Prion protein promotes copper toxicity in Wilson disease by Raffaella Petruzzelli, Federico Catalano, Roberta Crispino, Elena V. Polishchuk, Mariantonietta Elia, Antonio Masone, Giada Lavigna, Anna Grasso, Maria Battipaglia, Lucia Vittoria Sepe, Banu Akdogan, Quirin Reinold, Eugenio Del Prete, Diego Carrella, Annalaura Torella, Vincenzo Nigro, Enrico Caruso, Nicole Innocenti, Emiliano Biasini, Ludmila V. Puchkova, Alessia Indrieri, Ekaterina Y. Ilyechova, Pasquale Piccolo, Hans Zischka, Roberto Chiesa, Roman S. Polishchuk

“…Here, using genome-wide screening, we identified the cellular prion protein (PrP) as an important mediator of Cu toxicity in WD. Loss of ATP7B stimulates hepatic expression of PrP, which promotes endocytic Cu uptake, leading to toxic Cu overload. …”
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Population Shrinkage and Spatio-Temporal Changes in Cultivated Land Use Efficiency in China’s Agro-Pastoral Ecotone by Lu Chen, Ning Zhao, Zhixun Zhang, Yun Zhang, Wenjie Zuo, Youshuo Wang, Bin Wu, Monika Stanny, Yuheng Li, Guoming Du

“…The results show the following: (1) The rural population in all provinces and counties in the agro-pastoral ecotone in northern China showed a continuous loss trend. The southwest was a hot spot area for rural population reduction, and the northeast was a cold spot area for rural population reduction. (2) During 2000–2020, the cultivated land use efficiency in the agro-pastoral ecotone in northern China showed a fluctuating upward trend, rising from 0.595 in 2000 to 0.754 in 2020. …”
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Adversarial measurements for convolutional neural network-based energy theft detection model in smart grid by Santosh Nirmal, Pramod Patil, Sagar Shinde

“…It not only results in revenue loss but also disrupts the quality of electricity, increases generation costs, and raises overall electricity prices. …”
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A tannic acid-based intumescent flame retardant for improving flame retardancy of epoxy composites by Xiaosui Chen, Yaoting Ma, Shuzheng Liu, Aiqing Zhang, Wei Liu, Shengchao Huang

“…Additionally, its peak heat release rate (PHRR), total heat release (THR) and average mass loss rate (av-MLR) decreased by 23.2%, 15.5% and 30.2% respectively. …”
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The Mla pathway promotes Vibrio cholerae re-expansion from stationary phase by Deborah R. Leitner, Franz G. Zingl, Alexander A. Morano, Hailong Zhang, Matthew K. Waldor

“…Here, we performed a transposon insertion site sequencing loss-of-function screen to identify Vibrio cholerae genes that promote pathogen fitness in stationary phase. …”
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Electroacupuncture Improves Clearance of Amyloid-β through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer’s Disease by Pei-zhe Liang, Li Li, Ya-nan Zhang, Yan Shen, Li-li Zhang, Jie Zhou, Zhi-jie Wang, Shu Wang, Sha Yang

“…Background. Memory loss and cognitive impairment characterize the neurodegenerative disorder, Alzheimer’s disease (AD). …”
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East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol by Michael Doherty, Roshan das Nair, Ana Valdes, Reuben Ogollah, Paul Greenhaff, Bonnie Millar, Michelle Hall, Amy Fuller, Polykarpos Angelos Nomikos, David A Walsh, A Abhishek

“…The UK National Institute for Health and Care Excellence OA guidelines recommend education, exercise and weight loss advice (if overweight) as core interventions before pharmacological adjuncts. …”
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Comparison of the efficacy of the modified S-P approach and the Ganz method for surgical hip dislocation in Pipkin I fractures: an early follow-up study by Hanwen Zhang, Wei Deng, Shengtao Wang, Yong Yin

“…We found that the mS-P approach was associated with a smaller incision, shorter operative time, and reduced intraoperative blood loss compared to the GSD approach (P < 0.05). The mean MHHS was 83.5 ± 9.14 and 75 ± 9.22 in the mS-P group and GSD group, respectively, P = 0.048. …”
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Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis by Binglin Cui, Jing Lin, Yuanchun Huang, Huachen Zhu, Huachen Zhu, Huachen Zhu, Jinbo Zou, Jiesheng Qin, Hui Pan, Hui Pan, Jian Chen

“…We present a rare case of dysgeusia, strawberry tongue, and psoriasis-like eruptions after simultaneous administration of adalimumab, sulfasalazine, and etoricoxib.Case descriptionA 36 year-old male with ankylosing spondylitis presented with progressive loss of taste for 3 months and rashes on his upper trunk for 5 days. …”
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GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues by Meng-Ke Song, Meng-Fan Gu, Ling Liu, Lian-Jun He, Peng Ye, Kui Yang, Dan-Dan Wang, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo

“…Conclusion RA-associated inflammation induces GPIHBP1 secretion of endothelial cells, which facilitates blood TG hydrolysis and uptake to compensate the loss in WAT.…”
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Functionalization of sawdust biochar using Mg-Fe-LDH and sodium dodecyl sulfonate enhanced its stability and immobilization capacity for Cd and Pb in contaminated water and soil by Xin Pan, Shaoping Kuang, Xiao Wang, Habib Ullah, Zepeng Rao, Esmat F. Ali, Qumber Abbas, Sang Soo Lee, Sabry M. Shaheen

“…The resistance to carbon loss by H2O2, thermal recalcitrance index R 50, and degree of graphitization in MSB were significantly improved compared to SB, indicating a more stable carbon fraction sequestered in MSB following aging in soil. …”
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Dynamin-1 is a potential mediator in cancer-related cognitive impairment by Ding Quan Ng, Casey Hudson, Tracy Nguyen, Sukesh Kumar Gupta, Yong Qin Koh, Munjal M. Acharya, Alexandre Chan

“…Dynamin-1 (DNM1) is crucial for synaptic activity, neurotransmission, and associative memory, positioning it as a potential biomarker of cancer-related cognitive impairment (CRCI), a neurological consequence of cancer treatment characterized by memory loss, poor concentration, and impaired executive function. …”
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"Preparation and curing kinetics of “bottlebrush-like structure” green bio-based ultra-low-temperature polyfarnesene nanocomposites" by WU Ming-li, LI Yong-xu, CAO Lan?鄢

“…In the range of 100-700 ℃, the mass loss fraction of GO was 48.22% and that of iGO was 58.49%. …”
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Stigmatization of people with mental illness – a matter of milieu-specific worldviews? Results from a population-based survey in Germany by Jenny Spahlholz, Eva Baumann, Sven Speerforck, Sven Speerforck, Christian Sander, Christian Sander, Matthias C. Angermeyer, Georg Schomerus, Georg Schomerus

“…Two stigma measures associated with the stereotype and status loss/discrimination components were assessed (i.e., the Social Distance Scale and a list of well-known stereotypes associated with depression or schizophrenia). …”
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Identifying specific subgroups of older patients at risk of repeated hospital readmissions and death after discharge in a prospective multicentre cohort in France by Jean-Baptiste Beuscart, Fabien Visade, Genia Babykina, Jesus Carretero-Bravo, Guillaume Deschasse, Vincent Vandewalle

“…A multivariate logistic regression analysis identified only four characteristics weakly associated with the risk of being in subgroup 2 (at least one hospital admission in the 6 months preceding the index hospital admission, cancer, polymedication and weight changes (gain or loss) during the index hospital admission). The area under the receiver operating characteristic curve was 63%.Conclusion A latent class analysis showed that a population of older adults hospitalised in an AGU is divided into two subgroups with regard to the postdischarge outcomes: one subgroup (70% of the individuals) will have a low rate of hospital readmission and a moderate death rate, whereas the other will have a high rate of hospital readmission and a very high death rate. …”
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Marigold: a machine learning-based web app for zebrafish pose tracking by Gregory Teicher, R. Madison Riffe, Wayne Barnaby, Gabrielle Martin, Benjamin E. Clayton, Josef G. Trapani, Gerald B. Downes

“…First, we examined novel aspects of the touch-evoked escape response in techno trousers (tnt) mutant embryos, which contain a previously described loss-of-function mutation in the gene encoding Eaat2b, a glial glutamate transporter. …”
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Effects of Minimally Invasive Versus Open Pancreatoduodenectomy on Short-Term Surgical Outcomes and Postoperative Nutritional and Immunological Statuses: A Single-Institution Prope... by Shinsei Yumoto, MD, Hiromitsu Hayashi, MD, PhD, Kosuke Mima, MD, PhD, Daisuke Ogawa, MD, Rumi Itoyama, MD, PhD, Yuki Kitano, MD, PhD, Shigeki Nakagawa, MD, PhD, Hirohisa Okabe, MD, PhD, Hideo Baba, MD, PhD

“…Compared with OPD, MIPD was significantly associated with less estimated blood loss (P < 0.0001), fewer intraoperative blood transfusions (P = 0.001), longer operative time, shorter postoperative hospital stay (P < 0.0001), fewer postoperative complications (P = 0.001) (especially clinically relevant postoperative pancreatic fistula [P = 0.018]), and a higher rate of textbook outcome achievement (70.7% vs 48.5%, P = 0.001). …”
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baran Luka Korban Kecelakaan Lalu Lintas yang Dilakukan Pemeriksaan di RSUP Dr. M. Djamil Padang by Isnu Lucky Riandini, Rika Susanti, Amel Yanis

“…<br />Kata kunci: kecelakaan lalu lintas, luka, VeR</p><p> </p><p>Abstract<br />Traffic accident is a condition involving vehicle or other street user, causing human victim or material loss. The objective of this study was to find the description of injuries to the victims of traffic accidents conducted an examination at RSUP Dr. …”
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Coupling mechanism of seepage and coal and rock mass destruction during coal and gas outburst by Shiling ZHANG, Junfei CUI, Shudong HE

“…From the energy point of view, the seepage force reflects the gas pressure energy loss per unit length. Permeability and surrounding rock supporting pressure act together on the coal body of the working face，which becomes an important inducement to destroy the coal body. …”
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Dual antiplatelet therapy with ticagrelor vs clopidogrel in patients with TIA or minor stroke with or without symptomatic carotid artery stenosis: a post hoc analysis of the CHANCE... by Yongjun Wang, Yilong Wang, Xingquan Zhao, Jing Jing, Hao Li, Xia Meng, Anxin Wang, Yong Jiang, Jinxi Lin, Qin Xu, Xuewei Xie, Pan Chen

“…We aimed to evaluate whether the superiority of aspirin-ticagrelor over aspirin-clopidogrel varies between patients with sCAS or not.Methods This was a post-hoc analysis of the High-Risk Patients with Acute Nondisabling Cerebrovascular Events-II (CHANCE-2) trial, all of which were CYP2C19 loss-of-function alleles carriers. The primary exposures of interest were the treatment group and sCAS status. …”
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