Mechanism of Bushen Zhuangjin Decoction to Promote BMSCs Homing and Protect Articular Cartilage in Mice by the SDF-1/CXCR4 Axis by HUANG Yanfeng, MA Dezun, FU Changlong, YE Jinxia, HUANG Yunmei, LI Xihai

“…The fluorescence intensity of SDF-1 and CXCR4 in each group was observed by confocal laser microscope. mRNA transcription level of homing-related regulatory factors were detected by qPCR.Results(1) In the animal experiment, the joint histomorphologic findings (micro-CT and hematoxylin-eosin staining) showed that compared with the sham group, there was a circular defect between the femoral condyles, with cortical separation and loss of chondrocytes in the model group (<italic>P</italic>&lt;0.05); compared with the model group, the annular defect between the femoral condyles was improved and the arrangement of chondrocytes was slightly disordered in the BZD group. …”
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Efek Pengurangan Durasi Tidur terhadap Jumlah dan Hitung Jenis Leukosit pada Tikus Wistar by Wahyu Tri Novriansyah, Ellyza Nasrul, Rosfita Rasyid

“…</p><p>                            <strong>Kata kunci:</strong> <em>sleep deprivation</em>, leukosit, eosinofil, neutrofil, limfosit, monosit</p><p><strong><em> </em></strong></p><p><strong><em>Abstract</em></strong></p><p><em>Sleep Deprivation (SD) is a complete loss of sleep for a certain period or a shorter sleep duration than the</em><em> </em><em>optimal time required. …”
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Diagnostic markers of severe diabetic macular edema in patients with type 2 diabetes by S.A. Suk, S.Yu. Mogilevskyy

“…Diabetic macular edema (DME) is one of the common causes of vision loss in patients with type 2 diabetes mellitus (DM). …”
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Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids by Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt

“…Conversely, ACSL1 induction is not needed for IFN-I’s ability to induce the prototypical IFN-stimulated protein signature or to suppress proliferation or macrophage metabolism. Loss of ACSL1 in IFN-I stimulated myeloid cells enhances apoptosis and secondary necrosis in vitro, especially in the presence of increased saturated fatty acid load, and in a mouse model of atherosclerosis associated with IFN overproduction, resulting in larger lesion necrotic cores. …”
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Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage by Marin Kuntić, Ivana Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Dilja Krueger-Burg, Huige Li, Sebastian Steven, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber

“…This results in the annual loss of 1.6 million healthy life years. Here, we investigated the protective effects of cardiovascular drug interventions against aircraft noise-mediated cardiovascular complications such as elevated oxidative stress or endothelial dysfunction. …”
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The Anthropology of Fear of God Based on Allameh Tabatabai's Perspective: A Psychological Approach by mahmood khaliliyan shalamzari

“…According to Allameh Tabatabai, absolute fear is not a morbid emotion; rather, it is considered an illness when it leads to the loss of nafs [weakness of will] and has three characteristics: 1) creating a state of confusion in a person, 2) moaning (alfaza), and 3) decreasing the ability to deal with the source of fear (Tabatabai, 1995, p. 321).Anthropological characteristics of fear of GodIn Allama Tabatabaei’s thought, the emergence of fear of God in humans is based on four characteristics: 1) purposefulness, 2) existential characteristics of humans (dependency and connectedness of humans), 3) motivated human beings to repel harm, and 4) levels of human knowledge of monotheism. …”
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KDM6A facilitates Xist upregulation at the onset of X inactivation by Josephine Lin, Jinli Zhang, Li Ma, He Fang, Rui Ma, Camille Groneck, Galina N. Filippova, Xinxian Deng, Chizuru Kinoshita, Jessica E. Young, Wenxiu Ma, Christine M. Disteche, Joel B. Berletch

“…This was associated with aberrant overexpression of genes from the Xi after differentiation, indicating loss of X inactivation potency. Consistent with KDM6A having a direct role in Xist regulation, we found that the histone demethylase binds to the Xist promoter and KO cells show an increase in H3K27me3 at Xist, consistent with reduced expression. …”
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Donor-derived cell-free DNA for detection of acute rejection in lung transplant recipients by Gökce Yavuz, Julia Walter, Julia Walter, Kaimo Hirv, Oliver Wachter, Andrea Dick, Julia Kovacs, Julia Zimmermann, Olaf M. Glueck, Maximilian Vorstandlechner, Nicole Samm, Jan M. Fertmann, Wulf Sienel, Sebastian Michel, Sebastian Michel, Michael Irlbeck, Nikolaus Kneidinger, Nikolaus Kneidinger, Nikolaus Kneidinger, Rudolf Hatz, Rudolf Hatz, Jürgen Behr, Jürgen Behr, Christian Schneider, Christian Schneider, Teresa Kauke, Teresa Kauke

“…%ddcfDNA levels were also elevated in patients with FEV1 loss compared to those with stable or improving FEV1 after 12 months (1.98% vs. 1.36%, p=0.04). …”
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Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation by Theresa Krauss, Ibrahim Halil Gürcinar, Ulrike Bourquain, Maren Hieber, Evelyn N. Krohmer, Nan Wu, Sergey Tokalov, Rüdiger Goess, Carmen Mota Reyes, Dieter Saur, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir, Okan Safak

“…Human pancreatic cancer cell lines were found to secrete TGFbeta1, which induced EMT of perineural epithelial cells, characterized by the loss of epithelial markers (CK19-9) and the acquisition of mesenchymal markers (alphaSMA, N-Cadherin). …”
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The Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis by Haomiao Shen, Jinlin Miao, Haoyang Sun, Kui Zhang, Renli Liu, Zichao Li, Leyang Zhang, Peiyan Zhang, Jiawei Wang, Bei Zhang, Longyu Chen, Zhaohui Zheng, Ping Zhu

“…<b>Objectives:</b> Angiogenic T cells (Tang) are crucial in promoting angiogenesis, with the loss of CD28 serving as a marker for highly differentiated and senescent T cells. …”
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[Translated article] Preoperative instillation of epinephrine and lidocaine can reduce surgical time in the endoscopic treatment of GTPS by R. Seijas Vazquez, F. Montaña I Pararols, A. Ferré-Aniorte, P. Laiz Boada, M. Vázquez Gómez, R. Cugat

“…Future research should focus on more direct outcomes such as intraoperative blood loss and between different instillation protocols. …”
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miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape by Fang Chen, Dandan Zhao, Yongfang Xu, Yi Zhang, Min-Hsuan Chen, Khyatiben V. Pathak, Nate Hansen, Brooke Lovell, Yong Liang, Katrina Estrella, Wei-Le Wang, Lucy Ghoda, Russell Rockne, Xiwei Wu, Haris Ali, Jianhua Yu, Michael A. Caligiuri, Stephen J. Forman, Jeff M. Trent, Ya-Huei Kuo, Ling Li, Piotr Swiderski, Jianying Zhang, Marcin Kortylewski, Le Xuan Truong Nguyen, Patrick Pirrotte, Mark Boldin, Guido Marcucci, Bin Zhang

“…In CML murine models, miR-142 deficit impairs thymic differentiation of lymphoid-primed multipotent progenitors (LMPP) into T cells and prevents T cells’ metabolic reprogramming, thereby leading to loss of T cells and leukemia immune escape. Correcting miR-142 deficit with a miR-142 mimic compound (M-miR-142), alone or in combination with immune checkpoint antibodies, restores T cell number and immune activity, leading to LSC elimination and prolonged survival of BC CML murine and patient-derived xenograft models. …”
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APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology by Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

“…By contrast, in PS19 mice, ApoeCh suppresses the microglial and astrocytic responses to tau-laden neurons and does not reduce tau accumulation or phosphorylation, but partially rescues tau-induced synaptic and myelin loss. We compared how microglia responses differ between the two mouse models to elucidate the distinct DAM signatures induced by ApoeCh. …”
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Integrated proteogenomic characterization of ampullary adenocarcinoma by Qiao Zhang, Xiaomeng Xu, Dongxian Jiang, Yunzhi Wang, Haixing Wang, Jiajun Zhu, Shaoshuai Tang, Ronghua Wang, Shuang Zhao, Kai Li, Jinwen Feng, Hang Xiang, Zhenmei Yao, Ning Xu, Rundong Fang, Wenjia Guo, Yu Liu, Yingyong Hou, Chen Ding

“…Genomic data illustrate that 4q loss causes fatty acid accumulation and cell proliferation. …”
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Sarcopenic obesity is attenuated by E-syt1 inhibition via improving skeletal muscle mitochondrial function by Chao Song, Wu Zheng, Guoming Liu, Yiyang Xu, Zhibo Deng, Yu Xiu, Rongsheng Zhang, Linhai Yang, Yifei Zhang, Guoyu Yu, Yibin Su, Jun Luo, Bingwei He, Jie Xu, Hanhao Dai

“…To investigate the regulatory role of E-syt1 in muscle metabolism, we performed in vivo and in vitro experiments through E-syt1 loss- and gain-of-function on muscle physiology. …”
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Coal mining-induced composite damage to geological bodies and geological guarantee against damage reduction by Shuangming WANG, Qiang SUN, Xin HU, Jishi GENG, Enke HOU, Shengquan WANG, Shutao ZHOU, Qingmin SHI, Shihao YUAN, Kai CHEN, Shijie SONG

“…., a precise exploration system, an intelligent perception system, a rapid interpretation system, a risk assessment system, an engineering loss reduction system, and a comprehensive analysis platform for mining-induced composite damage. …”
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A human visual cognitive mechanism based network for surface defect detection(基于人类视觉认知机制的表面缺陷检测) by 崔丽莎(CUI Lisha), 代润鹏(DAI Runpeng), 姜晓恒(JIANG Xiaoheng), 李飞蝶(LI Feidie), 陈恩庆(CHEN Enqing), 徐明亮(XU Mingliang)

“…Additionally, the fusion branch introduces the feature preserving downsampling (FPD) module that employs patch merging technique, effectively alleviating the issue of minor defect information loss caused by traditional downsampling. HVCM-Net achieves superior detection performance on defect datasets GB-DET, NEU-DET, and DAGM2007 compared to other algorithms, demonstrating the effectiveness of the proposed method.…”
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EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis by Yang Chen, Shanshan Dong, Xin Zeng, Qing Xu, Mingwei Liang, Guangneng Liao, Lan Li, Bin Shen, Yanrong Lu, Haibo Si, Peifang Wei

“…The effects of EZH2, miR-142-3p, and HMGB1 on ER stress and pyroptosis and the hierarchical regulatory relationship between them were analyzed by chromatin immunoprecipitation, luciferase reporters, gain/loss-of-function assays, and rescue assays in interleukin (IL)-1β-induced OA chondrocytes. …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Dietary protocatechuic acid (600 mg/kg) was effective to alleviate Salmonella infection, as it suppressed the levels of cytokines and complement protein by inhibiting MAPK, I-κB kinase/NF-κB and enhancing the mTOR signaling pathway, thus offset the decline in weight loss and intestinal injury caused by infection.…”
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Catastrophic expenditure associated with childhood hospitalisation for acute illness in Kenya and Uganda: a cross-sectional study by Sassy Molyneux, Johnstone Thitiri, Laura Mwalekwa, Molline Timbwa, Anna Vassall, Kirkby D Tickell, Judd L Walson, James Berkley, John Mukisa, Ezekiel Mupere, Peter Olupot-Olupot, Priya Sukhtankar, Sheila Murunga, Julie Jemutai, George Paasi, Benson Singa, Shalton Mwaringa, Rebecca Gathoni Njuguna, Yoko V Laurence, Caroline Ogwang, Mwanajuma Juma, Narshion Ngao, Christina Lancioni, Md Fakhar Uddin

“…Caregivers reported losing a median of 7 (4–11) days of productive time during a child’s hospitalisation with a mean loss of income of US$10 (SD US$25.6, median US$0 (US$0–US$10)). 92% and 74% of households experienced catastrophic expenditure at thresholds of 10% and 25% of monthly income, respectively. …”
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