CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…In vitro studies using human and murine liver cancer cells (n = 3 biological replicates) demonstrated reduced sensitivity to ferroptosis upon CPEB4 depletion when induced by erastin or RSL3 (p <0.01). Mechanistically, CPEB4 deficiency suppressed hepcidin expression, leading to elevated ferroportin levels, decreased intracellular iron accumulation, and reduced lipid peroxidation (p <0.05). …”
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FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy by Liang Zhao, Long Sun, Kaili Fu, Qin Lin, Xiaoyuan Chen, Qicong Luo, Hua Wu, Jianhao Chen, Yangfan Zhou, Yizhen Pang, Guoqiang Su, Haojun Chen

“…Further mechanistic studies have shown that 177Lu-DOTA-2P(FAPI)2 combined with αPD-L1 mAb can reprogram the TME, enhancing antitumor intercellular communication, which activates antitumor-related intercellular contacts such as FasL-Fas interactions between T cells and NK cells with tumor cells and increasing the proportion of infiltrating CD8+ T-cells while reducing regulatory T cells and inhibiting tumor progression. …”
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L-selenomethionine inhibits small intestinal ferroptosis caused by ammonia exposure through regulating ROS-mediated iron metabolism by Xinxin Zhang, Lepeng Gu, Ying Chen, Tianqi Wang, Houjuan Xing

“…The results showed that ammonia exposure up-regulated the levels of iron, ROS, MDA, and LPO in the small intestinal tissue and the IPEC-J2 cell, down-regulated the activities of antioxidant enzymes and the content of GSH, inhibited the Nrf2 pathway, significantly altered the expression of ferroptosis (TFR-1, FPN-1, FTH1, SLC7A11, GPX4, ACSL4) and intestine tight junctions (Claudin-1, Occludin, ZO-1) genes. …”
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Askeri Harcamalar ve Ekonomik Büyüme: Orta Doğu Ülkeleri Açısından Benoit Hipotezinin Sınanması by İbrahim Tuğrul Çınar, Yusuf Ünsal

“…Bu çalışmada dokuz Orta Doğu ülkesi üzerinden askeri harcamaların ekonomik büyüme üzerindeki etkisinin Asimetrik ARDL yaklaşımı kullanılarak incelenmesi amaçlanmıştır. …”
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Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and fatty acid metabolism-associated gene by Hong Li, Yongyun Xu, Aiting Wang, Chuanxin Zhao, Man Zheng, Chunyan Xiang

“…Results The study pinpointed seven FAMGs with a close association to AS: ACSBG2, ELOVL4, ACSL3, CPT2, ALDH2, HSD17B10, and CPT1B. Analysis of their biological functions underscored their significant involvement in critical processes such as fatty acid metabolism, small molecule catabolism, and nucleoside bisphosphate metabolism. …”
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Differentially expressed transcript isoforms associate with resistance to tuberculin skin test and interferon gamma release assay conversion. by Jason D Simmons, R Max Segnitz, Kimberly A Dill-McFarland, Catherine M Stein, Glenna J Peterson, Harriet Mayanja-Kizza, W Henry Boom, Thomas R Hawn

“…<h4>Materials and methods</h4>Monocytes from 49 RSTR versus 52 subjects with latent Mtb infection (LTBI) were infected with M. tuberculosis (H37Rv) or left unstimulated (media) prior to RNA isolation and sequencing. …”
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Primary Hyperparathyroidism-Phosphaturic Mesenchymal Tumour: An Unusual Association and a Probable Syndrome by Gwendolyn Fernandes, Avanika, Gloria Khumanthem

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Resmi Kalkınma Yardımları Vergi Gelirleri İlişkisi: Türkiye Özelinde İkame Etkisinin Analizi by Şehnaz Altunakar Mercan

“…Bununla birlikte yardımlar bileşenlerine ayrıştırılarak hibeler ve krediler olarak ayrı ayrı incelenmiştir. ARDL sınır testi yönteminin kullanıldığı çalışmada 1984-2016 dönemi Türkiye verilerinden faydalanılmıştır. …”
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Spatiotemporal Dynamics of Drought and the Ecohydrological Response in Central Asia by Keting Feng, Yanping Cao, Erji Du, Zengguang Zhou, Yaonan Zhang

“…The findings indicate that, from 2000, Central Asia’s annual precipitation decreased at a rate of 1.80 mm/year (<i>p</i> < 0.1), and its annual temperature increased slightly, at a rate of 0.008 °C/year (<i>p</i> = 0.62). …”
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ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression by Xin Liu, Xinghua Pan

“…Studies have shown that ALKBH3 is upregulated in most tumors, but the role of ALKBH3 in AML remains unclear.Methods: In this study, we investigated the function of ALKBH3 in AML cells (KG-1) by immunofluorescence, ELISA, flow cytometry, HE staining, and Western blotting.Results: Our results revealed that ALKBH3 is upregulated in AML and that the downregulation of ALKBH3 inhibited KG-1 cell proliferation and promoted cell apoptosis; at the same time, ALKBH3 upregulated ATF4 expression through m1A demethylation, and the knockdown of ATF4 resulted in increased ferrous iron content; TFR1, ACSL4, and PTGS2 expression; and ROS and MDA levels, whereas SOD and GSH levels and the expression levels of ATF4, SLC7A11, GPX4, and FTH1 decreased in KG-1 cells, thereby promoting ferroptosis. …”
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Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension by Jéssica Moraes Cruvinel, Elizabeth S. Greene, Rachel W. Read, Kichoon Lee, Sami Dridi, Paula R. Chen

“…Abundance of transcripts related to lipid synthesis and oxidation, acyl-CoA synthetase long chain family member 1 (ACSL1) and carnitine palmitoyltransferase 1A (CPT1A), were increased in the differentiation cultures compared to the control cultures. …”
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Comparative Evaluation of Tear Film and Corneal Surface in Chronic Smokers and Non Smokers: A Cross-sectional Study by Ruchi Dabas, Meena Kumari, Manisha Rathi, Monika Dahiya, Rajni Yadav, Sumit Sachdeva

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Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer by Feifei Yao, Feng Guo, Chuanzhong Sun, Erdong Wang, Hang Wang, Na Li

“…Therapeutic targets like GPX4, SLC7A11, P53, FSP1, Nrf2, LSH, STYK1/NOK, and ACSL4 are prominent. …”
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LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation by Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Deming Zhu, Wenhu Zhao, Chao Xu, Xiangyu Ling, Qingpeng Lv, Xiaoming Ai, Lianbao Kong, Wenzhou Ding

“…Nile red staining and lipid assays showed that LRP11 knockdown significantly reduces lipid accumulation in HCC cells, with a concurrent decrease in key lipid metabolism markers such as FSAN, ACLY and ACSL4, as demonstrated by Western blotting. Mass spectrometry (MS) and co-immunoprecipitation (Co-IP) revealed that LRP11 recruits USP5, enhancing USP5-mediated deubiquitination of RACK1. …”
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Assessment of Water Quality and Heavy Metal Contamination in River Water and Fish Species from the Bangshi River, Tangail, Bangladesh by Mausumi Rehnuma, Jannatul Firdous Jui, Jannatul Hasna, Umme Habiba, Anamul Haque

“…This study assessed water quality and heavy metal concentrations in the river, focusing on two fish species, Tengra (Mystus nigriceps) and Tara baim (Macrognathus aral). …”
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siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study by Muhammad Hossein Ashoub, Ali Afgar, Alireza Farsinejad, Razieh Razavi, Samira Anvari, Ahmad Fatemi

“…This was characterized by the upregulation of ferroptosis promoters (lipid-ROS, Fe²⁺, ACSL4) and suppression of inhibitors (GSH, GPx, SLC7A11, GPx4). …”
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Research Review and Prospect of Litchi Fruit Cracking by Xiwen LI, Haoshuang SUN, Xuequn PANG, Zhaoqi ZHANG

“…Litchi is the most important high-quality fruit tree species in South China, and is also a representative fruit tree with aril as the edible part in the Sapindaceae family. …”
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Mental Health Literacy among Accredited Social Health Activists in a Community Development Block, West Bengal, India: A Mixed-method Study by Ankita Moulik, Santanu Ghosh, Amrita Samanta

“…Results: The mean age of participants was 37±13.5 years, with 70.1% being Hindus and 47.8% being unreserved. The MHL score ranged from 50 to 115. The Independent samples t-test revealed a statistically significant difference in means between the two age groups (less than 38 years vs. 38 years or older). …”
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Identification of a Ferroptosis-Related Signature Associated with Prognosis and Immune Infiltration in Adrenocortical Carcinoma by Xi Chen, Lijun Yan, Feng Jiang, Yu Lu, Ni Zeng, Shufang Yang, Xianghua Ma

“…Ferroptosis, a new form of cell death, differs from other forms of cell death and plays a vital role in tumor progress. …”
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Volatility dynamics of stock returns, liquidity and exchange rates in ASEAN Countries by David Umoru, Beauty Igbinovia, Emoabino Muhammed, Rashidat Inobemhe Ali

“…By employing FIGARCH-DCC and ARDL models, the study aimed to provide a more robust understanding of stock market dynamics. …”
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