NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…While the preferential loss of mDANs has not been fully understood yet, the cell type-specific vulnerability has been linked to a unique intracellular milieu, influenced by dopamine metabolism, high demand for mitochondrial activity, and increased level of oxidative stress (OS). …”
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A Cause Analysis of the High-Content Nitrogen and Low-Content Hydrocarbon in Shale Gas: A Case Study of the Early Cambrian in Xiuwu Basin, Yangtze Region by Yizhou Huang, Kun Zhang, Zhenxue Jiang, Yan Song, Shu Jiang, Chengzao Jia, Weiwei Liu, Ming Wen, Xuelian Xie, Tianlin Liu, Xin Li, Xin Wang, Xiaoxue Liu, Ye Zhang, Ling Tang

“…In the Jurassic, the magmatic activities occurred frequently in the surrounding areas, which not only brought nitrogen from the deep crust-upper mantle but also increased the value of paleo-heat flow even though the basin began to uplift, which promoted the graphitization of organic matter and the collapse of organic pores and accelerated the loss of shale gas. Based on the study above, an explanation model was summarized to expound the causes of high-content nitrogen and low-content hydrocarbon in shale gas plays near the plate-active region in Xiuwu Basin, Lower Yangtze Region.…”
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Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice by Xinyu Sun, Long Yun, Keming Xie, Renhui Liu, Xinyue Ren, Bokun Zeng, Xudong Cao, Zhi Li, Guihao Zhou, Bang Liu, Luo Peng, Lihong Yuan

“…The effects were assessed through physiological parameters, intestinal barrier integrity, inflammation, gut microbiota composition, and transcriptomic changes.ResultsLV149 significantly improved pathological symptoms, including weight loss and disease activity index (DAI), and reduced colon shortening in a dose-dependent manner and inflammatory damage. …”
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Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile aci... by Jian Chen, Kanwar K. Malhi, Xiaowei Li, Xiangwen Xu, Jianxun Kang, Bichen Zhao, Yaru Xu, Xuenan Li, Jinlong Li

“…Weaning stress causes substantial economic loss in the swine industry. Moreover, weaning-induced intestinal barrier damage and dysfunction of the gut-liver axis are associated with reduced growth performance in piglets. …”
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Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-in... by Tengwen Liu, Shuping Li, Xuerui Wang, Mingjiang Liu, Yuchen Wang, Jie Ying, Shuwen Zhang, Yan Lin, Ning Wang, Yungjing Bai, Lan Xie, Tengfei Chen, Quansheng Feng, Xiaolong Xu

“…We revealed that XYP injection significantly reduced mortality, weight loss, lung viral titers, and lung pathology in IAV-infected mice. …”
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High-Pressure Treatment in Combination with Reduced Sodium for Improving the Physicochemical Properties and Sensory Qualities of Pork Gels by Weitong Wang, Jingying Cai, Satomi Tsutsuura, Tadayuki Nishiumi

“…High-pressure treatment applied within the range of 150–200 MPa significantly reduced cooking loss while maintaining moisture content and provided an ideal network structure for reduced-sodium pork gels. …”
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The Role of Human Agency in Global Urban Health by Kai Michael Gensitz, Catherine Woods, Tadhg MacIntyre, Claudio R. Nigg

“…., climate change, environmental degradation, biodiversity loss, increasing non-communicable diseases), particularly within urban settings (e.g., cities) where over half of the global population resides (Romanello et al., 2024). …”
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Species Diversity, Biomass Production and Carbon Sequestration Potential in the Protected Area of Uttarakhand, India by Geetanjali Upadhyay, Lalit M. Tewari, Ashish Tewari, Naveen Chandra Pandey, Sheetal Koranga, Zishan Ahmad Wani, Geeta Tewari, Ravi K. Chaturvedi

“…Ecosystem functioning and management are primarily concerned with addressing climate change and biodiversity loss, which are closely linked to carbon stock and species diversity. …”
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Identification of ecological security pattern in the Qinghai-Tibet Plateau by Wangping Li, Yadong Liu, Qingrun Lin, Xiaodong Wu, Junming Hao, Zhaoye Zhou, Xiuxia Zhang

“…However, this region is increasingly threatened by climate change and human activities, leading to degradation of ecosystems and loss of biodiversity. Understanding and protecting the ecological security pattern (ESP) of the QTP is essential for ensuring its long-term resilience and stability. …”
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Long non-coding RNA Malat1 modulates CXCR4 expression to regulate the interaction between induced neural stem cells and microglia following closed head injury by Qin Dong, Pengyu Chen, Wenqiao Qiu, Zhijun Yang, Yanteng Li, Yuhui Zhou, Lili Guo, Dan Zou, Ruxiang Xu, Mou Gao

“…Subsequently, we predicted the target genes and performed gain- and loss-of-functional studies, dualluciferase reporter, RNA immunoprecipitation, biotin-coupled miRNA pulldown, fluorescence in situ hybridization and cell transplantation assays to further elucidate the mechanism underlying the immunoregulatory effects of iNSCs. …”
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PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…Plasmid DNA has the greatest effect on apoptosis induction.The analysis of reduction and restoration of BMC subpopulations as the mice progressed to death revealed a virtually complete loss of the 12–20-mkm fraction of the cell population (about 3–4 % vs. 35–40 % in the control), which corresponds to the maximum leukopenia on day 3 after CP treatment. …”
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Users’ Perspectives of Direct-to-Consumer Telemedicine Services: Survey Study by Kate Churruca, Darran Foo, Andrew Turner, Emily Crameri, Maree Saba, Samantha Spanos, Matthew Vickers, Jeffrey Braithwaite, Louise A Ellis

“…These include DTC services that are web-based, largely asynchronous, and offer targeted treatment pathways for specific health issues (eg, weight loss or sexual function). It has been argued that DTC telemedicine improves access to health care and promotes patient empowerment. …”
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Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents by Zifeng Huang, Yi Xu, Shuo Wang, Ping Liu, Xingfang Zen, Yuwen Wang, Fang Li, Runmei Zou, Cheng Wang

“…Abstract Background Both psychogenic pseudosyncope (PPS) and vasovagal syncope (VVS) in children and adolescents are diseases of transient loss of consciousness. It is difficult to distinguish them clinically. …”
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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…We further engineered a new Kcnq2 DEE mouse model (K557E) based on the K556E variant and characterised it using behavioural, electrophysiological, and transcriptome analysis. Results: A mild loss of function was observed only when the mutant channel was co-expressed with KCNQ3 in the heterologous system. …”
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Anti-PD-1 amplifies costimulation in melanoma-infiltrating Th1-like Foxp3+ regulatory T cells to alleviate local immunosuppression by Fernando Alvarez, Fan Huang, Sonia V Del Rincon, Mikhaël Attias, Tho-Alfakar Al-Aubodah, Roman Istomine, Paige McCallum, Abrahim Sleiman, Tamiko Nishimura, Yasser Riazalhosseini, Ciriaco A Piccirillo

“…While these cells are potently suppressive outside tumor environments, costimulatory and inflammatory signals present in the tumor microenvironment lead to their local acquisition of Th1-like characteristics and loss of suppression of effector T cells.…”
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Estudio genético en adultos con glomeruloesclerosis focal y segmentaria by Melissa Pilco-Terán, Amir Shabaka, Mónica Furlano, Ana Tato Ribera, Isabel Galán Carrillo, Eduardo Gutiérrez, Roser Torra, Gema Fernández-Juárez

“…Abstract: Focal segmental glomerulosclerosis (FSGS) is a histological pattern of injury that derives from various pathological processes that affect podocytes, resulting in loss of selectivity of the glomerular filtration membrane, proteinuria and the development of renal failure that progresses to end-stage kidney disease in a significant number of patients. …”
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Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins by Anna-Sophia Hartke, Cara S. Schreiber, Kristina Lau, Ivo Wiesweg, Inken Waltl, Ulrich Kalinke, Franziska Richter, Christopher Käufer

“…As expected, the LPS dosage induced transient acute symptoms and mild weight loss in mice, with full recovery after 7 days. In aSyn over-expressing mice, this single low dose of LPS was sufficient to alter the expression of specific markers on blood and brain immune cells and induced brain region-specific microgliosis that were present at 7 days post LPS injection. …”
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Can exercise as a complementary technique manage inflammatory markers in women with breast cancer who are overweight and obese? A systematic review and meta-analysis by Liang Tan, Jinyu Mei, Ruihong Tang, Duo Huang, Kai Qi, Zbigniew Ossowski, Xiaoning Wang

“…Future researchers may consider exploring the combined effects of exercise and dietary control, weight loss, and other factors, and formulate a comprehensive treatment plan accordingly.…”
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Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease by Rebecca M. Beiter, Tula P. Raghavan, Olivia Suchocki, Hannah E. Ennerfelt, Courtney R. Rivet-Noor, Andrea R. Merchak, Jennifer L. Phillips, Tim Bathe, John R. Lukens, Stefan Prokop, Jeffrey L. Dupree, Alban Gaultier

“…Lastly, we demonstrate that clusterin deletion in mice prevents myelin loss in the 5XFAD model. Discussion: Our data suggest that clusterin could play a key role in Alzheimer's disease myelin pathology.…”
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Evaluation of CellerateRX Surgical Powder utility in reducing groin complications after femoral exposure by Vy C. Dang, BS, Eric K. Peden, MD, Trisha Roy, MD, PhD, Alan B. Lumsden, MD, Linda Le, MD, Charudatta S. Bavare, MD, Sohaib K. Mhaidi, MD, Maham Rahimi, MD, PhD

“…These complications include but are not limited to the development of seromas, hematomas, skin necrosis, or infection requiring reintervention leading to readmission, increased length of stay, and increased morbidity and mortality, including limb loss. In this non-concurrent cohort study, we evaluate the usefulness of CellerateRX Surgical Powder in preventing postoperative groin complications. …”
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