Repairbads: An automatic and adaptive method to repair bad channels and segments for OPM-MEG by Fulong Wang, Yujie Ma, Tianyu Gao, Yue Tao, Ruonan Wang, Ruochen Zhao, Fuzhi Cao, Yang Gao, Xiaolin Ning

“…Direct rejection leads to data loss, and when the number of sensors is limited, interpolation using neighboring sensors can cause significant signal distortion and cannot repair bad segments present in all channels. …”
Get full text

Comparación de un hemoglobinómetro portátil (Verio Q Red) con los resultados del laboratorio clínico en la práctica clínica habitual by Boris Trenado-Luengo, Rosa García-Sierra, Verónica Moreno Gómez, Marina Montenegro Calvo, Jordi Anguita Lapido, Pere Torán-Monserrat

“…Over 18 years old. No abandonment or loss was obtained. Main interventions and measurements: Sex, age, and reason for the blood test were collected from the medical history. …”
Get full text

Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non–Small Cell Lung Cancer With High Programmed... by Alvin H.K. Cheung, MBBS, PhD, Zeta Mui, MPhil, Walter W. Yeung, PhD, Chit Chow, PhD, Mandy F. Yu, BSc, Olivia H. Chen, MD, PhD, Kit-Yee Wong, MPhil, Fuda Xie, MPhil, Yat Ming Lau, MBBS, Alfred S-L. Cheng, PhD, Wei Kang, PhD, Ka-Fai To, MBChB, Tony S. Mok, MD, Molly S.C. Li, MBBS

“…Investigation of the tumor samples from 15 patients revealed some degree of HLA loss in the HLA class I loci in 40% (6/15) of patients, and no significant difference in tumor mutation burden was found among patients with different treatment responses. …”
Get full text

Accurate space-based NO_<i>x</i> emission estimates with the flux divergence approach require fine-scale model information on local oxidation chemistry and profile shapes by F. Cifuentes, F. Cifuentes, H. Eskes, E. Dammers, E. Dammers, C. Bryan, F. Boersma, F. Boersma

“…An attractive aspect of the FDA is that the method simplifies three-dimensional atmospheric chemistry and transport processes into a two-dimensional (longitude–latitude) steady-state continuity equation for columns that balances local <span class="inline-formula">NO_<i>x</i></span> emissions with the net outflow and chemical loss of <span class="inline-formula">NO_<i>x</i></span>. …”
Get full text

Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…Intranasal administration in mice allows the maintenance of homeostatic transcriptomic immune profile in lungs, prevents body-weight loss, decreases viral load and shedding, and protects mice from death caused by SARS-CoV-2 variants. …”
Get full text

Analysis of depression status and nursing interventions in 163 patients with liver disease (163例肝病患者抑郁状况调查及护理干预效果分析) by WANG Yundan (望运丹), WANG Weixian (王伟仙), HU Deying (胡德英), LIU Yilan (刘义兰)

“…Items with high total score included: Item ④: Feeling tired or lack of energy; Item③: Difficulty falling asleep, restless sleep or excessive sleep; Item①: Not feeling energetic or interested in doing things; Item⑤: Loss of appetite or eating too much. After implementation of nursing interventions, 3 patients with moderate-to-severe depressive liver disease were identified as been mildly depressed, 4 patients with moderate-to-severe depression and 2 patients with severe depression were identified as been moderately depressed. …”
Get full text

Sistemas Fisiográficos del Área Natural Protegida "Valle Cretácico"; Provincia de Río Negro by Nora Romina Solorza, Marcos Damián Mare

“…As an example, it is enough to mention the practice of not regulated sport activities that are aggressive for environment, which contribute to accelerate erosion processes, loss of vegetation and soils, etc., while the unplanned urban development characterized by the lack of basic services in the suburbs, has led to a high rate of extraction of wood resources of the bush, the emergence of unauthorized micro rubbish dumps, greater frequency in the fire occurrence, etc. …”
Get full text

Pregnancy after kidney and liver transplantation by A Wise, N E Diana, B Bobat, R T Saggers, S Bhoora, S Budhram, L Chauke, V G Lala, A Mahomed, D Mokgoko, M Seabi, B Moore, S Naidoo, R B Nyakoe, N Odell, G Paget, L Wium, J Zamparini

“…Despite the increased risk of maternal and fetal complications, the overall risk of graft loss during pregnancy is low. Graft survival rates are comparable between pregnant and non- pregnant transplant recipients, except for pregnancies occurring within 1 year of transplantation. …”
Get full text

Revealing the biological features of the axolotl pancreas as a new research model by Hui Ma, Hui Ma, Hui Ma, Guangcong Peng, Yan Hu, Binbin Lu, Binbin Lu, Yiying Zheng, Yingxian Wu, Weimin Feng, Yu Shi, Xiangyu Pan, Li Song, Ina Stützer, Yanmei Liu, Jifeng Fei, Jifeng Fei, Jifeng Fei

“…The mutation of Pdx1 resulted in hyperglycemia and a significant reduction in pancreatic cell mass, including a complete loss of endocrine cells, although it did not lead to a lethal phenotype.DiscussionThis study examines the axolotl pancreas, highlighting the conservation of pancreatic development. …”
Get full text

Investigation of the Prevalence of Infectious Myonecrosis Virus (IMNV) from 2022 to 2023 by Ruidong XU, Jitao XIA, Ping LI, Xingtong YU, Liang YAO, Wenqiang LI, Tianchang JIA, Qingli ZHANG

“…Infectious muscle necrosis (IMN) caused by infectious myonecrosis virus (IMNV) broke out for the first time in Chinese shrimp in 2020, causing substantial economical loss to the shrimp farming industry. To understand the prevalence of Chinese IMNV in recent years, an epidemiological survey of IMNV was conducted in major Chinese shrimp farming areas between 2022–2023. …”
Get full text

Estimación de Erosión Hidrica de Suelos para plan de Manejo del Campo Forestal Aguas Frías, Patagonia Argentina by Ana Cecilia Dufilho, María Cristina Frugoni, Pablo Macchi, Alan Thot

“…The estimation of the potential erosion of the floors of the forest field was carried out utilizing the Universal Soil Lost Equation (USLE) and ArcGis 9,2 (ESRI, 2006) to carry out the spatial analysis, obtaining a map of annual soil loss ( tn/has/year) with a spatial resolution of 30 m. …”
Get full text

Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era by Ayotola Fatola, Michael D. Evans, Jenna Brown, Elizabeth Davis, Andrew Johnson, Ana G. Antun, Andrew M. Farland, Ryan Woods, Ara Metjian, Yara A. Park, Gustaaf de Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Susan Eubanks, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, J. Evan Sadler, Meera Sridharan, Ronald S. Go, Keith R. McCrae, Harsh Vardhan Upreti, Ming Y. Lim, Nicole K. Kocher, Radhika Gangaraju, X. Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Marshall Mazepa, Shruti Chaturvedi

“…In the prospective cohort, overall RFS progressively shortened after each episode of rituximab treatment with the first episode having the longest RFS (2.8 years; interquartile range, 2.0-6.0) and this loss of response durability was most pronounced in Black patients. …”
Get full text

Systematic review of integrated mental and physical health services for children and young people with eating and functional symptoms by Efthalia Massou, Josefine Magnusson, Naomi J Fulop, Saheli Gandhi, Angus IG Ramsay, Isobel Heyman, Sara O’Curry, Sophie Bennett, Tamsin Ford, Stephen Morris

“…Limitations The lack of conceptual consistency about the definition of integrated care may have driven false screening and loss of some evidence. The same limitation applies in terms of the definition of functional symptom disorders. …”
Get full text

Brief Report: Clinical Characteristics and Outcomes of Patients With Thoracic SMARCA4-Deficient Undifferentiated Tumors by Alissa J. Cooper, MD, Andrea Arfe, PhD, Biagio Ricciuti, MD, Andréanne Gagné, MD, PhD, Lynette M. Sholl, MD, Alessandro Di Federico, MD, Mark M. Awad, MD, PhD, Mihaela Aldea, MD, PhD, Maria Rosa Ghigna, MD, Miruna Grecea, MD, Phoebe Clark, MS, Jamie E. Chaft, MD, Mark G. Kris, MD, Gregory J. Riely, MD, Charles M. Rudin, MD, PhD, Ibiayi Dagogo-Jack, MD, Mari Mino-Kenudson, MD, Lingzhi Hong, MD, PhD, Neda Kalhor, MD, Natalie Vokes, MD, Anita Bowman, MS, Soo-Ryum Yang, MD, Natasha Rekhtman, MD, PhD, Adam J. Schoenfeld, MD

“…Methods: We collected clinical, pathologic, and demographic variables from five institutions for patients whose tumors met criteria for SMARCA4-UTs (undifferentiated phenotype and loss of SMARCA4 (BRG1) by immunohistochemistry). …”
Get full text

Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma by Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. deAraujo, Heidi A. Neubauer, Anna Orlova, Sanna H. Timonen, Diaaeldin I. Abdallah, Aleksandr Ianevski, Heikki Kuusanmäki, Marta Surbek, Elisabeth Heyes, Thomas Eder, Christina Wagner, Tobias Suske, Martin L. Metzelder, Michael Bergmann, Maik Dahlhoff, Florian Grebien, Roman Fleck, Christine Pirker, Walter Berger, Emir Hadzijusufovic, Wolfgang R. Sperr, Lukas Kenner, Peter Valent, Tero Aittokallio, Marco Herling, Satu Mustjoki, Patrick T. Gunning, Richard Moriggl

“…We found that both AML/NKCL cells hijack STAT3/5 signaling through either upstream activating mutations in kinases, activating mutations in STAT3, mutational loss of negative STAT regulators, or genetic gains in anti‐apoptotic, pro‐proliferative, or epigenetic‐modifying STAT3/5 targets. …”
Get full text

STR profiling in a cohort of Saudi patients with acute leukemia by Husein A. Alhatim, PhD Student, Muhammad NH Abdullah, PhD, Suhaili A. Jamaludin, PhD, Armania B. Nurdin, PhD, Sayed A. Amer, PhD

“…Results: Approximately 59.3% of patients with leukemia exhibited mutations at the STR loci. Loss of heterozygosity (LOH) occurred in 40.7% of the patients at D19S433, D16S539, vWA, D13S317, TH01, FGA, and D2S1338. …”
Get full text

Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in MiceSummary by Kensuke Hamada, Yuki Nakanishi, Yu Muta, Mayuki Omatsu, Kosuke Iwane, Munehiro Ikeda, Jiayu Chen, Yoko Masui, Naoki Aoyama, Nobukazu Agatsuma, Go Yamakawa, Takahiro Utsumi, Hiroki Kitamoto, Makoto Okabe, Yoshiro Itatani, Takumi Adachi, Koubun Yasuda, Shuji Yamamoto, Akihisa Fukuda, Etsushi Kuroda, Masaki Ohmuraya, Kazutaka Obama, Seiichi Hirota, Hiroki Ikeuchi, Kenji Nakanishi, Hiroshi Seno

“…Results: The expression of RBBP9 was reduced in human UC and CAC samples. The loss of RBBP9 enhanced the activation of interferon (IFN)/JAK/STAT1 signaling, resulting in susceptibility to DSS-induced colitis and AOM/DSS-induced CAC tumors by increasing epithelial cell apoptosis and immune activation. …”
Get full text

Logistic Regression Model in a Machine Learning Application to Predict Elderly Kidney Transplant Recipients with Worse Renal Function One Year after Kidney Transplant: Elderly KTbo... by Ubiracé Fernando Elihimas Júnior, Jamila Pinho Couto, Wallace Pereira, Michel Pompeu Barros de Oliveira Sá, Eduardo Eriko Tenório de França, Filipe Carrilho Aguiar, Diogo Buarque Cordeiro Cabral, Saulo Barbosa Vasconcelos Alencar, Saulo José da Costa Feitosa, Thais Oliveira Claizoni dos Santos, Helen Conceição dos Santos Elihimas, Emilly Pereira Alves, Marcio José de Carvalho Lima, Frederico Castelo Branco Cavalcanti, Paulo Adriano Schwingel

“…The primary endpoint was to compare elderly versus younger KT recipients by analyzing the risk covariables involved in worsening renal function, proteinuria, graft loss, and death one year after KT. The secondary endpoint was to create a robot based on logistic regression capable of predicting the likelihood that elderly recipients will develop worse renal function one year after KT. …”
Get full text

Modern theoretical-methodological and economic-legal problems of implementing the concept of sustainable development of tourism and recreation in Ukraine by Ion Dubovich, Alla Anishchenko, Nadia Yurkiv, Yuliia Volkovska, Rostyslav Matsko, Oleh Rozhkovych, Mariana-Nadiia Dubovich, Oksana Pylypiak

“…It is emphasized that the main problems that are currently hindering the implementation of the concept of sustainable development of tourism and recreation in Ukraine today are, first of all, the fact that hundreds of hectares of the territory of Ukraine are mined, the territories are contaminated with ammunition, large areas of the forest fund have been destroyed, the infrastructure has been destroyed, etc.It is noted that the Methodology for determining damage and losses, approved by the Ministry of Environmental Protection and Natural Resources of Ukraine, takes into account only a part of economic losses, while other significant losses that directly relate to the tourism and recreation industry (loss of life and health of the population of Ukraine, separation Ukrainian families, destroyed living conditions of Ukrainian citizens, damaged or destroyed residential buildings, moral, aesthetic and many other damages) are not taken into account.It is substantiated that for an objective assessment of damage and the amount of damage, it is also necessary to take into account environmental damage and destroyed natural resources, including mined and polluted hundreds of hectares of the territory of Ukraine, etc. …”
Get full text

Bridge Employment Model of Qualified Employees in Iran's Public Organizations by Seyedeh Sanaz Sadafi Mousavi, Mir ali Syed nagavi, Seyed Mehdi Alvani, Alireza Koushki Jahromi

“…Just as research is conducted to optimize a person’s working life, it is essential to think and research about the stage after his working life so that the retirement stage is not considered an abnormal stage and does not cause a loss of balance in the individual’s life. For nearly thirty years, retirement has been discussed not as a momentary event but as a process. …”
Get full text