments coexisted. …”
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Development and validation of a multidimensional, culturally and socially inclusive Child Resilience Questionnaire (parent/caregiver report) to measure factors that support resilie... by Deirdre Gartland, Elisha Riggs, Rebecca Giallo, Stephanie Janne Brown, Karen Glover, Kelsey Hegarty, Amanda Mitchell, Jane Yelland, Josef Szwarc, Sue Casey, Donna Weetra, Mardi Stowe, Sharon Mongta, Helen Herman, Selena White, Tanya Koolmatrie, Georgie Paxton

“…Criterion validity was supported: scales had low to moderate negative correlations with SDQ total difficulty score (Rs= -0.2/–0.5. p<0.001); children with emotion/behavioural difficulties had lower CRQ-P/C scores (β=−14.5, 95% CI −17.5 to −11.6, adjusted for gender).Conclusion The CRQ-P/C is a new multidomain measure of factors supporting resilience in children. …”
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A Systematic Review and Meta-Analysis Comparing the Safety and Efficacy of Spinal Anesthesia and Spinal Anesthesia Combined with Obturator Nerve Block in Transurethral Resection of... by Wanxin Deng, Qiang Zhang, Hongmei Yao

“…The meta-analysis showed that the use of SA + ONB anesthesia during TURBT was associated with a smaller incidence of bladder perforation (RR = 0.24, 95% CI (0.11, 0.53), Z = −3.48, P=0.0005), a smaller incidence of obturator nerve reflex (RR = 0.22, 95% CI (0.13, 0.36), Z = −6.11, P=0.0001), a significantly shorter length of hospital stay (MD = −1.81, 95% CI (−2.65, −0.97), Z = −4.24, P=0.0001), and a significantly lower tumor recurrence rate (RR = 0.46, 95% CI (0.29, 0.73), Z = −3.30, P=0.001) compared with SA alone. …”
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Predicting pregnancy loss and its determinants among reproductive-aged women using supervised machine learning algorithms in Sub-Saharan Africa by Tirualem Zeleke Yehuala, Sara Beyene Mengesha, Nebebe Demis Baykemagn

“…The use of antenatal care and family planning services can significantly impact the risk of pregnancy loss. Women from lower-income backgrounds may face challenges in accessing prenatal care or safe reproductive health services, leading to higher risks of loss. …”
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Projecting the Potential Budget Impact Analysis of Paliperidone Palmitate in Egyptian Adult Patients with Schizophrenia by Gihan Elsisi, Mohamed Ezzat, Mohamed Ramadan

“…Sensitivity analyses showed that the percent of hospitalizations for both oral antipsychotics and PP had the greatest impact on the results. **Conclusion:** The lower hospitalization rates associated with PP offset the increase in drug costs. …”
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Free senior high school devours basic education in Ghana: rescue the children by Inusah Fuseini

“…An educational policy at any level must consider the basic policies of education that enhance inclusivity and equity at the lower levels of education. This will help in maximizing the effective implementation of the policies. …”
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Augmentation index as a predictor of right ventricular dysfunction in coronary artery disease: a cross-sectional study by Arash Rahimi, Babak Geraiely, Hamed Vahidi, Mohammadreza Eftekhari, Ramyar Rahimi Darehbagh, Somayeh Mohammadi, Golrokh Ghaffari, Meysam Khoshavi

“…Results Patients with high AIx (> 80%, n = 53) had significantly worse RV systolic function compared to those with normal AIx (≤ 80%, n = 68), as evidenced by lower tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), RV free wall longitudinal strain (RVLS), and RV systolic velocity (RV S’) (all P < 0.05). …”
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Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum by Ana Gabriela de Oliveira do Rêgo, Francesca D'Amico, Vincenza D’Angelo, Silvia Cardarelli, Debora Cutuli, Davide Decandia, Eugenia Landolfo, Laura Petrosini, Manuela Pellegrini, Marcello D’Amelio, Nicola Biagio Mercuri, Mauro Giorgi, Giuseppe Sancesario

“…Consequently, the cyclic nucleotide levels were significantly increased in HET mice, but unexpectedly the mean percentage variation was higher for cGMP equal to 153.23 %, and lower for cAMP equal to 16.41 %. Therefore, to try to explain the preponderant increase of cGMP to cAMP we evaluated other PDE enzymes functionally related to PDE2A. …”
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Association Between Walking Speed and Urinary Incontinence in the Older Women. Which Patients Should be Referred to Geriatricians? by Volkan Atmis, Basak Guler

“…Patients with urinary incontinence detected to have a longer duration of Timed Up and Go test, higher Geriatric Depression Scale score and BMI with p-values 0.005, 0.004, and <0.01 respectively; and lower Activities of Daily Living (Katz-Activities of Daily Living) score with a p-value of <0.01 results. …”
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The Relationship between the Activity Balance Confidence and Mobility Tests among Older Adults in Indonesia by Indri Hapsari Susilowati, Sabarinah Sabarinah, Susiana Nugraha, Sudibyo Alimoeso, Bonardo Prayogo Hasiholan, Supa Pengpid, Karl Peltzer

“…Unsteady gait, instability, and lower extremity muscle weakness are some of the risk factors for falls. …”
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Cost minimization analysis of nasopharyngoscope reprocessing in community practice by Ameen Biadsee, Lauren Crosby, Winsion Chow, Leigh J Sowerby

“…Conclusions The UV light system appears to be the most cost-effective method in high volumes of reprocessing, and Revital-Ox is cheaper in lower volumes and when performed by clinic staff rather than physicians. …”
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Lyophilized human platelet lysate: manufacturing, quality control, and application by Kerstin Wendland, Kerstin Wendland, Lea Koblin, Lea Koblin, Dirk Stobbe, Anna Dahms, Anna Dahms, Debora Singer, Debora Singer, Sander Bekeschus, Sander Bekeschus, Jan Wesche, Janosch Schoon, Konstanze Aurich

“…Additionally, we determined cell yield, proliferation capacity, viability and trilineage differentiation potential of hMSCs following expansion in HPL- and L-HPL-supplemented cell culture media.ResultsQuantification of the quality parameters revealed non-altered pH, osmolality and potassium concentrations and slightly lower total protein, sodium and chloride concentrations of L-HPL compared to HPL. …”
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Clinicopathologic characteristics, therapeutic modalities and survival outcomes of plasmablastic lymphoma: A real-world study by Yan-Hua Zheng, Kun Xie, Hong-Yuan Shen, Zhuo Wan, Shan Gao, Wen-Rui Sun, Guang-Xun Gao, Li Liu, Juan Feng

“…Patients with a higher Ann Arbor stage at diagnosis were at higher risk of death than those with a lower stage. Chemotherapy alone or chemotherapy combined with radiotherapy could significantly reduce the risk of death and extend the patients’ survival, yielding a HR of 0.209 (95% CI: 0.152–0.288) and 0.187 (95% CI: 0.089–0.394), respectively. …”
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富硒生物活性肽的制备、生物活性及构效关系研究进展 "Progress on the preparation, bioactivity and structure-activity relationship of selenium-enriched bioactive peptides"... by 侯春艳，杨趁仙 HOU Chunyan, YANG Chenxian

“…The raw materials of selenium-enriched bioactive peptides mainly come from the transformation of biocarriers, such as plant sources, animal sources, and microbial sources.The selenium-enriched bioactive peptides can be prepared by enzymatic hydrolysis and microbial fermentation methods, which have a wide range of bioactivities, such as antioxidant, anti-fatigue, blood pressure lowering, anti-inflammatory, and so on. The bioactivities of selenium-enriched bioactive peptides are the results of the joint action of selenium and peptides, which are closely related to the sequence, spatial structure and interaction force of amino acids, but their structure-activity relationships need to be further studied. …”
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Implementation of multidisciplinary team decisions on the management of complex bone and joint infections: an observational study by Jaap L.J. Hanssen, Henrica M.J. van der Linden, Martha T. van der Beek, Robert J.P. van der Wal, Marco F. Termaat, Mark G.J. de Boer, Henk Scheper

“…Trauma surgeons were more likely to not implement an MDT decision (odds ratio 2.4, p = 0.01) The cure rate of patients who received a different surgical strategy than decided by the MDT was 33%. The cure rate was lower if a patient chose to deviate from the MDT decision (46%) than when the treating physician chose to deviate from the MDT decision (77%). …”
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Comparison of Perinatal, Newborn, and Audiometry Results of COVID-19 Pregnant Women by Mehmet Yilmaz, Şerif Aksin, Deniz Balsak, Fazil Avci, Osman Özdoğru, Bekir Helvacıoğlu, Mahmut Erdemoğlu, Yasemin Aboalhasan, Gülsüm Doğan

“…White blood cell (WBC), neutrophil, aspartate aminotransferase (AST), and C-reactive protein (CRP) parameters were found to be significantly higher, and lymphocyte and neutrophil/lymphocyte (N/L) ratios were significantly lower (p<0.05). There was no statistically significant difference between the two groups (χ2=0.001; p=1,000). …”
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Impact of “Enhanced Recovery After Surgery” (ERAS) protocols vs. traditional perioperative care on patient outcomes after colorectal surgery: a systematic review by Vaishnavi Kannan, Najeeb Ullah, Sunitha Geddada, Amir Ibrahiam, Zahraa Munaf Shakir Al-Qassab, Osman Ahmed, Iana Malasevskaia

“…Furthermore, patients in ERAS groups showed notably reduced postoperative complications and opioid consumption, with patients experiencing lower pain scores on the Visual Analogue Scale (VAS) and reduced reliance on opioids. …”
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Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the SEER Database and an Institutional Registry by Wenjie Huang, Yu Zhang, Hao Li, Zhiying Liang, Shumin Zhou, Jie Pan, Hui Xie, Chao Luo, Shuqi Li, Guangying Ruan, Fei Ai, Yanfeng Chen

“…Results Among 518 curative‐intent OTSCC patients, the number of PLNs independently predicted overall survival (OS), surpassing other pathological nodal features, including extranodal extension, laterality, and lower neck involvement. Patients with 1 or 2 PLNs had comparable worse OS than those with no PLN (median OS of 1 PLN vs. 2 PLNs vs. 0 PLN: 35.1 vs. 30.5 vs. 40.2 months), but better than those with ≥ 3 PLNs (median OS of 1–2 PLNs vs. 3 PLNs: 32.1 vs. 19.0 months). …”
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