NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model by Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth J Shpall, Jack A Roth

“…Restoration of NPRL2 exhibited significantly slower tumor growth in humanized-mice, which was associated with increased presence of human cytotoxic-T, and DC and decreased percentage of Treg, MDSC, and TAM in TME. …”
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Risk Factors for Stress Fractures in Female Runners: Results of a Survey by Therese E Johnston, Allison E Jakavick, Caroline A Mancuso, Kathleen C McGee, Lily Wei, Morgan L Wright, Jeremy Close, Ayako Shimada, Benjamin E Leiby

“…Women running 11:00-11:59 minutes/mile or slower were less likely to have a stress fracture compared to those running 9:00-9:59 minutes/mile (OR 0.43-0.54). …”
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Study on Mechanical Performance of Prestressed UHPFRC U-Beam Bridges by Mengying Liu, Eugen Brühwiler, Fengkun Cui, Yue Xu

“…The farther away from the center the measurement point is, the slower its strain changes. Therefore, the load is mainly caused by the central rib and the loading center plate. …”
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Hameaux et villages paysans de la période romaine en plaine d’Alsace by Antonin Nüsslein, Pascal Flotté, Mathias Higelin, Muriel Roth-Zehner

“…The examples of rural settlements presented here are almost all located west of Strasbourg, in the area of the lower Bruche valley and in the Kochersberg area. …”
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The Impact of the Coexpression of MET and ESR Genes on Prognosticators and Clinical Outcomes of Breast Cancer: An Analysis for the METABRIC Dataset by Nehad M. Ayoub, Ghaith M. Al-Taani, Amer E. Alkhalifa, Dalia R. Ibrahim, Aymen Shatnawi

“…Patients with high MET/ESR1 coexpression had favorable clinicopathologic tumor characteristics and prognosticators compared to low MET/ESR1 coexpression in terms of greater age at diagnosis, reduced Nottingham Prognostic Index, lower tumor grade, hormone receptor positivity, HER2-negative status, and luminal subtype p<0.001. …”
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Turkish suicide patterns: Longitudinal analysis of suicide trends in Turkiye (2000 -2022) by Ayhan Tabur, Feruza Turan Sonmez

“…While the overall rate among individuals aged 65 and older was lower (2.9/100,000), a significant increase was noted in recent years, peaking at 4.2/100,000 in 2019. …”
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Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression by Ming Sun, Huanmin Cheng, Zheng Yang, Jiangqin Tang, Shengshu Sun, Zhanglin Liu, Shaozhen Zhao, Lijie Dong, Yue Huang

“…Consequently, meibomian gland obstruction model rats were established successfully with corneal damage and lower tear film stability. Meibomian gland obstruction is a causative factor of MGD, which led to abnormal histological structure in MG, differential expression of PPAR signaling pathway and TRPV3.…”
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The Predictive Role of Lactate in the Emergency Department in Patients with Severe Dyspnea by Maciej Niczewski, Szymon Gawęda, Paulina Kluszczyk, Mikołaj Rycerski, Daria Syguła, Anna Danel, Szymon Szmigiel, Konrad Mendrala, Aleksandra Oraczewska, Czarosław Kijonka, Monika Nowicka, Michał Wita, Tomasz Cyzowski, Grzegorz Brożek, Maciej Dyrbuś, Szymon Skoczyński

“…Patients who died were more frequently initially assigned to the red triage risk group, more burdened with comorbidities, and the median SpO2 on admission was significantly lower than in patients who survived the follow-up period. …”
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Transcriptome analysis of ovarian cancer uncovers association between tumor-related inflammation/immunity and patient outcome by Jingfang Wang, Wenrui Zhu, Xia Li, Yuanyuan Wu, Wenhui Ma, Yangzhou Wang, Weihong Zhao, Fang Wei, Wenhao Wang

“…Further analysis revealed that the high-risk group had a higher abundance of M2-type macrophage infiltration, more active anti-tumor immune response, higher tumor stemness score, potentially worse prognosis, and lower response rates to multiple chemotherapy drugs and immune checkpoint inhibitors.ConclusionThese findings provide new perspectives and potential targets for immunotherapy and prognostic evaluation of ovarian cancer and offer new strategies and directions for clinical treatment and patient management. …”
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Seaweed Fly Larvae Cultivated on Macroalgae Side Streams: A Novel Marine Protein and Omega-3 Source for Rainbow Trout by Niklas Warwas, Emma L. Berdan, Xintian Xie, Elisabeth Jönsson, Jonathan A. C. Roques, Darragh Doyle, Markus Langeland, James Hinchcliffe, Henrik Pavia, Kristina Sundell

“…The feed conversion ratio of fish fed the BSFL and SWFL diets was higher compared to the control, suggesting lower bioavailability of both insect meals compared to fish meals. …”
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Pelletization of composted swine manure solid fraction with different organic co-formulates: effect of pellet physical properties on rotating spreader distribution patterns by Elio Romano, Massimo Brambilla, Carlo Bisaglia, Niccolò Pampuro, Ester Foppa Pedretti, Eugenio Cavallo

“…Introduction In Europe, because of the high production levels of livestock farming in general and pig farming in particular, animal waste management has become increasingly important to comply with the required lowering of livestock farming environmental pressure. …”
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Response Analysis of a Ballasted Rail Track Constructed on Soft Soil by 3D Modeling by Iram Lamiya Hoque, Shamontee Aziz, Joya Rani Mallick, Md. Arifuzzaman Nayeem, Tamanna-E-Hafiz Maisha, F. M. Zahid Hossain, A. F. M. S. Amin

“…Moreover, a high subballast stiffness can counterbalance the potential of forming permanent deformation by generating lower strains. However, a stiffer subballast does not play a prominent role in reducing the displacement of ballast or vertical stresses. …”
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Severe primary graft failure: Are there lasting impacts? Analysis from the PHTS Database by Jennifer Conway, MD, Tara Pidborochynski, MSc, James K. Kirklin, MD, Ryan Cantor, PhD, Hong Zhao, PhD, Aryaz Sheybani, MD, Jacqueline Lamour, MD, Lakshmi Gokanapudy Hahn, MD, Leslie Collins, MD, Jessica Laks, MD, Darren H. Freed, MD, PhD

“…Patients with PGF were younger, with higher proportion of congenital heart disease, longer cardiopulmonary bypass and ischemic times (IT), and more likely to be on extracorporeal membrane oxygenation or ventilator at HTx (all p < 0.0001, IT p = 0.0006). PGF resulted in lower overall survival (1 year: 54% vs 94%, p < 0.001). …”
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Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis by Yandan Zhou, Min Xu, Wei Gong, Xiaoming Kang, Renzhong Guo, Jie Wen, Dinggang Zhou, Manjing Wang, Dazhi Shi, Qiancheng Jing

“…Serum MRGPRX2 and MMP-12 levels were lower in the effective group than the ineffective group. …”
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The impact of dietary fiber on colorectal cancer patients based on machine learning by Xinwei Ji, Lixin Wang, Pengbo Luan, Jingru Liang, Weicai Cheng

“…Additionally, four machine learning models—Logistic Regression (LR), Random Forest (RF), Neural Network (NN), and Support Vector Machine (SVM)—were developed based on nutritional and clinical indicators.ResultsIn the observation group, levels of procalcitonin (PCT), beta-endorphin (β-EP), C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) were significantly lower compared to the control group (p &lt; 0.01). …”
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Cash transfer, maternal and child health outcomes: a scoping review in sub-Saharan Africa by Emery L. Ngamasana, Jessamyn Moxie

“…Across all categories of reported measures, evidence emerges that cash transfer programmes improved some health outcomes (e.g. improved infant and child survival, reduced incidence of illnesses, improved cognitive and motor development, improved general health, delayed sexual debut, lower transactional sex, etc.), while in some of the studies, outcomes such as depression did not show significant improvements. …”
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Spatiotemporal distribution patterns of cephalopods and their responses to changes in the marine environment in the coastal waters of Zhejiang, China by Jun Liang, Jun Liang, Yongdong Zhou, Yongdong Zhou, Tian Wu, Feng Chen, Feng Chen, Kaida Xu, Kaida Xu, Guangjie Fang, Yazhou Zhang, Yazhou Zhang

“…In autumn, U. duvaucelii and Abralia multihamata were the dominant species, and the coastal waters of Zhejiang presented two high-density distribution areas in the northern and central waters, with lower resource density in the southern waters. Analysis of the alpha diversity index revealed relatively low cephalopod community diversity, with significant differences in spatial and seasonal distributions. …”
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Evolving racial/ethnic disparities in AML survival in the novel therapy era by Xin Wang, Phyllis A. Gimotty, Andrew H. Matthews, Ronac Mamtani, Selina M. Luger, Elizabeth O. Hexner, Daria V. Babushok, Shannon R. McCurdy, Noelle V. Frey, Ximena Jordan Bruno, Saar Gill, Mary Ellen Martin, Vikram R. Paralkar, Ivan Maillard, David L. Porter, Alison W. Loren, Alexander E. Perl, Keith W. Pratz, Kelly D. Getz, Catherine Lai

“…Non-Hispanic Black (NHB) and Hispanic patients were younger and more likely to have lower socioeconomic status than non-Hispanic White (NHW) patients, with no differences in the distributions of key disease features. …”
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Repairable electronic products for the circular economy: a review of design for repair features, practices and measures to contrast obsolescence by Nataliia Roskladka, Gianmarco Bressanelli, Nicola Saccani, Giovanni Miragliotta

“…The systematic analysis revealed that, while DfR features (and the relative practices and measures) that contrast mechanical, technological and service obsolescence have been frequently investigated by the literature, lower attention has been dedicated to DfR features preventing relative obsolescence. …”
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Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases by Kuang Pan, Lingna Deng, Peiying Chen, Qingxia Peng, Jingrui Pan, Yanfeng Wu, Yidong Wang

“…Compared with previous studies, the incidence of adverse events was nearly consistent or even lower for headache, fever, nausea, and neck pain. …”
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