Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells by Xiaoming Kang, Xiaoming Kang, Lu Ma, Lu Ma, Lu Ma, Jie Wen, Jie Wen, Wei Gong, Wei Gong, Xianlin Liu, Xianlin Liu, Yihan Hu, Yihan Hu, Zhili Feng, Zhili Feng, Qiancheng Jing, Qiancheng Jing, Yuexiang Cai, Yuexiang Cai, Sijun Li, Xinzhang Cai, Kai Yuan, Yong Feng, Yong Feng, Yong Feng, Yong Feng, Yong Feng

“…Furthermore, significant alterations were noted in the PI3K-Akt signaling pathway and the calcium signaling pathway, which could potentially influence gap junction function and contribute to hearing loss. In summary, our study based on patient-derived iPSCs sheds new light on the molecular mechanisms by which TMEM43 mutations may lead to ANSD. …”
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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…Findings – The paper’s findings reveal severe, systematic destruction of Gaza’s educational infrastructure, including schools and universities, with extensive loss of life among students and educators. The research shows that this “Educide” disrupts educational access for current and future generations, stifles intellectual growth and threatens the preservation of Palestinian identity and heritage. …”
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Urban monitoring, evaluation and application of COVID-19 listed vaccine effectiveness: a health code blockchain study by Tao Wang, Hongyan Li, Chaoqun Li, Zheheng Li

“…Virus variation aggravates the loss, and then increases the deviation. Simulation case 1 assumes the unvaccinated rate of 0.8, the ongoing VR of 0.1, the completed VR of 0.1 and an average infection rate of 2% for the variant virus. …”
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Experimental analysis of micro-cavity influence on the effective solar absorptance of white sand curtain on porous obstructions of particle heating receivers by Rageh Saeed, Shaker Alaqel, Eldwin Djajadiwinata, Nader S. Saleh, Abdulelah Alswaiyd, Hany Al-Ansary, Syed Noman Danish, Abdelrahman El-Leathy, Zeyad Al-Suhaibani, Sheldon Jeter, Redhwan Almuzaiqer, Zeyad Almutairi

“…Within this curtain, micro-cavities are generated, which dramatically reduce radiation loss to the sky by facilitating multiple reflections, effectively trapping intercepted rays, and thereby maximizing solar absorptance. …”
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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Plain language summary The BISTRO trial was commissioned by the National Institute for Health and Care Research Health Technology Assessment after wide public consultation to establish whether the use of bioimpedance to guide fluid management in haemodialysis patients could slow down the loss of their remaining kidney function. It was clear that the design and conduct of the trial would present particular challenges as it asked a lot of participants over a 2-year period. …”
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Prevalence of anxiety symptoms and associated factors at 2 months postpartum, results from a 2021 French national prospective cohort study by Alexandra Doncarli, Virginie Demiguel, Camille Le Ray, Catherine Deneux-Tharaux, Elodie Lebreton, Gisèle Apter, Julie Boudet-Berquier, Catherine Crenn-Hebert, Marie-Noëlle Vacheron, Nolwenn Regnault, Sarah Tebeka, Members of the ENP2021 Study Group

“…Associated risk factors were: age ≤ 34 years (maximum aPR = 1.38 [1.22–1.58] obtained for persons aged 25–29 years vs. 35–39 years), poorer health literacy (1.15 [1.07–1.23]), a history of medical termination of pregnancy (1.32 [1.05–1.68]), psychological (1.31 [1.17–1.47]) or psychiatric (1.42 [1.24–1.63]) care history since adolescence, nulliparity (1.23 [1.12–1.35]), no weight gain or loss (1.29 [1.03–1.61] vs. 9–15 kg gain) or gain ≥23 kg (1.20 [1.00–1.43]) during pregnancy, ≥3 pregnancy-related emergency consultations (1.16 [1.03–1.31] vs. none), poor/good support during pregnancy, (1.16 [1.00–1.34] and 1.15 [1.05–1.26], respectively, vs. very good), sadness (1.52 [1.36–1.69]), anhedonia (1.48 [1.27–1.72]), or both (1.99 [1.79–2.21]) during pregnancy, not at all/not very satisfied with pain management during childbirth (1.16 [1.01–1.32] vs. quite/very satisfied). …”
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Biodegradable Mg alloy modified with bioactive exosomes for cardiovascular stent application by Ya-chen Hou, Jing-an Li, Chang Cao, Chang Su, Zhen Qin, Ge Zhang, Jia-cheng Guo, Jun-nan Tang, Jin-ying Zhang, Shao-kang Guan

“…The electrochemical test and weight loss test reflected the MgF2-PDA/exosome coating increase the corrosion resistance of the Mg-Zn-Y-Nd alloy. …”
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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

“…Finally, we show with single-cell resolution that the loss of function of DNMT3A is directly associated with increased chromatin accessibility in mutant cells. …”
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Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis by Marco Rosina, Silvia Scaricamazza, Flaminia Riggio, Gianmarco Fenili, Flavia Giannessi, Alessandro Matteocci, Valentina Nesci, Illari Salvatori, Daniela F. Angelini, Katia Aquilano, Valerio Chiurchiù, Daniele Lettieri Barbato, Nicola Biagio Mercuri, Cristiana Valle, Alberto Ferri

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective loss of motor neurons. The contribution of peripheral organs remains incompletely understood. …”
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Surface prereacted glass-ionomer particles incorporated into resin composites promote biocompatibility for restoration of subgingival dental defects by Yueyi Yang, Jing Huang, Xuchen Hu, Meiling Jing, Yujie Zhang, Chenci Xu, Wenduo Tan, Xiaoyu Liu, Chenguang Niu, Zhengwei Huang

“…These defects commonly accompany lesions involving marginal alveolar bone loss and gingival recession, and their clinical management is challenging. …”
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Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans by Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang

“…Abstract Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. …”
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Pyrolysis conversion of crown-ether-based covalent networks to kagome metal-organic frameworks on Au(111) and Ag(111) by Yifan Liang, Jianing Wang, Ruoting Yin, Zhengya Wang, Xiaoqing Wang, Jie Meng, Shijing Tan, Chuanxu Ma, Qunxiang Li, Bing Wang

“…For the Ag(111) surface, further annealing at 520 K initiates a unique dehydrogenative reaction within the macrocyclic rings, resulting in the loss of six hydrogen atoms. At an elevated temperature of 720 K, breaking of the second C−O bonds yields a long-range ordered triphenylene-based MOF structure. …”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…Cell-cycle analysis showed a complete loss of proliferating cells with a simultaneous increase in S-phase arrest beginning at a threshold dose of 30 μM. …”
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Dense Nursery Stock Detecting and Counting Based on UAV Aerial Images and Improved LSC-CNN by PENG Xiaodan, CHEN Fengjun, ZHU Xueyan, CAI Jiawei, GU Mengmeng

“…Finally, the model was trained using label smooth cross-entropy loss function and grid winner-takes-all strategy, emphasizing regions with highest losses to boost tree feature recognition.…”
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Cutin formation in tomato is controlled by a multipartite module of synergistic and antagonistic transcription factors by Yuan Shi, Changhao Deng, Xiangyin Lu, Yan Wang, Yaowen Pan, Deding Su, Wang Lu, Yuxiang Lin, Rui Li, Junnan Han, Yanwei Hao, Yi Chen, Ghassen Abid, Julien Pirrello, Mondher Bouzayen, Yudong Liu, Zhengguo Li, Baowen Huang

“…Summary: Cuticles protect plants from water loss and pathogen attack. We address here the functional significance of SlGRAS9, SlZHD17, and SlMBP3 in regulating cutin formation in tomato fruit. …”
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Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium by Kaifeng Chen, Lili Li, Nanwei Wang, Zhouping Zhou, Peng Pan, Chenggang Xu, Dage Sun, Jiayi Li, Changzhi Dai, Dai Kuang, Ming Liao, Jianmin Zhang

“…In in vivo experiments, mice challenged with 269ΔSTM0343 experienced greater weight loss, and the bacterial loads in the spleen, liver, and intestines were elevated by fivefold, 30-fold, and 21-fold, respectively, accompanied by more severe pathological damage. …”
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Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia by Haotian Ma, Zhifeng Yan, Runxia Gu, Yingxi Xu, Shaowei Qiu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang

“…However, the inability to sustain tumor-free survival and the possibility of relapse due to antigen loss have raised concerns. A dual targeting of CD33 and CD123 is needed for better outcomes. …”
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GATA2 mutated allele specific expression is associated with a hyporesponsive state of HSC in GATA2 deficiency syndrome by Laetitia Largeaud, Vincent Fregona, Laura A. Jamrog, Camille Hamelle, Stéphanie Dufrechou, Naïs Prade, Esmaa Sellam, Pauline Enfedaque, Manon Bayet, Sylvie Hébrard, Mathieu Bouttier, Christine Didier, Bastien Gerby, Eric Delabesse, Marlène Pasquet, Cyril Broccardo

“…Defects in the CMP mature compartment, along with the inflammatory molecular signature, explain the loss of heterogeneity in HPC compartment observed in patients. …”
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Representación del trabajo manual en tres piezas de Lope de Vega : Barlán y Josafá, San Nicolás de Tolentino, y San Diego de Alcalá by Anna Sinouet

“…Il transmet ainsi l’image du paysan dévot et charitable telle que la décrit Noël Salomon.Il convient de remarquer que les œuvres dont le phénix s’est inspiré le Flos sanctorum de Pedro de Rivadeneyra, et les Discursos sobre la vida y milagros del glorioso padre San Diego, de la orden del seráfico padre San Francisco de Melchor de Cetina, évoquent deux types de travaux différents. …”
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Gambaran Pasien Tuli Mendadak di Bagian THT-KL RSUP Dr. M. Djamil Padang by Hedo Hidayat, Yan Edward, Noza Hilbertina

“…</p><p><strong>Kata kunci:</strong> tuli mendadak, retrospektif, gejala klinis</p><p>1Mahasiswa FK Unand, 2Bagian Pulmonologi FK Unand, 3Bagian Patologi Anatomi FK Unand</p><p><strong><em>Abstract</em></strong></p><p><em>Sudden</em><em> deafness is a sensorineural hearing loss  in less than 72 hours. Sudden deafness is </em><em>a neurotological </em><em>emergency and</em><em> </em><em>requiring an </em><em>early </em><em>management</em><em> to avoid </em><em>the </em><em>defects</em><em> that can be caused. …”
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