A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade by Manush Sondhi, Megan Lear, Saleha Dar, Madiha Tariq

“…During a rheumatology visit, he reported weight loss, fatigue, muscle weakness, and trismus. Further evaluation indicated signs of dermatomyositis, and laboratory tests revealed anti-TIF1 antibodies, prompting further investigation. …”
Get full text

NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis by Jung Hwan Yoon, Jeong-Kyu Kim, Jung Woo Eun, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Won Sang Park

“…These abnormalities corresponded with elevated levels of genomic instability markers, indicating compromised genomic integrity. Furthermore, the loss of NKX6.3 resulted in altered expression of key regulatory proteins involved in mitosis and DNA repair pathways, suggesting a mechanistic link between NKX6.3 and the maintenance of genomic stability in gastric epithelial cells. …”
Get full text

Pediatric Intracochlear Schwannoma: Case Series and Review of the Literature by Enrico Liaci, Maurizio Negri, Francesco Maccarrone, Silvia Piccinini, Enrico Pasanisi, Andrea Bacciu, Filippo Di Lella

“…The most common symptom at presentation was progressive sensorineural hearing loss (66%). Mean pure tone average at diagnosis was 74.2 dB. …”
Get full text

Trying to Kill a Killer; Impressive Killing of Patient Derived Glioblastoma Cultures Using NK-92 Natural Killer Cells Reveals Both Sensitive and Highly Resistant Glioblastoma Cells by Jane Yu, Hyeon Joo Kim, Jordyn Reinecke, James Hucklesby, Tennille Read, Akshata Anchan, Catherine E. Angel, Euan Scott Graham

“…This enabled direct comparison of the degree of glioblastoma cell loss across a broader range of glioblastoma cultures. …”
Get full text

Clinical characteristics of female Fabry disease patients with hypertrophic cardiomyopathy with mid-ventricular obstruction by Natsuko Inagaki, Yasuyoshi Takei, Tsuguhisa Hatano, Yasuyuki Takada, Yoshinao Yazaki, Hisanori Kosuge, Masatake Kobayashi, Shinji Suzuki, Tomohiro Umezu, Masahiko Kuroda, Kazuhiro Satomi, Takeharu Hayashi

“…Fabry disease (FD) is an X-linked lysosomal storage disease caused by mutations in GLA, which encodes α-galactosidase A (GLA). The loss or reduced activity of GLA leads to damage to multiple organs, resulting in the intracellular accumulation of globotriaosylceramide in various organs, including the heart, kidneys, and nervous system. …”
Get full text

Nursing of a patient with radiotherapy- and chemotherapy-induced adverse reactions treated with aruricualr acupoint pressing combined with meridian acupoint Tuina (耳穴贴压联合经穴推拿治疗放化疗后... by JIN Yi (金艺), MIN Tingyan (闵婷燕)

“…After 1 week of outpatient chemo-radiotherapy, the patient developed various adverse effects including common problems including bone marrow suppression, nausea and loss of appetite. Based on the comprehensive nursing evaluation and the concept of Traditional Chinese Medicine syndrome differentiation and care, this case adopts the method of combining auricular acupoint pressing and meridian acupoint Tuina for intervention. …”
Get full text

Development and Validation of the Self-Stigma Scale for Secondary Vocational Students (SSS-SVS) by Leng J, Cai H, Liu F, Shi X, Fan Z

“…In the second stage, the SSS-SVS, Social Recognition of Secondary Vocational Students (SR-SVS), Intensity of Willingness to Become a Secondary Vocational Student (IWB-SVS), Stigma-Consciousness Scale (SCS), Learning Adjustment Scale (LAS), Professional Identity Scale for Secondary Vocational Students (PIS-SVS), and the Self-Compassion Scale (SCoS) were administered to 1079 vocational secondary school students.Results: The SSS-SVS consisted of 21 items which were divided into three dimensions of negative characteristics, self-deprecation, and opportunity loss, reflecting secondary vocational students’ perception of negative public evaluation, self-feeling under the influence of stigma, and cognition of negative impact on their identity. …”
Get full text

Characterization of LY3324954 a long-acting glucagon-receptor agonist by William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger

“…In diet-induced obese mice, LY3324954 treatment stimulates energy expenditure, weight loss, and a reduction of adiposity in a dose-dependent manner. …”
Get full text

Brain glucose metabolism as a neuronal substrate of the abnormal behavioral response to stress in the mdx mouse, a model of Duchenne muscular dystrophy by Sébastien Goutal, Marion Lancien, François Rivier, Nicolas Tournier, Cyrille Vaillend

“…Our data support the hypothesis that enhanced stress reactivity due to loss of brain Dp427 relies on abnormal activation of the brain fear circuit and deregulation of a hypothalamus-dependent pathway.…”
Get full text

Prediction model for unfavorable treatment outcome for complicated sever acute malnutrition (SAM) in under five children admitted in hospitals at Amhara Region by Almaw Genet Yeshiwas, Zelalem Alamrew Anteneh, Tilahun Degu Tsega, Ahmed Fentaw Ahmed, Chalachew Yenew

“…Decision curve analysis indicated a higher net benefit compared to treating all or none, especially for threshold probabilities above 21%.ConclusionOur model and risk score demonstrate excellent discrimination and calibration, with minimal accuracy loss from the original, ensuring robust predictive performance. …”
Get full text

Associations of dietary oxidative balance score with sarcopenia in adults: an NHANES-based cross-sectional study by Qiang Zhou, Shang Zhou, Zuo-xi Chen, Wu-jie Zhou, Jia Su, Yong Wang

“…Abstract Background Sarcopenia, a prevalent muscle disorder in the older adults, is characterized by accelerated loss of muscle mass and function, contributing to increased risks of falls, functional decline, and mortality. …”
Get full text

Efficacy of soft palatal augmentation prosthesis for oral functional rehabilitation in patients with dysarthria and dysphagia: a protocol for a randomised controlled trial by Naoki Kodama, Tomonori Yokoyama, Takao Mukai, Kana Takao, Takashi Hiraoka, Nobuyuki Arai, Jitsuro Yano, Hiroaki Nagatsuka, Yousuke Manda, Kozo Hanayama, Shogo Minagi

“…Introduction Palatal augmentation prosthesis (PAP) is used in patients with articulation and swallowing disorders caused by postoperative loss of tongue tissue due to tongue cancer, cerebrovascular disease sequelae and age-related hypofunction. …”
Get full text

Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review by Xiaoli Liu, Xiaoli Liu, Shenglian Mao, Shenglian Mao, Yuxue Yuan, Yuxue Yuan, Zilin Wang, Zilin Wang, Yang Tian, Yang Tian, Yang Tian, Liang Tao, Liang Tao, Jiahe Dai, Jiahe Dai

“…Diabetic cognitive dysfunction is one of the important comorbidities and complications of diabetes, which is mainly manifested by loss of learning ability and memory, behavioural disorders, and may even develop into dementia. …”
Get full text

Phosphorylation of Arabidopsis NRT1.1 regulates plant stomatal aperture and drought resistance in low nitrate condition by Yuchen Kou, Bodan Su, Shunyao Yang, Wei Gong, Xi Zhang, Xiaoyi Shan

“…Results In this study, we observed that seedlings expressing the phosphorylated form of NRT1.1 (NRT1.1T101D, T101D) exhibited increased drought tolerance compared to dephosphorylated NRT1.1 (NRT1.1T101A, T101A) mutants under low nitrate (LN) condition, characterized by decreased stomatal aperture and water loss. Moreover, we found that the drought-induced depolarization of membrane potential was diminished in T101D mutants in comparison to T101A seedlings. …”
Get full text

Toward zero-excess lithium sulfur batteries: a systematic cell parameter study by Joshua H Cruddos, James B Robinson, Paul R Shearing, Alexander J E Rettie

“…Furthermore, we employ x-ray computed tomography to elucidate the morphological changes and degradation processes occurring within the positive electrode composite, revealing the irreversible loss of Li _2 S/S _8 during cycling, which is exacerbated at high rates. …”
Get full text

A Lightweight YOLO Model for Rice Panicle Detection in Fields Based on UAV Aerial Images by Zixuan Song, Songtao Ban, Dong Hu, Mengyuan Xu, Tao Yuan, Xiuguo Zheng, Huifeng Sun, Sheng Zhou, Minglu Tian, Linyi Li

“…Additionally, we integrate a Normalization-based Attention Module (NAM) and introduce a Minimum Point Distance-based IoU (MPDIoU) loss function to further improve the detection capability. …”
Get full text

Selective and persistent toxicity of seven insecticides to five egg parasitoids of Spodoptera frugiperda by Hao-Ran Li, Cheng-Yang Li, Peng Dai, Lian-Sheng Zang, Nicolas Desneux, Wei Xu

“…Abstract Background Spodoptera frugiperda, a major migratory and invasive pest, inflicts significant yield loss on rice and maize in China. As part of an integrated pest management system, biological control agents can be used against S. frugiperda, especially egg parasitoids. …”
Get full text

Soy polysaccharide maintains colonic homeostasis to protect from dextran sulphate sodium-induced colitis by modulating gut microbiota and intestinal epithelial regeneration by Nana Zhang, Jianlin Liu, Weiyue Zhang, Xinxin Guo, Shuying Li, Hongtai Zhang, Minjie Wang, Bei Fan, Fengzhong Wang

“…Pre-treatment with SP at a dosage of 400 mg/kg·day alleviated colitis symptoms, preventing the weight loss and colon shorten. SP suppressed DSS-induced inflammatory response and enhanced M1 to M2 macrophage polarization. …”
Get full text

Development of an in vitro triculture model of intestine inflammation to assess the immunomodulatory properties of cassava and roselle, two African green leafy vegetables by Nelly Fioroni, Maria Del Carmen Ponce de León Rodríguez, Nicolas Leconte, Claire Mouquet-Rivier, Caroline Guzman, Frédéric Boudard, Claudie Dhuique-Mayer, Myriam Collin, Anaïs Deglos, Emmanuelle Reboul, Ángela Bravo-Núñez, Caroline Laurent-Babot

“…Stimulation of this model with lipopolysaccharide/interferon-γ resulted in mucus over-production, higher pro-inflammatory cytokine release and loss of intestinal barrier integrity due to increased permeability. …”
Get full text

Effects of different doses of remimazolam on the quality of sedation and cardiac function in elderly patients: a double-blind randomised controlled study by Liu Minghong, Qizhu Feng, Huichun Chen, Ju Li, Jun Shi

“…The blood pressure, heart rate, BIS values, cardiac function before induction (T0), after induction (T1) and after intubation (T2), as well as the length of loss of consciousness, duration of sedation, and extubation and adverse events were recorded.ResultsAt T1 and T2, systolic and diastolic blood pressure in Group M were lower than those in Group L, but higher than those in Group H, with statistically significant differences (P < 0.05). …”
Get full text