Trabeculectomy versus stepwise treatment for breaking the attack of acute primary angle closure in patients with long attack duration: study design and protocol for a multicentre r... by Jing Jiang, Qing Zhang, Bo Qu, Chao Dai, Mingguang He, Ye Zhang, Ning-Li Wang, Shuning Li, Guangxian Tang, Su Jie Fan, Zhi Li, Chi Liu, Xinqi Chang, Yanyan Cheng

“…However, patients with APAC in China and developed countries differ in disease characteristics as the Chinese have longer attack duration and lower success rate in breaking the attack with solely medication or laser therapy. …”
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DepRescribing inapprOpriate Proton Pump InhibiTors (DROPIT): study protocol of a cluster-randomised controlled trial in Swiss primary care by Stefan Neuner-Jehle, Katharina Tabea Jungo, Sven Streit, Sven Trelle, Nicolas Rodondi, Carole Elodie Aubert, Kristie Rebecca Weir, Enriqueta Vallejo-Yagüe, Samantha Chan, Marie Roumet, Pascal Juillerat, Sofia Carolina Zambrano Ramos, Jennifer Inauen, Angela Edith Schulthess-Lisibach, Renata Vidonscky Lüthold, Clémentine Tombez, Martina Zangger, Flurina Jenal, Yvonne Mattmann, Christof Bieri, Michaela Barbier

“…Successful implementation of our PPI deprescribing strategy has the potential to improve patient outcomes and lower costs.Trial registration number NCT06129474.…”
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Calculated parameters for the diagnosis of Wilson disease by Nada Syazana Zulkufli, Pavai Sthaneshwar, Wah-Kheong Chan

“…Results: Caeruloplasmin, total copper, NCC, NCC%, CCR, adjusted copper and discriminant function were significantly lower in WD compared to non-WD. Discriminant function showed the best diagnostic specificity (99.4%), sensitivity (98.2%) and classification accuracy (99.1%). …”
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Are Elite Collegiate Female Athletes PRIME for a Safe Return to Sport after ACLR? An Investigation of Physical Readiness and Integrated Movement Efficiency (PRIME) by Courtney R Chaaban, Darren Hearn, Benjamin Goerger, Darin A Padua

“…The ACLR group, however, had lower LESS scores, indicative of better movement quality. …”
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A New Nomogram to Predict the Success of Shock Wave Lithotripsy in Ureteral Stones by Muhammed Fatih Simsekoglu, Engin Derekoylu, Mustafa Ozkaya, Muhammet Demirbilek, Ugur Aferin, Berin Selcuk, Ahmet Erozenci, Bulent Onal

“…A stone load larger than 1 cm2, age older than 45.5 years, the presence of multiple stones, new- (third-) generation lithotripter use, and pre-SWL catheterization had statistically significant effects on lower stone-free rates in patients who underwent SWL due to ureteral stones. …”
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Surgical fear and sleep quality effect the postoperative quality of recovery in patients undergoing brain tumor surgery: cross sectional study by Özge Çimen, Yeliz Sürme

“…Results The mean fear of surgery score of women was higher than men, and sleep quality and postoperative quality of recovery were lower than men (p = 0.045). A moderate negative correlation between fear of surgery and sleep quality was found (r = -0.377; p = 0.000). …”
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Morphological analysis of lacrimal punctum using anterior segment optical coherence tomography in different age groups by Hasan Naz, Shruthi Tara, Jagadeesh K Reddy, V Rajesh Prabu, Mithun Thulasidas

“…The selected eyes from healthy patients were divided into four age groups (21–35 years, 36–50 years, 51–65 years, 66–80 years), and lower lacrimal puncta were analyzed using AS-OCT. …”
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EFFICACY OF THIONONTRITE-S FOR PREVENTION OF METABOLIC LIVER DISEASE IN CATTLE by Ye. V. Tyapkina, M. P. Semenenko, Ye. V.  Kuzminova, A. A.  Abramov

“…At the end of the experiment the level of alanine aminotransferase in the first group was 1.8 times less than the control levels, the level of aspartate aminotransferase was 1.6 times lower than the negative control levels. The positive effect of thionontrite-S was also observed with regard to pigment metabolism; the concentration of total bilirubin in the experimental group was within physiological limits (4.28 ± 0.55 µM/l), whereas in the control group hyperbilirubinemia was 1.6 times higher than the upper limit of normal. …”
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Non-Redox-Based Electrochemical Detection of Adrenaline: A Simple and Reliable Approach Using Glass Nanopipets by Ralph J. Page, Gene Koifman, Noel Manring, Jessica L. Smeltz, Pavithra Pathirathna

“…The sensor achieved a detection limit of 5 pM in Tris buffer using DB24C8 and 50 pM with DB18C6, both significantly lower than the physiological concentration of Adr. …”
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Second Trimester Umbilical Cord Coiling Index and Perinatal Outcomes by Yusuf Aytaç Tohma, Mehmet Metin Altay, Derya Turgut, Selcan Coşkun, Eylem Ünlübilgin, Sertaç Esin, Orhan Gelişen, Okyar Erol

“…The birth weights were lower in patients with hypocoiled umbilical cord structure. …”
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Exploring the growth performance, antioxidant capacity, and metabolism of Babylonia areolata in response to yeast selenium supplementation by Yunting Wang, Waqas Ahmed, Sajid Mehmood, Mohsin Mahmood, Lu Wang, Wenjie Ou, Jiannan Li, Jie Yang, Weidong Li, Lianshun Wang

“…The SOD, CAT, T-AOC levels in the M-YSe group were significantly increased by (34.05 %, 151.62 % and 131.5 %, respectively) than in the CK groups, while the MDA concentration was significantly decreased by (66.67 % lower). Additionally, our results suggest that yeast selenium supplementation activated related metabolites and glutamine metabolic pathways in B. areolata. …”
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Prognostic value of circulatory growth factors to predict responsiveness to chemotherapy and remission status of patients with acute myeloid leukemia by Mohammad Ahmad Bani-Ahmad, Duaa Ghanem

“…Results As compared to control subjects, AML patients had significantly lower average levels of Ang-1 (170.8 ±12.7 versus 59.2 ±12.5 ng/ml) and VEGF-A (56.0 ±13.1 versus 98.6 ±11.9 ng/dl) that coincide with a higher average level of Ang-2 (18.5 ±4.1 ng/ml versus 7.5 ±0.8 ng/ml). …”
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Evaluation of Antidiabetic Properties of the Leaves Extract of Ficus vallis-choudae Delile in a Model of Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin by Kilenma Kolefer, David Miaffo, Roger Ponka

“…In addition, it dramatically reduced body mass, body mass index (BMI), atherogenic index (AI), coronary heart risk index (CRI), and abdominal fat and increased homeostatic model assessment of β-cell function (HOMA-β), high-density lipoprotein cholesterol (HDL-c) levels, and cardioprotective index (CI). The AEFV also lowered blood glucose levels, insulinemia, homeostatic model assessment of insulin resistance (HOMA-IR) index, and total cholesterol (TC), triglycerides (TG), low-density lipoproteins cholesterol (LDL-c), and very-low-density lipoproteins cholesterol (VLDL-c) levels. …”
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Effect and curative effect of Sanqitongshu capsule combined with argatroban on neurological deficits elderly patients with acute ischemic stroke by Fang Hu, Yunping Liu, Jia Li, Hui Xuan, Huijuan Wang, Xuehai Lv

“…[Results] After treatment, the total effective rate of the study group was significantly higher than that in the control group (P<0.05).The NIHSS score, plasma fibrinogen level, plasma viscosity, erythrocyte aggregation index and the expression levels of ET-1, CD41, CD62P and sICAM-1 in peripheral blood in the two groups were significantly decreased (P<0.05), and these indicators in the study group were significantly lower than those in the control group (P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). …”
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The effect of carbonate mineral additions on biogeochemical conditions in surface sediments and benthic–pelagic exchange fluxes by K. Biçe, K. Biçe, T. Myers Stewart, T. Myers Stewart, G. G. Waldbusser, C. Meile

“…Fluid composition in sediments is altered through the mineralization of organic matter which, under oxic conditions, further lowers both pH and the carbonate saturation state. …”
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Assessing the Risk Factors of Violent and Non-violent Suicide Attempt Methods: A Population-based Cross-sectional Study by Amin Moradi, Ehsan Mosafarkhani, Fateme Nikbakht, Zahra Amiri, Ali Vafaee Najar

“…The chance of using violent methods was found to be 64% lower in women than in men (OR=0.36, 95%CI=0.30-0.43) and 45% higher in single individuals than in married people (OR=1.45, 95%CI=1.20-1.75).Conclusion: This study found that several factors influenced the choice of method for committing suicide. …”
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Potential Antioxidant Activity of New Tetracyclic and Pentacyclic Nonlinear Phenothiazine Derivatives by Godwill Azeh Engwa, Eugene Lekem Ayuk, Benardeth Ujunwa Igbojekwe, Marcellus Unaegbu

“…The malondialdehyde level in groups 1 and 2 animals was lower than that in group 3 that received the reference compound (ascorbic acid) and group 4 that received the solvent suggesting the ability of the phenothiazine derivatives to prevent lipid membrane damage. …”
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Levels of burnout and its association with resilience and coping mechanisms among orthopaedic surgery residents: a single institution experience from Singapore by Sean WL Ho, Ernest BK Kwek

“…Severe burnout was associated with lower grit scores (p <0.05). Coping mechanisms, such as planning and positive reframing, were protective while behavioural disengagement and substance use may increase burnout risk. …”
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MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis by Huifang Bai, Qianqian Dang, Guoliang Chen, Lingfeng Xie, Saining Wang, Ning Jiang, Xiaoxia Wu, Shuyan Zhang, Xuelin Wang

“…MyD88 promoter methylation results showed that the methylation levels in the 5 d group were lower compared to the control group (P < 0.05). Furthermore, the methylation led to an imbalance in anti-inflammatory regulation in the infected mice. …”
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Residual HCV-RNA and Elevated Platelet-to-Lymphocyte Ratio Predict Poor Long-Term Outcomes in Patients with Chronic Hepatitis C After Treatment by Anna Wróblewska, Mateusz Gliwiński, Magda Rybicka, Małgorzata Cheba, Beata Lorenc, Piotr Trzonkowski, Krzysztof P. Bielawski, Katarzyna Sikorska

“…Patients with residual HCV-RNA had higher levels of macrophage-derived chemokine (MDC/CCL22) (p = 0.026) and interleukin-18 (IL-18) (p = 0.009), but lower levels of fractalkine/CX3CL1 (p = 0.007), interferon gamma (IFNγ) (p = 0.016), IL-13 (p = 0.009), and lymphotoxin alpha (LTα) (p = 0.007) compared to those without OCI. …”
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