CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling by Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu, Jilei Li, Kedeerya Aishanjiang, Yujie Ma, Chang Yu, Bo Yu, Chunhong Cui, Hui Wang, Xianming Kong, Shibo Li, Xiaoni Kong, Ying Tong, Hailong Wu

“…We explored the functions of circUCK2(2,3) using gain- and loss-of-function assays. Techniques such as RNA-sequencing, RNA immunoprecipitation (RIP), polysome fractionation, RNA pulldown, dual luciferase reporter assay, inhibitors of EGFR downstream signaling, CRISPR–Cas9, and medium transfer assays were employed to investigate the regulatory mechanisms and the protumoral activities of circUCK2(2,3). …”
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Surgeon Preference and Clinical Outcome of 3D Vision Compared to 2D Vision in Laparoscopic Surgery: Systematic Review and Meta-Analysis of Randomized Trials by Rawin Amiri, BSc, Maurice J. W. Zwart, PhD, Leia R. Jones, BSc, Mohammad Abu Hilal, PhD, FRCS, Harrie P. Beerlage, PhD, FEBU, Mark I. van Berge Henegouwen, PhD, Wytze W. Lameris, PhD, Willem A. Bemelman, PhD, Marc G. Besselink, MD, MSc, PhD

“…This benefit was mostly seen in bariatric surgery (−16.3%; 95% CI, −1.28 to −0.21; P = 0.006; 2 studies; n = 58; I2 = 0%) and general surgery (−6.7%; 95% CI, −0.34 to −0.01; P = 0.036; 9 studies; n = 1056; I2 = 41%). Blood loss was nonsignificantly reduced by 3D vision (SMD, −0.33; 95% CI, −0.68 to 0.017; P = 0.060; n = 1830; I2 = 92%). …”
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Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration by Ying Wang, Zhibang Li, Ruiqing Yu, Yi Chen, Danyang Wang, Weiwei Zhao, Shaohua Ge, Hong Liu, Jianhua Li

“…Additionally, we illustrate their primary applications in addressing inflammatory bone loss, regenerating critical-size bone defects, and enhancing implant-bone integration. …”
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Diagnostic properties of differing BP thresholds for adverse pregnancy outcomes in standard-risk nulliparous women: A secondary analysis of SCOPE cohort data. by Laura Slade, Maya Blackman, Hiten D Mistry, Jeffrey N Bone, Milly Wilson, Nuhaat Syeda, Lucilla Poston, Peter von Dadelszen, Laura A Magee, SCOPE Consortium

“…Excluded were pregnancies ending in fetal loss at <20 weeks' gestation, and those terminated at any point in pregnancy. …”
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Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis by Joan Chang, Adam Pickard, Jeremy A Herrera, Sarah O'Keefe, Richa Garva, Matthew Hartshorn, Anna Hoyle, Lewis Dingle, John Knox, Thomas A Jowitt, Madeleine Coy, Jason Wong, Adam Reid, Yinhui Lu, Cédric Zeltz, Rajamiyer V Venkateswaran, Patrick T Caswell, Stephen High, Donald Gullberg, Karl E Kadler

“…Overexpression of VPS33B led to loss of fibril rhythmicity and overabundance of fibrils, which was mediated through integrin α11β1. …”
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Individual and community level factors associated with household level food insecurity of Ethiopia: multilevel mixed effects analysis of 2021 Performance Monitoring for Action Ethi... by Eyob Ketema Bogale, Tadele Fentabel Anagaw, Misganaw Guadie Tiruneh, Eneyew Talie Fenta, Destaw Endeshaw, Ousman Adal, Abiyu Abadi Tareke, Natnael Kebede, Amare Mebrat Delie

“…Households who have not been educated (AOR: 5.62 with 95% CI: 2.74, 11.5), having primary educational status (AOR: 2.58 with 95% CI: 1.35, 4.92), having secondary educational status (AOR: 2.20 with 95% CI: 1.17, 4.14), households having middle wealth status (AOR: 3.00 with 95% CI: 1.05, 8.50), households having poor wealth status (AOR: 5.18 with 95% CI: 2.00, 13.4), households doesn’t owned any livestock (AOR: 1.68 with 95% CI: 1.09, 2.84), and complete household income loss since COVID-19 restrictions began (AOR: 3.63 with 95% CI: 1.76, 7.50) were statistically associated with household-level food insecurity. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

“…In this paper, a triplet loss-based autoencoder developed by geometric deep learning (GDL) is trained using multi-task learning, which combines supervised and unsupervised learning approaches. …”
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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

“…TGF-β signaling has been implicated in cerebrovascular dysfunction, loss of blood-brain barrier (BBB) integrity, and age-related neuroinflammation. …”
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Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…This process not only leads to visible signs of skin aging, such as wrinkles and elasticity loss, but also predisposes individuals to a spectrum of age-related diseases. …”
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Correlation Between Learning and Memory Impairment and Changes in Cerebral White Matter Nerve Fibers and Pericytes in Rats with Chronic Cerebral Ischemia by HUANG Jia, WANG Mengxue, NI Jinglei, LIANG Shengxiang, LIN Bingbing

“…Compared with the sham operation group, the times of crossings of the platform and the proportion of target quadrant time in the 28 days after operation group and the 56 days after operation group were significantly lower (<italic>P</italic>&lt;0.05). (2) Changes of white matter nerve fibers in corpus callosum and hippocampus: compared with the sham operation group, the MD values of white matter nerve fibers in the left and right corpus callosum and the left and right hippocampus in the 28 days after operation group and the 56 days after operation group were significantly lower (<italic>P</italic>&lt;0.05). (3) Correlation analysis between learning and memory ability and MD values of corpus callosum or hippocampus: there was a positive correlation between the times of crossings of the platform and MD values of corpus callosum or hippocampus (<italic>r</italic>=0.832, <italic>P</italic>&lt;0.01; <italic>r</italic>=0.777, <italic>P</italic>&lt;0.01). (4) Morphology of nerve fibers in the corpus callosum: compared with the sham operation group, the structure disorder and loss of myelin sheath occurred in the corpus callosum after chronic cerebral ischemia. …”
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Tree shrew as a new animal model for musculoskeletal disorders and aging by Xiaocui Wei, Honghao Li, Jingyang Qiu, Jianlin Jiao, Xiongtian Guo, Gaosheng Yin, Ping Yang, Yi Han, Qiongzhi Zhao, Hao Zeng, Zhi Rao, Xuefei Gao, Kai Li, Pinglin Lai, Sheng Zhang, Chengliang Yang, Di Lu, Xiaochun Bai

“…Age-related spontaneous IDD in parallel with a gradual disappearance of notochordal cells were commonly observed in tree shrews upon skeletal maturity with no sex differences, while age-related osteoporotic changes including bone loss in the metaphyses were primarily presented in aged females, similar to observations in humans. …”
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Studying the Beneficial Indicators of Intercropping of Safflower (Carthamus tinctorius L.) with Chickpea (Cicer arietinum L.), Lentil (Lens culinaris Medik), and Bitter Vetch (Lath... by Amin Yari, Farzad Mondani, Alireza Bagheri, Hamid Reza Chaghazardi

“…The beneficial indicators of intercropping, including Land Equivalent Ratio (LER), Relative Crowding Coefficient (RCC), System Productivity Index (SPI), and Actual Yield Loss (AYL) were calculated. The LER indicates the amount of land required for the crop in monoculture in order to achieve a similar yield as intercropping. …”
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Ethnic and racial discrimination in maternal health care in Mexico: a neglected challenge in the search for universal health coverage by Edson Serván-Mori, Sergio Meneses-Navarro, Rocío García-Díaz, Diego Cerecero-García, David Contreras-Loya, Octavio Gómez-Dantés, Arachu Castro

“…They faced significant health coverage loss due to the dismantling of Seguro Popular, a public health insurance mechanism in place until the end of 2019, right before the start of the Covid pandemic. …”
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Application of intellectualized double-check system combined with fine management in management of hazardous chemicals in the operating room (智能化双人核对模式联合精细化管理在手术室危险化学物品管理中的应用)... by WAN Lina (万丽娜), SHEN Jianhui (沈剑辉), GAO Xinglian (高兴莲), ZHU Yan (朱艳)

“…Conclusion The intellectualized double-check system combined with fine management is potentially effective to reduce the loss of hazardous chemicals in the operating room, ensure the accuracy of recording storage and improve the quality in management of hazardous chemicals in the operating room (目的 探讨智能化双人核对管理模式联合精细化管理在手术室危险化学物品管理中的应用效果。…”
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Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

“…Our analysis revealed that chief cells and parietal cells exhibited a loss of detoxification ability and that surface mucous cells displayed a reduced antimicrobial defense ability in CAG lesions. …”
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Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…In vitro experiments demonstrated that variants in Kv7 channels induced loss-of-function (LoF) effects, while those affecting Kv3.1 or KNa1.1 led to gain-of-function (GoF). …”
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Response mechanism of water status and photosynthetic characteristics of Cotoneaster multiflorus under drought stress and rehydrated conditions by Qiu-liang Huang, Miao-miao Zhang, Chang-shun Li, Chang-shun Li, Bo-yang Li, Sheng-lan Zhuo, Yu-shan Yang, Yu-da Chen, An-na Zhong, Hao-yang Liu, Wen-feng Lai, Zhen-bei Huang, Ming-hui Cao, Zong-sheng Yuan, Guo-fang Zhang

“…Finally, C. multiflorus will strengthen the drought defense mechanism by gene regulation of various metabolisms, such as promoting stomatal closure, reducing transpiration water loss, and vigorously regulating water balance. C. multiflorus responded to drought stress by avoiding or reducing water deficit in plant organs and tissues. …”
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Needs for rehabilitation in China: Estimates based on the Global Burden of Disease Study 1990–2019 by Tian Tian, Lin Zhu, Qingzhen Fu, Shiheng Tan, Yukun Cao, Ding Zhang, Mingxue Wang, Ting Zheng, Lijing Gao, Daria Volontovich, Yongchen Wang, Jinming Zhang, Zhimei Jiang, Hongbin Qiu, Fan Wang, Yashuang Zhao, Rongman Jia

“…The highest contribution to the need for rehabilitation was musculoskeletal disorders with about 322 (95% UI: 302–343) million persons in seven aggregate disease and injury categories, and hearing loss with over 95 (95% UI: 84–107) million people among 25 health conditions. …”
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Untargeted metabolomics and functional analyses reveal that the secondary metabolite quinic acid associates with Angelica sinensis flowering by Pei Liu, Weimeng Feng, He Yang, Guang Yu, Erxin Shang, Sen Zhang, Hui Yan, Jin-ao Duan

“…Early flowering causes changes in secondary metabolic flow and results in the loss of medicinal quality. Based on untargeted metabolomics studies, quinic acid was identified as a metabolite present in significantly higher concentrations during the early-flowering stage in A. sinensis leaves. …”
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Construction of “Biomigration – Regional Cooling” Multi-functional Ecological Network in Wuhan Urban Agglomeration by Jiajie LI, Yuanyuan GU, Zhong XING

“…ObjectiveRapid urbanization has encroached on large ecological spaces, causing ecological issues like biodiversity loss, heat island effect, and flooding. To address this, ecological networks composed of source sites, corridors, and stepping-stone patches are proposed to restore landscape connectivity and integrity, thereby ensuring ecological security. …”
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