Development, opportunities, and challenges of siRNA nucleic acid drugs by Bowen Xiao, Shaopeng Wang, Yu Pan, Wenjun Zhi, Chensheng Gu, Tao Guo, Jiaqi Zhai, Chenxu Li, Yong Q. Chen, Rong Wang

“…Currently, all approved drugs target the liver. The high blood flow, natural filtration function, and drug delivery methods of the liver overall ensure high efficacy and stability of the drugs themselves. …”
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High-Speed Counter-Current Chromatography in Separation and Identification of Saponins from Beta vulgaris L. Cultivar Red Sphere by Aneta Ewa Spórna-Kucab, Sławomir Wybraniec

“…The system was used in the head-to-tail mode. The flow rate of the mobile phase was 3 mL/min and the column rotation speed was 860 rpm. …”
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A Validated HPLC-DAD Method for Simultaneous Determination of Etodolac and Pantoprazole in Rat Plasma by Ali S. Abdelhameed, Samar A. Afifi

“…Optimal chromatographic separation of the analytes was achieved on a Waters Symmetry C18 column using a mobile phase that consisted of phosphate buffer pH~4.0 as eluent A and acetonitrile as eluent B in a ratio of A : B, 55 : 45 v/v for 6 min, pumped isocratically at a flow rate of 0.8 mL min−1. The eluted analytes were monitored using photodiode array detector set to quantify samples at 254 nm. …”
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Supervised and Self-Supervised Learning for Assembly Line Action Recognition by Christopher Indris, Fady Ibrahim, Hatem Ibrahem, Götz Bramesfeld, Jie Huo, Hafiz Mughees Ahmad, Syed Khizer Hayat, Guanghui Wang

“…Various feature extractors and localization models were benchmarked using a new assembly dataset, with the I3D model achieving an average mAP@IoU=0.1:0.7 of 85% without optical flow or fine-tuning. The comparative study was extended to self-supervised learning via a modified SPOT model, which achieved a mAP@IoU=0.1:0.7 of 65% with just 10% of the data labeled using extractor architectures from the fully-supervised portion. …”
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Linear Bending Wave Propagation in Laminar and Turbulent Disks by Callum W. Fairbairn

“…Although the turbulence can be quantified with an effective α parameter, the bending waves behave distinctly from a classical viscous evolution and are readily disrupted when the turbulent velocity is comparable to the induced warping flows. This may have implications for the inclination damping rates induced by planet–disk interactions, the capture rate of black holes in active galactic nucleus disks or the warped shapes assumed by disks in misaligned systems.…”
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Insecticide chlorfenapyr confers induced toxicity in human cells through mitochondria-dependent pathways of apoptosis by Longfei Wang, Zheng Qu, Yifan Xu, Guangqing Yu, Xiangyang Liu, Meizi Wang, Shiheng An, Xinming Yin, Risong Na, Youwu Hao

“…Chl's ability to induce DNA damage and apoptosis in human cells was confirmed through alkaline comet assay, immunofluorescence assay, and flow cytometric analysis. Further research showed that Chl induced mitochondrial damage (the collapse of mitochondrial membrane potential and the opening of mitochondrial permeability transition pore) with up-regulated expression of Bax/Bcl-2 leads to the release of cytochrome c from mitochondria which in turn activated the apoptotic pathway. …”
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Estimation and identification of parameters in a lumpedcerebrovascular model by Scott R. Pope, Laura M. Ellwein, Cheryl L. Zapata, Vera Novak, C. T. Kelley, Mette S. Olufsen

“…The model is combined with experimentalmeasurements of blood flow velocity from the middle cerebral artery andarterial finger blood pressure. …”
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Clinical case of treatment of subacute endocarditis in a patient after occluder closing of the patent foramen ovale by G.I. Kovtun, S.O. Sheludko, D.O. Loskutov, H.Yu. Melnyk

“…Transesophageal echocardiography showed no residual blood flow through the interatrial septum. The postoperative period was uneventful. …”
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Influence of Blade Profiles on Plastic Centrifugal Pump Performance by Hui Zhang, Lingfeng Tang, Yongtao Zhao

“…The numerical simulation of the internal flow field was performed. From the contours of the velocity and pressure, the vapor volume fraction distribution, and fluid-structure interaction analysis of impellers, the impeller drawn by the logarithmic spiral method was better than others. …”
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Dynamic Fracturing Behavior of Layered Rock with Different Inclination Angles in SHPB Tests by Jiadong Qiu, Diyuan Li, Xibing Li, Zilong Zhou

“…Meanwhile, a numerical model of layered rock and SHPB system are established by particle flow code (PFC). The numerical results show that the shear stress is the main reason for inducing the damage along bedding plane at θ = 0°~75°. …”
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Numerical Investigation of Complex Thermal Coal-Gas Interactions in Coal-Gas Migration by Xiaoyan Ni, Peng Gong, Yi Xue

“…In this study, the fully coupled transient model combines the relationship of gas flow, heat transfer, coal mass deformation, and gas migration under variable temperature conditions and represents an important nonlinear response to gas migration caused by the change of effective stress. …”
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Comparison and Correction of Runoff Simulation Based on XGBoost and SWAT by LIANG Lisha, JIANG Xiaolei, HU Leyi, SHEN Jing, ZHANG Liping, FU Xiaolei

“…The results show that: ① The simulation effect of the XGBoost model is good, and the Nash-Sutcliffe efficiency (NSE) of daily runoff simulation of the XGBoost model is 15.66% higher than that of the SWAT model. ② The SWAT model is underestimated at high flow rates, while the XGBoost model results in basically consistent simulation values and observed values, and the simulated hydrograph has a high degree of fitting, showing a good correlation. ③ After XGBoost correction, the simulation accuracy of the SWAT model is obviously improved, which can effectively improve the runoff simulation effect. …”
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Static Properties and Current-Driven Dynamics of Domain Walls in Perpendicular Magnetocrystalline Anisotropy Nanostrips with Rectangular Cross-Section by Eduardo Martinez

“…A slow creep regime, where the motion is controlled by wall pinning and thermal activation, and a flow regime with linear variation of the DW velocity, are observed. …”
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Solid-state mantle convection coupled with a crystallising basal magma ocean by Labrosse, Stéphane, Morison, Adrien, Tackley, Paul James

“…A sample calculation shows that the persistence of the BMO and its long term evolution drastically changes the dynamics of the solid mantle by promoting downwelling currents and large scale flow. The gradual increase of the FeO content in the BMO and in the solid that crystallises from it leads to the stabilisation of large scale thermo-compositional piles at the bottom of the mantle, possibly explaining the observations from seismology.…”
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Study on Plastic Coated Overburnt Brick Aggregate as an Alternative Material for Bituminous Road Construction by Dipankar Sarkar, Manish Pal, Ashoke K. Sarkar

“…Bulk density, Marshall Stability, flow, Marshall Quotient, ITS, TSR, stripping, fatigue life, and deformations have been determined accordingly. …”
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Optimizing MPPT Control for Enhanced Efficiency in Sustainable Photovoltaic Microgrids: A DSO-Based Approach by Debabrata Mazumdar, Pabitra Kumar Biswas, Chiranjit Sain, Furkan Ahmad, Rishiraj Sarker, Taha Selim Ustun

“…The suggested method performs noticeably faster than many other methods currently in use, and in addition to offering the highest power, it can also use bidirectional power flow regulation in both constant and variable air conditions. …”
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Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae by Dong Liu, Zhifu Chen, Yue Yuan, Haiming Jing, Jintao Zou, Xiaoli Zhang, Xi Zeng, Weijun Zhang, Quanming Zou, Jinyong Zhang

“…In the current study, we established an acute pneumonia model of K. pneumoniae respiratory infection in mice and confirmed that the injury was most severe 48 h post infection. Flow cytometric assay demonstrated that alveolar macrophages were the predominant cells in BALF before infection, and neutrophils were quickly recruited after infection, and this was in consistent with the kinetics of chemokine expression. …”
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Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis by Yunzhi Xu, Qi Zhu, Jinglve Song, Hongli Liu, Yutong Miao, Fan Yang, Feiyan Wang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He, Guangjie Chen

“…Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme-linked immunosorbent assay. mRNA expression of cytokines and transcriptional factor were quantified by RT-PCR. …”
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Adaptive identification of critical nodes for fault‐on voltage support in islanded microgrids by Shiran Cao, Lipeng Zhu, Jiayong Li, Wen Huang, Lili He, Wei Zhang, Huimin Zhao, Zhikang Shuai

“…Furthermore, a higher‐order transition matrix reconstruction strategy with power propagation characteristics is proposed to reduce the higher‐order complexities arising from remote end faults' current flowing path length. Ultimately, the transition matrix is optimized by integrating it with the PageRank algorithm and highlighting the importance of source nodes. …”
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Estimation of bed shear stress and settling velocity with inertial dissipation method of suspended sediment concentration in cohesive sediment environments by Jongwi Chang, Guan-hong Lee, Ojudoo Darius Ajama, Wenjian Li

“…Over the past few decades, various methods have been developed to infer bed shear stress using noninvasive, high-resolution flow observations from acoustic instruments. However, there is room for improvement in these methods. …”
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