Functional characterization of endocytic signals in the SynDIG/PRRT family members SynDIG1 and SynDIG4 in heterologous cells and neurons by David J. Speca, Chun-Wei He, Christina M. Meyer, Erin C. Scott, Erin C. Scott, Elva Díaz

“…The transmembrane protein Synapse Differentiation Induced Gene 4 (SynDIG4), also known as Proline-rich transmembrane protein 1 (PRRT1), is an AMPA-type glutamate receptor (AMPAR) auxiliary factor that is necessary for maintaining extra-synaptic pools of GluA1. Loss of SynDIG4, and the subsequent decrease in extra-synaptic GluA1, has been found to significantly impact synaptic plasticity in the hippocampus. …”
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Trade-Off Between Enzymatic Antioxidant Defense and Accumulation of Organic Metabolite Affects Salt Tolerance of White Clover Associated with Redox, Water, and Metabolic Homeostase... by Min Zhou, Yuting Wu, Yuchen Yang, Yan Yuan, Junnan Lin, Long Lin, Zhou Li

“…Results demonstrated that salt stress significantly induced chlorophyll loss, water imbalance, and accumulations of malondialdehyde (MDA), hydrogen peroxide (H₂O₂), and superoxide anion (O₂<sup>.…”
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Frequency and Molecular Characteristics of Mismatch Repair-deficient Status among Multiple Synchronous Colorectal Cancers by Kenichi Chikatani, Noriyasu Chika, Noriko Tanabe, Yoshiko Mori, Okihide Suzuki, Takatoshi Matsuyama, Keiichiro Ishibashi, Hidetaka Eguchi, Yasushi Okazaki, Tatsuro Yamaguchi, Hideyuki Ishida

“…The combinations of synchronous tumor sites were the left-sided colon/rectum only (n=67, 50.4%), both the right-sided colon and left-sided colon/rectum (n=42, 31.6%), and the right-sided colon only (n=24, 18.0%). IHC showed a loss of expression of at least one MMR protein in 10 (7.5%) of 133 patients and 17 (5.5%) of 309 lesions. …”
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Storage Resistance and Volatile Matter Changes in Two Varieties of Raspberries by Chao GE, Peng ZHANG, Jiangkuo LI, Xiaoyu JIA, Di WU, Chunyuan LI, Ling LIU

“…The relative content of alcohols in 'Haritaz' raspberries increased significantly with storage time (P<0.05), while the relative content of terpenes and esters decreased significantly, resulting in flavor loss. In contrast, the proportion of volatiles in 'Nova' raspberries remained stable, maintaining their flavour. …”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…Examples of circadian disruptions during sepsis and septic shock include alteration or loss of hormonal rhythms controlling blood pressure and inflammation, white blood cell counts, and cytokine secretions. …”
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Analysis of the sensitization activity of Moringa oleifera leaves protein by Juan Lu, Juan Lu, Xiaoxue Liu, Xiaoxue Liu, Wenjie Li, Wenjie Li, Chuyu Xi, Chuyu Xi, Dan Feng, Dan Feng, Shuang Song, Shuang Song

“…The study of the hemagglutination characteristics of Moringa oleifera leaves protein revealed that the protein exhibited high stability at temperatures below 60°C, with complete loss of activity occurring at temperatures above 110°C for 20 min. …”
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Comparative Evaluation of AI-Based Multi-Spectral Imaging and PCR-Based Assays for Early Detection of <i>Botrytis cinerea</i> Infection on Pepper Plants by Dimitrios Kapetas, Eleni Kalogeropoulou, Panagiotis Christakakis, Christos Klaridopoulos, Eleftheria Maria Pechlivani

“…Early detection of this pathogen is crucial for a reduction in fungicide reliance and economic loss prevention. Traditionally, visual inspection has been a primary method for detection. …”
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The impact of dietary phosphorus levels on growth, slaughter, and digestive metabolism in growing sheep by Shoupei Zhao, Xiaojun Ni, Jia Zhou, Xiaoqi Zhao, Xiao Wen, Xiaolin Wang, Mingyu Cao, Yanfei Zhao, Chong Shao, Lianghao Lu, Yuanyuan Chen, Bao Zhang, Huaming Yang, Bai Xue, Guobo Quan

“…P levels also affected P, calcium, protein, and energy metabolism, as well as apparent digestibility of acid detergent fiber (p &lt; 0.05). Using endogenous loss and comparative slaughter methods, the P maintenance requirement was determined as: Retained p = 0.5436 × Intake P – 0.0614 (R2 = 0.83, p &lt; 0.01). …”
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Leveraging Autofluorescence for Tumor Detection, Diagnosis, and Accurate Excision with Surgical Margin Assessment in Tumor Excision by Antonis Perdiou, Ramona Dumitrescu, Daniela Jumanca, Octavia Balean, Ruxandra Sava-Rosianu, Serban Talpos, Dacian Virgil Lalescu, Atena Galuscan

“…<b>Methods:</b> A prospective cohort of 80 patients was randomized into two groups: the control group underwent excision with a 10 mm margin based on clinical judgment, while the experimental group used autofluorescence guidance with a 5 mm margin beyond fluorescence visualization loss. Autofluorescence imaging was performed using the OralID device, which employs a 405 nm excitation laser to detect abnormal tissue. …”
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Thermal Response and Degressive Reaction Study of Oxo-Biodegradable Plastic Products Exposed to Various Degradation Media by S. M. Al-Salem, A. Y. Al-Nasser, M. H. Behbehani, H. H. Sultan, H. J. Karam, M. H. Al-Wadi, A. T. Al-Dhafeeri, Z. Rasheed, M. Al-Foudaree

“…The specimens were also exposed to degressive media, namely, accelerated (UV induced) weathering and soil burial field testing. The weight loss measured exceeded 58% after soil burial indicating deterioration under natural environmental stressors. …”
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Activation of Delta-Opioid Receptor Protects ARPE19 Cells against Oxygen-Glucose Deprivation/Reoxygenation-Induced Necroptosis and Apoptosis by Inhibiting the Release of TNF-α by Runjie Guo, Ping Chen, Tiantian Fu, Ren Zhang, Yuan Zhu, Nange Jin, Hong Xu, Yong Xia, Xuesong Tian

“…This study provides an innovative idea for clinical treatment strategies for retinal damage and vision loss due to RIRI.…”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Huanyu Z. Li, Ashley C. W. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer

“…Finally, using these structural, localization, and S1P transport results, we identify how pathogenic mutations ablate the protein’s export activity and thereby lead to hearing loss.…”
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Etude préliminaire de l'influence des disponibilités alimentaires et des activités humaines sur l’utilisation spatiale de l’habitat par les chimpanzés et les bonobos by Victor Narat, Marie Cibot, Jean Christophe Bokika Ngawolo, Richard Dumez, Sabrina Krief

“…Great apes are endangered due to poaching, deforestation, habitat loss and habitat fragmentation. Studying the interactions between great apes, their environment and local population is necessary for understanding the adaptability of great apes to habitat disturbance and to assess the specific threats in the local context. …”
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Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States by Dazheng Zhang, Bingyu Zhang, Qiong Wu, Ting Zhou, Jiayi Tong, Yiwen Lu, Jiajie Chen, Huiyuan Wang, Deena J. Chisolm, Ravi Jhaveri, Rachel C. Kenney, Russell L. Rothman, Suchitra Rao, David A. Williams, Mady Hornig, Linbo Wang, Jeffrey S. Morris, Christopher B. Forrest, Yong Chen

“…Within the severe group, Asian American/Pacific Islanders (AAPI) had a higher prevalence of fever/chills and respiratory signs and symptoms, Hispanic patients showed greater hair loss prevalence in severe COVID-19 cases, while Non-Hispanic Black (NHB) patients had fewer skin symptoms in comparison to NHW patients. …”
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Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…Forensic and histological studies of the cerebral cortex revealed diffuse loss of neurons, neuronophagia, satellitosis, deformed pyramidal neurons with apical dendrites and manifestations of homogenising necrosis, angiomatosis microfoci and neuropil vacuolation, mineralization of the tissue and a moderate glial reaction around the petrifications. …”
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Efficacy of laparoscopic cardiectomy combined with side overlap anastomosis for the treatment of terminal achalasia by Jing-Tao Wang, Yu-Xiang Sun, Rui-Xin Li, Yun-Fei Zhang, Heng-Xuan Ding, Guo-Jun Wang, Bu-Lang Gao

“…The surgical time ranged 60–180 min (median 100 min) with an intraoperative blood loss 20-200 ml (median 50 ml). Five (20%) patients experienced complications within a week after surgery, with fever (> 38.5 ℃) in two (40%) patients within 3 days after surgery, abdominal incision infection in one (20%), and anastomotic leak in two (40%). …”
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Smart packaging tools for selected Indian traditional buffalo milk products: a case for on-package freshness indicators by Narender Raju Panjagari, Ashish Kumar Singh, Sangita Ganguly, Rajan Sharma, Vivek Sharma

“…It was found that the initial yellow color of freshness indicators was changed to reddish-dark brown in the case of khoa and burfi while to pale pink in the case of dahi and misti dahi at the end of the storage periods, indicating loss of freshness. The total color difference (TCD) in the freshness indicators was correlated with the quality attributes of the products. …”
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Instituto de Investigaciones en Procesos Tecnológicos Avanzados, Universidad Nacional del Chaco Austral. Presidencia Roque Sáenz Peña, Chaco, Argentina by Sebastiana Failla, Michela Contò, Antonio Borghese, Vittoria Lucia Barile

“…This effect is partially lost when the forage is hayed, particularly to the loss of leaves. Hence, hay wrapping could limit these losses and increase the forage quality. …”
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Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomiz... by Hui-Min Hu, Hui-Min Hu, Wen-Hui Liu, Wen-Hui Liu, Chen Li, Chen Li, Qing Shi, Qing Shi, Chun-Hua Liu, Chun-Hua Liu, An-Xiang Liu, An-Xiang Liu, Yi-Fan Li, Yi Zhang, Peng Mao, Bi-Fa Fan

“…PurposePostherpetic neuralgia (PHN) is a type of refractory neuropathic pain that causes significant suffering, disability, economic loss, and medical burden. In this study, we aim to evaluate the efficacy and safety of interferon (IFN)-α1b injection into the intervertebral foramen of patients with PHN.Patients and methodsThis is a study protocol for a randomized, double-blind placebo-controlled multicenter clinical trial. …”
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Effects of hydrolyzed collagen supplementation for Skin Anti-Aging by Anna Gliwa, Marek Kurowski, Karolina Kuczapska, Monika Ryglewicz, Dariusz Fabian, Elbieta Leszczynska-Knaga, Natalia Jakubczyk, Weronika Rutkowska-Kawalec, Paweł Moczydłowski, Karolina Michhalczuk

“…Collagen is an essential component of the structure of the skin.With age, the amount of collagen in the skin decreases, there is a loss of elasticity as a result,wrinkles form and the appearance of the skin deteriorates. …”
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