IOP-lowering therapy and ocular surface in glaucoma. Part 1. The effects of drug substances of glaucoma medications on the ocular surface by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy

“…Dose- and exposition-dependent loss of goblet cells, corneal epithelial toxicity, meibomian gland dysfunction, increased activity and expansion of fibroblasts, and pro-inflammatory cytokine release from goblet cells account for the development and progression of symptoms and signs of dry eye as demonstrated by progressive deterioration in Ocular Surface Disease Index (OSDI), Norn’s test, and Schirmer’s test. …”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…In vitro, rat brain microvascular endothelial cells and astrocytes were stimulated with serum from the sepsis model rats. The loss of MAF1 protein levels and the molecular mechanisms leading to cell damage were investigated. …”
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OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review by Cristian Metrangolo, Simone Donati, Marco Mazzola, Liviana Fontanel, Walter Messina, Giulia D’alterio, Marisa Rubino, Paolo Radice, Elias Premi, Claudio Azzolini

“…Neovascular AMD (nAMD) is responsible for the majority of cases of severe visual loss in eyes with AMD. Optical coherence tomography (OCT) is the most widely used technology for the diagnosis and follow-up of nAMD patients, which is widely used to study and guide the clinical approach, as well as to predict and evaluate treatment response. …”
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A Fine-Grained Aircraft Target Recognition Algorithm for Remote Sensing Images Based on YOLOV8 by Xiao-Nan Jiang, Xiang-Qian Niu, Fan-Lu Wu, Yao Fu, He Bao, Yan-Chao Fan, Yu Zhang, Jun-Yan Pei

“…Initially, this article designs a local detail feature module to tackle the problem of information loss in shallow networks. This module enhances the capture of semantic information while extracting shallow features, thereby preserving more fine-grained features and improving the network's feature extraction capability. …”
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Mapping Drug-Resistant Tuberculosis Treatment Outcomes in Hunan Province, China by Temesgen Yihunie Akalu, Archie C. A. Clements, Zuhui Xu, Liqiong Bai, Kefyalew Addis Alene

“…The outcome variable, the proportion of poor treatment outcomes, was defined as a composite measure of treatment failure, death, and loss to follow-up. Sociodemographic, economic, healthcare, and environmental variables were obtained from various sources, including the WorldClim database, the Malaria Atlas Project, and the Hunan Bureau of Statistics. …”
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The prevention opportunities of retinopathy in diabetic patients – position paper endorsed by the Polish Lipid Association by Maciej Banach, Stanisław Surma, Grzegorz Dzida, Jacek Jóźwiak, Bogusław Okopień, Jacek Rysz, Konrad Szosland, Andrzej Grzybowski

“…If not treated well it might result in the need for eye surgery or even vision loss. Fenofibrate has had a long history of evidence suggesting its preventive role in primary and especially secondary prevention of retinopathy, what has been investigated since the FIELD trial 19 years ago. …”
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Advancements and challenges in agriculture: a comprehensive review of machine learning and IoT applications in vertical farming and controlled environment agriculture by Binoy Sasmal, Gobinda Das, Preeti Mallick, Sneha Dey, Suman Ghorai, Subrata Jana, Chiranjibe Jana

“…Regardless of soil pollution, water pollution, land pollution, energy loss, climatic conditions, electricity waste, and transportation costs, another option will be better for the food production industry. …”
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Randomised, multicentre, placebo-controlled trial of fenofibrate for treatment of diabetic macular oedema with economic evaluation (FORTE study): study protocol for a randomised co... by Gerald Liew, Paul Mitchell, Bamini Gopinath, Helen Nguyen, Richard Kha

“…If left untreated or inadequately treated, DMO can lead to irreversible vision loss and blindness. Intravitreal injections using antivascular endothelial growth factor (anti-VEGF) and laser are the current standard of treatment for DMO. …”
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Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers by Kiki W. K. Kuijpers, Karl Andersson, Karl Andersson, Maria Winkvist, Marieke Niesters, Monique van Velzen, Fred Nyberg, Albert Dahan, Markku D. Hämäläinen

“…Videos captured by smartphones at ~50 lux and ~ 500 lux documented the eye’s reaction before and after controlled intake of single doses of oral oxycodone (20 mg), lorazepam (2 mg), lisdexamphetamine (70 mg) and inhaled cannabis flos (65 mg with 22% THC) over a 5-h test period. …”
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Probabilistic prediction of aero engine remaining useful life based on Bayesian graph attention transformer by Yanyan HU, Yating BAI

“…Optimal approximate distribution parameters are obtained by minimizing the Kullback–Leibler divergence between the real posterior and approximate distributions. Consequently, the loss function of the proposed model network consists of two parts: minimum mean square error, which reflects the distance between the predicted remaining useful life and the actual remaining useful life, and distribution approximation error measured by Kullback–Leibler divergence. …”
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Using large language models for extracting stressful life events to assess their impact on preventive colon cancer screening adherence by Dmitry Scherbakov, Paul M. Heider, Ramsey Wehbe, Alexander V. Alekseyenko, Leslie A. Lenert, Jihad S. Obeid

“…Stressful life events, such as divorce, marriage, or sudden loss of job, have a unique position among the social determinants of health. …”
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Photodegradation of norfloxacin adsorbed on clay and carbon-clay nanomaterials: an evaluation based on antimicrobial tests by Zelaya-Soulé, María Emilia, Horue, Manuel, Torres Sánchez, Rosa María, Castro, Guillermo Raúl, Mártire, Daniel Osvaldo, Fernández, Mariela Alejandra, Arce, Valeria Beatriz

“…The IP treatment caused a loss of antibiotic activity in all cases. For DP, the carbon samples showed better results than those of clay, evidencing the importance of oxygenated carbonaceous groups in the photolysis of norfloxacin.…”
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Effect of Plant Extract on Vase Life in Gerbera var. Pre Intenzz by B. V. Vinithbabu, S. P. Preetham, B. C. Patil, M. P. Naveen, J. S. Hiremath, G. Kirankumar, A. Prashantha

“…Among the effect of plant extract on gerbera flowers held in vase solution containing 8-HQS @ 0.8% (Standard check) recorded the longest vase life (11.54 days), cumulative uptake of vase solution (CUV) of 31.72 g days-1, cumulative transpiration loss of vase solution (CTL) of 40.86 g days-1, minimum microbial load 2.92 cfu×10-5 which was on par with Ocimum sanctum @ 5.0% recorded the longest vase life (11.00 days), CUV of 30.82 g days-1, CTL of 39.66 g days-1, minimum microbial load 3.15 cfu×10-5. …”
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Y2O3NPs induce selective cytotoxicity, genomic instability, oxidative stress and ROS mediated mitochondrial apoptosis in human epidermoid skin A-431 Cancer cells by Hanan RH Mohamed, Shrouk H.A Hemdan, Ahmed A. El-Sherif

“…This selective cytotoxicity appears to be associated with Y2O3NPs’ ability to induce excessive ROS production and subsequent oxidative stress, leading to significant genomic DNA fragmentation, loss of mitochondrial permeability, and alterations in apoptotic and mitochondrial genes’ expression, ultimately promoting apoptosis in A-431 cancer cells. …”
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Lung-delivered IL-10 therapy elicits beneficial effects via immune modulation in organic dust exposure-induced lung inflammation by Aaron D. Schwab, Todd A. Wyatt, Amy J. Nelson, Angela Gleason, Rohit Gaurav, Debra J. Romberger, Jill A. Poole

“…The results showed that IL-10 treatment reduced ODE (25%)-induced weight loss by 66% and 46% at Day 1 and Day 2 post-exposure, respectively. …”
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Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema by Lorraine T. Dean, Anagha Kumar, Taehoon Kim, Matthew Herling, Justin C. Brown, Zi Zhang, Margaret Evangelisti, Renata Hackley, Jiyoung Kim, Andrea Cheville, Andrea B. Troxel, J. Sanford Schwartz, Kathryn H. Schmitz

“…Tailoring physical activity and weight loss interventions designed to address BCRL severity by resource rather than race should be considered.…”
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Changes in the visual analyzer occurring as a result of space flight by M.A. Valyakh, N.G. Baeva

“…Also, velvet-like exudates were ophthalmoscopically revealed and visual field loss was recorded. National scientists have reported a varying severity of optic nerve swelling in astronauts after long space missions.…”
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A Cross-Stage Focused Small Object Detection Network for Unmanned Aerial Vehicle Assisted Maritime Applications by Gege Ding, Jiayue Liu, Dongsheng Li, Xiaming Fu, Yucheng Zhou, Mingrui Zhang, Wantong Li, Yanjuan Wang, Chunxu Li, Xiongfei Geng

“…Finally, to enhance the model’s robustness, WIoUv2 loss function was employed, ensuring a balanced treatment of positive and negative samples. …”
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Assessing Durability and Stability of Calcium Sulfoaluminate Cement-Stabilized Soils Under Cyclic Wet–Dry Conditions by Ayesha Rauf, Sung-Woo Moon, Alfrendo Satyanaga, Jong Kim

“…The findings indicate that after seven W–D cycles, the UCS value of 10% cemented samples dropped by 14% after 28 days of curing, whereas 3% specimens experienced a 28% loss in strength. Similarly, UCS values for 5% and 7% cement content reduced from 666 kPa to 509 kPa and from 1587 kPa to 1331 kPa, respectively, indicating improved resilience with higher CSA content. …”
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Transcriptome and weighted gene co-expression network analysis of jujube (Ziziphus jujuba Mill.) fruit reveal putative genes involved in proanthocyanin biosynthesis and regulation by Wenqiang Wang, Yunfeng Pu, Hao Wen, Dengyang Lu, Min Yan, Minzhe Liu, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…Transcriptome analysis revealed that the differentially expressed genes (DEGs) were mainly enriched in ribosome, glycolysis/gluconeogenesis, fructose and mannose metabolism. 17 DEGs encoding PAL, CHS, CHI, CHS, F3’H, LAR, ANR, C4Hs, 4CLs, FLSs, DFRs and UFGTs involved in PA biosynthesis were relatively abundant. …”
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