Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice by Kotou Sangare, Shufeng Liu, Prabhuanand Selvaraj, Charles B. Stauft, Matthew F. Starost, Tony T. Wang

“…Here, we systematically assessed the effect of individual mutations of Omicron BA.1 on the pathogenicity of the virus in hACE2 transgenic mice and found that combination of 5 mutations of Nsp14, E, and M of BA.1 variant significantly lowered brain viral load and reduced lethality. These results provide new insights into how SARS-CoV-2 Omicron BA.1 is attenuated.…”
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The clinical application and anatomical analysis of proximal peroneal artery perforator in free fibula flap based on CTA by Yitong Zhao, Danwei Xiang, Lina Song, Zhujiajun Cui, Xingwu Zheng, Tianyu Zhang, Huihui Yang, Yongzhen Fu, Qilin Liu

“…Results Among the 100 lower limbs evaluated, a successful identification rate of 98% for proximal perforators was achieved via CTA. …”
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Interactive effects of atmospheric oxidising pollutants and heat waves on the risk of residential mortality by Nan Ren, Huimin Huang, Baoying Liu, Chuancheng Wu, Jianjun Xiang, Quan Zhou, Shuling Kang, Xiaoyang Zhang, Yu Jiang

“…Results Atmospheric oxidising pollutants increased the risk of residential mortality at lower concentrations, and O3 and Ox were positively associated with a maximum risk of 2.19% (95% CI: 0.74–3.66) and 1.29% (95% CI: 0.51–2.08). …”
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Correlation between uterine microbiota and pregnancy outcomes of embryo transfer in overweight and obese women by Ying Yan, Ying Li, Lingling Wu, Yuxuan Zhang, Hong Guo, Yazhong Ji

“…After regrouping based on β-hCG results 10-12 days post-transfer, in the Con-negative group (the group with negative β-hCG in the Con group, n=16) the relative abundances of pathogenic bacteria such as Klebsiella (p<0.001), Parasutterella (p=0.004), Dialister (p=0.01), and Gardnerella (p=0.029) were significantly higher than in the Con-positive group (the group with positive β-hCG in the Con group, n=15).ConclusionOverweight and obese women possess a distinct uterine microbiota, characterized by a lower relative abundance of Lactobacillus and an increased relative abundance of pathogenic bacteria, along with specific genera strongly associated with obesity. …”
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Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis by Kun Wang, Wenchao Ma, Leina Sun, Fangcheng Su

“…Conversely, the control group had a lower occurrence of ischemic events compared to the trial group (OR=0.35, 95%CI 0.24-0.50). …”
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Preconception diet quality and modified natural cycle in vitro fertilisation outcomes by Janine P.M. Faessen, Irene Homminga, Marion E.C. Buso, Ruxandra A. Nagy, Jannie van Echten-Arends, Edith J.M. Feskens, Uwe J.F. Tietge, Annemieke Hoek, Elske M. Brouwer-Brolsma

“…Higher DHD2015 adherence was linked to a reduced probability of achieving an ongoing pregnancy (HR = 0.77, 95%CI: 0.62–0.96), live birth (HR = 0.78, 95%CI: 0.62–0.98), and showed a non-significant trend towards a lower probability of a positive pregnancy test (HR = 0.85, 95%CI: 0.71–1.01). …”
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Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis by Tim Salinger, Kai Hu, Dan Liu, Scharoch Taleh, Sebastian Herrmann, Daniel Oder, Daniel Gensler, Jonas Müntze, Georg Ertl, Kristina Lorenz, Stefan Frantz, Frank Weidemann, Peter Nordbeck

“…LDL-cholesterol values were lower in the slow progression group (100 ± 32.6 mg/dl vs 110.8 ± 36.6 mg/dl; P=0.005). …”
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Physiological and transcriptomic analysis of the effect of overexpression of the NTPIP2;4 gene on drought tolerance in tobacco by Xu Luo, Yuanshuai Shi, Jie Tan, Tao Long, Juntao Song, Yang Liu

“…Physiological analyses showed that overexpression plants showed low wilting under drought conditions compared to wild-type (WT), and NtPIP2;4 overexpression tobacco plants showed enhanced superoxide dismutase (SOD) and catalase (CAT) activities, lower levels of superoxide anion (O2 -), malondialdehyde (MDA), and hydrogen peroxide (H2O2) than the control, and significantly higher proline (Pro) content than the control. …”
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Levilactobacillus brevis CD2 as a multifaceted probiotic to preserve oral health: results of a double-blind, randomized, placebo-controlled trial in healthy adults by Serena Altamura, Francesca Lombardi, Francesca Rosaria Augello, Antonella Barone, Mario Giannoni, Benedetta Cinque, Davide Pietropaoli

“…Salivary glucose and D-lactate levels were lower in the probiotic group post-treatment and after washout. sIgA values increased and remained stable after washout in the probiotic group. …”
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The Effect of Aggregate-Forming Minerals on Thermodynamic Parameters Using Surface Free Energy Concept and Its Relationship with the Moisture Susceptibility of Asphalt Mixtures by Gholam Hossein Hamedi, Mohammad Reza Esmaeeli, Vahid Najafi Moghaddam Gilani, Seyed Mohsen Hosseinian

“…The adhesion free energy (AFE) between bitumen and aggregates with higher CaO and less SiO2 amounts was more than AFE between bitumen and aggregates with lower CaO and higher SiO2 amounts, in dry conditions. …”
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Cryptosporidium Infection and Associated Risk Factors among Cattle in the Central Region of Ghana by Kwabena Dankwa, Patrick K. Feglo, Samuel V. Nuvor, Michael Aggrey-Korsah, Mohamed Mutocheluh

“…Cattle in the forest zone had a lower risk of being infected with the parasite compared to those from the coastal savanna zone (OR 0.408; 95% CI, 0.182-0.915). …”
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Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes by Guoqing Li, Hongyi Chen, Jiacheng Shen, Yimin Ding, Jingqiong Chen, Yongbin Zhang, Mingrui Tang, Nan Xu, Yuxuan Fang

“…The qPCR analysis of plasma exosomes in TNFi patients found that the expression of hsa-circ0002715 was higher than that in patients who didn’t reach ACR20, and the expression of hsa-circ0001946 was lower than that in patients who didn’t reach ACR20. …”
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Composite submental flaps in facial reconstructive surgery involving the zygoma and orbit by Usman Khan, Sebastian Haupt, Matthew Rigby, S. Mark Taylor, Martin Corsten, Jonathan Trites

“…While the reconstructive applications of the SIF have been demonstrated in the lower face, there are limited reports on its utility as a composite flap for reconstructing defects of the upper facial skeleton. …”
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Communicative health literacy with physicians in healthcare services– results of a Hungarian nationwide survey by Frederico Epalanga Albano Israel, Ferenc Vincze, Róza Ádány, Éva Bíró

“…The easiest task was explaining health concerns while getting enough time in the consultation was rated as the most difficult one. COMM-HL was lower among females, while it was higher among people aged 66–75 years (compared with 18–25 years), those with greater social support and those without financial deprivation. …”
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Growth, fat metabolism and hepatic health in largemouth bass fed varying fat-level diets by Digen Qin, Jiale Chen, Junxiong Li, Zhiyou Liu, Weibin Huang, Yuanzhi Yang, Jing Zhang, Beiping Tan, Xiaohui Dong

“…The results revealed that fish fed HFD exhibited significantly better protein efficiency ratio (PER) and lower feed conversion ratio (FCR) than LFD group (P<0.05), but survival rate (SR) and weight gain rate (WGR) were unaffected (P>0.05). …”
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Demographic disparities in access to COVID-19 clinical trial sites across the United States: a geospatial analysis by Raphael Cuomo, Tiana McMann, Qing Xu, Zhuoran Li, Joshua Yang, Julie Hsieh, Christine Lee, Milena Lolic, Richardae Araojo, Tim Mackey

“…Areas with greater concentrations of Black or African American residents had significantly lower concentrations of observational (p < 0.001) and government-sponsored COVID-19 studies (p = 0.003) in national analysis and significantly fewer concentrations of study sites in both Los Angeles (p < 0.001) and New York (p = 0.007). …”
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The fate and mobility of chromium, arsenic and zinc in municipal sewage sludge during the co-pyrolysis process with organic and inorganic chlorides by Mahboub Saffari, Masomeh Moazallahi, Rezvan Mashayekhi

“…Ecological risk index assessments revealed that PVC treatments consistently resulted in lower RI values at both temperatures and concentrations, keeping them below the low-risk threshold. …”
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The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis by Shizhe Guo, Xianshan Guo, Hongya Zhang, Xuan’e Zhang, Zhen Li

“…Compared with control, additional diacerein also lowered body weight and CRP level in T2DM, but increased the rate of gastrointestinal syndromes.…”
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DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge by Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

“…In addition, the adjuvant activity of DDO268 allows for the use of lower antigen doses during vaccination.…”
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A Novel Prognostic Signature Revealed the Interaction of Immune Cells in Tumor Microenvironment Based on Single-Cell RNA Sequencing for Lung Adenocarcinoma by Xing Jin, Zhengyang Hu, Qihai Sui, Mengnan Zhao, Jiaqi Liang, Zhenyu Liao, Yuansheng Zheng, Hao Wang, Yu Shi

“…Patients with higher risk scores had a significantly lower immunotherapy response rate. Conclusion. Our observations implied that immune cells played a pivotal role in TIME and established a 5-gene signature (including IDH2, ADRB2, SFTPC, CCDC69, and CCND2) on the basement of nature killer markers targeted by WGCNA analysis. …”
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