Path Analysis of Morphological Traits on Weight Traits of Breeding Mya japonica by Xiaoyan XU, Meirong DU, Tinghao WANG, Zengjie JIANG

“…For the intuitive shell size traits of shellfish, without the intuitive weight traits of the soft body and gonadal wet weights, the shellfish must be dissected and weighed pre-data collection in the laborious shellfish death after dissection is a significant loss to the breeding plant. It is crucial to determine weight trait growth (gonadal wet, soft body wet, and total wet weights) by measuring visual data (shell length, width, and height). …”
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Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…Background: premature ovarian failure (POF) is a significant condition characterized by the early loss of ovarian function, often leading to infertility and other health complications. …”
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Mechanism of Qingjie Fuzheng Granules on alleviating 5-FU chemotherapy-induced intestinal mucositis in a mouse model of Colorectal Cancer by regulating Cathepsin B/NLRP3 pathway by Yuan Yingfei, Lin Jiumao, Lin Minghe, Zhao Jinyan, Chen Xuzheng, Liu Jinhong, Zhu Xiaoqin

“…The mRNA expression levels of ZO-1 and Occludin in the jejunum tissue were detected by real-time quantitative PCR, and the protein expressions of ZO-1, Occludin, Cathepsin B, NLRP3, ASC and cleaved Caspase-1 in the jejunum tissue were detected by Western blot.ResultsDuring the experimental period, Qingjie Fuzheng Granules significantly alleviated the diarrhea symptoms induced by 5-FU (<italic>P</italic>&lt;0.05), but did not significantly improve the body weight loss induced by 5-FU (<italic>P</italic>&gt;0.05). …”
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Increasing Planting Density with Reduced Topdressing Nitrogen Inputs Increased Nitrogen Use Efficiency and Improved Grain Quality While Maintaining Yields in Weak-Gluten Wheat by Wenyin Zhou, Suhui Yan, Abdul Rehman, Haojie Li, Shiya Zhang, Yudong Yong, Yang Liu, Longfei Xiao, Chengyan Zheng, Wenyang Li

“…Increasing density significantly improved dry matter accumulation in the population, partially compensating for the yield loss due to nitrogen reduction by increasing the effective number of spikes, thereby further improving grain quality and nitrogen use efficiency. …”
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Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings by Muhammed Al-Huda Ballouk, Mohamed Altinawi, Abeer Al-Kafri, Talar S. Zeitounlouian, Piotr S. Fudalej

“…Abstract Background and objectives Gingivitis and periodontitis are common periodontal diseases that can significantly harm overall oral health, affecting the teeth and their supporting tissues, along with the surrounding anatomical structures, and if left untreated, leading to the total destruction of the alveolar bone and the connective tissues, tooth loss, and other more serious systemic health issues. …”
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The hypoxia adaptation strategy of the big-belly seahorses (Hippocampus abdominalis) with tuft gills by Long-Wu Jia, Le-Le Zhang, Hong-Wei Yang, Chun-Yu Hou, Lin Shi, Yu-Ping Hou, Guo-Dong Zheng, Xiao-Lei Su, Kai Wang

“…The average oxygen tension threshold for loss of equilibrium (LOEcrit) of BBS (2.68 mg·L−1) was higher than that of the common hypoxia-sensitive fish. …”
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The fungal microbiota modulate neonatal oxygen-induced lung injury by Isaac Martin, Mary Silverberg, Ahmed Abdelgawad, Kosuke Tanaka, Brian A. Halloran, Teodora Nicola, Erin D. Myers, Jay P. Desai, Catrina T. White, Ibrahim Karabayir, Oguz Akbilgic, Laura Tipton, Samuel J. Gentle, Namasivayam Ambalavanan, Brian M. Peters, Luan D. Vu, Viral G. Jain, Charitharth V. Lal, Stephania A. Cormier, Joseph F. Pierre, Tamás Jilling, Ajay J. Talati, Kent A. Willis

“…After using a pseudohumanized model to show that transfer to the neonatal microbiome from infants with BPD increased the severity of lung injury, we used gain and loss of function approaches to demonstrate that modulating the extent of initial neonatal fungal colonization affected the extent of BPD-like lung injury in mice. …”
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Feasibility and safety evaluation of ultra-remote robot-assisted laparoscopic hysterectomy by Juyuan Huang, Li'an Li, Jing Cheng, Jing Liao, Yurou Chen, Yi Peng, Sha Wang, Qiongyan Zou, Guoyan Zhao, Wei Zhao, Mengya You, Jingying Yang, Yan Xiong, Kunxian Zhang, Chang Chen, Jiaqiang Xiong, Haotong Guan, Renjie Liu, Peng Zhou, Wuyi Zhao, Yangyang Dong, Xiuli Sun, Sichen Liang, Wei Zhang, Jianliu Wang, Yuanguang Meng

“…The intraoperative blood loss was approximately 20 ​mL, and the surgery lasted about 70 ​min. …”
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The efficacy of sinustrabeculectomy in the modern clinical practice by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy, A.Ya. Vuks

“…The "complete" STE failure due to the loss of filtration and the onset of indications for repeat surgery was reported in 20 (4.5%) cases. …”
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Disparities in dolutegravir utilisation in children, adolescents and young adults (0–24 years) living with HIV. An analysis of the IeDEA Pediatric West African cohort by Valériane Leroy, Anandi Sheth, Julie Jesson, Jean Jacques Koffi, Antoine Jaquet, François Dabis, Didier Koumavi Ekouevi, Karen Malateste, Olivia Keiser, Lehila Bagnan, Simon Boni, Madeleine Amorissani Folquet, Mariam Sylla, Olivier Marcy, Raoul Moh, Gildas Boris Hedible, Sophie Desmonde, Joycelyn Dame, Agatha David, Madeleine Amorissani-Folquet, Sylvie N'Gbeche, Elom Takassi, François Tanoh Eboua, Kouadio Kouakou, Lehila Bagnan Tossa, Caroline Yonaba, Jocelyn Dame, Sylvie Marie N’Gbeche, Fatoumata Dicko Traore, Oliver Ezchechi, Rosemary Audu, Charlotte Bernard, Caroline Couturier, Marie Kerbie Plaisy, Elodie Rabourdin, Thierry Tiendrebeogo, Désiré Dahourou, Emile Sodinyessi, Jean-Claude Azani, Kadidja Diarra, Maika Bengali, Abdoulaye Cissé, Guy Gnepa, Eric Komena, Séverin Lenaud, Eulalie Kangah, Igho Ofotokun, Cecile Delille Lahiri, Noëlle Benzekri, Geoffrey Gottlieb

“…Baseline varied by clinic and was defined as date of first DTG prescription; patients were followed up until database closure/death/loss to follow-up (LTFU, no visit ≥7 months), whichever came first. …”
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Retinal status in moderate myopia and age-related macular degeneration. Management strategies by L.K. Moshetova, I.B. Alekseev, I.V. Vorobyeva, Yu.A. Nam

“…</i> </p> <p> <i><b>Conclusion</b>: our findings on visual field loss (MD, PSD) in AMD depending on stage and OCT findings in AMD are in line with the results of other authors. …”
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Waste marble sludge and calcined clay brick powders in conventional cement farina production for cleaner built environment by Mehmet Serkan Kırgız, Jamal Khatib, Andre Gustavo de Sousa Galdino, Said Kenai, Ahmed Ashteyat, Raul D.S.G. Campilho, Roberto Alonso Gonzalez Lezcano, Gideon Olukunle Bamigboye, N. Nagaprasad, Krishnaraj Ramaswamy

“…In addition to the microstructure analyses, the chemical features of the marble and brick wastes, including oxides, loss on ignition, pH, total organic content and clay content, were determined in accordance with current standards. …”
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Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report... by Yohei Ishiki, Atsuko Tamaki, Ken-ichiro Honma, Ken Yonaha, Takamitsu Yabiku, Taiki Teruya, Moriyuki Uehara, Yoshiro Nakayama, Rei Chinen, Tsugumi Uema, Sawako Nakachi, Shiki Okamoto, Hiroaki Masuzaki

“…Pituitary function tests revealed GH deficiency, hypogonadism, hypothyroidism and hypoadrenocorticism. MRI revealed loss of the pituitary stalk, whilst the hyperintense signal from distal axon of hypothalamus was still identified. …”
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A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

“…Methods RNA sequencing was performed to examine the mRNA expression of known deubiquitinating enzymes in CRC tissues from patients with alternate response to chemotherapy. Gain- and loss-of-function experiments were performed to evaluate the function of USP4 in regulation of stemness and drug sensitivity in CRC. …”
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SF1-specific deletion of the energy sensor AMPKγ2 induces obesity by Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López

“…Results: Our findings reveal that, in contrast to the obesity-protective effect of the genetic deletion of AMPKα subunits, the loss of AMPKγ2 in SF1 neurons leads to a sex-independent and feeding-independent obesity-prone phenotype due to decreased thermogenesis in brown adipose tissue (BAT) and reduced browning of WAT, resulting in lower energy expenditure. …”
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A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation r... by Gregory A. Swan, Gregory A. Swan, Chika Fujii, Mia E. Guzynski, Sheridan M. Page, Isabelle V. Meyers, Yordan P. Penev, Sejiro Littleton, Sejiro Littleton, Adinda Azzahra, Christine Richardson, Sophia D. Sarafova, Sophia D. Sarafova

“…In vivo, NCE-sufficient transgenic mice exhibited upregulation of Cd4 reporter EGFP mRNA levels at the INT stage and a corresponding upregulation of EGFP fluorescence, whereas NCE-deficient mice showed a significant loss of Cd4 reporter EGFP mRNA and no detectable EGFP production in any post-selection thymocytes.DiscussionThis study demonstrates that the canonical enhancer function of coreNCE/E4m is essential for CD4 upregulation following positive selection. …”
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Chikungunya virus infection in the skin: histopathology and cutaneous immunological response by Natália Gedeão Salomão, Natália Gedeão Salomão, Luciana Araújo, Luiz José de Souza, Anna Luiza Young, Carlos Basílio-de-Oliveira, Rodrigo Panno Basílio-de-Oliveira, Jorge José de Carvalho, Priscilla Conrado Guerra Nunes, Juliana Fernandes da Silva Amorim, Douglas Valiati dos Santos Barbosa, Marciano Viana Paes, Kíssila Rabelo, Kíssila Rabelo, Flavia Dos Santos

“…TNF-α, IL-6, RANTES, and VEGFR2 were expressed in the epidermis, blood vessels, sweat glands, and migrating cells. Loss of contact among adjacent keratinocytes, epidermis presenting necrotic cells, and fibroblasts with dilated cisternae in the endoplasmic reticulum and mitochondria with few cristae was observed by transmission electron microscopy. …”
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Medication related osteonecrosis (MRONJ) in the management of CTIBL in breast and prostate cancer patients. Joint report by SIPMO AND SIOMMMS by Francesco Bertoldo, Cristina Eller-Vainicher, Vittorio Fusco, Rodolfo Mauceri, Jessica Pepe, Alberto Bedogni, Andrea Palermo, Umberto Romeo, Giuseppe Guglielmi, Giuseppina Campisi

“…Background: Low-doses of bone modifying agents (LD-BMAs) compared to those used to treat bone metastases are used in breast or prostate cancer patients on adjuvant endocrine therapy to prevent Cancer Treatment Induced Bone Loss (CTIBL). Their use is associated with an increased risk of developing Medication-Related Osteonecrosis of the Jaw (MRONJ). …”
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Relationship Between Diaphragm Function and Sarcopenia Assessed by Ultrasound: A Cross-Sectional Study by Takahiro Shinohara, Toru Yamada, Shuji Ouchi, Suguru Mabuchi, Ryoichi Hanazawa, Kazuharu Nakagawa, Kanako Yoshimi, Tatsuya Mayama, Ayane Horike, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Haruka Tohara, Akihiro Hirakawa, Takuma Kimura, Takeshi Ishida, Masayoshi Hashimoto

“…<b>Background/Objectives</b>: The diaphragm is important for respiration, but the effects of age-related muscle loss and sarcopenia on diaphragm function are unclear. …”
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Epidemiological analysis primary open-angle glaucoma incidence and prevalence in Russia by A.B. Movsisyan, A.V. Kuroyedov, M.A. Arkharov, V.V. Prokhorenko, I.A.Chepurnov

“…An increase in&nbsp;visual disability and, therefore, rapid loss of working capacity in various age groups due to "late" diagnosis and treatment are also likely. …”
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