Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…Current preclinical models, including animal studies, fail to accurately replicate human pregnancy conditions, resulting in gaps in drug safety and pharmacokinetics predictions. …”
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Conflicto sin final, espejismo de la paz. Diálogos exploratorios en el Gobierno de Álvaro Uribe con el ELN (2005-2007) by Óscar Mauricio Castaño Barrera

“…Mediante un análisis de caso de las condiciones necesarias para la generación de una mesa de paz formal según la teoría de los procesos de paz de Vincenç Fisas, se explica cómo se dio el reconocimiento político del ELN sin reconocimiento del conflicto simultáneamente por parte del Gobierno nacional, se reconstruyen los rasgos que fueron de mayor valor sobre las actitudes cooperativas y competitivas de las partes que posibilitaron pese a la agenda restringida del Gobierno nacional, tanto el inicio del proceso de paz como su ruptura; y finalmente se realiza un balance descriptivo de la organización de las terceras partes mediadoras durante el proceso y algunos incidentes que pusieron en jaque este aspecto.…”
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Development of a mnemonic card game for sustainability literacy in Master of Business Administration programmes by Magdalena J. Grobler

“…Motivation for the study: Traditional teaching methods often fail to engage students with the complexity of the SDGs, limiting retention and comprehensive understanding. …”
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Clinical advances in kidney autotransplantation: a review by Shengjie Lin, Jingci Gai, Shangjin Huang, Yingzhen He, Da Hao, Shuhang Luo, Yilong Lin, Jiang Qiu, Jun Li, Changxi Wang, Chenglin Wu

“…Kidney autotransplantation may be indicated for the rare condition of loin pain-hematuria syndrome when conservative measures fail. Additionally, individuals with solitary or bilateral kidney disease benefit from kidney autotransplantation to preserve their renal function. …”
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« Ce n’est pas ce que j’ai vu, ce n’est pas ce que j’ai pensé»  by Lindsey Dodd

“…(AHMED, 2014) While much influential scholarship is dedicated to top-down analyses French post-war memorial culture (mémoire), less attention is given to personal souvenirs of “ordinary” or “unimportant” people, particularly those who were children; such voices and the claims they make have at times been characterised as competitive and damaging to the “coherence of the national narrative” (WIEVIORKA, 2012). Yet by failing to listen, dominant historical discourse may provoke damaging sentiments of resentment, exclusion and shame.…”
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Exploring the Role of Entrepreneurship Education in Boosting Innovation among Students – A Case Study of Two KwaZulu-Natal Universities by Mtshali Thabo Wonder, Mashau Pfano, Gamede Vangeli Wiseman

“…The labour market is struggling to create opportunities and failing to counteract unemployment with relevant skills. …”
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Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Ísak Valsson, Matthew T. Warren, Charlotte M. Deane, Aniket Magarkar, Garrett M. Morris, Philip C. Biggin

“…However, current models lack robust evaluation and fail on tasks encountered in (hit-to-) lead optimisation, such as ranking the binding affinity of a congeneric series of ligands, thereby limiting their application in drug discovery. …”
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A hybrid multiscale feature fusion model for enhanced cardiovascular arrhythmia detection by Md. Alamin Talukder

“…Traditional arrhythmia classification methods often struggle with class imbalance and fail to capture critical multiscale temporal and spatial features, leading to suboptimal diagnostic performance. …”
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PROSPECTS AND CHALLENGES OF RESCUING THE SHRINKING LAKE CHAD THROUGH THE UNITED NATIONS’ GREEN CLIMATE FUND by DAIYABU HASSAN MUHAMMAD

“…Although there is a new initiative by the Italian government and the Chinese construction company PowerChina in partnership with Bonfica to resurrect the idea, the paper argues that the LCBC has failed to access and utilize the adaptation facilities under the United Nations adaptation funds. …”
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Risk factors for difficult peripheral venous cannulation in hospitalised patients. Protocol for a multicentre case–control study in 48 units of eight public hospitals in Spain by Jose Miguel Morales-Asencio, Ian Blanco-Mavillard, Miguel Angel Rodríguez-Calero, Ismael Fernandez-Fernandez, Luis Javier Molero-Ballester, Catalina Matamalas-Massanet, Luis Moreno-Mejias, Joan Ernest de Pedro-Gomez

“…Patients who present one of the following conditions will be assigned to the case group: two or more failed punctures, need for puncture support, need for central access after failure to achieve peripheral access, or decision to reject the technique. …”
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Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study by Mohsen Shaygan Tabar, Maryam Nilghaz, Azita Hekmatdoost, Fereshteh Pashayee-Khamene, Zeinab Mokhtari, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Zahra Yari

“…Although the first model of the analysis by adjusting the results for age and sex failed to show a significant increase in the risk of mortality in patients (HRQ4 vs. …”
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The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. by David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon

“…During development, hematopoietic progenitor cells in mon mutants fail to express normal levels of hematopoietic transcription factors, including gata1, and undergo apoptosis. …”
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PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages by Sreelakshmi K. Sreenivasamurthy, Carlos Gustavo Baptista, Christopher M. West, Ira J. Blader, Jeffrey D. Dvorin

“…PfFBXO1-deficient gametocytes are abnormally shaped and fail to fully mature. Proteomic analysis identified PfSKP1 as one of PfBXO1’s stable interacting partners, while other major proteins included multiple IMC pellicle and membrane proteins. …”
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Functional Outcome by Evaluation of DASH Score on Drop Hand Patient Treated with Jones’ Tendon Transfer: A Retrospective Study by Tito Sumarwoto, Seti Aji Hadinoto, Adhitya Indra Pradhana

“…Tendon transfer becomes the last option when nerve repair fails to achieve restoration. The most popular method is the Jones tendon transfer to restore wrist dorsiflexion and extension of the thumb and fingers. …”
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Influence and prediction mechanisms for discomfort and memory disturbance due to structure borne sound from a metro masked with fountain sound by Wang Qiaochu, Hongwei Wang, Cai Yangsheng, Zhang Yang, Yang Chenxi

“…However, these studies failed to identify the primary, secondary and significant influencing factors on the discomfort after mitigation, which hindered the proposal of optimal masking strategy and undermined the scientific validity of models. …”
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Individual variability in cortical representations of tonic pain by Bettina Deak, Anne Stankewitz, Astrid Mayr, Viktor Witkovsky, Pauline Jahn, Enrico Schulz

“…Therapies to relieve pain that rely on the modulation of brain regions will fail unless they are adapted to an individual's unique pain processing characteristics.…”
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Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity by Evelyn F Okal, Philip A. Romero, Pete Heinzelman

“…Surrogate substrates used in traditional high-throughput screening methods for peptidases often fail to accurately mimic native substrates, leading to less effective enzyme variants. …”
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“It’s not what I saw, it’s not what I thought”: by Lindsey Dodd

“…(AHMED, 2014) While much influential scholarship is dedicated to top-down analyses French post-war memorial culture (mémoire), less attention is given to personal souvenirs of “ordinary” or “unimportant” people, particularly those who were children; such voices and the claims they make have at times been characterised as competitive and damaging to the “coherence of the national narrative” (WIEVIORKA, 2012). Yet by failing to listen, dominant historical discourse may provoke damaging sentiments of resentment, exclusion and shame.…”
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Spin-down of Solar-mass Protostars in Magnetospheric Accretion Paradigm by Shinsuke Takasao, Masanobu Kunitomo, Takeru K. Suzuki, Kazunari Iwasaki, Kengo Tomida

“…With a particular focus on the propeller regime for solar-mass stars, we propose a new picture of stellar spin-down based on our recent 3D magnetohydrodynamic simulation and stellar evolution calculation. We show that failed magnetospheric winds, unique to 3D models, significantly reduce the spin-up accretion torque, which make it easier for the star to spin-down. …”
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Persistent intestinal myiasis caused by Oestrus ovis in a Nigerian university student: a case report by Winifred N. Adiri, Bruno Basil, Chinwe P. Onyia, Joy O. Ugwuanyi, Chinyere Azifuaku, Sam C. Iheukwumere, Olivia Obienu, Uchenna N. Ijoma, Sylvester C. Nwokediuko

“…Initial treatment with standard anti-helminthics failed, leading to prolonged treatment with ivermectin, nitazoxanide, and colonic washes, combined with levofloxacin for Helicobacter pylori eradication, resulting in the resolution of symptoms with no recurrence after 6 months. …”
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