The bronchoalveolar lavage fluid CD44 as a marker for pulmonary fibrosis in diffuse parenchymal lung diseases by Magda Suchankova, Magda Suchankova, Eszter Zsemlye, Eszter Zsemlye, Jan Urban, Peter Baráth, Lenka Kohútová, Barbara Siváková, Barbara Siváková, Martina Ganovska, Elena Tibenska, Kinga Szaboova, Eva Tedlova, Dominik Juskanic, Dominik Juskanic, Kristina Kluckova, Kristina Kluckova, Michaela Kardohelyova, Tetiana Moskalets, Anna Ohradanova-Repic, Patrik Babulic, Maria Bucova, Vladimir Leksa

“…Receiver operating characteristics curve analysis confirmed CD44 in BALF as a specific and reliable biomarker of IPF and other types of DPLD accompanied with pulmonary fibrosis.…”
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Integrating the GRACE Score with the Ceramide Risk Score Enhances the Predictive Accuracy of Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome Undergoing Percut... by Xiaofei Wang, Chengzhe Liu, Fu Yu, Zizhuo Zhang, Jiale Wang, Xiaoyu Shi, Tianyou Xu, Qiang Deng, Liping Zhou, Wanyue Sang, Hong Jiang, Lilei Yu

“…Results: During the 12-month follow-up period, 35 of the 210 participants experienced a MACE. …”
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Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

“…Introduction Motor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2–3 months. …”
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First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer by Lini Pandite, Simon Metenou, Debra L Richardson, Erika Hamilton, Linda Van Le, Bo Ma, Fatima Rangwala, Nehal J Lakhani, Justin Call, Daphne Stewart, Lauren E Dockery, Guanfang Wang, Jade Huguet, Elliot Offman

“…SL-172154 Cmax and area under the curve increased with dose with greater than proportional exposure noted at 3.0 and 10.0 mg/kg. …”
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β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease by Bing Xu, Kang Xiao, Xiaoxi Jia, Rundong Cao, Donglin Liang, Ruhan A, Weiwei Zhang, Chunjie Li, Liping Gao, Cao Chen, Qi Shi, Xiaoping Dong

“…Receiver operating characteristics (ROC) curves and area under the curve (AUC) values were used to assess the diagnostic performance of β-syn. …”
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Measles Outbreaks in Afghanistan by Abubakr Yosufi, Hedayatullah Ehsan, Ali Maisam Eshraqi, Abdul Majeed Momeni

“…Severe widespread poverty, decades of civil unrest, armed conflict, and recently coronavirus disease 2019 (COVID-19) pandemic, and lack of funding have been a huge obstacle to curb the disease. …”
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Pretreatment Hemoglobin Level Is an Independent Prognostic Factor in Patients with Lung Adenocarcinoma by Yue-Hua Zhang, Yuquan Lu, Hong Lu, Meng-Wei Zhang, Yue-Min Zhou, Xiang-Lei Li

“…Person-years and case fatality rate (CFR) were calculated from May 2010 to June 2017. …”
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An Empirical Assessment of Factors Influencing Injury Severities of Motor Vehicle Crashes on National Highways of Pakistan by Hanif Ullah, Asim Farooq, Akhtar Ali Shah

“…Due to the high number of road traffic crashes and resulting fatalities, a random parameters logit model was estimated to determine the risk factors that influence the severity of injuries caused by motor vehicle crashes on national highways. …”
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6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy by Qiao You, Jing Wu, Ruining Lyu, Yurong Cai, Na Jiang, Ye Liu, Fang Zhang, Yating He, Deyan Chen, Zhiwei Wu

“…Abstract Background Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), and can cause severe cerebral complications and even fatality in children younger than 5 years old. However, there is no specific medication for EV71 infection in clinical practice. …”
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Parasite-Specific IL-17-Type Cytokine Responses and Soluble IL-17 Receptor Levels in Alveolar Echinococcosis Patients by Christian J. Lechner, Beate Grüner, Xiangsheng Huang, Wolfgang H. Hoffmann, Peter Kern, Peter T. Soboslay

“…Alveolar Echinococcosis (AE) caused by the cestode Echinococcus multilocularis, is a severe helminth infection of man, where unrestricted parasite growth will ultimately result in organ failure and fatality. The tissue-infiltrative growth of the larval metacestode and the limited efficacy of available drugs complicate successful intervention in AE; patients often need life-long medication, and if possible, surgical resection of affected tissues and organs. …”
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Statistical analysis and characteristics of hospital medical waste under novel Coronavirus outbreak by H.A. Abu-Qdais, M.A. Al-Ghazo, E.M. Al-Ghazo

“…One of thesources of infection as a result of coronavirus disease treatment is the medical waste generated during the health care activities. Since the registration of the first infected case of coronavirus in Jordan the daily number of patients fluctuated from as low as zero to as high as 40 with a recovery ratio and case fatality risk of 39% and 1.7%, respectively. …”
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Automatic Segmentation of Abdominal Aortic Aneurysm From Computed Tomography Angiography Using a Patch-Based Dilated UNet Model by Merjulah Roby, Juan C. Restrepo, Haehwan Park, Satish C. Muluk, Mark K. Eskandari, Seungik Baek, Ender A. Finol

“…NURBS enables the creation of continuous curves that seamlessly conform to the intricate contours of anatomical structures, offering a significant improvement in segmentation accuracy. …”
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Comparative analysis of cancer statistics in China and the United States in 2024 by Yujie Wu, Siyi He, Mengdi Cao, Yi Teng, Qianru Li, Nuopei Tan, Jiachen Wang, Tingting Zuo, Tianyi Li, Yuanjie Zheng, Changfa Xia, Wanqing Chen, Jing Ni

“…Data from the Global Burden of Disease study (GBD) and a decomposition approach were used to estimate the contributions of four determinants to the change in cancer deaths. …”
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Epidemiological features and risk factors of human psittacosis in Hangzhou City, eastern China by Zhou Sun, Ke Xu, Liangliang Huo, Xingliang Zhang, Yi Wang, Yonghui Gong, Bingbing Chen

“…A community-based 1:3 matched case-control study was performed to investigate the risk factors associated with Chlamydia psittaci infection.ResultsDuring the study period, 137 confirmed cases of human psittacosis were identified through laboratory tests, of which 24 (17.52%) were classified as critical cases, including one fatality. …”
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Outcomes of adults hospitalized with COVID-19 at the University Teaching Hospital of Butare in Rwanda and validation of the Universal Vital Assessment (UVA) mortality risk score. by Dona Fabiola Gashame, Kwame A Akuamoah Boateng, Jean Damascene Twagirumukiza, Jean de Dieu Mahoro, Christopher C Moore, Theogene Twagirumugabe

“…For each participant, we calculated UVA, SOFA, and qSOFA risk scores and determined their area under the receive operating characteristic curve (AUC). We used logistic regression to determine predictors of mortality. …”
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Mortality risk prediction model in AIDS patients with pneumocystis pneumonia in China by Xi Wang, Letian Liu, Wen Wang, Yang Zhang, Hui Chen, Zhangli Wang, Jianwei Li, Yue Gao, Yanqun Huang, Lijun Sun, Tong Zhang, Aixin Li

“…We aimed to develop a risk model for the near-term prognosis of people with HIV/AIDS and PCP and verify its effectiveness.MethodsThis single-center, retrospective observational study was conducted at Beijing Youan Hospital from January 2012 to October 2022. 972 AIDS patients with Pneumocystis pneumonia met our criteria were recruited. The patients were divided into death group and survival group according to clinical outcome during hospitalization. …”
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Predictive modelling and identification of critical variables of mortality risk in COVID-19 patients by Olawande Daramola, Tatenda Duncan Kavu, Maritha J. Kotze, Jeanine L. Marnewick, Oluwafemi A. Sarumi, Boniface Kabaso, Thomas Moser, Karl Stroetmann, Isaac Fwemba, Fisayo Daramola, Martha Nyirenda, Susan J. van Rensburg, Peter S. Nyasulu

“…Our results show that Deep MLP had the best overall performance (F1 = 0.92; area under the curve (AUC) = 0.94) when CV and the synthetic minority oversampling technique (SMOTE) were applied without PCA. …”
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