Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach by Punchita Rujirachaivej, Teerapong Siriboonpiputtana, Kornkan Choomee, Kamonlapat Supimon, Thanich Sangsuwannukul, Pucharee Songprakhon, Krissada Natungnuy, Piriya Luangwattananun, Pornpimon Yuti, Mutita Junking, Pa-thai Yenchitsomanus

“…Chimeric antigen receptor (CAR) T-cell therapy targeting BCMA has shown efficacy in relapsed or refractory MM, but it faces resistance due to antigen loss and the tumor microenvironment. Bispecific T-cell engaging (BITE) antibodies also encounter clinical challenges, including short half-lives requiring continuous infusion and potential toxicities. …”
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The Effect of FOXA3 Overexpression on Hepatocyte Differentiation and Liver Regeneration in a Fah cKO Mouse ModelSummary by Shao Li, Chupeng Ou, Jiajun Zhang, Min Zeng, Kangyan Liang, Qing Peng, Yi Gao

“…After RF3 spheroid transplantation, Fah cKO mice exhibited increased survival, reduced weight loss, normalization of liver function and hepatocyte structure, and enhanced expression of hepatocyte differentiation factors. …”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…VSIG4 deficiency recovered the antigen presentation (B2m, H2-k1, H2-d1) of TAMs and activated antigen-specific CD8+ T cells by promoting their in vivo proliferation and intratumoral infiltration. Notably, loss of VSIG4 in TAMs significantly reduced the production of lactate and histone H3 lysine 18 lactylation, resulting the decreased transcription of SPP1 mediated by STAT3, which collectively disrupted the cell-cell interactions between TAMs and neutrophils. …”
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Effect of Irrigation Interval and Corn (Zea mays L.)-Sorghum (Sorghum bicolor L.) Intercropping on the Quantitative and Qualitative Characteristics of Fodder by Saeed Sadeghzadeh Hemayati, Hamed Mansouri, Mohsen Shahsavarpour

“…In order to calculate the benefits of intercropping, the evaluation indicators of intercropping including Land Equivalent Ratio (LER), Actual Yield Loss (AYL) and Intercropping Advantage (IA) were used (Javanshir et al., 2000). …”
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Large errors in soil carbon measurements attributed to inconsistent sample processing by R. J. Even, M. B. Machmuller, M. B. Machmuller, J. M. Lavallee, J. M. Lavallee, T. J. Zelikova, T. J. Zelikova, M. F. Cotrufo, M. F. Cotrufo

“…For % SOC, quantification by loss on ignition had a relatively low coefficient of variance (5.42 <span class="inline-formula">±</span> 3.06 %) but the least agreement (<span class="inline-formula"><i>R</i>²</span> <span class="inline-formula">=</span> 0.83) with the reference method. …”
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IOP-lowering and neuroprotective treatment for glaucoma: reality and prospects by A.E. Egorov, N.G. Glazko, A.B. Movsisyan

“…It was demonstrated that elevated intraocular pressure (IOP) is still an important and well-studied risk factor for vision loss in both open-angle and angle-closure glaucoma. …”
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Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis by Virginie Carrière, Muhammad Imran Arshad, Jacques Le Seyec, Benjamin Lefevre, Muhammad Farooq, Aurélien Jan, Christelle Manuel, Laurence Touami-Bernard, Catherine Lucas-Clerc, Valentine Genet, Hugues Gascan, Jean-Philippe Girard, Frédéric Chalmel, Lucie Lamontagne, Claire Piquet-Pellorce, Michel Samson

“…The IL-33 KO mice were more sensitive to L2-MHV3 infection exhibiting higher levels of AST/ALT, higher tissue damage, significant weight loss, and earlier death. An increased depletion of B and T lymphocytes, NKT cells, dendritic cells, and macrophages was observed 48 h postinfection (PI) in IL-33 KO mice than that in WT mice. …”
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Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility by Rosalyn W Sayaman, Masaru Miyano, Eric G Carlson, Parijat Senapati, Arrianna Zirbes, Sundus F Shalabi, Michael E Todhunter, Victoria E Seewaldt, Susan L Neuhausen, Martha R Stampfer, Dustin E Schones, Mark A LaBarge

“…In addition to age-dependent directional changes in gene expression, we observed increased transcriptional variance with age that contributed to genome-wide loss of lineage fidelity. Age-dependent variant responses were common to both lineages, whereas directional changes were almost exclusively detected in luminal epithelia and involved altered regulation of chromatin and genome organizers such as SATB1. …”
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Impact of healthy lifestyle on diabetes incidence among adults of different socioeconomic status in Guizhou province: a prospective cohort study by Yiying WANG, Min CHEN, Lieqiang ZHANG, Xin WANG, Wei ZHAN, Yunxi PAN, Xiaodeng ZHAO, Tao LIU

“…After excluding those with a history of diabetes at baseline, unclear diabetes status, loss to follow-up, and unclear follow-up outcomes, 4 747 adults were included in the final analysis. …”
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Determinants of Uterine Rupture and Its Management Outcomes among Mothers Who Gave Birth at Public Hospitals of Tigrai, North Ethiopia: An Unmatched Case Control Study by Meresa Berwo Mengesha, Desta Abraha Weldegeorges, Yared Hailesilassie, Weldu Mammo Werid, Mulu Gebretsadik Weldemariam, Fissaha Tekulu Welay, Senait Gebreslasie Gebremeskel, Berhanu Gebresilassie Gebrehiwot, Hagos Degefa Hidru, Hirut Teame, Haftay Gebremedhin, Natnael Etsay Assefa

“…Obstetrical complications like abdominal hysterectomy in 75 (55.6%) of mothers and excessive blood loss in 84 (57.8%) were additional untoward outcomes of uterine rupture. …”
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The effect of using red algae powder on growth indices, some serum and mucus indices, and mucus protein patterns in common carp (Cyprinus carpio) fry by Fatemeh Abdollahnejad, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradlou, Mohamdreza Imanpuor

“…The main reason for using these stimulants is their benefits, which include increasing growth, reducing food loss, increasing production, and obtaining a high-quality product. …”
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Real-World Evidence of Clinical Outcomes of the Use of the Adalimumab Biosimilar SB5 in Rheumatic and Gastrointestinal Immune-Mediated Inflammatory Diseases: 12-Month Data from the... by Bruno Fautrel, Yoram Bouhnik, Carine Salliot, Franck Carbonnel, Mathurin Fumery, Christophe Bernardeau, Yves Maugars, Mathurin Flamant, Fabienne Coury, Ben Braithwaite, Salima Hateb, Janet Addison, the PERFUSE investigators

“…Conclusions SB5 provides clinically effective treatment of both gastrointestinal and rheumatic IMIDs for ADL-naïve and switched patients, with no loss of control observed when switching. Persistence was comparable between naïve and switched populations, though the reasons for non-persistence differed. …”
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Medical Jousting: Going for the kill! by Dr.Fuad Ahmed Khan Niazi

“…In a study it was shown that among all the comments that were made about another doctor during patient consultation, 67% were accusing or critical while only 29% were supportive.6 This unnecessary evil, encompassing our ‘noble profession,’ can result in, not only the loss of confidence and faith in the medical professionals, but also, respect in the eyes of the common man. …”
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HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature by Dimitra P. Vageli, Panagiotis G. Doukas, Dimitrios Georgiou, Michailangelos P. Prokopiou, Nefeli E. Ladaki, Androniki Papadopoulou, Sotirios G. Doukas, Konstantina Zacharouli, Konstantinos P. Makaritsis, Maria Ioannou

“…Increased HIF-1α in vascular smooth muscle cells, macrophages, or endothelial cells, under hypoxia, chronic loss of nitric oxide (NO), or reduced micro ribonucleic acid (miRNA)-17 and miR-20, is associated with the upregulation of pro-inflammatory molecules, such as interleukin-1 beta (IL-1β) or tumor necrosis factor-alpha (TNF-α), increased migration inhibitory factor of macrophages, glycolytic flux, lipid accumulation, necroptosis via miR-383, and adverse effects in atherosclerosis and plaque vulnerability. …”
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Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…In a data set generated from BC patients refractory to conventional therapy we showed that ESR1 mutations are correlated in advanced diseases with downregulation of molecules involved in antigen presentation and with loss HLA Class I gene expression. ESR1-mutated BC had a decrease in immune cell infiltration. …”
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Preparation of Composite Films Based on Methyl Cellulose/Polyvinyl Alcohol-loaded Nanosilver (AgNPs@PVA/MC) and Its Effect on Storage Quality of Ougan by Shuaishuai DAI, Weijie WU, Xiangjun FANG, Hangjun CHEN, Jun HUANG, Ruiling LIU, Huizhi CHEN, Ben NIU, Haiyan GAO

“…Infrared spectroscopy and thermogravimetric analysis showed that composite film with 0.1% AgNPs content had good bonding and thermal stability. 0.1%AgNPs@PVA/MC composite film could effectively reduce the weight loss rate of Ougan during storage, and reduce the consumption rate of soluble solid, titratable acid and VC, delay the maturation of Ougan and significantly inhibit the growth of Penicillium citrinum, which could better maintain the quality of Ougan during the storage period, this study provided support for the sustainable development of Ougan industry.…”
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The diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia by Liping Fan, Jiahao Chen, Chong Chen, Yongwei Zhang, Yeqing Yang, Zhe Chen

“…Conclusion The levels of TC, FFAs, IL-6, ApoA1, and ApoB could contribute to changes in bone metabolism, moreover, FFAs could induce an increase in IL-6 further aggravating bone mass loss and leading to osteoporosis. Based on the comparison of the AUC results, the combination of TC, FFAs, and IL-6 with ApoA1 or the ApoA1/ApoB ratio can better predict osteoporosis or osteopenia in patients, and the diagnostic efficiency is significantly better than that of any individual indicator. …”
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Osteopenia Metabolomic Biomarkers for Early Warning of Osteoporosis by Jie Wang, Dandan Yan, Suna Wang, Aihua Zhao, Xuhong Hou, Xiaojiao Zheng, Jingyi Guo, Li Shen, Yuqian Bao, Wei Jia, Xiangtian Yu, Cheng Hu, Zhenlin Zhang

“…A few metabolites were identified as candidate early-warning biomarkers by machine learning analysis, which could indicate bone loss and provide new prevention guidance for osteoporosis.…”
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The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby cou... by Wenxin Zhang, Wenxin Zhang, Hongbo Teng, Hongbo Teng, Tianyi Zhao, Tianyi Zhao, Roberts I. Eglitis, Xv Wang, Xv Wang, Zhengxuan Yu, Shurong Qu, Shurong Qu, Haijing Wang, Haijing Wang, Yaru Zhao, Yaru Zhao, Bowen Fan, Bowen Fan, Shuangli Liu, Shuangli Liu, Yan Zhao, Yan Zhao

“…It was found that inhibiting GSK3β could protect cells from cisplatin-induced damage by activating autophagy.DiscussionThese findings suggest that compound 19 is capable of preventing ototoxicity by activating autophagy via the LRP6/GSK3β axis and consequently inhibiting oxidative stress, offering a new approach for treating CIO and sensorineural hearing loss.…”
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A prospective cohort study on the impact of healthy lifestyles on all-cause and cardiovascular disease mortality among adult residents in Guizhou province by Jie ZHOU, Ling LI, Ji ZHANG, Lisha YU, Yujin REN, Wei JI, Yingjiao MU, Tao LIU

“…After excluding participants with incomplete baseline lifestyle information and loss to follow-up, 9 085 adult residents were finally included. …”
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