Evaluation of current gene pool of Kholmogor and Black-and-white cattle breeds based on whole genome SNP analysis by A. V. Dotsev, A. A. Sermyagin, A. V. Shakhin, I. A.  Paronyan, K. V. Plemyashov, H. Reyer, K. Wimmers, G. Brem, N. A. Zinovieva

“…During last decades, in the Russian Federation, local livestock populations were either crossbred or replaced by highly productive imported breeds, which led to a loss of the major part of original breeds identities. …”
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Assessment of Knowledge, Attitudes and Needs of Accredited Social Health Activist (ASHA) in Community based Cancer Awareness and Screening Programme: A Mixed Method Study from a Ru... by L Meenu, N Divyamol, K Anupriya, TK Abdu Saleem

“…Breast lumps 6 (20%) and blood loss 5 (16.67%) were the common danger signs known. …”
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Subclinical Inflammatory Status in Rett Syndrome by Alessio Cortelazzo, Claudio De Felice, Roberto Guerranti, Cinzia Signorini, Silvia Leoncini, Alessandra Pecorelli, Gloria Zollo, Claudia Landi, Giuseppe Valacchi, Lucia Ciccoli, Luca Bini, Joussef Hayek

“…Rett syndrome (RTT) is a devastating neurodevelopmental disorder, mainly caused by de novo loss-of-function mutations in the gene encoding MeCP2. …”
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Irisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway by Shangman Xing, Yifan Ma, Bing Song, Bing Song, Min Bai, Kexin Wang, Wenjing Song, Tingting Cao, Chao Guo, Yanying Zhang, Zhandong Wang, Yongfeng Wang, Yongfeng Wang

“…In vivo, irisin reduced bone marrow fat deposition in aging mice and effectively alleviating the occurrence of bone loss.ConclusionIrisin mediates the Wnt signaling pathway, thereby influencing the fate determination of BMSCs. …”
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Feasibility study of a randomised controlled trial of preoperative and postoperative nutritional supplementation in major lung surgery by Amelia Swift, Sebastian T Lugg, Babu Naidu, Nikolaos Efstathiou, Amy Kerr, Hazem Fallouh, Maninder Kalkat, Richard Steyn, Salma Kadiri, Ehab Bishay, Krishna Kholia, Venessa Rogers

“…Objectives Malnutrition and weight loss are important risk factors for complications after lung surgery. …”
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Influence of Abutment Screw-Tightening Methods on the Screw Joint: Immediate and Long-Term Stability by Manlin Sun, Yusen Shui, Yuqiang Zhang, Ruiyang Ma, Yuwei Zhao, Hongyu Chen, Ping Yu, Zhi Li, Tingting Wu, Haiyang Yu

“…The PRTs were 4.08 ± 0.77–29.86 ± 0.65 Ncm for method A, 4.04 ± 0.40–29.60 ± 0.36 Ncm for method B, and 2.98 ± 0.26–26.38 ± 0.59 Ncm for method C, and the PRTs of methods A and B were 11.77%–44.87% higher than that of method C (P≤0.016). The removal torque loss rates of methods A (12.49% ± 0.99%–65.88% ± 4.83%) and B (12.84% ± 0.96%–65.35% ± 1.95%) were 3.04%–7.74% lower than that of method C (16.58% ± 0.56%–71.10% ± 1.58%) (P≤0.017). …”
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IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…IGF-1 expression was also reduced, but surprisingly this loss was confined to interneurons. Interneuron connectivity was reduced in tandem with IGF-1 deficiencies. …”
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circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer by Taofang Hao, Yuanyuan Li, Qianyao Ren, Ying Zeng, Leyi Gao, Wenbo Zhu, Jiankai Liang, Yuan Lin, Jun Hu, Guangmei Yan, Shuxin Sun, Jing Cai

“…Further gain-of-function and loss-of-function experiments have shown that circ-1584 can selectively enhance the anti-pancreatic cancer effects of the M1 virus in vitro and in vivo. …”
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Substitute for polyethylene (PE) films: A novel attapulgite super absorbent polymer applied in a semi-humid drought-prone region of the Loess Plateau by Xiaofan Pan, Hengjia Zhang, Shouchao Yu, Haoliang Deng, Xietian Chen, Chenli Zhou, Fuqiang Li, Haiyan Li

“…Residual film and microplastics are widely used to prevent soil water loss in arid farming areas of the Loess Plateau, China; however, pollution and farm land quality decline plaque this management strategy. …”
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Biomedical and candidate SN P markers of chronopathologies can significantly change affinity of ТАТА -binding protein for human gene promoters by D. A. Rasskazov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Podkolodnaya, V. V. Suslov, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

“…In the [–70; –20] region of promoters of 14 human genes (location of proven binding sites of ТВР), we found 32 known and candidate SNP markers of circadian- rhythm disturbances, including rs17231520 and rs569033466 (both: risk of chronopathologies in liver); rs35036378 (behavioral chronoaberrations); rs549858786 (rheumatoid arthritis with a chronoaberration of IL1B expression); rs563207167, rs11557611, and rs5505 (all three: chronopathologies of the tumor – host balance, blood pressure, and the reproductive system); rs1143627 (bipolar disorder with circadian dependence of diagnosis and treatment); rs16887226 and rs544850971 (both: lowered resistance to endotoxins because of the imbalance between the circadian and immune systems); rs367732974 and rs549591993 (both: circadian dependence of heart attacks); rs563763767 (circadian dependence of myocardial infarction); rs2276109 and rs572527200 (both: circadian dependence of asthma attacks); rs34223104, rs563558831, and rs10168 (circadian optima of treatment with methotrexate and cyclophosphamide); and rs397509430, rs33980857,rs34598529, rs33931746, rs33981098, rs34500389, rs63750953, rs281864525, rs35518301, and rs34166473 (all: neurosensory hearing loss and restless legs syndrome). For these SNPs, we evaluated α (significance) of changes in the affinity of ТВР for promoters, where increased affinity corresponds to overexpression of the genes, and decreased affinity to deficient expression (Z-test). …”
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Optimal power flow using recent red-tailed hawk optimization algorithm by Ahmed M Nassef, Mohammad Ali Abdelkareem, Mohamed Louzazni

“…The goals may include factors such as overall generating cost, voltage variations, voltage stability, active power transmission losses, and security enhancement. During the optimization phase, modifying the system's control variables is possible. …”
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Securing black lion tamarin populations: improving habitat-based inputs and risks for population viability analysis to inform management decisions by Francy Forero-Sánchez, Francy Forero-Sánchez, Gabriela Cabral Rezende, Gabriela Cabral Rezende, Cláudio Valladares-Pádua, Cláudio Valladares-Pádua, Fabio Stucchi Vannucchi, Fabio Stucchi Vannucchi, Leandro Jerusalinsky, Leandro Jerusalinsky, Luciana Pacca, Kathy Traylor-Holzer

“…Key among these are habitat loss and degradation, which results in smaller, isolated populations that are vulnerable to stochastic effects. …”
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Image-based robotic (ROSA® knee system) total knee arthroplasty with inverse kinematic alignment compared to conventional total knee arthroplasty by Henriëtte M. Eijking, Isobel M. Dorling, Emil H. van Haaren, Roel Hendrickx, Thijs Nijenhuis, Martijn G.M. Schotanus, Lee Bouwman, Jasper Most, Bert Boonen

“…Secondary outcomes include clinical metrics (leg alignment, implant and patient survival), surgical parameters (adverse events, surgery duration, blood loss, hospital stay length, medication use), patient-reported outcomes (symptoms, quality of life, pain), mobility and physical activity measurements, metabolic syndrome, cost-efficacy, and gait and continuous glucose monitoring. …”
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Geophysical and geotechnical assessment of Obiaruku-Agbor road failure in Western Niger-Delta, Nigeria by Ogheneovo Akpoyibo, Ezekiel Onoriode ABRIKU, Felix Chukwuka Ugbe, Ochuko Anomohanran

“…The bulk of soils from failed sections had significant values of linear shrinkage (> 8%), a large proportion of fine particles (> 40%), and pore water pressure occurred as a result in a loss of soil index strength. The majority of fines particles in lateritic soils, low California bearing ratio (08–63% un-soaked), intermediate and high OMC above guideline for most soil samples (07.4–20.1), maximum dry density (MDD) (<2000 kg/m3), and liquid limit (20.9–58.7) are the main causes of the observed degree of instability. …”
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Multi-centre comparison between device-independent web-browser perimetry (Melbourne Rapid Fields-web) and SITA-Faster for glaucoma by Joyce Tiang, Algis J. Vingrys, Algis J. Vingrys, Sarah Lin, Selwyn M. Prea, Adam Ahmed Moktar, Allan Bank, Ashish Agar, Ashish Agar, Yu Xiang George Kong, Yu Xiang George Kong, Yu Xiang George Kong

“…No significant differences were found in false positive and fixation loss rates. Test time was approximately one minute longer for MRF-web compared to SITA-Faster. …”
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Prevalence and Predictors of Self-Reported Sexual Abuse in Severely Obese Patients in a Population-Based Bariatric Program by Danielle L. Gabert, Sumit R. Majumdar, Arya M. Sharma, Christian F. Rueda-Clausen, Scott W. Klarenbach, Daniel W. Birch, Shahzeer Karmali, Linda McCargar, Konrad Fassbender, Raj S. Padwal

“…Sexual abuse may be associated with poorer weight loss outcomes following bariatric treatment. Identifying predictors of abuse would enable focused screening and may increase weight management success. …”
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Biodegradation of Phenol at High Initial Concentration by <i>Rhodococcus opacus</i> 3D Strain: Biochemical and Genetic Aspects by Tatiana O. Anokhina, Tatiana Z. Esikova, Valentina N. Polivtseva, Nataliya E. Suzina, Inna P. Solyanikova

“…In this work, it is shown that the immobilized cells can be stored for a long time (up to 2 years) without significant loss of their degradation activity. An assessment of the induction of genes potentially involved in this process was taken. …”
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

“…Initial removal of the non-canonical disulfide resulted in a loss of PD-1 affinity and cross-reactivity, which led us to explore protein engineering approaches to recover these. …”
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Association of Vitamin D Levels and Clothing Pattern in Women of Reproductive Age Group Having Chronic Back Pain by Shubham Saraswat, Anuj Rastogi, Farid Mohammad, Rachhanaa Pawaskar

“…Background: Chronic low back pain has been one of the most common musculoskeletal problems from the public health perspective owing to its high impact on disability and loss of productive years. The usefulness of Vitamin D in musculoskeletal health is widely acknowledged. …”
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PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

“…Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. Loss of PTEN function has been implicated in the pathogenesis of a number of different tumors, particularly endometrial carcinoma (ECa). …”
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