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Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Published 2025-01-01“…In the presence of rituximab (RTX), cytotoxicity of all three types of CFR T cells against CD20+ Raji-wt, K562-CD20+, and primary tumor cells was significantly higher than that of the mock T cells (P < 0.001). When herceptin was used, all three types of CFR T cells exhibited significant cytotoxicity against HER2+ cell lines of SK-BR-3, SK-OV-3, and HCC1954 (P < 0.001). …”
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Role of Fcγ receptors in HER2-targeted breast cancer therapy
Published 2022-01-01“…Margetuximab enhances Fc-dependent ADCC in vitro more potently than the combination of pertuzumab (another approved mAb directed against an alternate HER2 epitope) and trastuzumab. …”
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Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis
Published 2015-01-01“…Lower concentration FcE 2 exhibited better inhibition than FcE 20, consistent with previous FcE studies referencing a biphasic dose-response curve. …”
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Fermentation characteristics of lactofermented cucumbers using an isolated Lactiplantibacillus plantarum NCHU–FC1 strain
Published 2025-06-01“…The isolated LAB strain was identified as a Lactiplantibacillus (Lpb.) plantarum strain coding as Lpb. plantarum NCHU–FC1. The pH value was quickly lower than 4.6 (aka high-acid foods), while total nitrite contents were below the standard limit using 1 × 107 colony forming unit (CFU)/mL Lpb. plantarum NCHU–FC1 at 4 °C for 5 days. …”
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Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn
Published 2024-12-01“…Furthermore, IgG1-YTE displayed a pH switch for the avidity enhancement factor at pH 6.2, reflecting strong receptor binding to both sides of the YTE-containing Fc, while avidity was abolished at pH 7.4. When compared with classical surface plasmon resonance (SPR) technology and complementary methods, the use of switchSENSE demonstrated superior capabilities in differentiating affinity from avidity within a single measurement. …”
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Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB
Published 2015-01-01“…Fc gamma receptor IIB (FcγRIIB) is the only Fc gamma receptor (FcγR) which negatively regulates the immune response, when engaged by antigen- (Ag-) antibody (Ab) complexes. …”
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Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells
Published 2015-01-01“…In addition to the well-characterized IgE/FcεRI-mediated degranulation, a variety of biological substances can induce MCs activation and release of their granule content. …”
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Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
Published 2024-12-01“…Bapi-Fab8D3 showed high brain uptake and the brain-to-blood ratio of its FcRn mutated form was significantly higher in AppNL-G-F mice than in WT mice 12 h after injection and increased further up to 168 h. …”
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Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants
Published 2025-01-01“…In ACE2 transgenic mice, the Fc-binding nanodisc protected better than sACE2-Fc alone with two more log reduction in lung viral titer. …”
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Polymeric Multivalent Fc Binding Peptides‐Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA‐4
Published 2025-01-01“…In this study, polymeric multivalent Fc‐binding peptides (PLG‐Fc‐III‐4C) are employed to fabricate a bispecific antibody (PD1/CTLA‐4 BsAb) to potentiate dual immunotherapy targeting PD1 and CTLA‐4. …”
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Development and Evaluation of an In-House ELISA to Detect Anti-FcεR1α IgG Autoantibodies in Chronic Spontaneous Urticaria Patients
Published 2022-01-01“…ELISA revealed that healthy people had a basal level of IgG anti-FcεR1α autoAbs, whereas their levels were significantly lower than autoAbs levels in CSU patients. …”
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Approximatives (More than/Less than) in Modern Japanese Language
Published 2012-04-01Get full text
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SẢN XUẤT THỬ NGHIỆM CHẾ PHẨM MEN VI SINH VÀ CHẾ PHẨM XỬ LÝ MÔI TRƯỜNG CHO SINH VẬT THỦY SINH
Published 2012-03-01Get full text
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Local structural–functional coupling with counterfactual explanations for epilepsy prediction
Published 2025-02-01“…Compared with previous methods, the proposed patterns quantify the relationship between SC and FC in terms of subgraphs rather than whole connections or single brain regions. …”
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CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens
Published 2025-02-01“…This isoform contains an inhibitory ITIM motif within a cytoplasmic tail anchored to the cortical cytoskeleton. We thus generated a non-signaling CD32B1 mutant lacking the ITIM motif (termed ITIM-less CD32B1, or ILCD32B1) and successfully expressed it in human T cells which normally do not express this FcR. …”
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FINITE ELEMENT MODELING OF THIN CIRCULAR SANDWICH PLATES DEFLECTION
Published 2016-10-01Get full text
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DEFORMATION CRITERION OF OPTIMIZATION OF ROUTES OF THIN HIGH-CARBON WIRE DRAWING
Published 2012-11-01Get full text
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Behavior of Hollow Thin Welded Tubes Filled with Sand Slag Concrete
Published 2016-01-01Get full text
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