A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA by Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li, Robert Chunhua Zhao

“…Characteristics of lncRNA were revealed mainly by RACE and RNA FISH. Loss- and gain-of function experiments in vivo and in vitro were used to analyze effects of lncRNA. …”
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Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation by Yu Tang, Ruizhi Zhang, Gan Mao, Chong Li, Yisong Gao, Xuebing Zhou, Wenxiang Nie, Tianyu Song, Suao Liu, Kaixiong Tao, Peng Zhang, Wei Li

“…Results ARID1A expression demonstrated a positive correlation with CD8+ T cell infiltration and clinical prognosis. The loss of ARID1A expression led to impaired Th1-type chemokines. …”
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Chemical composition and insecticidal potential of botanical fractionation extracts for the management of Sitophilus zeamais Motschulsky, 1855 (Coleoptera: Curculionidae) in stored... by Fikadu Kifle, Melaku Girma, Araya Gebresilassie, Yitbarek Woldehawariat, Estifanos Ele

“…Experiment tests were carried out at different doses (5, 10, and 15 g/kg) on adult S. zeamais to investigate adult mortality rate, progeny inhibition rate, repellent effect, fumigation effects, and effects on grain weight loss. Mortality of adult S. zeamais was observed after application at 24, 48, and 98 h. …”
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A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer by Dali Xiong, Jiaran Li, Li Li, Fuhao Xu, Tao Hu, He Zhu, Xiaohui Xu, Yawen Sun, Shuanghu Yuan

“…The results showed that indocyanine green fluorescence imaging significantly reduced intraoperative blood loss [Weighted mean difference (WMD), –88.75; 95 % CI, –128.48 to –49.02, p < 0.05], transfusion rate [Odds ratios (OR), 0.5; 95 % CI, 0.36–0.7, p < 0.05], hospital stay duration [WMD, –1.11; 95 % CI, –1.79 to –0.43, p < 0.05], and the overall complication rate [OR, 0.59; 95 % CI, 0.44–0.79, p < 0.05]. …”
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Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage by Jiao Lv, Miao-Miao Chen, Zhi-Hao Mu, Fang Wang, Zhong-Yi Qian, Lei Zhou, Qiu-Ting Guo, Zhi-Min Zhao, Yu-Ping Pan, Xin-Yu Liao, Zhi-Hong Yang, Ning Cai, Ying-Ying Zou, Shu-De Li

“…In diabetic rats given bevacizumab injection, the ganglion cell loss and alterations of retinal thickness were ameliorated. …”
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Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord by Michal Kosinski, Anna Figiel-Dabrowska, Wioletta Lech, Lukasz Wieprzowski, Ryszard Strzalkowski, Damian Strzemecki, Lukasz Cheda, Jacek Lenart, Krystyna Domanska-Janik, Anna Sarnowska

“…Sometimes the regeneration process of bone loss is impaired, significantly slowed down, or does not occur, e.g., in congenital defects. …”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…Results: Our findings suggest that SM has antioxidant and neuroprotective potential, as evidenced by a decrease in ROS accumulation, Ca2+ overload, mitochondrial membrane potential (MMP) loss, and apoptosis in HT-22 cells subjected to glutamate-induced oxidative stress. …”
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Microvascular decompression: a contemporary update by Inibehe Ime Okon, Sidharth Sunil Menon, Mahmoud Osama, Maidan Aiman, Luis F. Fabrini Paleare, Don Lucero-Prisno Eliseo, Muhammad Danish Shafqat, Chizowa Okwuchukwu Ezeaku, Márcio Yuri Ferreira, Youssef Razouqi, Marianna Kapsetaki, Jovy Dia Remolino Saniel, Naneta M. Panit, Asad Gul Rao, Umer Iqbal, Daniel David Otobo, Ibraheem M. Alkhawaldeh, Felipe Salvagni Pereira, Imad Akbar, Omar Kasimieh, Bipin Chaurasia

“…Despite these advancements, complications such as hearing loss (1–2%) and cerebrospinal fluid leakage (2–4%) persist, highlighting the need for continuous refinement of techniques. …”
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Planetary health education in undergraduate medical education in Germany: results from structured interviews and an online survey within the national PlanetMedEd Project by Fabio Grieco, Sandra Parisi, Anne Simmenroth, Michael Eichinger, Michael Eichinger, Janina Zirkel, Janina Zirkel, Sarah König, Jana Jünger, Jana Jünger, Eva Geck, Eva-Maria Schwienhorst-Stich

“…BackgroundIn light of the accumulating evidence, awareness and urgency to act upon the three planetary crises – climate change, biodiversity loss, and pollution – the concept of Planetary Health underscores their profound implications for health and promotes actionable solutions to advance both wellbeing and ecological sustainability. …”
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Can Ethiopia eliminate malaria? Malaria burden: insights from the pre-elimination era, current challenges and perspectives by Dagmawi Woldesenbet, Yalewayker Tegegne, Abdulhakim Mussema, Elias Tamene, Kemal Mohamed, Wagaw Abebe, Melese Mekuria, Kasahun Bogale, Habtamu Geremew, Mufta Muzemil Shifa, Mulugeta Aemero Tegegne

“…The focus was on challenges of malaria elimination in Ethiopia, such as drug resistance, vectors’ insecticide resistance and the loss of the diagnostic potential of rapid diagnostic kits.Main textRecent trend analyses and World Health Organization reports indicate resurgence in malaria cases in Ethiopia. …”
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Temporal dynamics of climate sensitivity of litter decomposition in a semi-arid grassland by Zhen Li, Fuwei Wang, Yue Wen, Chenglong Ye, Peng Wang, Tongshuo Bai, Xudong Gu, Liang Guo, Yunpeng Qiu, Yi Zhang, Yi Wang, Shuijin Hu

“…We assessed the effects of warming, precipitation changes and N addition, alone and in combination, on litter loss at various stages of the decomposition process in a semi-arid grassland. …”
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NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…Results NUAK1 expression was negatively correlated with CD8+ T cell infiltration in tumor tissues from HCC patients and mice xenograft model. Both gain and loss of functions have identified NUAK1 promoted PD-L1 expression at transcriptional level in HCC cells. …”
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Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Utilizing computational pathology analysis, biopsy images were analyzed to identify the pathologic stromal changes associated with future allograft loss or vasculopathy. Biopsy images were then analyzed to assess which historical inflammatory events drive progression of these pathologic stromal changes. …”
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Robot-assisted pyeloplasty and laparoscopic pyeloplasty in children: A comparison of single-port-plus-one and multiport surgery by Jianglong Chen, Jianglong Chen, Huihuang Xu, Huihuang Xu, Shan Lin, Shan Lin, Shaohua He, Shaohua He, Kunbin Tang, Kunbin Tang, Zhixiang Xiao, Zhixiang Xiao, Di Xu, Di Xu

“…Also, the volume of blood loss was lower in the robotic groups (RMPY and RSPY) than that in the laparoscopic groups (LMPY and LSPY), although there was no statistical difference (P = 0.11). …”
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis by Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian

“…Results The coculture of VSMC with serum exosome mediated dedifferentiation of VSMC. Through gain- and loss-of-function approaches, miR-199a-5p over-expression significantly increased expression of VSMC marker genes and inhibited VSMC proliferation and migration, whilst the opposite effect was observed when endogenous miR-199a-5p was knocked down. …”
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Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma by Minh-Khang Le, Masataka Kawai, Kenta Masui, Takashi Komori, Takakazu Kawamata, Yoshihiro Muragaki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Tetsuo Kondo

“…Using the concept of multiple-instance learning, we developed an AI framework named GLioma Image-level and Slide-level gene Predictor (GLISP) to predict nine genetic abnormalities in hematoxylin and eosin sections: <i>IDH1/2</i>, <i>ATRX</i>, <i>TP53</i> mutations, <i>TERT</i> promoter mutations, <i>CDKN2A/B</i> homozygous deletion (CHD), <i>EGFR</i> amplification (<i>EGFR</i>amp), 7 gain/10 loss (7+/10−), 1p/19q co-deletion, and <i>MGMT</i> promoter methylation. …”
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Pegloticase and Methotrexate Cotherapy in Patients With Uncontrolled Gout With Prior Pegloticase Monotherapy Failure: Findings of an Open‐Label Trial by Orrin M. Troum, John K. Botson, Katie Obermeyer, Bo Chao, Yang Song, Jennifer Zarzoso, Kjerstina Gutierrez, Supra Verma, Lissa Padnick‐Silver, Brian LaMoreaux

“…One patient (9%) maintained response during month 6; 10 patients prematurely discontinued treatment (loss of SU lowering [n = 8], IR [n = 2]). Eight patients (73%) experienced ≥1 AE, most commonly gout flare. …”
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Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays by Cristina Fortuno, Inés Llinares-Burguet, Daffodil M. Canson, Miguel de la Hoya, Elena Bueno-Martínez, Lara Sanoguera-Miralles, Sonsoles Caldes, Paul A. James, Eladio A. Velasco-Sampedro, Amanda B. Spurdle

“…Results Aberrant transcript profile consistent with loss of function, and for which a PVS1 (RNA) code would be assigned, was observed for 42 (71%) of prioritised variants, of which aberrant transcript expression was over 50% for 26 variants, and over 80% for 15 variants. …”
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El IAPI y el financiamiento de la expansión industrial entre 1946 y 1955 by Julio Ruiz

“…This analysis must distinguish the cash used in IAPI loss of the borrowed funds as credits, as well as to distinguish genuine funds generated by the normal activity of the Institute from those provided from the state orbit. …”
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Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension by José A. Matamoros, Sara Rubio-Casado, José A. Fernández-Albarral, Miguel A. Martínez-López, Elena Salobrar-García, Eva M. Marco, Victor Paleo-García, Rosa de Hoz, Inés López-Cuenca, Lorena Elvira-Hurtado, Lidia Sánchez-Puebla, José M. Ramírez, Juan J. Salazar, Meritxell López-Gallardo, Ana I. Ramírez

“…Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. …”
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